Muon's Case

[Muon]

I've uploaded a collection of labtest all done at one lab.

Click here

Notes:

Pages are in chronological order.
The glucose accuchecks were done during the lactose hydrogen breath test.
The elevated ALAT 159 test from 2014 was done the day after I had a flare of intense pain in the liver area.
Helicobacter was negative
Catecholamines: I believe it was norepinephrine measured in a supine position, normal.

[Muon]

Standing an sitting puts pressure on my lower spine resulting in weakness of upper legs and gives me stress which triggers symptoms in other parts of the body. I can't function due to this symptom. My spine triggered too frequently last year which increased its reactivity. POIS/arousal and stress affect that same area paving the way for increased sensitivty to spinal pressure. Joints in spine feel stiff and it feels like something is stuck in lower back.

I get relieve by laying down, bending forward, pulling legs towards my chest or doing a spinal decrompression exercise but relieve is only for a few minutes. Also starting to get problems with pressure on neck joints which can result in a headache in centre of brain.

Synovial Mast Cells: Role in Acute and Chronic Arthritis
Pressure--->Synovial mast cell activation--->joint inflammation?

My doctor doesn't even take a serious look at this while it affects me 24/7 every day in a major way. I'm so angry and frustrated.

Also had a brief moment of arousal which brought my brain into a different state. It took hours before it returned to the state prior to arousal. Something in my brain didn't stabilize.

The spinal problems are worse than POIS at this point in time.

[Journey]

Standing an sitting puts pressure on my lower spine resulting in weakness of upper legs and gives me stress which triggers symptoms in other parts of the body. I can't function due to this symptom. My spine triggered too frequently last year which increased its reactivity. POIS/arousal and stress affect that same area paving the way for increased sensitivty to spinal pressure. Joints in spine feel stiff and it feels like something is stuck in lower back.

I get relieve by laying down, bending forward, pulling legs towards my chest or doing a spinal decrompression exercise but relieve is only for a few minutes. Also starting to get problems with pressure on neck joints which can result in a headache in centre of brain.

Synovial Mast Cells: Role in Acute and Chronic Arthritis
Pressure--->Synovial mast cell activation--->joint inflammation?

My doctor doesn't even take a serious look at this while it affects me 24/7 every day in a major way. I'm so angry and frustrated.

Also had a brief moment of arousal which brought my brain into a different state. It took hours before it returned to the state prior to arousal. Something in my brain didn't stabilize.

The spinal problems are worse than POIS at this point in time.

I get a bit of "stuck feeling" and tightness in lower back too when stressed.

[Clues]

I get a bit of "stuck feeling" and tightness in lower back too when stressed.

Yep me too. I think it correlates with some of my cognitive symptoms as well. E.g.: If I play a hectic videogame for a couple of hours, my lower back (probably psoas), hamstrings and glutes are all tight and aching, and my articulation and OCD get a bit worse.

[Muon]

A potential candidate responsible for my elevated IgG4:

Nerve growth factor specifically induces human IgG4 production

Nerve growth factor: a neuroimmune crosstalk mediator for all seasons

IL-13 and NGF are now on my radar for selective increase in IgG4.

[Muon]

Sodium, POTS, Beta1-blockers: RAS involvement?

It regulates sodium retention, vasoconstriction and blood pressure. Renin can be produced through activation of β1 adrenergic receptors.

Mast cells can affect that system as well. Mediators: Renin, Chymase, ACE2.

https://en.wikipedia.org/wiki/Renin

https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system

https://poiscenter.com/forums/index.php?topic=2301.msg34195#msg34195

https://poiscenter.com/forums/index.php?topic=3236.0

[Muon]

My grandma did feel better in general and recovered to some extent after they injected something in her throat via the oral way. The substance is unknown. A friend of her recommended to go to that doctor because he helped that friend with getting fertile again. So the oral cavity was being skipped, the question is what was the substance involved? Was it a hormone?

[Muon]

A potential candidate responsible for my elevated IgG4:

Nerve growth factor specifically induces human IgG4 production

Nerve growth factor: a neuroimmune crosstalk mediator for all seasons

IL-13 and NGF are now on my radar for selective increase in IgG4.

