Mast Cell Activation Syndrome

[Muon]

Vagal influences over mast cells. GI mast cell numbers may have changed. This could explain the links between autonomic/vagal dysfunction and IBS/IBD.

[Hopeoneday]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC96436/
Borrelia burgdorferi Spirochetes Induce Mast Cell Activation and Cytokine Release

[Hopeoneday]

The results of the present study support the biological plausibility of how mercury could contribute to ASD pathogenesis by inducing VEGF and IL-6 release from mast cells, and as a result disrupt the BBB and thus permit brain inflammation. Further studies should investigate the effect of mercury and thimerosal alone or together with allergic and non-immune triggers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850891/

[Hopeoneday]

Muon, did any of the poisers monitor the condition with PTH hormone.
PTH is a major trigger for MCAS.
PTH extracts calcium from the bones, and it usually does when
low levels of vitamin D in the body.
The main role of vitamin D is to work on the absorption of calcium
from the gut into the blood.
I think that for those poisers who were helped by vitamin D, it is a matter of reducing the triggering of MCAS and
modulation of immunity.
So low vitamine D induce elevation of MC trought PTH.

PTH controls the level of calcium in the blood. Calcium is a mineral that keeps your bones and teeth healthy and strong. It's also essential for the proper functioning of your nerves, muscles, and heart. If calcium blood levels are too low, your parathyroid glands will release PTH into the blood.Jul 31, 2020
https://medlineplus.gov/lab-tests/parathyroid-hormone-pth-test/

Parathyroid hormone as a stimulus to mast cell accumulation in bone
https://link.springer.com/article/10.1007/BF02017533

However, levels of 25-hydroxyvitamin D3 less than 20 ng per mL (52 nmol per L) triggers a compensatory increase in parathyroid hormone (PTH) and, hence, accelerates bone resorption. This suggests that vitamin D deficiency occurs before the lower limits of traditional population-based values for PTH.Jan 1, 2005
https://www.aafp.org/afp/2005/0101/p46.html

[Hopeoneday]

The mechanism of mast cell stabilization is not fully understood. Cumulative reports indicate that vitamin D (VitD) contributes to the homeostasis in the body. This study tests a hypothesis that VitD is required in the maintenance of the stability of mast cells.

https://pubmed.ncbi.nlm.nih.gov/27998003/

[Muon]

Mast cell stabilization means that only a subset of certain mediators are being inhibited regarding MC stabilizers/therapy. If you get symptoms from these specific mediators then stabilization by MC stabilizer X will help but if you get sick due to other mediators that aren't going to be suppressed by MC stabilizer X then nothing will happen and one concludes that it isn't MCAD. You can take a look at all the mast cell receptors and compare it to the POIS paper treatment summary thread.

Muon, did any of the poisers monitor the condition with PTH hormone.

Not that I'm aware of, no. But this is interesting stuff HOD. Since I suspect intracellular calcium going down in POIS. Does that mean that PTH changes due to POIS trigger? Calcium signaling? Impaired vit D signaling? My mother used Bisphosphonate for her osteoporosis for 5 years. Did not affect bone density, so another mechanism is at play here. She is now using a RANKL inhibitor.

[Muon]

Testicular mastocytosis

Mast Cells in the Human Testis and Epididymis from Birth to Adulthood

Mast Cells in the Testis, Epididymis and Accessory Glands of the Rat: Effects of Neonatal Steroid Treatment

Mastocytosis Occurring in the Testes From Patients With Idiopathic Male Infertility

Male Fertility as a Bull’s Eye for Mastocytosis

"Moreover, it was found that testicular mastocytosis is associated with blood-testis barrier malfunction"

AN UNUSUAL PRESENTATION OF A MAST CELL DISORDER: SCROTAL EDEMA

[Hopeoneday]

Emerging Roles of Mast Cells in the Regulation of Lymphatic Immuno-Physiology
https://www.frontiersin.org/articles/10.3389/fimmu.2020.01234/full

Mast cells contribute to homeostasis in the immune system. They serve as a first line of defense against antigens entering the body due to their location in the skin and mucosa (21). Mast cells are especially important in the homeostasis of the commensal bacteria of the gut (22).Jan 6, 2016

https://www.frontiersin.org/articles/10.3389/fimmu.2015.00620/full

Mast cels gental urinary and gut connection 

[Muon]

Relevant info regarding supplements containing Luteolin, will dump this in the MCAD thread:

Luteolin supplements: All that glitters is not gold

"Note: Any product of 60 capsules claiming 100 mg luteolin/capsule and priced <$35 is unlikely to contain high purity luteolin, which is very expensive."

[Hopeoneday]

Theoharides?

Is he actualy respon to your email ever?

[Muon]

Theoharides?

Is he actualy respon to your email ever?

Yes

[Hopeoneday]

His toughts about pois?

[Muon]

His toughts about pois?

He insinuated by sending me papers that potentially mast cells in the male reproductive system may be involved and/or mast cells elsewhere that could be activated due to neuroendocrine triggers. He has seen multiple MCAS patients in his practice with POIS symptoms.

[Hopeoneday]

This could be, my pois cascade start exectly like he descrribes...
histamine iching, drop of blod pressure,  inflamed ayes, then pain prostagladins then leukotrines shortenes of breath bumping heart etc etc...

Now i know why i suspected long time ago that i hawe testicular cancer,
nobody bolive me in thouse times... swolen lymph node in scortum and severe pois symptomes, it is like you dying... doctors think that i imagine all this as a
teeneger
 

[Muon]

Maybe you should find another doctor and ask if you could try some stuff from this thread: https://poiscenter.com/forums/index.php?topic=3551.0

[Hopeoneday]

https://www.researchgate.net/publication/233983858

Inhibitory effects of benzodiazepines on the adenosine A2B receptor mediated secretion of interleukin-8 in human mast cells

My only cure in thouse times   small those to survive anaplaxes.

[Muon]

https://www.researchgate.net/publication/233983858

Inhibitory effects of benzodiazepines on the adenosine A2B receptor mediated secretion of interleukin-8 in human mast cells

My only cure in thouse times   small those to survive anaplaxes.

Interesting, benzo's worked for my brother's POIS, he had to quit because they were too addictive. Need to ask him again how good they worked compared to other meds he tried. His IL-8 is slightly elevated. I could put benzo's on my list just to see if I get a response. The next one on my list is Neuroprotek (can reduce IL-8 and IFN-g in whole blood). That begs the question what the source of IL-8 is.  Endothelial cells are able to release IL-8 and 11-b-PG-F2a as well but the symptomatology fits mast cells much better. MCs also express peripheral benzodiazepine receptors.

Edit: He did not only stop due to the addictive effect but he built up a tolerance to it as well.

[Hopeoneday]

Yes, i dont want to take them because of adiction, only when needed.
Nothing else realy work from me but coffe in pois , for pain and cfs,
but coffe hawe side effects if not dozing smart.

[Muon]

I suspect you and I got the same root cause of POIS. Note: Mast cell mediators don't necessarily have to be dumped into circulation.

"The rank order of potency was diazepam > 4'-chlorodiazepam > flunitrazepam > clonazepam with clonazepam causing only a minor effect at a high concentration." Ref

[Muon]

What benzodiazepines have you tried HOD?