Author Topic: Muon's Case  (Read 20571 times)


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Muon's Case
« on: October 15, 2017, 03:06:21 PM »
I will first start showing privately funded test results regarding POIS(?) and will update this post along the way. Click here for time stamps and click here for an overview in table format.

My data:

My brother's data (who has POIS as well):

(I did use free PDF eraser software to delete private info so there is a watermark in the upperleft corner, please respect my privacy)
The only parameters my brother has tested before and after an orgasm were IL-8 and IgE, but these show no change.

Summary of Muon's abnormal parameters (under construction)

Date of testing might be relevant, since the state of the body changes over the years and seasons (Netherlands) affect me as well.

11Beta-Prostaglandin F2 Alpha (24h urine) (H)
Alanine-aminotransferase (H)
Alpha-2-Globulin (L) (needs further differentiation)
Candida Albicans LTT (Very high lymphocyte proliferation)
CD57+ Natural killer cells (L)
Cholesterol (L) (1, 2)
Cytomegalovirus IgG (H)
Cytomegalovirus LTT (Latent)
Epstein-Barr virus recombinant early antigen p138 IgG and p138 IgM (H)
Glucose (L)
Hematocrit (L) (1, 2)
Immunoglobulin G4 (H, exact value unknown due to cut-off limit) (1, 2)
Interleukin-2 (L) (1(L, L, L, N), 2(N), 3(N), 4(L), 5(L))
Interleukin-8 (H) (1, 2, 3, 4, 5)
Leukocytes (L)
Lymphocytes (absolute) (L)
Natural killer cells (L)
TH1/TH2 cytokine balance (H) (1, 2, 3, 4, 5)
Varicella zoster virus IgG (H)
Varicella zoster virus LTT (Latent)

Muon 6-1 Medlon: A collection of tests that were done at one lab. Vitamin D3 (L), B6 (H), B9 (H), Active B12 (H), Phosphate (L), ALAT (H).

Other reports/measurements

Heart rate and blood pressure data (2013)
Body fat percentage (L) (1, 2, 3) (This is not done at a medical clinic but at a local gym)

Summary of my brother's abnormal parameters (under construction)

Brain-derived neurotrophic factor (L) 14.9 ng/ml RR: 18.3 - 31.4 ng/ml
Eosinophil Cationic Protein (H) 34.5 ug/l RR: < 13.3 ug/l
Glucocorticoid receptor activity (L) 1.3 RR: 1.4 - 2.4
Interleukin-8 (H) (23.7, 24.0) RR: < 15 pg/ml
Interleukin 17 (L) 43.9 pg/ml RR: 49 - 446 pg/ml
Immunoglobulin E (H) (129.0, 125.0) RR: < 87.0 kU/l
Lipoprotein-associated phospholipase A2 (Lp-PLA2) (H) 214 nmol/mi/ml RR: < 151 nmol/mi/ml
Serotonin (L) 64.2 ug/ml RR: 80 - 400 ug/ml
Tryptophan (L) 1.10 mg/dl RR: 1.21 - 2.30 mg/dl
Type IV cellular sensitivity response against Rye, hazelnut and peanut 

My brother's genetic related results:

COMT-V158M-Genotyp M/M
MAOA-Gen (30bp-VNTR) Low
BDNF Val66Met-Polymorphismus V/V
Serotonin-Transp.-Promoter PCR Genotyp K/L

Reminder: He had other genetic tests done. Serotonin in serum has been checked multiple times at other hospitals and always turned up low. Ask him about it.

  • Chronic Fatigue Syndrome (Questionnaire+symptoms)
  • Bell's Palsy (left side, EMG)
  • Post Orgasmic Illness Syndrome (Subcutane skin prick+symptoms)
  • Postural Orthostatic Tachycardia Syndrome (>30BPM between supine and standing)
  • A possible Intestinal Bacterial Overgrowth and Lactose intolerance (positive lactose hydrogen breath test)
  • Structural Kyphosis (Cobb Angle = 70 degrees by scans)
  • Blepharitis (2019)
The only diagnose that isn't based on physical data is CFS.

  • Enlarged/swollen left testicle, at age ~19/20 I believe , prior to POIS diagnosis (scan revealed benign thickening)
  • Vitamin D deficiency (range:10-20)
  • Iron deficiency (once, when I was 7 years old, don't have the value)
  • Decreased urinary Sodium levels (Once, happened with onset of heavy POTS symptoms)
  • Elevated ALAT (multiple times)
  • Hypercobalaminemia
  • Lifelong Premature Ejaculation (<10s)
  • 3 Positive subcutane skin pricks with semen of 3 different men (same reaction as my own samples)
  • Calcium hydrogen phosphate stones in stool (analyzed it at local hospital)
  • White bumps/acne on shoulders and back
  • White/yellowish uneveness/spots inside cheek which closely resembles oral fordyce granules
  • Pearly penile papulas
  • (past)Fungal infection inside of mouth (2 times), Local fungal skin infections at chest, penis, navel and continuous (present day) toenail infections
  • Gastroscopy: Food from 9 hours ago was still in the stomach and Hyperaemia at the Z-axis. Conclusion was decreased corpus motility
  • Mouches Volentes/floaters (Left eye, black points)
  • Physiotherapist told me I was the only one who he could easily fold up in a certain way. Like pressing knees towards the face in a flat position. Hypermobile in certain positions.
  • March 2008: MRI of the skull and MR-angiography of the carotid arteries: Slight mucosal swelling in the area of ??the nasal sinuses
  • The fiber free diet I had to eat for a few days prior to the hydrogen lactose breath test gave me better stool
  • Steroid injection into the groin area resolved local symptoms completely for at least 4 hours. Reminder: look up in archives what they used for injection, steroid might have inhibited IL-33 mediated MC activation, compare steroid with paper.
  • I could not hold my left eye steady during measurements at the optometrist. I wasn't able to focus my eye to one point, it kept circling away and around that point. Something I noticed when reading but this time a professional noticed it as well.
  • During recovery of Bell's palsy: I could not close my left eye without smiling (contracting a muscle(s) around corner of mouth). Neurologist told me that something might have went wrong during recovery, in that, nerves could touch eachother. He injected Botulinum toxin to destroy end plates again to let it recover properly. It helped somewhat.
  • Reminder: Finding picture of anomaly in stool.

POIS Symptoms
  • Extreem fatigue
  • A tingling/burning sensation, it leans more towards tingling than burning. It's difficult to describe this symptom. I have the idea that most tissue being affected by this symptom is located in a layer close to the skin
  • Dark circles around eyes
  • Muscle ache
  • Stiff muscles
  • Muscle cramp
  • Joint pain
  • Exercise/motion intolerance
  • Heavy body
  • Feeling cold/warm, feeling cold happens far more often than warm
  • Decreased endurance, especially with the duration of standing and sitting straight
  • Sensitive teeth
  • Stinging pain at liver area
  • Yellowing of facial skin (only when POIS puts emphasis on liver area)
  • Pale skin and facial skin becomes like a babyskin
  • Decreased vocabulary
  • Articulation problems
  • Poor concentration
  • Grammar problems (constructing sentences suddenly becomes a puzzle)
  • Short term memory loss (temporary)
  • Motivation in general is being lowered and often completely wiped out
  • I become someone without personality
  • Indecision
  • Accelerated Bowel movement, loose stools and sometimes diarrhea
  • It amplifies my food intolerance/sensitivity
  • Decreased digestion
  • A sense of being full (digestion)
  • Fasciculations
  • Itching
  • Soar Throat
  • Mood swings
  • Bad body odor
  • Decreased accuracy of handwriting ,also problems with controlling videogames like aiming in FPS
  • Faster spreading of local fungal skin infection at feet in POIS
  • It can influence the heart, I suspect it's a change of heart rithm.
  • Lung problems (bronchoconstriction or dilation?)
  • Dry or greasy skin
  • Decreased sense of smell
  • Increased pressure in and/or behind the eyes, most frequent in left eye
  • Dry mouth and activity on surface layer inside mouth (inflammation of mucosal membranes?)
  • Stomach pain and/or makes stomach sensitive to foods, especially acidic food
(the above list is not complete, can also add frequency and relative intensity)

POIS Dynamics

Before desensitization:
Phase1 (Build up phase): POIS sets in immediately and builds up gradually. Sometimes the starting intensity is so low and speed of intensity build up (slope) slow that you only will notice it after some time (in some instances this could mean 30 min for example or in rare cases a few hours).

