Author Topic: POIS paper treatment summary  (Read 1268 times)

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
POIS paper treatment summary
« on: October 24, 2020, 01:54:09 PM »
All patients who tried treatment have been filtered from articles. Some articles lack data such as dose, symptom reduction or drug name.
Click here for a detailed treatment summary based on experiences from the community.
Table format doesn't present itself properly on mobile devices. Keeping the rough version below the table intact.
A#= Article number based on POIS paper thread
P#= Amount of patients that have tried treatment (multiple 1s for the same paper means different cases. #F= female included)
Yes= Benefit, needs context, doesn't tell you anything about efficacy.
No= No benefit. A 'No' without a patient number at the left side means the same patient as the 'Yes' above it.
Let me know if you think this thread can be improved in some ways or if you see any mistakes.
Note to editors: Adjustments of numbers in paper thread need to be adjusted here as well (first column).

Version 0.9

A#P#Y/N
Treatment
11YesBenzodiazepine+SSRI: Paroxetine+Citalopram: Mental state only, partial relief
NoAntihistamines (pre and post O), prednisone (pre and post O), NSAA: flutamide (max=3x early morning LH): Lower libido
1NoNSAA: Flutamide (max=3x early morning LH): Lower libido
21YesNorethisterone (oral tablets 5 mg 30 min pre O): 95% relief, additional 5 mg tablets daily following 2 days post O for residual symptoms. Occasionally 10 mg within a few mins post O: 100% relief.
NoProgesterone 8% cream (daily, around nostrils and upper lip), Dopamine agonist: bromocriptine (2.5 mg daily)
31YesNSAID: Diclofenac (75 mg 1-2 hours pre O and continue twice daily for 24-48h post O): 80% relief.
1YesTadalafil: Improvement of rapid ejaculation and erectile dysfunction leads to (better) ability to penetrate female partner and reduction of symptoms.
No Same trial of NSAID: Diclofenac as patient above.
5Autologous defrosted semen intracutaneously inoculated at the volar side of the left forearm. Harvested semen samples were defrosted at room temperature and diluted with saline 0.9%. In addition, 0.05 ml of each dilution was IC injected. Skin reactions were interpreted at 15 minutes after IC injection. Titrations were performed according to local skin reaction postinoculation, aiming at a wheal and flare response of 3+.

