POIS paper treatment summary

[Muon]

https://www.dinet.org/forums/topic/31629-mechanism-of-choline-deficiency-and-membrane-alteration-in-pots/?tab=comments#comment-285360

[demografx]

...If anyone wants to go through the 1000+ pages on Nakedscientist looking for cases describing treatment methods then be my guest, I'm not going to do that. Or perhaps some do remember POISers describing treatment/relief methods on certain pages, in that case dump the links here plz.

A Naked Scientists [aka TNS] forum search can be Googled easily: just put in the search term you’re looking for, and then “POIS” (for TNS’ POIS thread), plus the URL/link for TNS.

For example, if you’re looking for TNS posts that include testosterone, put this in the dialog box @ Google:

testosterone POIS https://www.thenakedscientists.com






TNS is a valuable historical universe of
20,000+ POIS posts starting in 2007. I was the main moderator/administrator. Until “Daveman” and I split from TNS to create this forum, POISCenter.com. I am still the main admin at TNS/POIS, however it has become posting-inactive recently, although it’s still very useful as a repository with a wealth of early POIS history.

Go visit!
https://www.thenakedscientists.com/forum/index.php?topic=6576.0

 

[Muon]

POISers on ketodiet:

Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism? (Hippocampus)

https://forums.phoenixrising.me/threads/second-study-confirms-neuroinflammation-in-me-subcortical-brain.80923/page-3#post-2295932

NAD, Niacin:
https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide

NAD+ protects against EAE by regulating CD4+ T-cell differentiation (NAD+ promotes IL-10 under Th1 conditions)

NAD+ regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4+ CD25+ Foxp3+ T cells independent



Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body beta-hydroxybutyrate

"Exercise induces DBHB levels in the hippocampus"

BDNF mediates adaptive brain and body responses to energetic challenges

BDNF plays a role in stress sensitivity btw.

TRT:
Testosterone modulates platelet aggregation and endothelial cell growth through nitric oxide pathway

" In rat aortic strips, 5–20 min treatment with physiological concentrations of testosterone significantly increased nitric oxide (NO) production. The
rapid action of the steroid was suppressed by the presence of an androgen receptor antagonist (flutamide). We obtained evidence that the enhancement in NO synthesis was dependent on the influx of calcium from extracellular medium, because in the presence of a calcium channel blocker (verapamil) the effect of testosterone was reduced."

Effects of opioid (tramadol) treatment on testicular functions in adult male rats: The role of nitric oxide and oxidative stress

Comparison of the Efficacy of Tramadol and Paroxetine in the Management of Premature Ejaculation

Caffeine's Vascular Mechanisms of Action

Nitric oxide and major depression

Nitric Oxide Modulators: An Emerging Class of Medicinal Agents

Recent developments in nitric oxide donor drugs

[Muon]

The patient has a history of irritable bowel syndrome (IBS) well-controlled on loperamide.
Trial of cetirizine, after 4 weeks (orgasm once per week): significant improvement in abdominal cramping and reduction of diarrhea

Loperamide is an opioid-receptor agonist and acts on the mu-opioid receptors in the myenteric plexus of the large intestine.

https://en.wikipedia.org/wiki/Loperamide#Mechanism_of_action

Tried naltrexone (LDN - 4.5 mg split in half, once daily) for two weeks and it actually increased my brain fog and other POIS-like symptoms and this weeks removed from last orgasm.  Very similar reaction to when I tried provigil for a period. It's a no go for me, sadly.

Naltrexone and its active metabolite 6?-naltrexol are competitive antagonists at the mu-opioid receptor (MOR)

https://en.wikipedia.org/wiki/Naltrexone

As of 2017, the therapeutic mechanism of action of modafinil for narcolepsy and sleep-wake disorders remains unknown.[35][36] Modafinil acts as an atypical, selective, and weak dopamine reuptake inhibitor which indirectly activates the release of orexin neuropeptides and histamine from the lateral hypothalamus and tuberomammillary nucleus, respectively all of which may contribute to heightened arousal

https://en.wikipedia.org/wiki/Modafinil#Pharmacology

Loss of muscle tone:
https://en.wikipedia.org/wiki/Orexin

[Muon]

Methylene blue acts directly on the nervous system, where you notice the problems. The nervous system governs the intestine, inflammation, hormones, metabolism, everything. You'll have to play around with the dose and see what works for you. I took 3-4mg yesterday and to my pleasant surprise, NO POIS. I'll keep you guys updated if this continues to work. There is a big thread on longecity forum about it if you want to check it out, but to my understanding, those guys are waaay underdosing it.

