Author Topic: POIS paper treatment summary  (Read 31881 times)

Muon

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Re: POIS paper treatment summary
« Reply #80 on: November 03, 2021, 08:56:01 AM »
Over-the-Counter Ocular Decongestants in the United States – Mechanisms of Action and Clinical Utility for Management of Ocular Redness
Nasal congestion
Red eyes
Naphazoline eye drops for neurosomatic disorders/neural network disorders are being used but higher concentration like 0.1%, 1 drop in each eye.

Running nose and nasal congestion can be related to vasomotor dysfunction (ANS, endothelial dysfunction?) which is unrelated to allergy, people might not be aware of this:

Vasomotor rhinitis

https://en.wikipedia.org/wiki/Nonallergic_rhinitis
« Last Edit: November 03, 2021, 10:16:28 AM by Muon »


Muon

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Re: POIS paper treatment summary
« Reply #82 on: November 03, 2021, 05:14:07 PM »

Muon

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Re: POIS paper treatment summary
« Reply #83 on: November 16, 2021, 06:45:42 PM »
Infliximab cured me(?)
https://poiscenter.com/forums/index.php?topic=4037.0

https://en.wikipedia.org/wiki/Infliximab
TNF-a inflammation of the GI tract?

Results from blood tests in no-POIS state:
- TNF alpha 32.6 pg/ml above reference range (<12.0)

Muon

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Re: POIS paper treatment summary
« Reply #84 on: November 18, 2021, 08:45:55 AM »
The One: Nanna1's immune competence therapy. Discrepancy of effectivity between his former stack and the immune competence stack.
https://poiscenter.com/forums/index.php?topic=3793.0

Muon

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Re: POIS paper treatment summary
« Reply #85 on: November 27, 2021, 10:39:25 PM »
pois1 15 ml liquid tumeric daily. https://poiscenter.com/forums/index.php?topic=4041.0

Hakira117 Tramadol (>30 drops, concentration?) or hydrocodone: 95% reduction. Suboxone 30% reduction.
https://poiscenter.com/forums/index.php?topic=2042.msg42992#msg42992

Surgery: Novel treatment for post-orgasmic illness syndrome: a case report and literature review

demografx

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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: POIS paper treatment summary
« Reply #87 on: December 20, 2021, 02:15:52 PM »
I'm thinking about making a new header on page 1 about cofactors of enzymes. Any enzyme. If you have already some knowledge about cofactors of certain enzymes, let me know in these comments.

Muon

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Re: POIS paper treatment summary
« Reply #88 on: January 06, 2022, 08:18:39 PM »
7. Testing This Hypothesis and Possible Interventions
Up to a year of abstinence from copulation or masturbation among POIS patients would be an interesting test for the hypothesis. However, it is very likely that the involvement of the opioid system and, later, the endocannabinoid system in the signaling mechanism of POIS have longer memory time ranges than the RBE. Therefore, this treatment option might be successful only if POIS is diagnosed very early after the primary injury. Dietary spermidine supplementation could be tested as an option prior to sexual activities. The first successful treatment has been reported with human chorionic gonadotropin [58], which seems to substantiate spermidine depletion in the etiology [59]. Moreover, Reisman presented successful treatment in 57% of POIS patients with the highly selective alpha 1 A-blocker, Sidosin [1]. The findings of Reisman could be explained by Sidosin improving blood flow and the respiratory capacity of the affected proprioceptive nerves, preventing the neuroenergetic TAD-like lesion at the terminals of these nerves in a high percentage of patients. The preventive use of Riluzole, an approved life-lengthening drug for amyotrophic lateral sclerosis treatment, prior to sexual activity could be another possibility based on its action mechanism [23,60]
.” https://www.mdpi.com/2073-4409/10/8/1867/htm
« Last Edit: January 06, 2022, 08:44:04 PM by Muon »

Muon

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Re: POIS paper treatment summary
« Reply #89 on: February 28, 2022, 07:41:58 PM »
From the varicocele poll thread:

Presence of The NLRP3 Inflammasome Components in Semen of Varicocele Patients

https://en.wikipedia.org/wiki/NLRP3
"The compound ?-Hydroxybutyrate has been shown to block NLRP3 activation, and thus may be of benefit for many of these diseases."

https://en.wikipedia.org/wiki/Beta-Hydroxybutyric_acid
"The concentration of ?-hydroxybutyrate in human blood plasma, as with other ketone bodies, increases through ketosis".

