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Los Angeles.
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General Alternative Causes and Treatments of POIS / Re: POIS CURED
« Last post by Iwillbeatthis on October 17, 2019, 05:19:54 PM »
h3 receptor has to be involved in POIS as it can inhibit the release of all neurotransmitters
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Where is the study taking place and are people going to fly out to there or something?
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Keynote with Alex Azar, Secretary of Health and Human Services,




Just Added
to
The NORD Rare Diseases & Orphan Products Breakthrough Summit
October 21-22 Washington, D.C.
https://nationalorganizationforraredisorders.cmail20.com/t/ViewEmail/j/D25F88ACCA17A7372540EF23F30FEDED/FFA142944D02FA97A29558A201773426
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General Alternative Causes and Treatments of POIS / Re: POIS CURED
« Last post by Iwillbeatthis on October 17, 2019, 03:29:10 PM »
Yes it might be a good test. Coffee and things like asprin can inhibit the dao enzyme and both of them some times can make me feel good but if I have too much days in a row I don't feel great
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Amazingly cool graphics!
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Like IDO, arginase-1 is also a major immune suppressor. While IDO depletes tryptophan, arginase depletes arginine and causes a reduction in NK cell activity.

Arginase-1 inhibitor options for testing purposes:
Viagra (sildenafil), 50mg, 90minutes prior to orgasm
Cialis (tadalafil), 20mg, 2.5 hrs prior to orgasm
caffeine, 150mg, 90minutes prior to orgasm
citrulline malate, 7g, 90minutes prior to orgasm

Ideally orgasm should happen at the time of peak concentration of the drug in the body. The below graphs justify the wait times (prior to orgasm) for each drug.

Figure 5: Mean Sildenafil (Viagra) Plasma Concentrations in Healthy Male Volunteers, from: https://www.pfizermedicalinformation.com/en-us/viagra/clinical-pharmacology


Tadalafil (Cialis) pharmacokinetics from: https://www.dovepress.com/comparison-of-tadalafil-pharmacokinetics-after-administration-of-a-new-peer-reviewed-fulltext-article-DDDT


Caffeine pharmacokinetics from: https://www.researchgate.net/figure/Time-caffeine-concentration-profiles-for-five-conditions_fig1_301562749

All of these drugs have been independently shown to increase Natural Killer cells, increase NK cell activity and prevent immune deficiency of effector lymphocytes. Caffeine and citrulline malate are over-the-counter (OTC), can be taken together and are generally safer than the PDE5 inhibitors (Viagra and Cialis). None of the other arginase inhibitors listed above can be taken together because of drug interaction. Before testing arginase inhibitors check with your doctor to make sure you are healthy enough and there are no drug interactions with medications you are currently taking.

Other ways to increase NK cell activity:
Active hexose correlated compounds (AHCC)
liposomal vitamin C (ascorbate, ascorbic acid, and ascorbyl palmitate).


Vitamin C partitioning in the immune system. Lymphocytes and platelets require the highest vitamin C levels to function properly.
 
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General Alternative Causes and Treatments of POIS / Re: Water on POIS
« Last post by demografx on October 16, 2019, 06:31:18 PM »
Thank you, Limejuice
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Auto-Immune Causes and Treatments / Re: Face swelling, lost of consciousness
« Last post by drop247 on October 16, 2019, 04:26:50 PM »
Nothing worked for me, till I rebooted my hard-drive aka metabolic system :) with NDT.  And now it seems that everything works for my POIS so much so, that I barely get POIS, life is good so far :)

Swell I see you tried liposimal glutathione did it help you at all in anyway and did you try Nad+? Was thinking of buying it but its kinda expensive and I already tried Nac for like a month which didn't do much apart from make me a little foggy.

Was also thinking about trying:
Nad+
L glutamate
creatine
LDN

How did you get NDT prescribed? Did you have a thyroid panel done that showed some low levels? If so what hormones should I request be checked?
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General Alternative Causes and Treatments of POIS / Re: Water on POIS
« Last post by Limejuice on October 16, 2019, 02:14:25 PM »
Limejuice, think I could try this with TRT?

Seems fairly safe to me and might elevate levels of free testosterone slightly with the increase of blood circulation. Kidney’s can remove 5gal of water/day, and study’s show nutrient removal starts with +2gal/day. I’m sure patient size/weight is an important variable too. So 3/4 gal (or 3 liters) seems relatively safe :)
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