Guanylyl cyclase inhibitor:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903110/table/Tab10/

Role of nitric oxide production in anaphylaxis and its relevance for the treatment of anaphylactic hypotension with methylene blue

Methylene blue for clinical anaphylaxis treatment: a case report

Nitric Oxide release during POIS activating Guanylyl cyclase in this case?

Soluble guanylyl cyclase: the nitric oxide receptor

[Muon]

Very nice: Supplement shopping search
Link can be found on page 1 of this thread under Products.

[Muon]

Some POISers have trouble with OI. Physical hacks all free. Added to page 1: Orthostatic intolerance

[Muon]

Regarding Anxiety (Added his personal list under Anxiety on page 1, could be helpful to some):

NAG may well be able to help. I suspect NAG works in cases when the anxiety is caused by underlying chronic brain inflammation, which is known to pump out lots of anxiety-provoking glutamate.

[aswinpras06]

Theanine and th1/th2 immune response

https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772912/&ved=2ahUKEwirqNiJivfuAhWdxjgGHdy6BqEQFjABegQIHBAD&usg=AOvVaw0RfN9ykDYhiwcLmeksOram

,
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377763/&ved=2ahUKEwirqNiJivfuAhWdxjgGHdy6BqEQFjACegQIHBAO&usg=AOvVaw0b4o2D6v0KWiqYx0DhwKUo

[Muon]

D3, b12, magnesium, coq10, alpha lipoic acid, skullcap, feverfew, valerian root, tumeric and black pepper:
Healing Your Painful & Unhealthy Nerves With Nutritional Supplementation - Dr. Alan Mandell, DC

[Muon]

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease

People who have (partial) succes with niacin could give butyrate a try to see if Gpr109a is involved.

[Charles_b]

One of my tests did show that I was low on butyrate, I?ll have to go back and dig up which one that was.  I wonder if that?s something common among POISers.

[Muon]

2- ALPHA   blocking was not observed  .Alpha power was low especially at posterior site .
3- Alpha Peak  frequency was also  LOW at  Cz.

Table 1: Alpha wave production:
l-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion

[Muon]

Immunoglobulin concentrate: https://microbiomelabs.co.uk/products/megaigg2000-2/

[Muon]

Share your links if you want to add anything to the 'specific targeting' section (I didn't make this thread for myself, it saves time):
https://poiscenter.com/forums/index.php?topic=3551.msg37338#msg37338

New suggestion:

https://pubs.acs.org/doi/10.1021/acschemneuro.0c00628

Maybe you could put this: Downregulating Sirt1 results in upregulated MAO-A = lower catecholamines. You can target this using Nicotinamide.

I ordered some nicotinamide riboside today as I've heard good things about it, it's good for boosting NAD+. Hopefully the effects are a lot better than standard Nicotinamide.

[Muon]

Some folks used a mega dose of Vitamin D3 with succes:
High-dose cholecalciferol supplementation significantly increases peripheral CD4+ Tregs in healthy adults without negatively affecting the frequency of other immune cells

B. Prietl researches vit D and Tregs.

[BoneBroth]

Maybe people with SIBO doesnt absorb much vitamin D, so they need 140,000 IU/month to absorb equally as much as people with healthy gut. I take about 5000 IU vitamin D3 per day, thats 150 000 IU per month and I still have as much POIS symptoms. I have a very stubborn SIBO, candida and bloated gut.

[Muon]

Maybe people with SIBO doesnt absorb much vitamin D, so they need 140,000 IU/month to absorb equally as much as people with healthy gut.

This has always been on my mind when it comes down to (auto)immune disease and low vit D. Could be the large intestine, which is densely populated. Bacteria spreading from the large to the small intestines. You could look up what section of the GI tract absorbs what vitamin. I'm not aware how malabsorption is defined or what the proposed mechanisms are...no idea. Perhaps the doc in my previous post did some of this research.

[berlin1984]

What if we had magic skin that could create vitamin D by collecting rays made by a giant star?

While megadoses might be an entirely different thing, I'd think checking sublingual vitamin D is a good idea (e.g. drops or candy?)

SUBLINGUAL VITAMIN D3 EFFECTIVE IN A PATIENT RESISTANT TO CONVENTIONAL VITAMIN D SUPPLEMENTATION
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685416/

Way to bone health may be just under the tongue! Sublingual vitamin D
https://www.jmnn.org/article.asp?issn=2278-1870;year=2014;volume=3;issue=1;spage=1;epage=2;aulast=Salam
^ this mentions how the GI transit can affect absorption..

(If you search for sublingual on the forum, there is some examples)

[Muon]

Larazotide acetate is on the market for leaky gut, closing tight junctions:
https://www.lvluphealth.com/ultimate-gi-repair/