Author Topic: Milnacipran - completely stopping my brain fog  (Read 9233 times)

hurray

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Milnacipran - completely stopping my brain fog
« on: May 27, 2020, 01:16:23 PM »
I've been suffering from POIS since 2000, posting on POIS forums since 2009 (Naked Scientist Forum) and more recently on here (since 2011), and I've finally found something that has consistently worked for me.

For the last 6 weeks, I've been taking milnacipran (Savella) before O. After O, there has been no brain fog - every time. My physical symptoms (dry hair, dry forehead, clicking knees) have also gone.

The milnacipran has an unusual side-effect - my Os feel much more intense, and last much longer. This hasn't happened with any other medicines I have tried, and I have tested many different medicines over the years. Again, this happens every time.

I have been taking one dose of 25mg approximately 1 to 1.5 hours before O. Initially I combined it with fenugreek, but now I take it on its own. The result has been 0% brain fog every time.

Milnacipran is an SNRI that inhibits norepinephrine reuptake even at low doses - other popular SNRIs venlafaxine and duloxetine (which I have tried) need much higher doses before there is any significant inhibition of norepinephrine reuptake. I believe that it is the norepinephrine action of milnacipran which is somehow preventing my post-O brain fog.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938282/

It is early days now, but I sincerely hope that milnacipran will continue to work for me in the long-term. If it becomes less effective or stops working, I will come back to this thread and update it.

I would be happy to answer any questions.
« Last Edit: August 10, 2020, 07:17:39 AM by hurray »

drop247

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Re: Milnacipran - completely stopping my brain fog
« Reply #1 on: May 27, 2020, 01:31:13 PM »
Interesting. If I take anti-histamines with pseudoephedrine they are more effective than anti-histamines alone (ie Allegra-D). Pseudoephedrine is a norepinephrine releasing agent.

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #2 on: May 27, 2020, 01:38:57 PM »
Interesting. If I take anti-histamines with pseudoephedrine they are more effective than anti-histamines alone (ie Allegra-D). Pseudoephedrine is a norepinephrine releasing agent.

Yes, there could be a connection there.

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #3 on: May 27, 2020, 01:40:49 PM »
Milnacipran was developed firstly as a treatment for fibromyalgia, and some countries prescribe it for depression. Interestingly, fibromyalgia sufferers refer to one of their major symptoms being "fibro fog"/"brain fog".

I've copied a few quotes from a milnacipran (Savella) comment section (from fibromyalgia sufferers):

https://www.rxlist.com/script/main/rxlist_view_comments.asp?drug=savella&questionid=fdb152224_pem

Quote
WONDERFUL for energy, pain & brain fog

Quote
Pain is significantly reduced, energy is up and brain fog is much, much better.

Quote
I think I am most surprised that my thinking is almost 100% clearer! I can concentrate on tasks and actually finish one before I start another. The fibrofog is gone!

So it's interesting that several other people have reported it as curing their brain fog.
« Last Edit: July 23, 2020, 02:43:27 PM by hurray »

demografx

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Re: Milnacipran - completely stopping my brain fog
« Reply #4 on: May 27, 2020, 02:13:42 PM »
Interesting, hurray!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

berlin1984

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Re: Milnacipran - completely stopping my brain fog
« Reply #5 on: May 27, 2020, 02:16:05 PM »
I'm curious if you're so long in the game, have you ever tried St. John's wort?

I've never tried it because I don't feel "depressed" as in the sense of sad. Sometimes unmotivated though :-). But if I understand correctly, St. John's Worth is also a reuptake inhibitor, but for more neurotransmitters than Milnacipran
My Protocol with adaoptogens, neurotransmitter precursors, energy production supplements helps with 80% of the symptoms with intercourse, 50% with masturbation.

Muon

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Re: Milnacipran - completely stopping my brain fog
« Reply #6 on: May 27, 2020, 02:34:01 PM »
Interesting. If I take anti-histamines with pseudoephedrine they are more effective than anti-histamines alone (ie Allegra-D). Pseudoephedrine is a norepinephrine releasing agent.