This score was intentionally maintained for a period of at least 2 years. Practically, concentrations of semen were periodically increased at a score of 2+ or less. Oppositely, in case the score exceeded 3+, semen concentrations were lowered. Wheal erythema of 21–30 mm = 2+, erythema of 31–40 mm = 3+, wheal > 15 mm or pseudopodia and erythema of >40 mm = 4+. Each session was planned every 2 weeks for the first year and followed by once a month in the second and third year.
1YesHyposensitization: Relief 60% intensity reduction (cognitive +physical) from 4 days to 48 hours, Lifelong PE: IELT went from 10s to 5-10 min.The inoculation (titer: 1 on 40,000) disclosed a wheal and flare reaction grade 4+, and was associated with the induction of mild POIS complaints. Initially, dilutions of 1:40,000 were applied and titers were gradually increased to 1 on 20 during a period of 31 months. After 8 months 1:6 was reached and at 14 months 1:3. Total length of treatment: 3 years.
1YesHyposensitization. Relief: 90%,  nearly complete disappearance of POIS. The inoculation (titer: 1 on 40,000) disclosed a wheal and flare reaction grade 4+. Initially, dilutions of 1 on 20,000 were applied and titers were gradually increased to 1 on 280 during a period of 15 months.
71NoNSAIDs and cetirizine
91NoIbubrofen (400 mg on demand), tramadol (50 mg one hour pre-coitally), selective serotonin re-uptake inhibitor (escitalopram 10 mg daily at bedtime for 3 months).
141YesThe patient received strong analgesic TRAMADOL and anti histamine LORASTIN to be taken shortly after intercourse , he reported some benefit.
161YesFlooding
181NoSerotonergics, Benzodiazepines
1YesNeuroleptics (olanzapine, aripiprazole), Antihistamines (cetirizine, loratadine,ebastine, mequitazine), Nicotinamide, Biperiden, Association "ambenonium chloride + lecithinsoy ".
NoNeuroleptics (amisulpride, haloperidol), Food supplements (Omega 3 and Mg).
1NoAntihistamines (cetirizine), Alpha-blocker, Relaxation
211YesSymptoms improved occasionally with analgesics
221YesHyposensitization: intralymphatic immunotherapy (ILIT), Relief. Using ultrasound guidance and a 25-gauge needle, autologous semen was aseptically injected into an inguinal lymph node at a dilution of 1:40,000. Then, the concentration was increased by 3-fold.
261NoHyposensitization: The patient was submitted to immunotherapy, and although he presented an improvement of symptoms in the first year of treatment, he quit immunotherapy after two years because the symptoms returned.
281Yes
  • hCG: raising serum testosterone (T), in this case via subcutaneous injections of human chorionic gonadotropin (hCG). Relief: near-complete resolution of symptoms. Treatment was initiated with hCG 1500IU injected subcutaneously three times per week. At six-week follow-up his symptoms had resolved completely. Continued hCG after 6 months. Patient had T deficiency.
  • Adderall provided some benefit for the brain fog.
  • Anxiety, treated with propranolol
  • Alprazolam provided minor benefit.
NoHe tried various diets, supplements, niacin, and antihistamines without benefit. Bupropion, and Vyvanse (lisdexamfetamine dimesylate).
291Yes
  • The patient has a history of irritable bowel syndrome (IBS) well-controlled on loperamide.
  • Trial of cetirizine, after 4 weeks (orgasm once per week): significant improvement in abdominal cramping and reduction of diarrhea
  • Trial of terazosin, followed by several months of alfuzosin: He reported significant improvement of all symptoms on both alpha-blockers. Decided to discontinue alpha-blockers due to dizziness and significant erectile dysfunction.
