| Parameter | Time | Value (pg/ml) | Reference (pg/ml) | Delta |
| IP-10 | ~10 min pre O | 211 | < 900 | |
| IP-10 | ~5 min post O | 234 | < 900 | +23 |
| IP-10 | ~32 min post O | 232 | < 900 | -2 |
| IP-10 | ~24 hour post O | 286 | < 900 | +54 |
| Parameter | Time | Value (ng/ml) | Reference (ng/ml) | Delta |
| TGF-beta | ~10 min pre O | 53.4 | 18.3 - 63.4 | |
| TGF-beta | ~5 min post O | 62.2 | 18.3 - 63.4 | +8.8 |
| TGF-beta | ~32 min post O | 54.4 | 18.3 - 63.4 | -7.8 |
| TGF-beta | ~24 hour post O | 50.1 | 18.3 - 63.4 | -4.3 |
| Parameter | Time | Value (pg/ml) | Reference (pg/ml) | Delta |
| IFN-g (Th1) | ~10 min pre O | 1806 | 374-1660 | |
| IFN-g (Th1) | ~5 min post O | 1664 | 374-1660 | -142 |
| IFN-g (Th1) | ~32 min post O | 1226 | 374-1660 | -438 |
| IFN-g (Th1) | ~24 hour post O | 1965 | 374-1660 | +739 |
| Parameter | Time | Value (pg/ml) | Reference (pg/ml) | Delta |
| IL-4 (Th2) | ~10 min pre O | 41.5 | 40-198 | |
| IL-4 (Th2) | ~5 min post O | 42.0 | 40-198 | +0.5 |
| IL-4 (Th2) | ~32 min post O | 34.7 | 40-198 | -7.3 |
| IL-4 (Th2) | ~24 hour post O | 46.8 | 40-198 | +12.1 |
| Parameter | Time | Value (pg/ml) | Reference (pg/ml) | Delta |
| IL-2 (Th0) | ~10 min pre O | 351 | 384-960 | |
| IL-2 (Th0) | ~5 min post O | 356 | 384-960 | +5 |
| IL-2 (Th0) | ~32 min post O | 347 | 384-960 | -9 |
| IL-2 (Th0) | ~24 hour post O | 416 | 384-960 | +69 |
| Parameter | Time | Value (pg/ml) | Reference (pg/ml) | Delta |
| IL-17 (Th17) | ~10 min pre O | 52.5 | 49-446 | |
| IL-17 (Th17) | ~5 min post O | 45.5 | 49-446 | -7 |
| IL-17 (Th17) | ~32 min post O | 49.5 | 49-446 | +4 |
| IL-17 (Th17) | ~24 hour post O | 43.7 | 49-446 | -5.8 |
| Parameter | Time | Value (pg/ml) | Reference (pg/ml) | Delta |
| IL-10 (T-reg) | ~10 min pre O | 989 | 760-1900 | |
| IL-10 (T-reg) | ~5 min post O | 902 | 760-1900 | -87 |
| IL-10 (T-reg) | ~32 min post O | 801 | 760-1900 | -101 |
| IL-10 (T-reg) | ~24 hour post O | 1052 | 760-1900 | +251 |
| Parameter | Time | Value (pg/ml) | Reference (pg/ml) | Delta |
| IL-8 | ~10 min pre O | 18.4 | < 15 | |
| IL-8 | ~5 min post O | 38.9 | < 15 | +20.5 |
| IL-8 | ~32 min post O | 18.2 | < 15 | -20.7 |
| IL-8 | ~24 hour post O | 34.3 | < 15 | +16.1 |
| Parameter | Time | Value in pg/ml | Reference range in pg/ml |
| IFN-g (TH1) | ~10 min before orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-1+Th1Th2+part2-1%2BIL-8%2BIgGsub%2BIgE+13-08-2015.pdf) | 1315 | 374-1660 |
| IFN-g (TH1) | ~15 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-2+Th1Th2+part2-2%2BIL-8+13-08-2015.pdf) | 1147 | 374-1660 |
| IFN-g (TH1) | ~45 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-3+Th1Th2+part2-3%2BIL-8+13-08-2015.pdf) | 978 | 374-1660 |
| IFN-g (TH1) | ~24 hour after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+3-6+Th1Th2+part2-4%2BIL4gen+14-08-2015.pdf) | 3053 | 374-1660 |
| Parameter | Time | Value in pg/ml | Reference range in pg/ml |
| IL-10 (T-reg) | ~10 min before orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-1+Th1Th2+part2-1%2BIL-8%2BIgGsub%2BIgE+13-08-2015.pdf) | 774 | 760-1900 |
| IL-10 (T-reg) | ~15 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-2+Th1Th2+part2-2%2BIL-8+13-08-2015.pdf) | 638 | 760-1900 |
| IL-10 (T-reg) | ~45 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-3+Th1Th2+part2-3%2BIL-8+13-08-2015.pdf) | 542 | 760-1900 |
