Time of day and POIS

[Muon]

Even if it's temporary and the effect barely noticable. If more than one interval applies, select the one where you feel best.

https://en.m.wikipedia.org/wiki/24-hour_clock

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation

The role of melatonin in the cells of the innate immunity: a review

[Journey]

I feel as POIS is less in night and Oing before sleep give bit less.

[Iwillbeatthis]

Always feel best at 9pm-12am, like I mean really good its a shame I don't feel the same in the mornings. I have recently bought some blue light blocking glasses off amazon and they do seem to increase wellbeing quite a bit, also my face looks a lot better after wearing them and the skin on my face looks much more healthy and brighter, eye bags go away. Also wake up feeling more refreshed.

[Muon]

I feel significantly better as a function of time (12 a.m - 3 a.m) when I'm approaching 3 a.m just like my brother. I get more energy, feel that I'm less inflamed and being less sensitive to triggers. I also get the impression that it (some circadian parameter) synergizes with a drop in ambient temperature at nightfall. I wish this effect was present during daytime rather than at night. There were some russians a while ago discussing about sleep deprivation being beneficial to their symptoms. I don't think it is that, it probably has to do with experiencing a rise in melatonin.

[certainlypois2]

I used to feel worse at night, but that doesn't happen anymore.

[Muon]

Melatonin receptor agonists for POIS? It also affects ion channels and regulate ion flux inside the cell.

https://en.wikipedia.org/wiki/Melatonin_receptor_agonist

https://en.wikipedia.org/wiki/Melatonin_receptor

https://en.wikipedia.org/wiki/G_protein-coupled_receptor

[Muon]

https://selfhacked.com/blog/th17/

Th17 cells seem to have a circadian rhythm. The amount of Th17 cells changes during the day-night cycle. Animal studies suggest that the production of Th17 is higher at midnight than at noon

Based mostly on animal findings, Th17 appears to have a protective role in combating fungi

[an-y-more]

I'm not sure about better but I do enjoy nightitme more for some reason. And my daytime regime in these years was always slipping to night much easier than other way around.
 During a summer I used to stay up at night and sleep during a day usually and it was pretty common that in the morning (vaguely around 7 o clock) I would start to feel shaky like I had tremor or some tension problems. This wasn't fatigue or anything like that. Seems about a time melatonin drops at your graph..