  • Self-started a probiotic containing Bacillus coagulans and fructooligosaccharide (not taking an antihistamine or alpha-blocker), which he reported improved his symptoms further
NoDiphenhydramine
331FYesIn addition to oral contraceptive (1) to (6) (order of events).
  • (1)After 2 months on 2 mg dienogest, post-orgasm pain decreased; however, the patient was experiencing adverse effects including worsening migraines, acne, and joint pain. Furthermore, her sexual desire had decreased.
  • (4)Transcutaneous electrical nerve stimulation (TENS) had a small but insufficient benefit.
  • (5) 3 months 150 mg GnRH antagonist (elagolix) daily, post-orgasmic pain relief without side effects while maintaining constant estradiol levels.
  • (6) Doubling the dose to 300 mg for ~ 2 months elimated pain but introduced tolerable side effects. Clinical response remained stable 12 months after starting elagolix.
No
  • (2) 1 month of 2.5 mg of norethindrone acetate.
  • (3)Did another trial of dienogest but benefit of dienogest was decreasing over
    time; she also had noticed a 10-pound weight gain.
  • (5) 10 mg of vaginal baclofen combined with 150 mg of gabapentin.
3514Y/NFlow diagram of treatment. All 14 patients start at 1: 1-->2-->3
  • 7/14*: 8 mg Silodosin, a highly selective alpha1A-blocker, 2 h before sexual activity. Relief: Completely prevents POIS symptoms. Causes anejaculation. * (effectively 8/14) 1 stopped due to side effects.
  • 2/7: NSAID: Ibuprofen 400 mg, twice a day starting 2 h before sexual activity, for 2 days. Relief: Improvement, no # given.
  • 4/5: Glucocorticoid: Prednisone, 30 mg, taken 2 h before sexual activity and continued with 20 mg the day after.
1/14: Unresponsive to all of the above.
361YesNSAID: diclofenac 25 mg twice a day, according to article 3. Oral administration of celecoxib 100 mg once a day was as effective as diclofenac. Relief: symptoms disappeared completely.
NoAntihistamines and herbal medicines.
371YesNSAID Celecoxib 200 mg was administered daily just after ejaculation. Immediately after the intake of the drug, headache and muscle pain were relieved, and the patient was able to ejaculate 3 days per week. However, general fatigue did not improve. In addition to NSAIDs, 250 mg of testosterone enanthate was administered as a TRT every 2 weeks because the patient's serum free testosterone level was lower than 70% of the average value in young adult men. His general fatigue significantly improved, and morning erection has been achieved every day. Therefore, he can ejaculate everyday by masturbation. The interval of drug administration was changed from 2 to 4 weeks. However, no recurrence of symptoms was observed. TRT was switched to testosterone ointment (Glowmin®; Daito Pharma, Tokyo, Japan), and his symptoms continually improved.
NoAntihistamines
381YesSertraline 100 mg a day for 6 weeks. Relief: Improved anxiety, diminished sexual desire. Post-orgasm symptoms have reduced in severity by 50% and now last 2-3 days (was 5 days).
1YesDoxycycline (an antibiotic) for 6 weeks. He feels there may be marginal improvement in his symptoms having orgasmed once in that period.
NoHigh-dose levocetirizine (an antihistamine), nicotinamide and progesterone.
39154Y/NOnline survey (N=302 men). Respondents reporting improvement in symptoms with:
Niacin: 19 of 25 (76%)
Nonsteroidal anti-inflammatory medications (NSAIDs): 17 of 23 (74%)
Antihistamine: 44 of 90 (50%)
Selective serotonin reuptake inhibitors (SSRI): 18 of 47 (38%)
Benzodiazepines: 9 of 33 (27%)