| IL-10 (T-reg) | ~24 hour after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+3-6+Th1Th2+part2-4%2BIL4gen+14-08-2015.pdf) | 1045 | 760-1900 |
| Parameter | Time | Value in pg/ml | Reference range in pg/ml |
| IL-2 (TH0)) | ~10 min before orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-1+Th1Th2+part2-1%2BIL-8%2BIgGsub%2BIgE+13-08-2015.pdf) | 433 | 384-960 |
| IL-2 (TH0) | ~15 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-2+Th1Th2+part2-2%2BIL-8+13-08-2015.pdf) | 415 | 384-960 |
| IL-2 (TH0) | ~45 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-3+Th1Th2+part2-3%2BIL-8+13-08-2015.pdf) | 335 | 384-960 |
| IL-2 (TH0) | ~24 hour after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+3-6+Th1Th2+part2-4%2BIL4gen+14-08-2015.pdf) | 281 | 384-960 |
| Parameter | Time | Value in pg/ml | Reference range in pg/ml |
| IL-4 (TH2)) | ~10 min before orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-1+Th1Th2+part2-1%2BIL-8%2BIgGsub%2BIgE+13-08-2015.pdf) | 45.5 | 40-198 |
| IL-4 (TH2) | ~15 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-2+Th1Th2+part2-2%2BIL-8+13-08-2015.pdf) | 35.7 | 40-198 |
| IL-4 (TH2) | ~45 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-3+Th1Th2+part2-3%2BIL-8+13-08-2015.pdf) | 31.1 | 40-198 |
| IL-4 (TH2) | ~24 hour after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+3-6+Th1Th2+part2-4%2BIL4gen+14-08-2015.pdf) | 43.1 | 40-198 |
| Parameter | Time | Value in pg/ml | Reference range in pg/ml |
| IL-17 (TH17)) | ~10 min before orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-1+Th1Th2+part2-1%2BIL-8%2BIgGsub%2BIgE+13-08-2015.pdf) | 51.6 | 49-446 |
| IL-17 (TH17) | ~15 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-2+Th1Th2+part2-2%2BIL-8+13-08-2015.pdf) | 40.8 | 49-446 |
| IL-17 (TH17) | ~45 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-3+Th1Th2+part2-3%2BIL-8+13-08-2015.pdf) | 31.3 | 49-446 |
| IL-17 (TH17) | ~24 hour after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+3-6+Th1Th2+part2-4%2BIL4gen+14-08-2015.pdf) | 57.1 | 49-446 |
| Parameter | Time | Value in pg/ml | Reference range in pg/ml |
| IL-8 | ~10 min before orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-1+Th1Th2+part2-1%2BIL-8%2BIgGsub%2BIgE+13-08-2015.pdf) | 89.8 | <15 |
| IL-8 | ~15 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-2+Th1Th2+part2-2%2BIL-8+13-08-2015.pdf) | 59.0 | <15 |
| IL-8 | ~45 min after orgasm (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+2-3+Th1Th2+part2-3%2BIL-8+13-08-2015.pdf) | 41.9 | <15 |
| IL-8 | ~24 hour after orgasm (https://www.dropbox.com/s/57tuml84rmebeu9/Muon%203-4%20Herpes%20Ig%27s%2BIL-8%2BZonulin%2BNKC%20function%2014-08-2015.pdf?dl=0) | 36.6 | <15 |
Something else, I had painfully stiff muscles due to POIS a week ago. The higher part of the back, shoulders and part of the upper arms were affected, the weird thing was it kept getting stiffer and stiffer up to the point I could barely move my right arm, it was that painful (there was only pain present during movement, not in rest). Moving my arm/shoulder, was like the feeling of almost tearing some muscles. I slept one night with clothes on because undressing was too painful. Quite a weird event, I have never experienced this intensity of stiffness before.
