Author Topic: METHYLENE BLUE!!!!  (Read 4894 times)

POIS_DICK

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METHYLENE BLUE!!!!
« on: November 20, 2014, 02:04:17 PM »
methylene blue acts directly on the nervous system, where you notice the problems. The nervous system governs the intestine, inflammation, hormones, metabolism, everything. You'll have to play around with the dose and see what works for you. I took 3-4mg yesterday and to my pleasant surprise, NO POIS. I'll keep you guys updated if this continues to work. There is a big thread on longecity forum about it if you want to check it out, but to my understanding, those guys are waaay underdosing it.
« Last Edit: November 20, 2014, 02:53:47 PM by POIS_DICK »

POIS_DICK

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Re: METHYLENE BLUE!!!!
« Reply #1 on: November 21, 2014, 04:04:48 PM »
so the thought of the experiment was a scary one, like it would be for any POIS sufferer, orgasm few times a day for a few days to see what happens. After that experiment I can conclude, I have zero POIS while taking this stuff. I jizz, and then feel the exact same right after.. there might be a slight cognitive decline, but its maybe 5% at most.

Pflug

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Re: METHYLENE BLUE!!!!
« Reply #2 on: November 23, 2014, 02:17:13 PM »
Wow. Where can I buy this?
Complete loss of focus, extreme fatigue, sweating, nasal irritation, joint pain, headaches and depression. Takes a full week to feel normal again. Hiding from life. Praying for a cure.

Quantum

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Re: METHYLENE BLUE!!!! - ***** DRUG AND FOOD INTERACTION WARNING !!!
« Reply #3 on: November 24, 2014, 01:52:47 AM »
Hi, Pois_Dick, and everyone,

As a pharmacist, I would like to make an IMPORTANT WARNING regarding possible major, and potentially fatal, interactions of methylene blue with many prescription drugs boositng serotonine level, with tryptophane supplements, and also with tyramine-containing food.

Most likely, the benefits of ingested methylene blue you have seen may come form the fact methylene blue is a potent monoamine oxydase inhibitor (MAOI), so it increases serotonin level.  I  would like to point out that ANYONE WHO WANTS TO INGEST METHYLENE BLUE MUST BE VERY CAREFUL !!!!  IT CAN BE VERY TOXIC, AnD EVEN DEADLY IF INTERACTIONS OCCUR WITH DRUGS ALSO BOOSTING SEROTONINE LEVEL AS WELL AS WITH FOOD CONTAINING TYRAMINE !! See https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor#Dangers

With tyramyne containing food, like aged cheese, wine, Bovril/Marmite\Vegemite meat extract, a severe hypertensive crisis can occur, possibly fatal. See a list of fod containing tyramine here:  https://en.wikipedia.org/wiki/Tyramine#Occurrence .  If you take MB, you must avoid them, unless you will trigger a massive norepinephrine release in yout body, leading to hypertension, anxiety, etc...

BUT there is an even worst risk - IMAO like Methylene blue interacts with Tryptophane supplements and with many drugs POISers on this board are taking. From Wiki?dia:" MAOIs should not be combined with other psychoactive substances (antidepressants, painkillers, stimulants, both legal and illegal etc.) except under expert care. Certain combinations can cause lethal reactions, common examples including SSRIs, tricyclics, MDMA, meperidine,[30] tramadol, and dextromethorphan.[citation needed] Agents with actions on epinephrine, norepinephrine, or dopamine must be administered at much lower doses due to potentiation and prolonged effect."

Form wikipedia again: "The most significant risk associated with the use of MAOIs is the potential for interactions with over-the-counter and prescription medicines, illicit drugs or medications, and some supplements (e.g., St. John's Wort, tryptophan). It is vital that a doctor supervise such combinations to avoid adverse reactions. For this reason, many users carry an MAOI-card, which lets emergency medical personnel know what drugs to avoid. (E.g., adrenaline dosage should be reduced by 75%, and duration is extended.)[27] The risk of the interaction of MAOI medications with other drugs or certain foods is particularly dangerous because those on the medication who would have to restrict their diets often are depressed patients who "don't care if they live or die."[28]

Tryptophan supplements should not be consumed with MAOIs as the potentially fatal serotonin syndrome may result."


So, DO NOT USE METHYLENE BLUE WITHOUT MEDICALAND PROFESSIONNAL SUPERVISION, AND WITHOUT CHECKING FOR POTENTIAL INTERACTIONS AND WITHOUT KNOWING ABOUT FOODS TO AVOID !!

And, if you still want to use it, be very careful and go with minimal dosage (as with any treatment, go for the minimum efficient dosage), though i recommand not to use it at all.


I do not want to scare anyone, but want you to stay safe !

Quantum
« Last Edit: November 24, 2014, 01:56:50 AM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

POIS_DICK

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Re: METHYLENE BLUE!!!!
« Reply #4 on: November 24, 2014, 11:33:01 PM »
my guess isn't because of the MAOI effect, but because it delays cellular senescence and enhances key mitochondrial biochemical pathways, especially in the brain. It is dangerous to take in combination with SSRI's, but I have not read anywhere about the toxicity you describe. In fact, it was shown to be safe at several grams/day.

Quantum

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Re: METHYLENE BLUE!!!!
« Reply #5 on: November 25, 2014, 02:37:57 PM »
Hi, Pois

In addition to the links already given in my previous posts, here are 2 other links, from the FDA, and from the Mayo Clinic:

The Drugs - Methylene Blue (MB) interactions are well documented:

https://www.fda.gov/Drugs/DrugSafety/ucm276119.htm

Tryptamine supplements are also interacting badly with MB

Based on the proven fact that MB has MAOI properties, the well known interactions with Tyramine-containing foods apply as well to MB, but tyramine content of food vary greatly, and personal tolerance from one person to the other differ also, so there is no clear guidelines as to how much of this and that food can be taken with this much of that much of an MAOI, including MB, without risk of an hypertension crisis.  For more details:

http://www.mayoclinic.org/diseases-conditions/depression/expert-answers/maois/FAQ-20058035

Moreover, the data for oral intake do not really exist, because MB is used in IV injections, in current medecal practice, so there is no data on the bioavailability of MB, that is, the % of the orally taken dose that will make it to the blood stream.

Take care!

Quantum
« Last Edit: December 03, 2017, 10:32:11 AM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259