Stress proteins?

[Muon]

Heat shock proteins in the therapy of autoimmune diseases: too simple to be true?

There are two basic sources of extracellular HSP in animals and humans, i.e., microbial- (both infectious and commensal) and self-derived HSP

HSP are a group of constitutive and/or stress-induced proteins present in all known cellular organisms. “Heat shock proteins” is something of a historical term for stress proteins. It seems insufficient because thermal stress is only one of many known stimuli of HSP in the cell.

Here are your triggers also seen in POISers:
Beside heat, diverse internal and external stresses like cold, ethanol, trace metals, ROS, NO, UV, infection, or inflammation constitute the most common HSP inducers mentioned in the scientific literature.

Autoimmunity towards heat shock proteins (HSP) has been observed in a number of experimental models of autoimmunity and in human autoimmune disease [1-6]. These responses may be manifested as either T cell proliferative responses or as autoantibodies towards the endogenous HSP. Ref

Will rapid changes of endogeneous parameters in the body (orgasm?) lead to cellular stress and will the released stress proteins act as autoantigens in POIS? If so other triggers of cellular stress may be mimicking POIS symptoms, which is reported by patients.

ER stress proteins in autoimmune and inflammatory diseases

Stress proteins may provide a link between the immune response to infection and autoimmunity

Does semen contain stress proteins?

Effects of Exercise on Testosterone Level, Heat Shock Protein, and Fertility Potential

Considering exercise as HSPs inducers has created a new research field. Available data show that various forms of acute and chronic exercise regulate several HSPs in the human skeletal muscles. For resistance to the damage of exercise, the expression of HSP may begin by mechanical damage to muscle proteins and its level may increase by the inflammation response, which occurs several days later. After the tolerance of aerobic activities, it is possible that the expression of HSPs is mediated with redox signaling, which induces the radicals. In general, as we mentioned before, HSP helps to the maintenance of organism health.

[Journey]

The weird muscle activeness that I have in POIS does seem like some sort of stressor type of state

[Muon]

The weird muscle activeness that I have in POIS does seem like some sort of stressor type of state

Yes local stress seems to lead to local inflammation (I assume you are not talking about the spasms?) at the same area. I'm not sure the HPA-axis is involved in this. Could be a local immune response to local leakage of stress proteins. Another reason would be MCA which has been discussed plenty of times already (it's a source of stress hormones outside the HPA-axis). There could be hundreds of other reasons though.

[VSmasher]

So if HSPs(stress proteins) are causing POIS... How do we lower them??