==========================================================
==========================================================

Treatment compilation of other conditions

Let me know if you find treatment compilations of other conditions which are based on literature or found better alternatives for the ones below. I will add them. Preferably one link per condition/disease.

Anxiety

Chronic Fatigue Syndrome(CFS)/Myalgic Encephalomyelitis(ME) (1), (PEM)

Ehlers-Danlos Syndromes (1)

Irritable Bowel Syndrome

Mast Cell Activation Disease

Osteoporosis

Postural Orthostatic Tachycardia Syndrome (1)

Small Intestinal Bacterial Overgrowth (SIBO)

Viral Infection (1)

Find treatment that targets the vagus nerve: "Treatments that target the vagus nerve increase the vagal tone and inhibit cytokine production"

==========================================================
==========================================================

Method of POIS relief central hub

Please help me out by locating threads from other members. Place a comment when your method needs to be updated.

POIScenter

abud (Neck Massage)
alex372 (Mountain honey + 5mg nortriptyline)
Animus (Castration, Video)
anon7022 (Antihistamine: Allegra)
Arun (Betablocker: Propranolol)
asdfdoc (Doctor's best REAL niacin timed release 500mg, minimal flushing, with focalin)
Berlin1984 (no masturbation only sex 1-2h before sleep, Bcomplex, Magnesium, L-theanine, Ashwagandha, Rosea Rhodiola, Tribulus Terestris)
Bizzy (Antihistamines, Doxepin)
b_jim (Taurine)
bletzer (Keto/carnivore diet)
Bob Morane (Non-systemic antibiotic: Rifaximin, probiotics, diet, stress reduction)
Buckaroobanzai88 (Prednisone, vitamine D)
Bulbo (Eggs)
cg83 (100 mg hydroxyzine and 60 mg sudafed)
CharlesB (Pepto Bismol)
Copperred (Picamilon)
CuriousCharacter (Modified POIS cascade stack)
David (TRT)
Daysleeper (Pumping the glands technique)
deloun (Boswellia serrata)
Demografx (TRT + benadryl for forced sleep)
doxepin (Doxepin)
Dusak92 (Niacin)
eccentricbipois (Antihistamines: Hydroxyzine and Loratadine)
Egordon (Celebrex, Niacin)
emirnazim (Mestinon(pyridostigmine, acetylcholinesterase inhibitor))
Erik (Red wine, some supplements and lifestyle)
fathom (Sam-e, Alpha-GPC/PhosphatadylCholine, EPA/DHA, Multi-vitamin, benadryl, Que, Bromelain, Vyvanse ,Gabapentin)
FernandoPOIS (Huge protocol, vagus nerve, allergy, spinal problems)
findacure (Ibuprofen and Loratadine)
FloppyBanana (Iceman breathing, Mytelase/Mestinon, progesterone)
Fox (Gluten-free diet)
fsol (Quantum's pre-pack)
G (TRT)
Going less Crazy (Modified AIP diet, 100%)
Green (Testosterone, Fexafenodine, Paroxitine, Tramadol, Niacin)
guy26 (Androgel >> GnRH antagonist:leuprolide acetate > depo provera)
Heather1111 (TRT)
happy2 (Antihistamine regime, Benadryl, Claritin, Zyrtec)
himanshu (Norethisterone)
holas (Physalis golden berries)
Hopeful Indian (Yoga)
Hopeoneday (Coffee, dose dependent)
hurray (Brainfog: Milnacipran)
IronFeather (Intense sweating, intense exercise)
Itsmel (Cromolyn)
Jacob (Psychotherapy, hypnotherapy, holotrophic breathing, meditation)
Jake81 (Benadryl)
john21 (Taurine, Pepto Bismol)
jotape_chile (Escitalopram)
Laotzu1980 (Diazepam (Valium))
Legendary Animal (Coffee)
Limitbreaker (Low dose Naltrexone with a bit of TRT)
lw (Diet, antibiotic, Yoga, stress control)
Mark (Niacin and massage)
melt (Massive protocol)
Monte (Calcium and more)
Moses (Physalis golden berries)
Muon (hyposensitization therapy)
nanna1 (POIS Cascade stack, Betaherpesvirinae stack)
Nas (Dexamethasone)
Nas.Car (Serenoa repens)
Nightingale (Neuroprotek)
Observer (Niacin protocol)
Olaf (CBD oil, Diclofenac also works)
Orlands (2 Gallons of water and Himalayan salt a day)
Outsider (Mytelase, cholinesterase inhibitor)
Physi (Physalis golden berries)
pois1 (Hyposensitization therapy)
POIS_DICK (Methylene blue)
POISrival (Acyclovir (zovirax), lamivudine)
Prospero (Ixprim : Paracetamol 325 mg + Tramadol 37,5 mg taken directly after O)
Qiao (Tension releasing exercises)
Quantum (Diet, exercise/yoga, abstaining, psychotherapy, mast cell stabilizers, 5-HTP and more)
Quasar (Tonsillectomy, antibiotic, Nolotil (Metamizol) and Paracetamol for pain. What fixed his POIS?)
redapples (Apples, red delicious)
Ricardo Brasil (Garlic: Brain fog)
Rinat (Niacin, methionin)
romies (prepack:5HTP, Que, curc, NAC, celebrex)
Saved (30ug thyroxine before sleeping, and 50ug selenium in the morning)
sop (Smoking Cannabis)
swell (Diet, Beef thyroid glandular, VitC, flavonoids, TMG, Sam-e, Carbonyl Iron, Glutathione, Butyric acid)
Syil (Adrenal boosting yoga)
Tantalus (Hyposensitization/desensitization therapy, 4 years, health progr. average 70%  top 90%)
ThisType (phosphatadylcholine, exercise, choline food)
tom (Certain strain of Cannabis)
Tryingtomakeitwork2 (L theanine for premature ejaculation)
UnderstandingPois (prozac, vit d, calcium, magnesium, ENERGIZE by ISATORI)
Vandemolen (hyposensitization therapy, CBD oil (need link))
Vincent M (Personal protocol)
vinred (Claritin (Combination of: Pseudoephedrine, Loratadine))
Wolf (Diphenhydramine Hydrochloride Tablets)
yesyesyes (Drotaverine, selective inhibitor of phosphodiesterase 4 (PDE4))

Anonymous member 1 (Cabergoline, HCG and testosterone)