Phase2 (constant intensity phase): After approximately 24 hours symptom intensity reaches its maximum. It stays a bit lower by a small margin than the max and constant from the ~24 hour mark up to day 4.

Phase3 (Recovery phase): After day 4 symptom intensity will decrease. It feels like flipping a switch at the end of day 4. This recovery phase can take up 1-3 days. After that I still have POIS symptoms, this is like a constant offset.

There is a peak/maximum of fatigue intensity during the recovery phase.
!Perhaps I need to draw a graph to make it more clear

Scenario with sticky ejaculate:

If the ejaculate is sticky some of it will stay behind post ejaculation, which leads to:
Burning sensation in urethra.
While it burns: The continues urge to urinate while having an empty bladder.
My anus starts to burn.

Urinating quickly after ejaculation helps prevent the above symptoms.

Lower part of spine/leg jolt:
core symptoms/cyclic ones
Lung/POIS dynamics:
Event of cold attack by POIS during hot day:
Cold/Warm dynamics:
Social isolation dynamics:
Add reminder: Dynamics of Pre-ejaculate release without ejaculation and combination of pre-ejaculate phase with orgasm.

Chronological order of events

2 days/1985: Cardiac arrest while my mother was breastfeeding me.
Age 7/1992: Iron deficiency. I looked very pale, had dark rings around my eyes and was thin.
Age 12/1997(age 10 or 12): My body failed regulating my breathing pattern, I had to do this manually which led to hyperventilaton. This happened on a very hot day.
Age 14/1999: Started to masturbate in my late 14's
Age 15/2000: Started to get really tired and I could not be in school on time early in the morning. There were also strange events like an erection that was not getting soft again and had no control over it. One time I was getting a burning sensation in my glans penis while I had a semi erection and was peeing.
Age 16/2001: I was questioning myself if there was something wrong immediately after a particular orgasm at one situation. I didn't take it that serious and shrugged it off. I was stupid not observing my general well-being the days after that orgasm.
Age 17/2002: I was playing a soccer match under hot weather conditions and felt like I didn't receive enough oxygen resulting in very deep and slow inhalations (blood pooling, typical POTS symptom). The same thing happened a few times during summer time on hot days in school where maintaining posture was more difficult than usual and displayed the same behaviour as the situation when I had that soccer match namely very deep and slow inhalations (not to be confused with hyperventilation). People sitting next to me were quite irritated by this breathing pattern.
Age 18/2004 Facial paralysis left side when I woke up in the morning after I visited someone who was celebrating her birthday. I drank 3 bottles of beer that night (I rarely drank alcohol at all, was never a drinker) which was a lot for me and also ate a lot of peanuts and remembered I was tired. This was a point where more symptoms starting to appear, it felt like an acceleration. Around this time I also did not get enough energy by meals even when I ate more because I was more physically active with sports. I could not get enough energy by eating.
Age 19 and up: Don't know the exact age and order, have to look it up. Oral fungal infection, tennis/golf elbow, heavy nerve pain at the inside of arms for one year, after that I got capal tunnel-like symptoms for a year, food intolerances went gradually worse in particular fruits.
Age 24/2009 POIS symptoms were so extreme that it became clear to me that ejaculation was the culprit. Searched the internet for sickness after orgasm, made an appointment with Prof. Dr. Waldinger, did get diagnosed with POIS and started hyposensitization treatment in early 2010.
Age 28/2013 Crisis year. Complete escalation during summer when I sat in a train and the sun shone on me, POTS symptoms exploded. Cardiovascular problems, autonomic instability, extreme temperature sensitive, tons of weird events. Around December food sensitivities suddenly became extreme out of nowhere, mucosal membranes were highly reactive to food.
Needs editing, to be continued Reminder: I can remember clearly I had food sensitivities around  8/9 years of age. Have to look it up if I had them before the age of 7. Liesproblemen vergeten. I have always been intolerant to hot baths as a kid. Slijmproductie in keel door Yoki. Doorslikken voedsel ging niet makkelijk als kind zijnde, moest appelmoes erbij eten. Lot of IBS-like symptoms early 20's (GP gave me Psyllium which made symptoms worse, took it a few times).

General Symptoms

List of triggers

Release of pre-ejaculate
High temperatures
Temperature change (Like going from >20 C inside and putting a garbage bag outside during winter <0 C without winter jacket (this can lead to sudden tension build up slightly above adam's apple at left and right side), however when dressed properly it has a positive effect)
Drinking tapwater
Airborne particles: Dust, Diesel exhaust, sigaret smoke, parfums, Food scent
Sleep deprivation
Large meals
Prolonged standing or sitting (sitting on a chair without back support wrecks me)
Prolonged discussions leads to fatigue which leads to more cognitive symptoms
Medicine/supplements: Citalopram 10 mg/day (headache), Daktarin oral gel (additional problem when addressing fungal oral infection)
Thunderstorm: breathing difficulties which can lead to hyperventilation at the moment before the storm hits.
Duration and frequency of triggers can make symptoms worse
Each trigger has its own dynamics and set of symptoms with overlap, I could add this later.

Synergy of triggers

Food (split up in food and diet?)

I react to everything at a certain degree. Below are some examples. On top of my head:
  • Apples. Wave of fatigue sets in approx ~1 mins after ingestion. Fatigue lasts about 10 or so mins. Different brands giving different intensity but same type of symptom.
  • Banana. Lightly Nauseous once it enters the stomach, oral and throat mucosa can react to it as well. Unripe green banana's are far better tolerable.
  • Fruit juices. Nauseous, fatigue, throat/stomach irritation, feeling it won't digest, horrible stuff.
  • Tomato's. Nasal drip, runny nose, within 30 sec.
  • Whole grains. Loose stools, heavy on my digestion system, other GI complaints which I have to look up, don't eat them anymore. Wheat can give me red pencil sized dots on my hand
  • Nuts. Loose stools or Diarrhea, nasal drip or runny nose. Walnuts can give me a painful tongue. Pistache nuts give me relatively the least symptoms.
  • Chocolate. Just not feeling well especially in my head, sometimes my brain react to it, brain fog. Sets in 60 min after ingestion but depends on the amount, you can clearly feel the difference from 50 g pure chocolate. Some chocolate brands give me sticky stool instead.
  • Spinach. Activity in oral mucosa upon contact. Sets in immediately.
  • Watermelon. Variable and depends on the amount. Fatigue. Sets in within a few mins I think. I can react to the scent of it as well. Watermelon is the best tolerable one out of all melons I have tried.
  • Spices. Nasal drip or runny nose.
  • Passion Fruit. Upper wall of mouth cavity hurts and nasal drip or runny nose.
  • Oak leaf lettuce. Dry mouth and slightly painful mouth cavity, looser stools than usual.
  • Citrus fruits. Just out of the question, sore mouth, sore throat, irritated lips with oranges. Green lemon Stool problems.
  • Mix of frozen grilled vegetables: Bell Peppers, Eggplant(Aubergine), zucchini. Painful tongue. Did test this mix multiple times, symptom consistent.
  • Chicken thights. (They used some spices, need to test them natural) Diarrhea.
  • Leeks. Can't remember exactly but I believe it gave me gum problems, haven't eaten this for a long time
  • Whey protein powders. Red Pencil like dots on hand, probably more symptoms but can't remember at this moment.
  • Shrimp. Diarrhea. Dutch shrimps are the best tolerable.
  • Potato skin. Fast and short lived flare of dryness at a spot within throat upon contact. Felt like center of spot being triggered and dryness spread out.

