Time of day and POIS

[Muon]

Even if it's temporary and the effect barely noticable. If more than one interval applies, select the one where you feel best.

https://en.m.wikipedia.org/wiki/24-hour_clock

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation

The role of melatonin in the cells of the innate immunity: a review

[Journey]

I feel as POIS is less in night and Oing before sleep give bit less.

[Iwillbeatthis]

Always feel best at 9pm-12am, like I mean really good its a shame I don't feel the same in the mornings. I have recently bought some blue light blocking glasses off amazon and they do seem to increase wellbeing quite a bit, also my face looks a lot better after wearing them and the skin on my face looks much more healthy and brighter, eye bags go away. Also wake up feeling more refreshed.

[Muon]

I feel significantly better as a function of time (12 a.m - 3 a.m) when I'm approaching 3 a.m just like my brother. I get more energy, feel that I'm less inflamed and being less sensitive to triggers. I also get the impression that it (some circadian parameter) synergizes with a drop in ambient temperature at nightfall. I wish this effect was present during daytime rather than at night. There were some russians a while ago discussing about sleep deprivation being beneficial to their symptoms. I don't think it is that, it probably has to do with experiencing a rise in melatonin.

[certainlypois2]

I used to feel worse at night, but that doesn't happen anymore.

[Muon]

Melatonin receptor agonists for POIS? It also affects ion channels and regulate ion flux inside the cell.

https://en.wikipedia.org/wiki/Melatonin_receptor_agonist

https://en.wikipedia.org/wiki/Melatonin_receptor

https://en.wikipedia.org/wiki/G_protein-coupled_receptor

[Muon]

https://selfhacked.com/blog/th17/

Th17 cells seem to have a circadian rhythm. The amount of Th17 cells changes during the day-night cycle. Animal studies suggest that the production of Th17 is higher at midnight than at noon

Based mostly on animal findings, Th17 appears to have a protective role in combating fungi

[an-y-more]

I'm not sure about better but I do enjoy nightitme more for some reason. And my daytime regime in these years was always slipping to night much easier than other way around.
 During a summer I used to stay up at night and sleep during a day usually and it was pretty common that in the morning (vaguely around 7 o clock) I would start to feel shaky like I had tremor or some tension problems. This wasn't fatigue or anything like that. Seems about a time melatonin drops at your graph..

[Muon]

Nanna1 posted a few things about sleep and circadian rythm, copy paste this section:

Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression (2013)

Figure 2 T Cell and Antigen Presenting Cell Activity During Sleep


Figure 5 T Cell and Antigen Presenting Cell Activity During Sleep




White circles: 24 hour sleep deprivation, Black circles: 24 hour normal sleep. Gray region (23:00 - 7:30): sleeping period
-Number and Function of Circulating Human Antigen Presenting Cells Regulated by Sleep


Effects of sleep and circadian rhythm on the human immune system

[Muon]

* Sex 1-2h before sleep only, not during day

Yes same, it's better to get sexual activity before bed time rather than during the day. My wellbeing seems to correlate with the melatonin curve. The rare events I had where an O led to zero POIS symptoms where actually at night time. Circadian rythm (Nor)epinephrine decreases during evening/night. Regarding the DA-->NE conversion and perhaps low levels of DA and/or NE, you would think POIS would be worse at night time. Or the latter is actually a factor but melatonin somehow dominates.

A few posts back about the melatonin receptors-->they both inhibit adenylyl cyclase. Nanna's theory is centered at the inhibition of adenylyl cyclase.

Melatonin attenuates VEGF levels. The latter increases blood brain barrier permeability and vascular endothelial permeability. Also Melatonin inhibits mast cells and modulates Th1/Th2 balance.

Guanylyl cyclase?

[Muon]

Diurnal variation of aldosterone and plasma renin activity: timing relation to melatonin and cortisol and consistency after prolonged bed rest

[Muon]

The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators

[Muon]

Being a woman, I can't say I've experienced NE, but I've had orgasms while asleep in the past. It doesn't happen frequently, only when I've been especially frustrated with abstinence. For me, they don't cause any symptoms at all. However, arousal does cause mild symptoms when awake.

I believe the reason why they don't make me sick is because, when they happen and I wake up afterwards, I don't experience any of the physical signs of arousal or sexual activity, I haven't produced any fluid and there haven't been any physical changes whatsoever. It's as if it was only in my brain, and my body was disconnected, even if all the sensations feel completely real in the dream. The only downside is that the thoughts remain and it's much easier to relapse the day after. I wonder if it works like this for anyone else.

[BoneBroth]

Cortisol lowers inflammation and increases blood pressure. The highest levels is in the morning between 6am and 12pm, I would guess that is why most people in the poll feels best during that time. I've made two blood cortisol tests in the morning and both showed levels slightly higher then normal. I believe many POIS'ers has long term hight cortisol due to many POIS inflammations cycles. Although cortisol is the most important player that controls the POIS-inflammation, long term hight levels are producing very bad side effects.

It might also be bad in the short run if its hight all day. When cortisol is hight, the body is closing down many processes, like digestion, repair and immune system. Our bodies dont get enough time to repair itself between the POIS cycles. Thats might be why many people experience problems with digestion, immune system, bad skin, liver/kidney issues.

Thats why we need to focus on things that minimize normal cortisol peaks, like stressmanagement, not drinking tooo much coffee, not too much intense training etcetera. I wish more POIS'ers could do and share more cortisol tests in this forum, specifically tests that shows cortisol many time during the first days after orgasm.

[Muon]

"Increased levels of melatonin causes a downregulation of leptin"
https://en.wikipedia.org/wiki/Leptin

Leptin and Premature ejaculation: https://poiscenter.com/forums/index.php?topic=139.msg44287#msg44287