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It seems that  ALL  homeostastis systems in the body are linked  to  endocannabinoids !

Some guys here report improvements by smoking weeds.
I wonder if Pois can't be caused by  endocannabinoids deficit after ejaculation.
I had zero symptoms with purifief cbd oil. But I made a mistake. When the bottle was almost empty I took it all wirhout measuring. The next day I was very sick and since then I am allergic to cbd oil. But it was oil from the lab. Over the counter cbd oil didn’t help me at all. Also didn’t thc oil.
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It seems that  ALL  homeostastis systems in the body are linked  to  endocannabinoids !

Some guys here report improvements by smoking weeds.
I wonder if Pois can't be caused by  endocannabinoids deficit after ejaculation.
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Yes.  For some, its a very big component.  I think as nanna1 postulates that POIS is an inflammatory response, so if your nerves are in the slightest compromised state (though still normal) however after POIS, with that increased inflammation, they will now will get significantly (clinically) pinched, disrupting nerve transmission and causing the symptoms - pain / paresis etc. 

Do you think POIS could have a neurological component?
Ok, swell. Thank you for your answer.

In fact, I think there are several people in this forum who suffer from chronic pelvic pain. I have seen that there is also a disease classified as rare called pudendal neuralgia ... the pudendal nerve is apparently responsible for the perceptions of the pelvic, genital area, etc ...

This is why I was asking about posible relationship with neurological problems.... Maybe there is any relationship with pudendal neuralgia and POIS when having chronic pelvic pain....
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I have uploaded heart rate and blood pressure measurements. You can find them over here. This has been measured during the summer of 2013 when POTS, cardiovascular and autonomic function related symptoms where at their peak. A few times measurements have been repeated on multiple healthy (read non POTS) humans to rule out device related issues. The second page has some notes in Dutch which you can translate yourself, if not ask me.
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Hormonal Causes and Treatments / Re: Testosterone
« Last post by hurray on Today at 12:59:08 PM »

Interesting about Clomid. My POIS came in a period when my weight went 20 kilo’s (44lb) up. I used to play soccer 3 times a week. And I ate at home. Eveyday a fresh made meal from my parents. I was skinny but healthy. Then I graduated from the university and got a job. I stopped with soccer and ate fastfood and pasta. And I live in The Netherlands where there normally is not much sun. I think in that period my vitamin D leverl dropped. And also my TRT level. I think that was one of the many triggers to develop POIS. So taking Clomid is interestting. Is there another person who took this? I don’t wanna take TRT pills or patches because I am 41 years old. But my TRT level is a bit low. See my level on the blood test topic. I will aks my POIS doctor what he thinks about taking Clomid.

There is also link between low TRT and prostatitis (my main problem):
https://www.issm.info/news/sex-health-headlines/researchers-find-connection-between-low-testosterone-and-cp-cpps/


I saw that Quantum already wrote about Clomid:


Well, the good news is that Clomid is cheap and readily available. It was approved as a fertility drug in 1967, and has been available in a generic form for a long time. Its secondary properties of raising testosterone levels in men were only discovered relatively recently.

I would be interested to know what your POIS doctor thinks about Clomid. It sounds like you have other good reasons for increasing your testosterone levels, and hopefully your doctor will take those into consideration.

I had not seen Quantum's information about Clomid in the other thread, he shares some very interesting thoughts.

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Support and Miscellaneous / Re: Muon's Case
« Last post by Muon on Today at 12:58:32 PM »
I have uploaded heart rate and blood pressure measurements. You can find them over here. This has been measured during the summer of 2013 when POTS, cardiovascular and autonomic function related symptoms where at their peak. A few times measurements have been repeated on multiple healthy (read non POTS) humans to rule out device related issues. The second page has some notes in Dutch which you can translate yourself, if not ask me.

Something else, I had painfully stiff muscles due to POIS a week ago. The higher part of the back, shoulders and part of the upper arms were affected, the weird thing was it kept getting stiffer and stiffer up to the point I could barely move my right arm, it was that painful (there was only pain present during movement, not in rest). Moving my arm/shoulder, was like the feeling of almost tearing some muscles. I slept one night with clothes on because undressing was too painful. Quite a weird event, I have never experienced this intensity of stiffness before.
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Adult POIS-patients don’t have acne. You have Pityrosporum folliculitis. See here:

https://poiscenter.com/forums/index.php?topic=2612.msg22850#msg22850

POIS is not the right term. There are many POIS-patients who have symptoms without orgasm or ejeculation. When I am sexually active and don’t finish my symptoms are even worse.

There is a topic with succesfull treatments (see below). You can look what you want to try. Maybe something helps to get you some relief. Maybe niacine or taurine. But you should see a doctor. Let him do some bloodtests. Check your vitamin D, B12, iron, testosterone and some other things. There is a topic with all bloodtest we did. When you have this knowledge you can do something about your health in general. Maybe it will only help your POIS for 10%, but you have to be happy with all progress.

https://poiscenter.com/forums/index.php?topic=2338.0
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and that these factors aren't mutually exclusive

Short bio:

I have been experiencing POIS for many years without ever knowing there was a term for it, how many other guys suffered and how different the symptoms could be. For me, problems probably started around mid to late puberty as I was doing a lot of PMO (porn, masturbation, orgasm). Aside from general symptoms of brain fog and tiredness which almost all guys in the Nofap (i.e. abstaining from PMO) communities report on without necessarily having POIS, my primary symptoms are and always have been varying levels of itching/urticaria and bad skin with acne and what I can only describe as dandruff with an oily scalp.