REDDIT

Akt1 (I use loratadine 10 mg one hour before O. that has worked well for me. But ginger and/or hemp tea before O also worked)
dexpois (Diet and sunlight)
I_BELIEVE_IT_FAM (Mega dose Vitamin D3)
ijustwanttofunction (875mg of Amoxicillin every 12 hours for 8 days, Probiotica 7, for NE:Prozac+ Benzodiazepine)
jjdoe6 (DNRS, diet, probiotics, Claritin 1x day, Zantac 2x a day, Cromolyn Sodium 30mins before eating)
Kurtosis (low FODMAP+VSL3, diet, vitamins+flavonoids, fatty acids)
ronyrockford (Vitamin D)
YemAli (Deltacortil, Taking it 4 hours before O. Started of with two tablets, then increased to three because two wasn’t doing it enough, slowly tapering it off by 1/3 of the medicine after 15 times of doing it. The tablet is 5 mg. + Montelukast sodium + esomeprazole magnesium delayed release)

NAKEDSCIENTISTS FORUM

drmmeha (Get rid of stress sources, stop masturbating with hand, exercise, supplements mg, ca, zn)
duke0knight (Yoga + some herbs)
EDS (Flush type Niacin 100 mg on empty stomach an hour before O, TRT (stopped due to side effects))
Tired of this (Niacin 100 minutes before an O)
Willem (Sublinqual hyposensitization therapy, Treatment process)

==========================================================
==========================================================

Various

Filter out treatments from the summary of treatment thread: https://poiscenter.com/forums/index.php?topic=75.0

All members' experiences with fenugreek: http://poiscenter.com/forums/index.php?topic=1057.msg9548#msg9548

All members' experiences with Vitamin B Complexes: http://poiscenter.com/forums/index.php?topic=1059.msg9571#msg9571

All members' experiences with antihistamines: http://poiscenter.com/forums/index.php?topic=1060.msg9574#msg9574

And lastly all members' experiences with saw palmetto: http://poiscenter.com/forums/index.php?topic=1061.msg9577#msg9577

Boosting Testosterone naturally

Nanna1's stacks: Immune competence therapy, POIS cascade and Betaherpesvirinae stack

Other stacks to be added.

==========================================================
==========================================================

Dietary intervention

List of diets (wikipedia)

Low histamine diet; food compatibility list

Low-Antigen-Content Diet (LAC-diet)

https://www.siboinfo.com/diet.html :
 
SIBO bi-phasic diet (B-PD)
Specific Carbohydrate Diet (SCD)
Gut And Psychology Syndrome Diet (Gaps diet)
Low FODMAP Diet (LFD) (Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols)
Cedars-Sinai Diet (C-SD)

Elemental Diet

Autoimmune Paleo diet (AIP)

anti-inflammatory diet (ITIS diet)

Mediterranean diet (1, 2, 3, 4, 5)

Find links for:

Carnivore diet
Keto Diet
Low-sulphur diet
Lectin free diet
Vegan Diet

==========================================================
==========================================================

Products used by members
Share the products you are using in the comments.

==========================================================
==========================================================

Cost/availability of medicine per country

Let me know if you have found a website that shows the cost/availability of medication in your country.

The Netherlands
« Last Edit: Today at 06:27:30 PM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #1 on: November 04, 2020, 04:01:17 AM »
ROUGH VERSION:

Article 1

Patient 1
Yes: Benzo+SSRI: Paroxetine+Citalopram(dose?): Mental state only partial relief
No: antihistamines (pre and post O), prednisone (pre and post O), NSAA: flutamide (max=3x early morning LH): Lower libido

Patient 2
No: NSAA: Flutamide (max=3x early morning LH): Lower libido

Article 2

Yes: Norethisterone (oral, 5 mg 30 min pre O): 95% relief, additional 5 mg tablets daily following 2 days post O for residual symptoms.
Occasionally 10 mg within a few mins post O: 100% relief.
No: Progesterone 8% cream (daily, around nostril and upper lip), Dopamine agonist: bromocriptine (2.5 mg daily)

Article 3

Patient 1
Yes: NSAID: Diclofenac (75 mg 1-2 hours pre O and continue twice daily for 24-48 post O): 80% relief.

Patient 2
Yes: Tadalafil: Improvement of rapid ejaculation and erectile dysfunction leads to (better) ability to penetrate female partner and reduction of symptoms.
No: Same trial of NSAID as patient 1.