"Pseudoephedrine acts on α- and β2-adrenergic receptors" Ref

Activation of β2-adrenergic receptors on mast cells is the primary pathway for adrenergic agents to inhibit mast cells.

Table 1 and chapter 5: Neuroendocrinology of mast cells: Challenges and controversies

Milnacipran is used for fibromyalgia and fibromyalgia is associated/comorbid with mast cell activation disease.

Iwillbeatthis

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Re: Milnacipran - completely stopping my brain fog
« Reply #7 on: May 27, 2020, 02:53:23 PM »
Have you tried amitriptyline before and also is it safe to take only before O and not regularly, as that is the case with most antidepressants.

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #8 on: May 27, 2020, 03:04:18 PM »
I'm curious if you're so long in the game, have you ever tried St. John's wort?

I've never tried it because I don't feel "depressed" as in the sense of sad. Sometimes unmotivated though :-). But if I understand correctly, St. John's Worth is also a reuptake inhibitor, but for more neurotransmitters than Milnacipran

Hi berlin1984  :)

Yes, I have tried St John's Wort, it worked fairly well as an anti-depressant while I was taking it. I didn't notice any effect on my POIS however  :(

I have tried other NRIs which had no comparable effect to milnacipran on my POIS symptoms - it seems to have a very unique effect.

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #9 on: May 27, 2020, 03:17:47 PM »
Have you tried amitriptyline before and also is it safe to take only before O and not regularly, as that is the case with most antidepressants.

I was considering asking my doctor for amitriptylene, but since milnacipran is working so well for me I may not have the opportunity now.

I was prescribed duloxetine and venlafaxine last year (sister SNRIs of milnacipran) - stopping taking duloxetine after a short period was uncomfortable, and stopping venlafaxine was quite a lot worse.

I can't give medical advice - you MUST speak to a doctor with regards to whether or not a prescription medicine is safe to take. Milnacipran has side-effects including nausea (which I have experienced) and increased blood pressure.

With regards to my own situation, I don't feel any withdrawal symptoms after only taking milnacipran before O - unlike venlafaxine and duloxetine.
« Last Edit: May 27, 2020, 03:20:17 PM by hurray »

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #10 on: May 27, 2020, 03:29:51 PM »
Interesting, hurray!

I'm hoping I can blow my brain fog away for good  ;D

certainlypois2

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Re: Milnacipran - completely stopping my brain fog
« Reply #11 on: May 27, 2020, 04:24:36 PM »
Interesting, hurray!

I'm hoping I can blow my brain fog away for good  ;D
Achoo to that.

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #12 on: May 27, 2020, 05:01:15 PM »

demografx

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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: Milnacipran - completely stopping my brain fog
« Reply #14 on: May 28, 2020, 02:24:21 AM »
I've been suffering from POIS since 2000, posting on POIS forums since 2009 (Naked Scientist Forum) and more recently on here (since 2011), and I've finally found something that has consistently worked for me.

For the last 6 weeks, I've been taking milnacipran (Savella) before O. After O, there has been no brain fog - every time. My physical symptoms (dry hair, dry forehead, clicking knees) have also gone.

The milnacipran has an unusual side-effect - my Os feel much more intense, and last much longer. This hasn't happened with any other medicines I have tried, and I have tested many different medicines over the years. Again, this happens every time.

I have been taking one dose of 50mg approximately 1 to 1.5 hours before O. Initially I combined it with fenugreek, but now I take it on its own. The result has been 0% brain fog every time.

Milnacipran is an SNRI that inhibits norepinephrine reuptake even at low doses - other popular SNRIs venlafaxine and duloxetine (which I have tried) need much higher doses before there is any significant inhibition of norepinephrine reuptake. I believe that it is the norepinephrine action of milnacipran which is somehow preventing my post-O brain fog.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938282/

It is early days now, but I sincerely hope that milnacipran will continue to work for me in the long-term. If it becomes less effective or stops working, I will come back to this thread and update it.

I would be happy to answer any questions.
Do you have social dysfunction symptoms and does this medication help with it?