I'm 25 now, and as stupid as it sounds never seen a doctor for these issues. I also haven't cured myself, but found periods of complete relief through Nofap, only to fall back into what can sometimes feel like a literal fire depending on how much and how often I give in to the desire of sexual release and my vices. Since it dawned on me that POIS (still without knowing the term) was the culprit I have sort of managed my symptoms for years by not going overboard with PMO, and trying but most often failing to do Nofap. The most I've managed has been around 20 days to a month only a handful of times, but anytime I go longer than a week or two it's almost as though I never even had this shit to begin with. Skin clears up with no excess oil and the itchy urticaria which when active is also onset by physical stress and sun exposure gradually fades away


Now, things to note that led me to believe this is true:

- acne is most definitely primarily hormonal in nature. there's a reason why teens and women who are pregnant are most affected and not prepubescents or other adults to the same degree

- my own symptoms can be onset just by sexual arousal alone (orgasm is a stronger and longer lasting trigger but still)


sidenotes:

diet especially can improve and worsen acne, but it probably happens through changing our hormones. see https://goo.gl/qrw96h

the only medicine that made my itch tolerable at its worst was antihistamines, which means there is an autoimmune reaction but again, because of the first two points this is probably also directly due to hormones. see https://www.ncbi.nlm.nih.gov/pubmed/18485675 for the most relevant possible evidence I could find in 20 seconds

see also https://www.ncbi.nlm.nih.gov/pubmed/19087438 for a possible explanation that ties in to the other references as to why a generally healthier diet seems to be the cure for some




Couldn't find much in the way of identical symptoms on the forum, but I hope that it can resonate with someone on everyone's journey to being free and finding a more clear cut cure
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Hormonal Causes and Treatments / Re: Iodine
« Last post by JohnJames on October 22, 2018, 02:55:49 PM »
There are some people out there doing an "Iodine Loading" protocol thing, which involves taking many many times more than the RDA. Some people are having alot of good success with it with autoimmune diseases.

See: https://www.westonaprice.org/health-topics/modern-diseases/the-great-iodine-debate/

Which has an interesting discussion on it. Seems some people think Halide poisoning is implicated in many autoimmune diseases.

I actually still think the gut is the culprit here atleast for me, and I would guess the reason why people on high dose iodine is successful is because iodine maybe has antimicrobial properties in the gut which would potentially remove/reduce the number of pathogenic bacteria in the microbiome?

Add that in with the salt loading they do, which also has antimicrobial properties.
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Hormonal Causes and Treatments / Re: Testosterone
« Last post by Vandemolen on October 22, 2018, 02:45:53 PM »
There is an interesting alternative to traditional TRT injections/gels called clomiphene (Clomid). According to the second link below, it does not have a negative effect on male fertility:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508437/

https://www.dontcookyourballs.com/can-clomid-treat-male-infertility/

Here's a quote from another paper regarding TRT and fertility:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/

Quote
"Alternatively, CC (clomiphene citrate) is commonly used as an alternative to TRT to treat hypogonadism in men wishing to preserve spermatogenesis. The ability to take an oral medicine that is relatively inexpensive and has good long-term safety data and is clinically efficacious at ameliorating hypogonadal symptoms is clearly advantageous."
Interesting about Clomid. My POIS came in a period when my weight went 20 kilo’s (44lb) up. I used to play soccer 3 times a week. And I ate at home. Eveyday a fresh made meal from my parents. I was skinny but healthy. Then I graduated from the university and got a job. I stopped with soccer and ate fastfood and pasta. And I live in The Netherlands where there normally is not much sun. I think in that period my vitamin D leverl dropped. And also my TRT level. I think that was one of the many triggers to develop POIS. So taking Clomid is interestting. Is there another person who took this? I don’t wanna take TRT pills or patches because I am 41 years old. But my TRT level is a bit low. See my level on the blood test topic. I will aks my POIS doctor what he thinks about taking Clomid.

There is also link between low TRT and prostatitis (my main problem):
https://www.issm.info/news/sex-health-headlines/researchers-find-connection-between-low-testosterone-and-cp-cpps/


I saw that Quantum already wrote about Clomid:


On the prescription only side, clomiphene ( Clomid) is an alternative to TRT.  Less side effects, but it is quite hard on the liver, and if you read my latest post on liver detoxification, you will know that any med toxic for the liver is not optimal for anyone, and surely not for someone with POIS  ( see at http://poiscenter.com/forums/index.php?topic=2431.msg20521#msg20521 about liver detoxification)   .  Note that clomiphene is known for treatment of infertility, but chances are your general practitioner may not know about it boosting testosterone levels.  On the long run, you have to decide which one between TRT and clomiphene would be a "lesser bad".  After all, that's why prescription only drugs are prescription only, don't they?

Raising the immune tolerance, as testosterone does, to whatever antigen we have in either the prostate or seminal glands or bulbourethral glands, is what I think is effective in TRT for POIS.  So raising T should help.  It's not the only issue in POIS, but one way to attack this multi-headed beast.
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