Article 5

Autologous defrosted semen intracutaneously inoculated at the volar side of the left forearm. Harvested semen samples were defrosted at room temperature and diluted with saline 0.9%. In addition, 0.05 ml of each dilution was IC injected. Skin reactions were interpreted at 15 minutes after IC injection. Titrations were performed according to local skin reaction postinoculation, aiming at a wheal and flare response of 3+. This score was intentionally maintained for a period of at least 2 years. Practically, concentrations of semen were periodically increased at a score of 2+ or less. Oppositely, in case the score exceeded 3+, semen concentrations were lowered. Wheal erythema of 21–30 mm = 2+, erythema of 31–40 mm = 3+, wheal > 15 mm or pseudopodia and erythema of >40 mm = 4+. Each session was planned every 2 weeks for the first year and followed by once a month in the second and third year.

Patient 1
Yes: Hyposensitization: Relief 60% (cognitive +physical) and shorter duration. Hyposensitization: The inoculation (titer: 1
on 40,000) disclosed a wheal and flare reaction grade 4+, and was associated with the induction of mild POIS complaints. Initially, dilutions of 1:40,000 were applied and titers were gradually increased to 1 on 20 during a period of 31 months. After 8 months 1:6 was reached and at 14 months 1:3. POIS went from 4 days to 48 hours while intensity reduction 60%. Total length of treatment: 3 years. Lifelong PE: IELT went from 10s to 5-10 min.

Patient 2
Yes: Hyposensitization. The inoculation (titer: 1 on 40,000) disclosed a wheal and flare reaction grade 4+. Initially, dilutions of 1 on 20,000 were applied and titers were gradually increased to 1 on 280 during a period of 15 months. Relief: 90%, nearly complete disappearance of POIS.

Article 7

No: NSAIDs and cetirizine
?: Recommended oral prednisone, no comment if it had any effect.

Article 8

?: A low dose Amitryptyline was prescribed along with Jacobson’s progressive muscular relaxation was done. He was prescribed Salbutiamine [Arcalion] for symptomatic relief from fatigue.

Article 9

No: Ibubrofen (400 mg on demand), tramadol (50 mg one hour pre-coitally), selective serotonin re-uptake inhibitor (escitalopram 10 mg daily at bedtime for 3 months).

Article 14

Yes: The patient received strong analgesic TRAMADOL and anti histamine LORASTIN to be taken shortly after intercourse , he reported some benefit.

Article 16

Yes: Flooding

Article 18

Patient 1
No: Serotonergics, Benzodiazepines

Patient 2
Yes: Neuroleptics (olanzapine, aripiprazole), Antihistamines (cetirizine, loratadine,ebastine, mequitazine), Nicotinamide, Biperiden, Association "ambenonium chloride + lecithinsoy ".
No: Neuroleptics (amisulpride, haloperidol), Food supplements (Omega 3 and Mg).

Patient 3
No: Antihistamines (cetirizine), Alpha-blocker, Relaxation.

Article 19 (Female only, recommendations)

Seizures (Orgasmolepsy): anti-epileptics
Headache (Coital Cephalalgia): beta?blockers and/or antimigraine medication. In patients who do not improve on these medications, indomethacin or a calcium channel antagonist such as verapamil can be tried. Anticonvulsants such as topirimate can be successful in some cases that are otherwise resistant to treatment.

Sneezing:antihistamines, nasal decongestants, and nasal anesthetics.
Muscle Weakness/Paralysis (Cataplexy): It may be that use of amphetamine, dextroamphetamine mixed salts, 2.5–10mg taken 30 minutes prior to sexual activity may help these patients as the pharmacologically mediated heightened adrenergic activity may counteract the cataplexic symptoms.

Peripheral Aversive Symptoms:
Genital Pain (Dysorgasmia): Reports claim low dose tricyclic antidepressant amitriptyline (50mg) can be helpful. If abnormal, magnetic resonance imaging of the sacral and lumbar spine should be considered. If pathology is noted, a focal epidural steroid and local anesthesia nerve block is likely to reveal diminution of distracting genital pain wth orgasm (dysorgasmia) symptoms.
Facial/Ear/Foot Pain: successful treatment involved a sympathomimetic agent to counteract the reduced post-orgasmic sympathetic nervous system activity.