I've had blood tests done multiple times during my worst fever episodes, and everything comes back normal except for very low levels of iron (I usually have normal or even high iron and hemoglobin levels), and through-the-roof amounts of C-reactive protein. This led doctors to think I could have mononucleosis or some kind of bacterial infection, but all specific tests came back negative. They put me on antibiotics anyway, and that solved most symptoms almost immediately and made me able to get out of bed and finally get better during the worst episode I've ever had.
Hello,i wanna tell sth,but first in private,maybe i'll post it
Considering that it is said that is possible for some Allergy,i tried to swallow my cum and guess what.After a few hours i couldn't swallow shit for about 3 weeks,i was anxious as fuck when trying to swallow anything solid. My Family MD told me that my throat is "red".Went to an Otorhinolaryngologist and he told me that it is allergy without me telling you what i did.Do you think i should that again and what could he check for in the blood if that repeats?
3) well, i don't know that,it was in my neck,my family doctor told me that my neck is "red" that's everything i know and i know that i couldn't swallow cause i didn't feel the food going down and was always anxious that i was gonna choke,cause the food is gonna go down the wrong pipe,i couldn't contract my muscles,lots of thing,was like i wasn't also feeling the lower part of my throat that you "consciously " contract when you swallow.It was weird cause everyone thought i was crazy,at least untill family md told me that my throat is "red"
What's your diet like anyway?
I don't eat any refined grains or sugars, though I do eat fruit and plenty of whole grains. My last IGG4 test showed a pretty strong candida response, which my physician said means I had an overgrowth at some point.
5.- Magnetic Resonance Imaging of the entire spine(June 2018):
multiple focal lesions were observed in the dorsal and lumbar spine, hyperintense in T2 and most of them isointense in T1, although the larger lesions have a trabecular structure suggesting that they are hemangiomas. However, given that the signal characteristics in the T1 sequence are not typical of hemangioma, it is recommended to do image control to assess evolution.
Translated with Google Translate from Maxwell of Russian POISCenter (http://www.poiscenter.net/viewtopic.php?f=19&p=17877&sid=da782426fd7894ea6d8ee10bfdc76149#p17877)
If you read my conclusion after the MRI of the "lumbosacral spine", you can find words like "the anterior and posterior longitudinal ligaments are compacted", which means the so-called "Ossification" written here http://avestasakh.com/ossifikatsiya-zadney-prodolnoy -svyazki-grudnogo-otdela-pozvonochnika and here http://24radiology.ru/kostno-myshechnaya-sistema/ossifikatsiya-zadnej-prodolnoj-svyazki/
... squeezes the spinal vertebral nerve ...
Ossification of the posterior longitudinal ligament of the thoracic spine is a permanent neurological disorder in which the nerves of the spinal canal are compressed as a result of hardening of the posterior longitudinal ligament, the purpose of which is to preserve the structure of the vertebrae in the spine, maintaining its balance and mobility. Including South Korea, in China, Japan and other Asian countries, this disease more often occurs in men over 40 years of age, which must be treated at an early stage due to the impossibility of restoring the functions of the damaged nerve if it is compressed for a long period.