At least two patients are able to suppress POIS through ketosis.

Muon

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Re: POIS paper treatment summary
« Reply #90 on: March 29, 2022, 11:43:43 AM »
https://twitter.com/eleswarapu/status/1316954006158278657
"Mirapex seems to help in some patients"

Muon

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Re: POIS paper treatment summary
« Reply #91 on: June 14, 2022, 05:08:02 AM »

Muon

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Re: POIS paper treatment summary
« Reply #92 on: August 22, 2022, 04:37:39 PM »
Another lucky poiser cured by antibiotics!
H pyl..  diagnosed, antibiotics cleared hidden infection
in his body i supouse!
https://www.reddit.com/r/POIS/comments/v7eyva/pois_im_cured_this_is_my_story_hope_it_can_help/

Clarithromycin and amoxicillin

Clari..: various infect, pneumonia,  h.pylo.. lyme disease etc...
Amoxi..: ear , strep, pneumoia an urinary tract infections
among others.
Another lucky poiser cured by antibiotics!

Amoxicilin-(Augmentin) https://en.wikipedia.org/wiki/Amoxicillin

https://www.reddit.com/r/POIS/comments/wu8i3f/i_somehow_cured_my_pois_and_heres_what_i_think/

So, how did the POIS go away like that? I'm suspecting that it has to do with the Antibiotics (Augmentin) that had been administered to me when I was confined in the hospital to prevent infection from happening.

Muon

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Re: POIS paper treatment summary
« Reply #93 on: October 27, 2022, 06:41:10 PM »
Copied demo's post: https://poiscenter.com/forums/index.php?topic=3006.msg45722#msg45722



Dr. Nicole Prause, NORD Co-Investigator,
2022 POIS Research Study



Masumi Padhye, MD Candidate 2023


Dr Prause is at a Urology Conference. It is a joint meeting of ISSM/SMSNA, at which Masumi Padhye (above) is presenting,

“Flibanserin For Post-Orgasmic Illness Syndrome”

In other words, "someone is trying it for POIS".


Padhye, M1; Trowbridge, P2; Rubin, D3

1 - Chicago Medical School (Rosalind Franklin University of Medicine & Science)
2 - Rush Medical College
3 - Georgetown University (MD Urologist)

Interesting: a case of POIS in a patient physician. I’ve always been curious how a physician handles his/her own POIS.

Also interesting: the novel
*off-label male use* of Flibanserin, which is a drug originally targeted at women - - Demo


Introduction:
Postorgasmic illness syndrome (POIS) is a rare disorder with ~50 cases recorded in the literature over the last 10 years. POIS is characterized by symptoms of flu-like fatigue, myalgias, fevers, mood disturbance, congestion, rhinorrhea and conjunctival pruritus, that begin within seconds to hours after an orgasm for a duration of 2-7 days. The most well described pathophysiologic hypothesis to date is immunologic based hypersensitivity reaction, but other hypotheses include withdrawal from endogenous opioids, dysregulated neuroendocrine response or autonomic nervous system. These mechanisms are elucidated by patient responses to different treatments including, antihistamines, dopamine agonists, benzodiazepines, NSAIDs and SSRIs. However, no standardized treatment has yet been developed.

Objective:
Here we describe a case of intractable POIS in a patient physician, who had a remarkable response to flibanserin nightly and gabapentin nightly for pain.