Article 21

Yes: Symptoms improved occasionally with analgesics

Article 22 (needs editing, more details)

Yes: Hyposensitization: intralymphatic immunotherapy (ILIT), Relief. Using ultrasound guidance and a 25-gauge needle, autologous semen was aseptically injected into an inguinal lymph node at a dilution of 1:40,000. Then, the concentration was increased by 3-fold.


Article 26

Yes/No: The patient was submitted to immunotherapy, and although he presented an improvement of symptoms in the first year of treatment, he quit immunotherapy after two years because the symptoms returned.

Article 28

Yes: hCG: raising serum testosterone (T), in this case via subcutaneous injections of human chorionic gonadotropin (hCG). Relief: near-complete resolution of symptoms. Treatment was initiated with hCG 1500IU injected subcutaneously three times per week. At six-week follow-up his symptoms had resolved completely. Continued hCG after 6 months. Patient had T deficiency.
Adderall provided some benefit for the brain fog. He was under the care of a psychiatrist for anxiety, treated with propranolol. Alprazolam provided minor benefit.
No: He tried various diets, supplements, niacin, and antihistamines without benefit. Bupropion, and Vyvanse (lisdexamfetamine dimesylate).

Article 29

Yes: The patient has a history of irritable bowel syndrome (IBS) well-controlled on loperamide.
Trial of cetirizine, after 4 weeks (orgasm once per week): significant improvement in abdominal cramping and reduction of diarrhea.
Trial of terazosin, followed by several months of alfuzosin: He reported significant improvement of all symptoms on both alpha-blockers. Decided to discontinue alpha-blockers due to dizziness and significant erectile dysfunction.
Self-started a probiotic containing Bacillus coagulans and fructooligosaccharide (not taking an antihistamine or alpha-blocker), which he reported improved his symptoms further.

No: Diphenhydramine

Article 33 (female)

In addition to oral contraceptive (1) to (6) (order of events).

Yes: (4)Transcutaneous electrical nerve stimulation (TENS) had a small but insufficient benefit. (5) 3 months 150 mg GnRH antagonist (elagolix) daily, post-orgasmic pain relief without side effects while maintaining constant estradiol levels. (6) Doubling the dose to 300 mg for ~ 2 months elimated pain but introduced tolerable side effects. Clinical response remained stable 12 months after starting elagolix.

Mixed: (1)After 2 months on 2 mg dienogest, post-orgasm pain decreased; however, the patient was experiencing adverse effects including worsening migraines, acne, and joint pain. Furthermore, her sexual desire had decreased.

No:(2) 1 month of 2.5 mg of norethindrone acetate. (3)Did another trial of dienogest but benefit of dienogest was decreasing over
time; she also had noticed a 10-pound weight gain. (5) 10 mg of vaginal baclofen combined with 150 mg of gabapentin.

Article 35

Flow diagram of treatment. All patients (14) start at 1. (1)-->(2)-->(3)
(1) 7/14*: 8 mg Silodosin, a highly selective alpha1A-blocker, 2 h before sexual activity. Relief: Completely prevents POIS symptoms. Causes anejaculation.
(2) 2/7:  NSAID: Ibuprofen 400 mg, twice a day starting 2 h before sexual activity, for 2 days. Relief: Improvement, no # given.
(3) 4/5: Glucocorticoid: Prednisone, 30 mg, taken 2 h before sexual activity and continued with 20 mg the day after.
1/14: Unresponsive to all above.
* (effectively 8/14) 1 stopped due to side effects.

Article 36

Yes: NSAID, diclofenac 25 mg twice a day, according to article 3. Oral administration of celecoxib 100 mg once a day was as effective as diclofenac. Relief: symptoms disappeared completely.

No: Antihistamines and herbal medicines.