Food that are relatively better tolerable:
Fresh big black ripe cherries (red ones or the smaller ones are giving symptoms)
Dragon Fruit (White Pitaya), maybe the best tolerable fruit for me.
Iceberg lettuce
Chicken filet and legs.
Potato's well-baked depends on brand.
Egg yolk (don't feel well on egg white)


  • Heavy body
  • Weakness
  • Fatigue
  • Pressure in lower spine
  • Feeling of low grade systemic inflammation as a function of temperature
  • Cardiac problems, blood pooling
  • Decreased digestion and GI motility.
  • Focal headache in centre of brain
  • Fasciculations
  • Stiff muscles
Tons of other symptoms to add here.

POTS Symtoms

Symptom dynamics/situations

Factors contributing to symptom reduction

  • 5 year long desensitization treatment 2010-2015 (permanent improvement, the amount varies with type of symptom. Fatigue is by far the most improved symptom, perhaps 80% reduction. For other symptoms it's harder to estimate how much they have been reduced, for most of them I think maybe around 50% but this is a very rough estimate). My POIS was quite extreme
  • A long and good night of sleep
  • Cold, especially Sub-zero environmental temperatures (perhaps have to put details about this one somewhere else)
  • Gradually feeling better after midnight and best at 3:00 am
  • Taurine (minor effect, 45 min before Orgasm ~1g)
  • Antihistamines (minor effect, only clemastine if I'm not mistaken)
  • Protein rich diet (minor). Quicker recovery. Best source for me is meat especially chicken.
  • CBD oil (minor effect, need at least 2 drops of 10% to feel something)
Desensitization peculiarities: A few occasions where I felt normal (never felt so good), the onset (rapid within minutes to max) is somewhere between 30-60 min after subcutaneous injection. Happened more than once. Mucous layer in mouth felt fully developed as in thick, no dry throat, muscle strength increased, no food reactions, better resistance to weather conditions/temperature. The effect diminished from the point of onset over the course of tens of minutes (after that maybe some minor effect still present over the course of a couple of hours, hard to say, I could have some notes about it somewhere). If this effect was permanently then my health issues would basically have been fixed in my opinion. And I wonder whether that was a window of opportunity to apply rush therapy as in getting another injection.

  • Intens (heavy weights) body building exercises (most of them in flat or inclined position). Short powerful movements, almost explosive with Reps between 3-5. The trick is you need to induce a pump. Need to add more details
  • Breathing slow and deeply (this is done instinctively when symptomatic)
  • Strong beta blocker (need to look it up what type and dose)
  • Low Carbohydrate diet
  • Cold (heat exacerbates it)
  • Laying flat (even the slightest head tilt can worsen symptoms)
  • Salt (water without salt can exacerbate symptoms)
Food reactions
  • Heating food by high temperatures. Cooking food in boiling water doesn't do much. Cooking in pans, ovens or fryers leads to significantly less food reactions. The thickness of food is relevant as well. For example I'm more tolerant to thin sliced potatoes than thicker ones, some semi raw regions inside the centre of ticker potatoes can still trigger reactions
General Symptoms
  • Eating less in general
  • Eating less sugar
  • Skipping grains, nuts & seeds, diary for improvement of stool density
  • Cold temperatures
  • Oral intake of Liquid Hydrogen Peroxide solution
  • Avoiding triggers
  • Gradually feeling better after midnight and best at 3:00 am
More to add and need to go more into dynamics
« Last Edit: Today at 02:48:17 PM by Muon »


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Re: Muon's Case
« Reply #1 on: December 16, 2019, 04:11:26 PM »
Family members

Family members on my mother's side show similar symptoms as I do. All the females who got health problems felt better during their pregnancies and felt worse during their menstrual cycle. My grandma actually looked forward to her pregnancy. My mother has 3 children, my aunt got one and my grandma has 4. They all felt physically better for every single pregnancy.

Younger brother:
  • Post-orgasmic illness syndrome (started in his 20's)
  • Pectus excavatum
  • Emphasis on neuropsychiatric symptoms
  • Burning feeling in brain
  • Very sensitive to food (had years of food sensitivities prior to the development of POIS)
  • Insomnia
  • High libido
  • Sleepwalking
  • Developed heat intolerance
  • Feeling at his best at 3:00 am.
  • High insulin, normal insulin sensitivity, reactive hypoglycemia
  • They did do a non-specific allergen degranulation test. My brother told me they observed degranulation before allergens were even applied. The source of degranulation is unknown
  • Did measurements of HR changes between flat and standing position on brother during summer, this gave changes within the range of 20-30 bps but all <30. Measurements of mother and father did not exceed 5 bps.
Tons of symptoms and he had other diagnosis, I have to ask him about it. Will add later.
2020 summer: He had an acute attack of blood pooling (he underestimated how heavy this symptom is).
2020 Dec: Episode of schizophrenia/depersonalization, psychosis, whole body weakness, breathing difficulties. All together and went on for days. He told me he had the impression that there was a lack of oxygen in the brain and thought he passed out a few times.

  • Osteoporosis (5 years on Bisphosphonate had no effect on her osteoporosis, 2020: Using prolia injections)
  • Carpal tunnel syndrome and delivering squeezing power with hand is difficult
  • Pollen induced hayfever (elevated IgE)
  • Low vitamin D
  • Intravaginal sensitivities: Burning sensation upon contact with semen. (Reminder: I believe there was more)
  • A cold sore every now and then
  • Easy bruising
  • Unexplained areas of the skin that can turn red
  • High cholesterol levels
  • Blood pressure problems
  • Calves feel heavy
  • Varicose veins in legs (painful lower legs)
  • Red eyes (Blood eyes, no visible eye white)
  • Alternating constipation
  • She had an accute attack of intestinal inflammation (Blood in stool, pain, elevated CRP)
  • Getting attacks of cold
  • Sense of feeling cold much of the time
  • Stiff muscles
  • She can touch her toes from a standing position while legs are straight
  • Fluctuating pattern of symptoms
  • Sometimes she feels and hears a big 'tick' inside her head, it's only one when it happens. Her most scary symptom.
  • Brain MRI shows a small black dot (need to ask her about the position)
  • My mother laying often on bed during the day when I were a young kid. She was stressed. She was probably in her early 40's.
  • Often forgetting things
  • Speaking mistakes (meaning one thing but saying something different)
  • Difficulty coming up with the right word, searching for that one word that completes her sentence.
  • Sometimes her tongue hurts by eating food, walnuts for example.
  • Problems with citrus fruits.
  • She can't sit still for a long time and has to be in motion.
  • Difficult to sit in 90 degree angles.
  • A flare of a nasty feeling around the heart area. (I got this as well, I think it's an inflammatory flare at the surface of the heart or heart muscle.)
  • Bladder infection (peeing blood, used antibiotic)
  • Eye Lid tremor
  • Early satiety
  • Idiopathic miscarriage
July 2020: She had to push against a mobile caravan for a short time window with alot of force and felt immediately better afterwards.

Aunt (my mother's sister):

She had some sort of reddish/blueish rash over her body when she was a few years old. She was placed in quarantine and doctors couldn't figure out what is was, they were thinking of Rubella. Her skin became like sandpaper, when that happened dermatologists literally peeled the upper layer off. When they got rid of this sandpaper like layer she recovered. Dental decay despite good hygiene and dental care. She had food sensitivities.

I have asked her about her symptoms a while ago because Waldinger was curious about it. I will translate it literally what she has sent me.
  • Persistent fatigue which is not restored with adequate rest and sleep.
  • Always feeling sick, broke, general malaise.
  • Temperature fluctuations (increase, hour later sub-temperature again, etc.)
  • Vegetative reactions (sweaty hands, dizziness, disorientation, unstable feeling on the legs (rubber legs)).
  • Orthostatic hypotension (seeing stars after squatting, getting up from a sitting position, etc.)
  • Immune problems (pick up every virus that prevails and then spend 2 or 3 weeks with it under the pans that others have or do not suffer from or get rid of within a day or three) (non-specific and specific defense)
  • Cognitive problems: difficulty concentrating, unable to focus, being woolly in the head, being unable to hold or complete thoughts, problems formulating sentences or coming to words. (one day better than the other, unpredictable).
  • Short attention span (unsure with translation: korte spanningsboog), cannot maintain concentration or perform work for long periods. Must have limits in it.
  • Light shyness (dutch = lichtschuwheid)
  • Difficulty reading, double vision, night blindness (for my feeling from one day to another, according to optician at the time nothing wrong with my eyes).
  • Sounds sound loud and penetrating (whiplash-like complaints).
  • Headaches, sore throat.
  • Regularly swollen glands in the neck and groin.
  • Urticaria (urtica's, allergic skin reactions but no idea what I'm triggering from, often after picking up a virus or the like and often at the time of menstruation but sometimes also without any apparent cause).
  • In the past: pituitary dysfunction resulting in no menstruation (approx. 3 to 4 years), sleep disorders, no melatonin production, disturbed biological clock (examined and determined by specialist), maternity mask (also called melasma) without being pregnant. Determined by dermatologist. Advice dermatologist at the time: have your thyroid function checked regularly. That done: TSH thyroid at 0.42 (on the lower limit). Just fell within the reference value so GP saw no reason for treatment. I gained 15 kilos in two weeks without changing my diet (blew up like a puffer fish), dry skin, night sweats, etc. I had all the symptoms of the transition while I was 32 or 33 years old. After taking blood samples I turned out not to be in transition, but my pituitary gland turned out to be working a little below standard but according to the doctor not to the extent that treatment was needed.
  • Leucocyte values ??always increased! Whenever I have blood sampled, always increased! Hemoglobin just on the border.
  • Adrenal dysfunction (cortisol, adrenaline) (mesologist diagnosis).
  • Calcium household problems (mesologist diagnosis)
  • Calf cramps (every day, night and morning to such an extent that it wakes me up).
  • Must always dose my activities, including fun activities. After a birthday o.i.d. overtired.
  • Avoid crowds regularly for that reason or have to plan that and reserve rest after that time to be able to refuel. And often that's not enough.
  • Battery is empty quickly and takes a long time to get some spare. Limited taxability in many respects.
  • Fungal infections are a common thread through my complaints. From about my 17th almost continuously suffer from vaginal fungal infections until around my 35th. Also regularly bladder infections where I got antibiotics from the doctor. But that naturally encouraged fungal formation. From around the age of 32 I was diagnosed with intestinal dysbiosis with opportunistic candida (by a nature doctor). Candida diet, anti-candidate drugs etc. These improved my health, mesological treatment has also contributed to this. To date, sensitive to yeast/fungi. Noticeable by stubborn athlete's foot and lime nails (sign that it is still not right). For years no longer suffer from vaginal fungus. Immune problems and others remain.

Grandma (My mother's side):
  • Brain aneurysm
  • Periods where weakness in legs led to bedriddeness and couldn't walk stairs.
  • She went swimming during summer, something locked in back when she went into the water, she couldn't get out of the water. This led to weakness in legs.
  • Multiple Transient ischemic attacks (TIA); One-sided facial droop etc
  • Colorectal polyp
  • She felt better when she did not eat
  • Was intolerant to chocolate
  • Even in her late 70s she could pick up her foot and plant it against her face
  • Fainting (had this since childhood). She felt it coming. She didn't feel well and was getting hot prior to fainting. She had to lay down for better circulation when these signs showed up and had to cool down her forehead and wrists.
  • Heavy pain around her feet and ankles. Did not happen a lot but it ramped up fast and she screamed. People had to put her feet into a tile of water. My mother can't remember what the temperature of the water needed to be, cold or warm.
  • They did do a muscle biopsy on her but found nothing. It's unknown what they were looking for.
  • Couldn't sit still for long periods of time. Need to be in motion.
  • Bladder infection
  • She felt better on Enterosalicyl.
  • Constipation
  • Bloating in the abdomen
  • Episodes of low blood pressure
  • They injected her something in her throat via the oral way and she did get better in general (substance unkown).
  • Went crazy and died just like her grandmother.
  • She used blood thinners because she had thick blood.
There was something with the hands, Raynaud?

Healthy Family members

These folks are, from what I know, basically healthy but there are some oddities.

My mother's younger brother
  • He did get rashes over his body as a kid when entering chlorinated swimming pools. He outgrow this symptom when he got older.
  • Depression
I heard he had more problems during the past years like gut pain (details unknown) after he stopped smoking weed (was a daily weed smoker from what I know).

My mother's older brother
  • Cardiac issues (details unknown to me)
  • He told me once that he finishes his showers with cold water and made him feel better.
  • Isolated lifestyle
My older brother's daughter
  • She reacted to dust and milk when she was a few years old. I asked if this was a true allergy but nobody knows.
  • Spontaneous bursts of saliva production
  • Sometimes she looks pale with dark coloration under her eyes.
  • Sugar cravings
  • Acne
  • She forgets to hydrate because she isn't thirsty. (I have this symptom, need to remind myself to drink)
  • She has light asthmatic-like symptoms at this moment in time (15 years of age, Dec 2019). Her lungs make sound when exhaling quick which makes her breath heavy afterwards.
  • Jan 2020, Runny nose when transitioning from warm to cold environment.

Other family members, health status unknown

The daughter of the brother of my grandmother (mother's side)
  • She walks around with a body temperature of 35.0 Degrees Celsius since birth and is always cold, sometimes it drops to 34.5.
  • Arthritis
  • Her daughter faints when her daughter's core temperature rises

Commentary and thoughts on symptoms

Symptom triggers are similar as seen in MCAS patients but are also a form of stress. Stress signaling/response could (be abnormal) affect the ANS which on its own could be in a state of sympathetic dominance outside of stress.

Looking at the factors which reduce symptoms I noticed that they increase parasympathetic activity by stimulating the vagus nerve.



Sympathetic overactivity or parasympathetic underactivity (Dysautonomia)
Mast cell activation disorder/cascade/hyperresponsive mast cells
Hyperpermeability/barrier dysfunction in genitourinary system (connective tissue problems)
Th2 response
Regulatory T cell dysfunction or abnormal numbers
Type IV Hypersensitivity
Denervation supersensitivity


Mast cell activation disorder:
Evidence of Mast Cell Activation Disorder in Postural Tachycardia Syndrome (P1.277)

''Triggering events include long-term standing, exercise, premenstrual cycle, meals, and sexual intercourse''
Hyperadrenergic Postural Tachycardia Syndrome in Mast Cell Activation Disorders

A New Disease Cluster: Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome, and Ehlers-Danlos Syndrome

Autoimmunity/Viral illness
Autoimmune Basis for Postural Tachycardia Syndrome

HPV vaccines:
Human Papillomavirus Vaccine and Postural Orthostatic Tachycardia Syndrome: A Review of Current Literature.

Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment

Transport-mediated choline deficiency:
Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts

Vascular Endothelial Dysfunction (abnormal sheer stress/NO response to acetylcholine & heat)
Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome

Decreased Microvascular Nitric Oxide?Dependent Vasodilation in Postural Tachycardia Syndrome

Endothelial NO Synthase Polymorphisms and Postural Tachycardia Syndrome

Relation between Endothelial dysfunction and autonomic nervous system dysfunction
The Relationship between Vascular Function and the Autonomic Nervous System

C-fiber involvement:
Small-fiber neuropathy with cardiac denervation in postural tachycardia syndrome.


Autonomic Nervous System Dysfunction in Adolescents with Postural Orthostatic Tachycardia Syndrome and Chronic Fatigue Syndrome Is Characterized by Attenuated Vagal Baroreflex and Potentiated Sympathetic Vasomotion

Bell's Palsy

Immunological concept/mast cell activation/hypersensitivity:
Immunological Concept for Bell's Palsy

An immunological concept for bell's palsy ? Experimental study**

Infection theory:
Frequent detection of Mycoplasma pneumoniae in Bell's palsy.

Hormonal metabolic changes?:
Familial juvenile onset of Bell?s palsy

Impairment of microcirculation of the facial nerves:

Blood viscosity:
Bell?s Palsy and Viral Infections

Elevated Serum Interferon Levels in Patients With Bell's Palsy


Disturbance to cholinergic pathways/vascular endothelial dysfunction
Prolonged acetylcholine?induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndrome

Premature Ejaculation

Autonomic nervous system dysfunction in lifelong premature ejaculation: analysis of heart rate variability.

The Role of Brain Derived Neurotrophic Factor in Etiology of Premature Ejaculation

''Our study indicates that premature ejaculation is significantly related with a higher level of seminal NO.''
Relevance of seminal plasma nitric oxide levels and the efficacy of SSRI treatment on lifelong premature ejaculation

''From these results it can be concluded that PE occurs because decreased levels of serotonin. Decreased levels of serotonin are associated with increased levels of IFN-g.'':
Flouxetine improved intravaginal ejaculatory latency time through decreased levels of interferon-gamma and increased levels of serotonin in patient with premature ejaculation

Elevated IFN-g/Th1 polarization

"It is consistently observed that mast cells [8] and mast cell-derived exosomes preferentially induce Th1-type responses as evidenced by the production of IL-2, IFN-g and IL-12 by activated lymphocytes."
Nonspecific B and T Cell-Stimulatory Activity Mediated by Mast Cells Is Associated with Exosomes

Latent Viral Infection:

Polarization switch from Th2 to Th1 due to desensitization?

Temporary IFN-g decrease after orgasm

1)Mast cell activation -> PGD2 -> activation of CRTH2 on Th2 cells -> Th2 response -> decreased IFN-g
2)Th2 response -> induction of IgG4 -> dampening of Th2 response -> Stops IFN-g decrease
(T-regs might play a role in this)

Th1 polarization + IL-8

Human Cathelicidin Peptide LL-37 (need ref)

Interferon-g enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus


"Importantly, Treg exert a direct effect on B cells, suppressing the production of allergen-specific IgE and inducing IgG4"
Role of Treg in immune regulation of allergic diseases

Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells.

Nerve growth factor specifically induces human IgG4 production

Potential drivers: IL-4, IL-5, IL-10, IL-13 (MC), IL-21, Follicular helper T cells, TGF-beta, expanded Tregs, IL-33?.

Mast cells have been suggested as an altenative source of TH2 cytokines, based on their colocalization with IL-4 and IL-13 in IgG4-RD lesions from salivary glands. Page 62: Ref

"Thus, our results do not support the hypothesis that T cells express the cytokines associated with IgG4-related disease; rather, our data indicate that mast cells are the source of these upregulated cytokines."
T helper 2 and regulatory T-cell cytokine production by mast cells: a key factor in the pathogenesis of IgG4-related disease

Hyper-IgG4 disease: report and characterisation of a new disease

What's your diet like anyway?

I don't eat any refined grains or sugars, though I do eat fruit and plenty of whole grains. My last IGG4 test showed a pretty strong candida response, which my physician said means I had an overgrowth at some point.

IL-8 (CXCL8)

CRH-->mast cell activation
Substance P (SP) Induces Expression of Functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in Human Mast Cells

Drop in IL-8: Combine
Specificity of the neuroendocrine response to orgasm during sexual arousal in men
Neuroendocrinology of mast cells: Challenges and controversies.

Increased gut MCs:
Comparative evaluation of Inflammatory cells and Interleukins in Irritable Bowel Syndrome subtypes

Essential involvement of interleukin?8 in acute inflammation

IL-33 (table 4)
Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?

LPA ---> LPA2 receptor, table 1:
Non-IgE mediated mast cell activation

"Stromal cell-derived factor-1 alpha (SF-1?) selectively produced IL-8 from human mast cells without degranulation as well. Activation of human cultured mast cells by CD30 ligands led to release of the chemokines IL-8 and MCP-1 without histamine and without degranulation. IL-33 induced IL-13 release independent of IgE stimulation" Ref

IL-13 can induce IgE and IgG4. IL-33 can induce IL-13 and IL-8.
Brother: Elevated IgE and IL-8. Me: Elevated IgG4 and IL-8. Thus IL-33 is a potential candidate.

"Stimulated T cells were found to generate microparticles that induce degranulation and cytokine (IL-8 and oncostatin M) release from human mast cells. Mast cell activation by T cell microparticles involved the MAPK signaling pathway." Ref

"We recently reported that extracellular vesicles are increased in the serum of children with ASD, contained mtDNA and stimulated cultured human microglia to secrete the pro-inflammatory molecules IL-1? and CXCL8 " Ref

Candida Albicans and mast cells (?-Hexosaminidase?):

OxLDL and mast cells:

Weakness in upper legs (+spasms) worsen with high temperature, standing, POIS and stress. Relief with exercise, laying down, bending forward.

P/Q-type VGCC antibodies? As in
Spinal stenosis? (pressure in lower back as well)

Female family members and decrease/increase of symptoms in pregnancies/menstrual cycle period

Neuroimmunoendrocrine disorder:
''These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy.''
Progesterone Inhibits Mast Cell Secretion

Progesterone triggers selective mast cell secretion of 5-hydroxytryptamine

Role of female sex hormones, estradiol and progesterone, in mast cell behavior

Shift in Th1/Th2/Th17 balance:
Inflammation and Pregnancy

REVIEW ARTICLE: Th1/Th2/Th17 and Regulatory T?Cell Paradigm in Pregnancy

Microbiome change during pregnancy:
Microbial Changes during Pregnancy, Birth, and Infancy


Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset

Progesterone Increases Systemic and Local Uterine Proportions of CD4+CD25+ Treg Cells during Midterm Pregnancy in Mice

Membrane progesterone receptors in human regulatory T cells: a reality in pregnancy

"Hepatic synthesis of corticosteroid-binding globulin more than doubles in pregnancy; that is, bound plasma cortisol in term pregnancy is approximately 2 to 3 times that of nonpregnant women"

hCG goes up as well during pregnancy.

Vagal tone during pregnancy???

Idiopatic miscarriage

Treg cells in pre-eclampsia, miscarriage and infertility

"In spite of MC heparin content, MCAD-induced coagulopathy (67) may spur placental microthrombi, preventing nidation or disrupting embryonic blood supply and threatening miscarriage" Ref

Burning sensation in vagina upon contact with semen in mother

Manifestations of immune tolerance in the human female reproductive tract

Low NK cell count

Stress, beta-AR activation:
Adrenergic regulation of innate immunity: a review

Decreased Alpha-2-globulin

High MMP 2 or 9 --> joint pain, which can bind to alpha-2-macroglobulin which is a subset of Alpha-2-globulin.

Accelaration of frequency and intensity of symptoms during period of intense exercise/sports on daily basis

The open window of susceptibility to infection after acute exercise in healthy young male elite athletes
« Last Edit: January 14, 2021, 07:05:33 PM by Muon »


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Re: Muon's Case
« Reply #2 on: December 16, 2019, 04:13:06 PM »
Data overview (Work in progress)

9th and 10th of July 2015

Muon 1-1:
TH1/TH2 Ratio: 43.5 Ref: 3.5 - 11 page1: 10:00 AM
TH1/TH2 Ratio: 39.6 Ref: 3.5 - 11 page3: 10:15 AM
TH1/TH2 Ratio: 35.3 Ref: 3.5 - 11 page4: 10:42 AM
TH1/TH2 Ratio: 42.0 Ref: 3.5 - 11 page5: 10:05 AM (24 hours later)

An ejaculation took place between the first and second measurement.
The last ejaculation before that took place at 23-06-2015.
They took blood samples while I was in the supine position.

August 13 and 14 2015 

TH1/TH2 Ratio: 28.9 Ref: 3.5 - 11 Muon 2-1: 10:15 AM
TH1/TH2 Ratio: 32.1 Ref: 3.5 - 11 Muon 2-2: Went in the blood collection room at 10:38 AM and left at 10:43 AM
TH1/TH2 Ratio: 31.5 Ref: 3.5 - 11 Muon 2-3: Went in at 11:10 AM and left at 11:16 AM
TH1/TH2 Ratio: 70.8 Ref: 3.5 - 11 Muon 3-6: 10:25 AM (next day)

An ejaculation took place between Muon 2-1 and 2-2 around 10:25 AM.
The ejaculation prior to this was 4 or 5 days back.
Blood samples were being taken in the supine position.

July 9 and 10 2015 data.

IP-10 July 9 and 10 2015

ParameterTimeValue (pg/ml)Reference (pg/ml)Delta
IP-10~10 min pre O211< 900
IP-10~5 min post O234< 900+23
IP-10~32 min post O232< 900-2
IP-10~24 hour post O286< 900+54

TGF-beta July 9 and 10 2015

ParameterTimeValue (ng/ml)Reference (ng/ml)Delta
TGF-beta~10 min pre O53.418.3 - 63.4
TGF-beta~5 min post O62.218.3 - 63.4+8.8
TGF-beta~32 min post O54.418.3 - 63.4-7.8
TGF-beta~24 hour post O50.118.3 - 63.4-4.3

Interferon-gamma (Th1) July 9 and 10 2015

ParameterTimeValue (pg/ml)Reference (pg/ml)Delta
IFN-g (Th1)~10 min pre O1806374-1660
IFN-g (Th1)~5 min post O1664374-1660-142
IFN-g (Th1)~32 min post O1226374-1660-438
IFN-g (Th1)~24 hour post O1965374-1660+739

IL-4 (Th2) July 9 and 10 2015

ParameterTimeValue (pg/ml)Reference (pg/ml)Delta
IL-4 (Th2)~10 min pre O41.540-198
IL-4 (Th2)~5 min post O42.040-198+0.5
IL-4 (Th2)~32 min post O34.740-198-7.3
IL-4 (Th2)~24 hour post O46.840-198+12.1

IL-2 (Th0) July 9 and 10 2015

ParameterTimeValue (pg/ml)Reference (pg/ml)Delta
IL-2 (Th0)~10 min pre O351384-960
IL-2 (Th0)~5 min post O356384-960+5
IL-2 (Th0)~32 min post O347384-960-9
IL-2 (Th0)~24 hour post O416384-960+69

IL-17 (Th17) July 9 and 10 2015

ParameterTimeValue (pg/ml)Reference (pg/ml)Delta
IL-17 (Th17)~10 min pre O52.549-446
IL-17 (Th17)~5 min post O45.549-446-7
IL-17 (Th17)~32 min post O49.549-446+4
IL-17 (Th17)~24 hour post O43.749-446-5.8

IL-10 (T-reg) July 9 and 10 2015

ParameterTimeValue (pg/ml)Reference (pg/ml)Delta
IL-10 (T-reg)~10 min pre O989760-1900
IL-10 (T-reg)~5 min post O902760-1900-87
IL-10 (T-reg)~32 min post O801760-1900-101
IL-10 (T-reg)~24 hour post O1052760-1900+251

IL-8 July 9 and 10 2015

ParameterTimeValue (pg/ml)Reference (pg/ml)Delta
IL-8~10 min pre O18.4< 15
IL-8~5 min post O38.9< 15+20.5
IL-8~32 min post O18.2< 15-20.7
IL-8~24 hour post O34.3< 15+16.1

Interferon gamma (Th1), august 13 & 14, 2015:

ParameterTimeValue in pg/mlReference range in pg/ml
IFN-g (TH1)~10 min before orgasm1315374-1660
IFN-g (TH1)~15 min after orgasm1147374-1660
IFN-g (TH1)~45 min after orgasm978374-1660
IFN-g (TH1)~24 hour after orgasm3053374-1660

IL-10 (T-reg) august 13 and 14, 2015:

ParameterTimeValue in pg/mlReference range in pg/ml
IL-10 (T-reg)~10 min before orgasm774 760-1900
IL-10 (T-reg)~15 min after orgasm638760-1900
IL-10 (T-reg)~45 min after orgasm542760-1900
IL-10 (T-reg)~24 hour after orgasm1045 760-1900

IL-2 (Th0) august 13 and 14, 2015:

ParameterTimeValue in pg/mlReference range in pg/ml
IL-2 (TH0))~10 min before orgasm433 384-960
IL-2 (TH0)~15 min after orgasm415384-960
IL-2 (TH0)~45 min after orgasm335384-960
IL-2 (TH0)~24 hour after orgasm281 384-960

IL-4 (Th2), August 13 & 14, 2015:

ParameterTimeValue in pg/mlReference range in pg/ml
IL-4 (TH2))~10 min before orgasm45.540-198
IL-4 (TH2)~15 min after orgasm35.740-198
IL-4 (TH2)~45 min after orgasm31.140-198
IL-4 (TH2)~24 hour after orgasm43.140-198

IL-17 (Th17), August 13 & 14, 2015:

ParameterTimeValue in pg/mlReference range in pg/ml
IL-17 (TH17))~10 min before orgasm51.649-446
IL-17 (TH17)~15 min after orgasm40.849-446
IL-17 (TH17)~45 min after orgasm31.349-446
IL-17 (TH17)~24 hour after orgasm57.149-446

IL-8, August 13 & 14, 2015:

ParameterTimeValue in pg/mlReference range in pg/ml
IL-8~10 min before orgasm89.8<15
IL-8~15 min after orgasm59.0<15
IL-8~45 min after orgasm41.9<15
IL-8~24 hour after orgasm36.6<15

Direction of slope July

- - +: IFN-g, IL-10
+ - +: IL-2, IL-4, IL-8, IP-10
- + -: IL-17
+ - -: TGF-beta

Direction of slope August

- - +: IFN-g, IL-4, IL-10, IL-17
- - -: IL-2, IL-8

Comparing slopes July and August

IFN-g and IL-10 show similar dynamics for both dates relative to eachother. Dynamics for both dates are the same.
IL-2 and IL-8 show similar dynamics for both dates relative to eachother. Dynamics for each date is different.