Myelopathy is a dysfunction of the spinal cord associated with abnormal pressure on the spinal cord. Unlike conditions that put pressure on individual nerve roots, this type of damage can lead to loss of nerve function anywhere in the spinal cord below the damaged area.
It was partially my fault, because I was in the midst of treating my candida infection and went overboard with antifungals and probiotics, making me feel terrible and compromising my immune system. On top of that, I was surrounded by family who probably brought all sorts of germs with them.
Page 52/61 from the file you provided:NAD+ (https://poiscenter.com/forums/index.php?topic=3551.msg38867#msg38867)
"NOTE: The presence of Candida in the GI tract diverts Pyruvate away from its preferred pathway (Kreb's Cycle), and results in less cellular energy."
I wonder whether blocking pyruvate decarboxylase helps.
However, due to covid, we started using bleach at home for general cleaning, and I developed some kind of reaction to it. It took me months to figure out that bleach was the cause, and it completely short-circuited everything in my body: I've had tachicardia, a continuous horrible feeling of shortness of breath, dizziness, loss of appetite, fever... somehow, I know this is all related to POIS, because I'm not allergic to bleach.
I'm homozygous for the GST and GPX genes which are the glutathione enzyme genes that detox chemicals, liposomal glutathione would be helpful for you.
I have been using lidocaine spray already for half year. It helps me a lot. It reduce all my symptoms for 95%. I just feel sleepy next day a bit. I spray it to penis head 30 minutes before sexual activity. There is just one problem.If you had some night dream, tiny amount of liquid (which seems like cum) may appear. And i think it does not influence me. Anybody tried it?https://en.wikipedia.org/wiki/Lidocaine
https://sci-hub.se/https://www.tandfonline.com/doi/abs/10.1080/13685530400004199
In male patients with cytochrome P450C17 (steroid 17a-hydroxylase/17,20-lyase; EC 1.14.99.9) deficiency, the progesterone levels are clearly elevated.
https://en.wikipedia.org/wiki/Steroid_17alpha-monooxygenase
It has 3 cofactors: NADH, NADPH, and Heme
I'm no longer going to reply on this thread as it's really long but yeah it's possibly some kind of pathogen that gets triggered by the fluoroquinolone class of antibiotics.=======================================
I'm still not recovered 3 years after the Ciprofloxacin, I've learnt to change my diet and that minimises my symptoms. I'm now very intolerant to strange things like sea salt and coffee so I have to be careful what I eat.
My Cipro issues are located in very specific areas of my body, like only one leg has some burning sensation, one ear has tinnitus, one hand has lost some of the fat padding. My working theory is maybe it's a systemic candida infection, I'm still looking for a cure.
Hi Muon,
Thanks for all this information that you share.
It is not uncommon among POIS sufferers to have other associated illnesses like those you mention. Dr Waldinger have noted, in particular, the high prevalence of premature ejaculation in POIS sufferers.
I would like to mention that skin prick test with own semen is no longer considered a diagnostic test for POIS. Waldinger himself have abandoned this approach. There is also the Chinese study where many control subjects ( with no POIS) have tested positive with the auto-semen prick test, which prove that it cannot be used to detect or diagnose POIS. So, we are still waiting for a test that could diagnose POIS, which for now can only be "diagnosed" with the 5 criteria of Dr Waldinger, based on clinical manifestation.
Thanks again for taking the time to post your data, even if you are restricted in energy, and take good care of yourself. I hope you'll find soon some relief and raise your level of energy and quality of life.
wow I never read this thread till today and was frozen while reading. Moun's your symptom match mine. Thank you for sharing these links. Not to badger you, but the link you posted: Impairment of microcirculation of the facial nerves catches my attention, talks about: Endothelin, which has potent vasoconstrictive effects, may contribute to the pathogenesis of the microcirculatory impairment that occurs in patients with Bell palsy, mainly by promoting secondary ischemia. I dont follow since we POISers have low BP and Endothelin constrict vessels raising BP. During POIS, I get severe burning in my Palsy areas, as if nerves are trying to fire up but unable to. When I take vasodilatory things (specially a med, gabapentin) that burning sensation stops but I dont know if vasodilatory is the key or its something else the key that helps. But I know that POIS creates a burning sensation also across all distal peripherals, like ankles, wrists, exact symptoms of Raynaud syndrome.