Article 37

Yes: Celecoxib 200 mg, which is an NSAID, was administered daily just after ejaculation. Immediately after the intake of the drug, headache and muscle pain were relieved, and the patient was able to ejaculate 3 days per week. However, general fatigue did not improve. In addition to NSAIDs, 250 mg of testosterone enanthate was administered as a TRT every 2 weeks because the patient’s serum free testosterone level was lower than 70% of the average value in young adult men. His general fatigue significantly improved, and morning erection has been achieved every day. Therefore, he can ejaculate everyday by masturbation. The interval of drug administration was changed from 2 to 4 weeks. However, no recurrence of symptoms was observed. TRT was switched to testosterone ointment (Glowmin®; Daito Pharma, Tokyo, Japan), and his symptoms continually improved.

No: Antihistamines

Article 38

Patient 1

Yes: Sertraline 100 mg a day for 6 weeks. Relief: Improved anxiety, diminished sexual desire. Post-orgasm symptoms have reduced in severity by 50% and now last 2–3 days (was 5 days).

Patient 2

Yes: Doxycycline (an antibiotic) for 6 weeks. He feels there may be marginal improvement in his symptoms having
orgasmed once in that period.

No: High-dose levocetirizine (an antihistamine), nicotinamide and progesterone.

Article 39

Sample size: 302 men. Just more than half (154, 51%) of respondents have sought treatment from a professional for their POIS symptoms. Treatment efficacy, as defined as sustained subjective improvement of symptoms, varied with 44 of 90 (50%) respondents reporting improvement in symptoms with antihistamine use, 19 of 25 (76%) with niacin, 18 of 47 (38%) with selective serotonin reuptake inhibitors, 17 of 23 (74%) with nonsteroidal anti-inflammatory medications, and 9 of 33 (27%) with benzodiazepines.

Editor section

Reminders:
Article 24, 29 contains recommendations, scrap article 19 recommendations? Make separate section?, scrap question marks? Formatting needs an overhaul. Check T#. Fix size, table codes. Article 26: find [C], made a comment about article 5? Ask doctor about updated treatment protocol. Check syntax errors and check order of med intake. Could add a note about recommendations. Could add links to treatment compilations of related conditions. Reduce amount of text for some articles, bloating.

Suggestions:
annonny2:
"Thanks, might be worth grouping the Yes and nos"
« Last Edit: November 04, 2020, 09:56:48 AM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #2 on: November 04, 2020, 04:03:43 AM »
Reserved 2

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #3 on: November 04, 2020, 04:06:56 AM »
Reserved 3

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #4 on: November 04, 2020, 04:11:49 AM »
Reserved 4

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #5 on: November 04, 2020, 04:18:50 AM »
Reserved 5

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #6 on: November 04, 2020, 04:28:06 AM »
Reserved 6

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #7 on: November 04, 2020, 04:34:21 AM »
Reserved 7

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #8 on: November 04, 2020, 04:40:02 AM »
Reserved 8

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #9 on: November 04, 2020, 04:46:13 AM »
Reserved 9

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #10 on: November 04, 2020, 04:50:09 AM »
Reserved 10
« Last Edit: November 22, 2020, 04:00:04 PM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #11 on: November 22, 2020, 03:59:45 PM »
Reserved Final

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #12 on: November 22, 2020, 04:04:46 PM »
Okay...Let's post links to threads where you explain your method of relief for POIS. I will incorporate them under the 'Method of POIS relief central hub' header. Also post links from other members please. See it as a central hub. Just place them in the comments. Help me out please.
« Last Edit: November 22, 2020, 07:48:27 PM by Muon »

ThisType

  • Jr. Member
  • **
  • Posts: 59
Re: POIS paper treatment summary
« Reply #13 on: November 23, 2020, 08:55:42 PM »
Hi Muon,
Thanks for pulling this together - a link to the latest on my end
https://poiscenter.com/forums/index.php?topic=2486.0

Rough cause for me appears to be genetic (see posts related to CMS)
Thanks!
TT

Muon

  • Hero Member
  • *****
  • Posts: 1697
    • MCAD Thread
Re: POIS paper treatment summary
« Reply #14 on: November 24, 2020, 07:20:23 AM »
Ok added, much appreciated ThisType. If anyone wants to go through the 1000+ pages on Nakedscientist looking for cases describing treatment methods then be my guest, I'm not going to do that. Or perhaps some do remember POISers describing treatment/relief methods on certain pages, in that case dump the links here plz.