Methods:
Patient is a 40 year old male with acquired post orgasmic illness syndrome that started 10 years prior. Symptoms include headaches, muscle pain, numbness, weakness, irritability, low energy, anhedonia, and brain fog. Symptoms start 30 minutes after every orgasm and persist for 1 week. He reports fluctuations in his libido when experiencing these symptoms. Orgasms feel good to him and do not change with POIS. Pre-ejaculate and ejaculate trigger his POIS. He reports no problems with erections. He has tension headaches with arousal which affect his day but he does not experience full POIS symptoms. He does not report issues with stress except during POIS symptoms. He is a nonsmoker and has up to two drinks per month. He denies trauma, general pain, back injuries or pain, bowel dysfunction or abnormal penile curvature. He has been able to reduce symptom duration from 1 week to 4 days with a combination of bupropion, lexapro, silodosin, ritalin, and tramadol; however, the duration and intensity of symptoms is still significant. Patient was trialed on a combination of flibanserin and gabapentin. He was advised to take 200 mg gabapentin nightly and 100 mg flibanserin nightly.

Results:
The combination of flibanserin and gabapentin significantly improved the patient's symptom duration and intensity. He now experiences mild symptoms for one day and has stopped taking his other medications. He also reports that his libido has markedly improved, helping him and his wife restore their intimate relationship.

Conclusions:
The use of flibanserin, a serotonin receptor 2A antagonist and serotonin receptor 1A partial agonist has not yet been described in the literature, and supports a role of serotonin in the pathogenesis of POIS. Serotonin 2A is a known inhibitor of the sexual response and has a significant impact on mood, memory and cognition. As such this neuroendocrine dysregulation could modulate many of the symptoms present in POIS including brain fog, anhedonia and low energy. The variability of medications that provide relief in different patients emphasizes the importance of taking a multidimensional and individualized approach to treating patients' distinct presentations.

Muon

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Re: POIS paper treatment summary
« Reply #94 on: October 28, 2022, 05:40:23 AM »
Crosstalk between PI3K/AKT/KLF4 signaling and microglia M1/M2 polarization as a novel mechanistic approach towards flibanserin repositioning in parkinson's disease
https://www.sciencedirect.com/science/article/pii/S1567576922006750

Muon

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Re: POIS paper treatment summary
« Reply #95 on: October 28, 2022, 09:17:00 AM »
please post name of the medicines
I got prescription of 2 medicaments, one is some modern bi polar medication, here it is called Bipodis, but originally it is Aripiprazol, it helps me a lot, especially with anxiety, but makes me very agressive, and low tempered. So I guit, got me into a trouble with a boss recently, and he was right, just it was impossible to control myself.
2nd is also a mood stabilizer so called here Karbapin, which is, Carbamazepine.
That one changed my life.
I take 50mg in the 10 am and 50mg in the 6 am. Made a miracle.
Again, pls, this is my experience, I advocate that no one take it to it?s own, check a professional for any medication.
And sorry for a bad English, I hope it is understandable.

Muon

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Re: POIS paper treatment summary
« Reply #96 on: November 07, 2022, 12:34:53 PM »
POIS after taking antibiotics, amoxicillin, for a long time. https://www.reddit.com/r/POIS/comments/yooi32/pois_after_antibiotics/

Muon

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Re: POIS paper treatment summary
« Reply #97 on: December 21, 2022, 06:28:48 PM »
https://www.reddit.com/r/POIS/comments/zrs9qo/related_to_allergic_rhinitis_nasal_drops/
"I took Refenax nasal drops (which have Diphenhydramine hydrochloride, and Naphazoline hydrochloride) and started to feel better from POIS."

Journey

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Re: POIS paper treatment summary
« Reply #98 on: December 21, 2022, 11:16:14 PM »
https://www.reddit.com/r/POIS/comments/zrs9qo/related_to_allergic_rhinitis_nasal_drops/
"I took Refenax nasal drops (which have Diphenhydramine hydrochloride, and Naphazoline hydrochloride) and started to feel better from POIS."
Offtopic but Muon please check Steam I sent you an important message there, the faster the better