Endocannabinoids inhibit release of nerve growth factor by inflammation-activated mast cells

[Journey]

My grandma did feel better in general and recovered to some extent after they injected something in her throat via the oral way. The substance is unknown. A friend of her recommended to go to that doctor because he helped that friend with getting fertile again. So the oral cavity was being skipped, the question is what was the substance involved? Was it a hormone?

Clomid?

[Muon]

I can react bad to a particular vitamin C complex. Sometimes I can tolerate it with no problems or get light symptoms from it, but other times I'm hanging above the toilet nauseous and close to the point of throwing up, just from 1 tablet (10-15 min after ingestion).

Ingredients:
Sweeteners (xylitol, sucralose), vitamin, filler (micro crystalline cellulose), mineral, echinacea-extract (echinacea purpurea), aroma (raspberry), stabilizer (magnesiumsalts from fatty acids).

Composition (1 tablet):
Vitamin C (l-ascorbic acid, calcium-l-ascorbate) 250 mg
Zinc (zinc citrate) 10mg
Echinacea-extract (4% polyphenols) 25mg

Had problems in the past with various supplements (calcium, vit B complex tablets) often in tablet form. I suspect it's the micro crystalline cellulose that is causing me problems.

Recognition and Management of Medication Excipient Reactivity in Patients With Mast Cell Activation Syndrome

[BoneBroth]

Could it be the Xylitol? "Xylitol is a high FODMAP sugar alcohol (polyol), that can wreak havoc on our digestive systems and trigger IBS symptoms".
https://alittlebityummy.com/what-is-xylitol-and-is-it-high-fodmap/

Remember Vitamin C draws copper from your body. Do you recognize any of theese symptoms of copper deficiency?
https://www.healthline.com/nutrition/copper-deficiency-symptoms#TOC_TITLE_HDR_7

[Muon]

Could be the first two ingredients for being FODMAPS but the onset of symptoms is quite fast. I think it's still in the stomach at that point. Don't know about the copper def, I've got some symptoms from that list. Total picture doesn't fit. Hmm the article mentions ATP which induces calcium influx into cells. Anyway the combination of active ingredients boosts the immune system, it already may be in an overactive state as in Th1 activation. I tried a magnesium supplement lately containing micro crystalline cellulose as well but could tolerate it just fine.

[Muon]

Hey man,
Ik zit jouw case door te nemen: https://poiscenter.com/forums/index.php?topic=2545.0

Er zitten zo onwijs veel gelijkenissen bij. Zelfs de gekke dingen zoals dat over-flexibel zijn.

Je hebt er misschien niet veel aan dit te weten, behalve een schrale troost. Toch wilde ik het even zeggen.

Translation:
"I'm going through your case:

There are so many similarities. Even the crazy stuff like being over-flexible.

Knowing this may not help you much, except for small consolation. Still, I just wanted to say it."

[Muon]

Not fully translated from Dutch: Took 2 Kurkuma capsules with black pepper ~ 10 min post O on an empty stomach in the morning and it started to have an effect ~10 min after intake.

Active ingredients 1 capsule:
Kurkuma 100mg
Including curcumine 3000 ug
Black pepper extract 10 mg
Including piperine 9,5 mg
Vitamine D 5 ug (100% RI)
Vitamine C 12 mg (15% RI)

Ingredients: Kurkuma (curcuma Longa L), vulstof (microkristallijne cellulose), Gelatine(rund/varken), Vitamine, Black pepper extract (Piper Nigrum), stabilisatoren (magnesium salts from fatty acids, siliciumdioxide)
Brand: Trekpleister
I get the impression it affected cardiovascular symptoms (inflammation?). Needs further testing could be a fluke, I have tested this before in the past with black pepper and it had no effect, could be the empty stomach thing or difference in formula.

For nasal symptoms: Using minimum dose of disodiumcromoglycate for about 14 days now. Concentration= 40 mg/ml, spraying once in both nostrils twice a day. Going to bump up dose soon.

Last months increased breathing problems. Low respiratory rate ~6 (once every 10 seconds) and sometimes it stalls and have to remind myself to breath, respiratory muscle are slightly weak (need force). This leads to Arrhythmia (not the other way around). One of these days I will get a heart attack. If I force myself to maintain a normal RR my body feels better instantly, brain and extremities ,especially the feet. Healtcare doesn't monitor these things, what a joke.

[Iwillbeatthis]

Not fully translated from Dutch: Took 2 Kurkuma capsules with black pepper ~ 10 min post O on an empty stomach in the morning and it started to have an effect ~10 min after intake.

Active ingredients 1 capsule:
Kurkuma 100mg
Including curcumine 3000 ug
Black pepper extract 10 mg
Including piperine 9,5 mg
Vitamine D 5 ug (100% RI)
Vitamine C 12 mg (15% RI)

Ingredients: Kurkuma (curcuma Longa L), vulstof (microkristallijne cellulose), Gelatine(rund/varken), Vitamine, Black pepper extract (Piper Nigrum), stabilisatoren (magnesium salts from fatty acids, siliciumdioxide)
Brand: Trekpleister
I get the impression it affected cardiovascular symptoms (inflammation?). Needs further testing could be a fluke, I have tested this before in the past with black pepper and it had no effect, could be the empty stomach thing or difference in formula.

For nasal symptoms: Using minimum dose of disodiumcromoglycate for about 14 days now. Concentration= 40 mg/ml, spraying once in both nostrils twice a day. Going to bump up dose soon.

Last months increased breathing problems. Low respiratory rate ~6 (once every 10 seconds) and sometimes it stalls and have to remind myself to breath, respiratory muscle are slightly weak (need force). This leads to Arrhythmia (not the other way around). One of these days I will get a heart attack. If I force myself to maintain a normal RR my body feels better instantly, brain and extremities ,especially the feet. Healtcare doesn't monitor these things, what a joke.

Just a thought maybe this would help your low respiratory rate

https://www.youtube.com/watch?v=RrYmc_Kg0BE

Primal scream therapy gets rid of neurotic holding patterns which affect your breathing pattern

Note It needs to be done from your lower abdomen not your throat

[Muon]

Nasal disodiumcromoglycate fixes sensitivities to airborne molecules. However it does not affect nasal symptoms (post nasal drip, runny nose) to stress and oral food triggers. Most food triggers my stomach leading to nasal activation, seems there is communication between the two and the food triggers are being amplified by (low grade) stress.

Trying Norethisterone at this moment targeting P4 receptors looking for a response, same dose as second POIS paper.

Next in line: Pyridostigmine-->increasing parasympathetic tone.

Pre-ejaculate keeps affecting me. Suspicion--->Seminal fluid protein/liposacharide specific IgG4 response to an antigen.

Reminder commercial clinics: Lower spinal problems, MRI? Checking for osteoporosis.

Possible self experimentation: Look at cost for IL-2, self-injections possible? Look into papers for treatment algorithm and dangers.

[Hopeoneday]

Nasall triger is the same for me, acidic, antioksidant food open my stuffy
nose. I think that vagus nerve is involwed, he regulate digestion.
 Cofee is still one of the best antipois suplement, it will be intresting
to se how pyridostigmine afect you.

[BoneBroth]

I believe one resaon that coffee works is because it temporarily increases the blood pressure. There are other things to try to increase the blood pressure as listed in thread How to increase blood pressure.  Please do the poll What's your normal blood pressure (SYS/DIA)?

[Hopeoneday]

Yeah but i think that is this:

Our data showed that caffeine decreased the LPS?induced inflammatory mediator, nitric oxide (NO). Caffeine treatment also reduced the expression of pro?inflammatory genes inducible nitric oxide synthase (iNOS), cyclooxygenase?2 (COX?2), interleukin (IL)?3, IL?6 and IL?12, and decreased IL?6 secretion and phosphorylated p38MAPK expression in LPS?treated RAW264.7 cells. Caffeine inhibited the nuclear translocation of nuclear factor ?B (NF??B) via I?B? phosphorylation. In addition, caffeine inhibited LPS?induced NO production in zebrafish.

Caffeine may inhibit LPS?induced inflammatory responses in murine macrophage by regulating NF??B activation and MAPK phosphorylation.

The only "medicine" that can kick pois after O in me
, and actually the only medicine and suplement  wich work for pois
in me,  second day 3th day
when i feel afull, coffe is capable to kick me out of that state
(by 50-60%)
(learned smart use of coffe ower time).

[BoneBroth]

How much coffee is needed, how many times a day and what quality? Brewed coffee? Dark/medium/light roasted?