But they may not be comparable because the time difference between Orgasm and the second data point is different for each date. 5 min vs 15 min post O for second data point. A graph would show a better picture...or not...because data points are scarce.

Comment august data
Release of cytokines need intracellular calcium, they all go down post O. Is there a decrease of intracellular calcium inside leukocytes? IFN-g may still be climbing days later as in a type IV reaction.

Muscle stiffness, spasms post-orgasm could indicate changes in intracellular calcium concentration. Another trigger is heat/high ambient temperatures especially during rest after movement (just taking a walk) through hot environments.

IL-4 and IL-17 return to their former values. IL-10 is slightly higher 24h. IL-2 and IL-8 don't seem to return to their values post O while IFN-g is higher. IFN-g may be suppressing IL-2 and IL-8. Everything is in normal range for the first measurment except IL-8, the latter may come from a different source. Low IL-2 can be a problem since "IL-2 plays a critical role in the maintenance of CD4+CD25+ FOXP3+ regulatory T cells (Tregs) in vivo." Ref

Something else, I had painfully stiff muscles due to POIS a week ago. The higher part of the back, shoulders and part of the upper arms were affected, the weird thing was it kept getting stiffer and stiffer up to the point I could barely move my right arm, it was that painful (there was only pain present during movement, not in rest). Moving my arm/shoulder, was like the feeling of almost tearing some muscles. I slept one night with clothes on because undressing was too painful. Quite a weird event, I have never experienced this intensity of stiffness before.

Throwing some ideas around:

Calcium signaling in immune cells

Calcium, Channels, Intracellular Signaling and Autoimmunity

Regulating T helper cell immunity through antigen responsiveness and calcium entry

Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase

Voltage gated calcium channel autoantibodies? Or mast cell mediators interfering with calcium homeostasis?

Reminder: Could take a look at AMPAR's/Calcium/L-Theanine?

Values dipping post O seen in other members.


No-POIS state:
TNF-alpha: 32.6 pg/ml above reference range (<12.0)

4 hours after ejaculation:
TNF-alpha < 12.0 pg/ml

Iron dipping during POIS?:
I've had blood tests done multiple times during my worst fever episodes, and everything comes back normal except for very low levels of iron (I usually have normal or even high iron and hemoglobin levels), and through-the-roof amounts of C-reactive protein. This led doctors to think I could have mononucleosis or some kind of bacterial infection, but all specific tests came back negative. They put me on antibiotics anyway, and that solved most symptoms almost immediately and made me able to get out of bed and finally get better during the worst episode I've ever had.

Hello,i wanna tell sth,but first in private,maybe i'll post it
Considering that it is said that is possible for some Allergy,i tried to swallow my cum and guess what.After a few hours i couldn't swallow shit for about 3 weeks,i was anxious as fuck when trying to swallow anything solid. My Family MD told me that my throat is "red".Went to an Otorhinolaryngologist and he told me that it is allergy without me telling you what i did.Do you think i should that again and what could he check for in the blood if that repeats?
3) well, i don't know that,it was in my neck,my family doctor told me that my neck is "red" that's everything i know and i know that i couldn't swallow  cause i didn't feel the food going down and was always anxious that i was gonna   choke,cause the food is gonna go down the wrong pipe,i  couldn't contract my muscles,lots of thing,was like i wasn't also feeling the lower part of my  throat that you "consciously " contract when you swallow.It was weird cause everyone thought i was crazy,at least untill family md told me that  my throat is "red"

People also complain about their muscles being locked up during POIS.

Spine MRI calcium related?:

The Immunological Contribution to Heterotopic Ossification Disorders

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway

"there was a trend towards a decrease in IFN-g, IL-17 and TNF production with an increase in IL-9 production in response to antigen"


Other tests and meds I tried

Hepatitis B, C, E: negative
Intestinal permeability test: Mannitol and lactulose in urine after ingestion-->negative
AIDS negative
Lyme negative
Lung capacity test: Slightly lower than normal
Did a bicycle test because of tissue around groin that gave problems with exercise. Oxygen gas and lactacte couldn't be measured at the end of the test because I got sick and had to throw up.

Tried oral NSAID and steroid for symptoms before POIS diagnosis, like joint pain: No effect
Acyclovir+(prednisone or diclofenac, can't remember which one) 14 days for Bell's palsy: No effect, not even side effects (dose unknown).
Norethisterone: No effect
Pyridostigmine: No effect
Niacin flush gives symptoms
Used some sort of gel for my acne on back, didn't do anything (name?)
Metronidazole 11-day trial for positive lactose H2 test: No effect


Results from people with similar syndromes:

Input: my Immune profile from IMD Berlin

Results of the German Cell Trend laboratory for POTS
« Last Edit: January 09, 2021, 11:59:58 AM by Muon »


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Re: Muon's Case
« Reply #3 on: December 16, 2019, 04:16:32 PM »
Past Events



Recent Events

Summer 2019

Intense flares of pressure at heart area accompanied by weakness in left arm.
All the time pressure at lower part of spine when standing plus weakness in legs.

Somehwere around November 2019

Walked in supermarket, felt some activity in brain (not at the middle of brain) at them same time my left side of my face was hanging for a moment, as in decreased muscle tension.

Also had a moment where I had to help someone with their homework. Got a bit stressed by prolonged talking, felt activity in brain and couldn't talk properly for a minute. Could not create any word with my lips.

There were a lot of days where I couldn't get warm and was cold all the time.

Late December 2019/early januari 2020

Activity at lower part of spine plus pressure at that area. Weakness in legs when standing.
Bladder control problems, Frequent urination, this was getting worse when there was more activity at lower spine.

Januari 2020

A few times tingling sensation at the glans penis and became very sensitive to any friction (not sexual related just limp penis).

Februari 2020

I ate some liver and suddenly became feverish and nauseous for less than 30 sec of duration immediately after ingestion. Perhaps 5-10 mins after there were migratory colds traveling over my body and turned into systemic cold (shivering) after the migratory cold ended.

Problems with stress as a trigger, most of the time physical stress by static body positions. Starts with tension -->stress---> inflammation.

Weak spot in lower part of spine ---> local tension ---> standing/sitting/bad posture ---> focal tension turns into focal inflammation ---> as time goes by other parts in body one by one, most often the weaker parts have a higher chance, getting smoldering focal inflammation ---> when it stays this way it turns into systemic symptoms, like fibromyalgic-like weakness around the hip area and fatigue.

This behaviour can be prevented if local/focal stress is reversed in time. There is a certain intensity threshold that when you cross it you are unable to reverse the above process.

Symptoms of stress can be very subtle, it can gradually increase without notice. Local/focal stress, even by immobilization is able to induce the following symptoms lately:

1) Very light burning on top of forearms and/or shoulders. Goes away immediately when stress stops.
2) Worsening of Blepharitis
3) Activating oral mucosa (sense of activity, surface fizzing) ---> bad taste ---> increased reactivity of food/mucosal contact
4) Runny nose (also when taking a walk in POIS and certain muscles can't handle standing posture thus again, focal stress turns into focal inflammation at the same weak spot--->runny nose)
5) Weakness in legs
6) Inflammation (especially at spine lately)
7) Some activity in the lower abdomen sexual organ related (only after multiple parts of the body are affected)
8 ) Some activity in lower part of abdomen GI related, same spot as triggered by temperature in summer 2014 (again only when after multiple parts of body are affected).
9) Joint pain, not sure if this is triggered by stress. Joint pain seem to be a late reaction, can't put my finger on it with certainty what triggered it.
10) Fatigue, only when inflammation by stress has affected mutliple spots.
11) Fibromyalgic weakness/pain around tendons of hip. Again, only when inflammation by stress has affected multiple parts of the body and is ongoing.