95% of my symptoms is same. Thanks for posting test results, it help us a lot for resarchcing.
Thank you for this information, I will get my leukocytes tested so I have a record of inflammation. Let us know how your bone markers beta-CTx and osteocalcin look.
Update: File Muon 5-1 N-Methylhistamine 24h is new.
Mast Cell Activation markers have been tested. Urine has been collected during 24h post ejaculation.
More info about the labtest: https://www.immqas.org.uk/TestItem.asp?id=575
Results for the other 3 parameters below will be received next week:
https://www.immqas.org.uk/TestItem.asp?id=182
https://www.immqas.org.uk/TestItem.asp?id=250
https://www.immqas.org.uk/TestItem.asp?id=184
I tested my interleukins and they looked normal. I believe a big part of my issues are "D-Lactic Acidosis" which can cause brain-fog and many other symptoms like burning sensations in limbs, perhaps you are suffering from the same issue.
I believe histamine intolerance and mast cell disorders are actually low DAO enzymes from gut dysbiosis. Try taking Bifidobacterium Infantis, it has fixed my histamine reaction.
I tested my interleukins and they looked normal.Which ones?I believe a big part of my issues are "D-Lactic Acidosis" which can cause brain-fog and many other symptoms like burning sensations in limbs, perhaps you are suffering from the same issue.If you believe so, you could test for blood plasma D-lactate concentration.I believe histamine intolerance and mast cell disorders are actually low DAO enzymes from gut dysbiosis.The gut isn't the only source of DAO and DAO isn't the only enzyme that breaks down histamine. Mast cells could also be activated by different pathways due to gut dysbiosis like via Toll-like receptors. I already took these theories into account in the past and there is no way of proving it. I have tried DAO capsules and all kinds of probiotics strains which had 0 effect. There hasn't been a single medicine or supplement so far that had significant effect on my POIS symtoms. Aside from that, symptoms can disappear all by itself over time or reappear after a period of absence without taking medicine or supplements.Try taking Bifidobacterium Infantis, it has fixed my histamine reaction.What do you mean by histamine reaction?
I have uploaded heart rate and blood pressure measurements. You can find them over here (https://www.dropbox.com/sh/nc2dt6pcwd5xpmu/AACyyDE6uhY1DHn1fAuxw86Ja?dl=0&preview=Muon+5-2+HR+and+BP+data.docx). This has been measured during the summer of 2013 when POTS, cardiovascular and autonomic function related symptoms where at their peak. A few times measurements have been repeated on multiple healthy (read non POTS) humans to rule out device related issues. The second page has some notes in Dutch which you can translate yourself, if not ask me.
Something else, I had painfully stiff muscles due to POIS a week ago. The higher part of the back, shoulders and part of the upper arms were affected, the weird thing was it kept getting stiffer and stiffer up to the point I could barely move my right arm, it was that painful (there was only pain present during movement, not in rest). Moving my arm/shoulder, was like the feeling of almost tearing some muscles. I slept one night with clothes on because undressing was too painful. Quite a weird event, I have never experienced this intensity of stiffness before.
I have uploaded the results of the prostaglandin D2 metabolites. It's file 5-3, click here (https://www.dropbox.com/s/d2bs22uh2e9nqxw/Muon%205-3%20PGD2%20metabolites%2024h.pdf?dl=0).
A certain area of my brain did react very aggressively (in terms of responsiveness and intensity) to release of any pre-ejaculate last week. If I have to make a guess it's somewhere around the hypothalamus area. My symptoms were, at the same time:
- A complete loss of appetite and hunger
- Low GI motility
- Poor digestion
- A complete loss of the sense of smell
- A complete loss of thirst
- Major disruption of breathing rithm (frequency cannot be maintained)
- