Author Topic: POIS paper treatment summary  (Read 27587 times)

Muon

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Re: POIS paper treatment summary
« Reply #80 on: November 03, 2021, 08:56:01 AM »
Over-the-Counter Ocular Decongestants in the United States – Mechanisms of Action and Clinical Utility for Management of Ocular Redness
Nasal congestion
Red eyes
Naphazoline eye drops for neurosomatic disorders/neural network disorders are being used but higher concentration like 0.1%, 1 drop in each eye.

Running nose and nasal congestion can be related to vasomotor dysfunction (ANS, endothelial dysfunction?) which is unrelated to allergy, people might not be aware of this:

Vasomotor rhinitis

https://en.wikipedia.org/wiki/Nonallergic_rhinitis
« Last Edit: November 03, 2021, 10:16:28 AM by Muon »


Muon

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Re: POIS paper treatment summary
« Reply #82 on: November 03, 2021, 05:14:07 PM »

Muon

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Re: POIS paper treatment summary
« Reply #83 on: November 16, 2021, 06:45:42 PM »
Infliximab cured me(?)
https://poiscenter.com/forums/index.php?topic=4037.0

https://en.wikipedia.org/wiki/Infliximab
TNF-a inflammation of the GI tract?

Results from blood tests in no-POIS state:
- TNF alpha 32.6 pg/ml above reference range (<12.0)

Muon

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Re: POIS paper treatment summary
« Reply #84 on: November 18, 2021, 08:45:55 AM »
The One: Nanna1's immune competence therapy. Discrepancy of effectivity between his former stack and the immune competence stack.
https://poiscenter.com/forums/index.php?topic=3793.0

Muon

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Re: POIS paper treatment summary
« Reply #85 on: November 27, 2021, 10:39:25 PM »
pois1 15 ml liquid tumeric daily. https://poiscenter.com/forums/index.php?topic=4041.0

Hakira117 Tramadol (>30 drops, concentration?) or hydrocodone: 95% reduction. Suboxone 30% reduction.
https://poiscenter.com/forums/index.php?topic=2042.msg42992#msg42992

Surgery: Novel treatment for post-orgasmic illness syndrome: a case report and literature review

demografx

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  • All of us working together to defeat POIS!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: POIS paper treatment summary
« Reply #87 on: December 20, 2021, 02:15:52 PM »
I'm thinking about making a new header on page 1 about cofactors of enzymes. Any enzyme. If you have already some knowledge about cofactors of certain enzymes, let me know in these comments.

Muon

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Re: POIS paper treatment summary
« Reply #88 on: January 06, 2022, 08:18:39 PM »
7. Testing This Hypothesis and Possible Interventions
Up to a year of abstinence from copulation or masturbation among POIS patients would be an interesting test for the hypothesis. However, it is very likely that the involvement of the opioid system and, later, the endocannabinoid system in the signaling mechanism of POIS have longer memory time ranges than the RBE. Therefore, this treatment option might be successful only if POIS is diagnosed very early after the primary injury. Dietary spermidine supplementation could be tested as an option prior to sexual activities. The first successful treatment has been reported with human chorionic gonadotropin [58], which seems to substantiate spermidine depletion in the etiology [59]. Moreover, Reisman presented successful treatment in 57% of POIS patients with the highly selective alpha 1 A-blocker, Sidosin [1]. The findings of Reisman could be explained by Sidosin improving blood flow and the respiratory capacity of the affected proprioceptive nerves, preventing the neuroenergetic TAD-like lesion at the terminals of these nerves in a high percentage of patients. The preventive use of Riluzole, an approved life-lengthening drug for amyotrophic lateral sclerosis treatment, prior to sexual activity could be another possibility based on its action mechanism [23,60]
.” https://www.mdpi.com/2073-4409/10/8/1867/htm
« Last Edit: January 06, 2022, 08:44:04 PM by Muon »

Muon

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Re: POIS paper treatment summary
« Reply #89 on: February 28, 2022, 07:41:58 PM »
From the varicocele poll thread:

Presence of The NLRP3 Inflammasome Components in Semen of Varicocele Patients

https://en.wikipedia.org/wiki/NLRP3
"The compound ?-Hydroxybutyrate has been shown to block NLRP3 activation, and thus may be of benefit for many of these diseases."

https://en.wikipedia.org/wiki/Beta-Hydroxybutyric_acid
"The concentration of ?-hydroxybutyrate in human blood plasma, as with other ketone bodies, increases through ketosis".

At least two patients are able to suppress POIS through ketosis.

Muon

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Re: POIS paper treatment summary
« Reply #90 on: March 29, 2022, 11:43:43 AM »
https://twitter.com/eleswarapu/status/1316954006158278657
"Mirapex seems to help in some patients"

Muon

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Re: POIS paper treatment summary
« Reply #91 on: May 27, 2022, 06:09:27 AM »
Dr. Rubin has treated a patient succesfully with Flibanserin (NDDI) + gabapentin. Patient had no allergy effects but had cluster 1 and muscle. She plans to write it up for the SMSNA. I will put it here in case it doesn’t happen.