Eating apples again and symptoms induced by apples have changed from fatigue to a runny nose. Reactivty with oral mucosa is worse when oral mucosa is being activated by stress/inflammation in other parts of the body.

New symptom, happened only once: Intense sharp pain for maybe 2-3 seconds at right kidney location. Never felt anything like it before.

June 2020

Developing symptom: Sharp localized pin point stings in urethra mostly by low grade stress.

Developing symptom: Neck tension/pain

Improved Brain fog (large improvement. It took at least 6 months, slow trending motion) and mood swings much better. Improvement in facial appearance.

October 2020

Had pinpoint activity next to my eye in my skin. This lead to a brown coloration of that part of the skin. Happened again at a later date close to the same spot, same behaviour, led to another dot of brown coloration.

Washing the glans penis during shower led to activation in lower back at the spinal area (which is already sensitive), no pain, just activation of something and it isn't muscle, no feeling of contraction. Activation stops when friction stops. Applying friction again flares up activity in my lower spine again.

Encountered multiple episodes where I'm suddenly out of breath during rest. The behaviour you see after taking a sprint, but I haven't done anything like that.

5 red dots with diameter 2-3 mm appeared on the upper palm of my right hand a few cm equally distant apart. Went away after one week. Same thing?

November 2020

Startled by one loud bang from a firecracker that someone threw. I felt physically better immediately.
« Last Edit: December 12, 2020, 12:27:20 PM by Muon »


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Re: Muon's Case
« Reply #4 on: December 16, 2019, 04:18:31 PM »
Random stuff

Spinal MRI and reminder to look for spinal findings in more patients (including MCAS):

5.- Magnetic Resonance Imaging of the entire spine(June 2018):
     multiple focal lesions were observed in the dorsal and lumbar spine, hyperintense in T2 and most of them isointense in T1, although the larger lesions have a trabecular structure suggesting that they are hemangiomas. However, given that the signal characteristics in the T1 sequence are not typical of hemangioma, it is recommended to do image control to assess evolution.

Translated with Google Translate from Maxwell of Russian POISCenter

If you read my conclusion after the MRI of the "lumbosacral spine", you can find words like "the anterior and posterior longitudinal ligaments are compacted", which means the so-called "Ossification" written here -svyazki-grudnogo-otdela-pozvonochnika and here
... squeezes the spinal vertebral nerve ...

Ossification of the posterior longitudinal ligament of the thoracic spine is a permanent neurological disorder in which the nerves of the spinal canal are compressed as a result of hardening of the posterior longitudinal ligament, the purpose of which is to preserve the structure of the vertebrae in the spine, maintaining its balance and mobility. Including South Korea, in China, Japan and other Asian countries, this disease more often occurs in men over 40 years of age, which must be treated at an early stage due to the impossibility of restoring the functions of the damaged nerve if it is compressed for a long period.

Myelopathy is a dysfunction of the spinal cord associated with abnormal pressure on the spinal cord. Unlike conditions that put pressure on individual nerve roots, this type of damage can lead to loss of nerve function anywhere in the spinal cord below the damaged area.

Chymase and cardiovascular problems:
Contributions of ACE and mast cell chymase to endogenous angiotensin II generation and leucocyte recruitment in vivo

In vivo, Ang II is primarily generated by ACE under basal conditions, but in inflammatory conditions, the release of MCP amplifies local Ang II concentrations and the associated inflammatory process. Thus, AT1 receptor antagonists may be more effective than ACE inhibitors for treating ongoing Ang II-mediated vascular inflammation."

Pressure Overload–Induced Transient Oxidative Stress Mediates Perivascular Inflammation and Cardiac Fibrosis through Angiotensin II

Bell's palsy?:

POIScenter member:
I feel exhausted after fetching drinks from the shop, carrying up a lot of stuff...
I can barely stand, want to just lie flat on the couch (yay for home office..)

Then I eat a salami sausage and drink one of those and I'm completely normal again:

The stuff is really magical. I really believe that it pushes all the liquid and minerals directly into your body.

wheat beer also contains Uridine btw.

Paper dump section

A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Balancing tissue homeostasis and inflammatory responses against Candida albicans infections: is it a matter of mast cells' immunological memory?

Gut fungi in irritable bowel syndrome : A painful recognition

Is burning semen syndrome a variant form of seminal plasma hypersensitivity?

Is skin testing reliable for confirming sensitization to seminal fluid proteins?

Review of flavonoids: A diverse group of natural compounds with anti-Candida albicans activity in vitro

Immunodominant Semen Proteins III: IgG1 and IgG4 Linkage in Female Immune Infertility

Patients with chronic prostatitis/chronic pelvic pain syndrome show T helper type 1 (Th1) and Th17 self?reactive immune responses specific to prostate and seminal antigens and diminished semen quality

IgG4 breaking the rules

Immediate hypersensitivity to seminal fluid and atopic dermatitis

"Serum from the husband and nonrelated men also contained antigen that provoked histamine release from the patient's leukocytes in vitro. The antigen in serum was associated with the globulin fraction and had a temporal relationship to ejaculation, appearing within 12 hours of ejaculation and disappearing within four days."

It's an antigen for the woman's leukocytes but circulates in the serum of men up to 4 days? Just like the timing seen in POISers.

A new manifestation of seminal fluid hypersensitivity

Manifestations of immune tolerance in the human female reproductive tract

Human seminal plasma allergy: a review of a rare phenomenon

-mefenamic acid, 500 mg 2 h before intercourse and every 4 h thereafter as needed.
-tranexamic acid abolished the symptoms

The seminal fluid of the partner of one of these three patients also contained IgE reactive with Candida albicans.

A comprehensive characterization of the peptide and protein constituents of human seminal fluid

Selective desensitization to seminal plasma protein fractions after immunotherapy for postcoital anaphylaxis


Low-Dose IL-2 Induces Regulatory T Cell–Mediated Control of Experimental Food Allergy

Targeting IL-2: an unexpected effect in treating immunological diseases

Androgen receptor modulates Foxp3 expression in CD4+CD25+Foxp3+ regulatory T-cells


Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin

Case of post-orgasmic illness syndrome associated with hypogonadism.

Neuroendocrinology of mast cells: Challenges and controversies.

Low tryptophan brother:
Low-dose IL-2 therapy compensates for metabolic shifts and reverses anxiety-like behavior in PD-1 deficiency-induced autoimmunity


Tried ~4 types of antihistamines. Only clemastine/Tavegyl had a minor effect. "Clemastine does also act as FIASMA (functional inhibitor of acid sphingomyelinase)".


Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease

Blood test reference ranges:

Wrinkled finger test, dysautonomia:

Brother IL-17, tryptophan:
Candida albicans Dampens Host Defense by Downregulating IL-17 Production

Oral candida infection:
IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils

Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice

IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut

Involvement of Cervical Muscle Lesions and Autonomic Nervous System in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS


Potential neuro-immune therapeutic targets in irritable bowel syndrome

Hormone regulation via vagus nerve, what hormones?

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway

"there was a trend towards a decrease in IFN-g, IL-17 and TNF production with an increase in IL-9 production in response to antigen"

Fungal infection in cerebrospinal fluid from some patients with multiple sclerosis

Nightingale had a candida infection:
It was partially my fault, because I was in the midst of treating my candida infection and went overboard with antifungals and probiotics, making me feel terrible and compromising my immune system.  On top of that, I was surrounded by family who probably brought all sorts of germs with them.

Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes

Potential involvement in exercise intolerance:

Acute Peripheral Facial Palsy: Recent Guidelines and a Systematic Review of the Literature (2020)

New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice
« Last Edit: January 09, 2021, 02:35:19 PM by Muon »


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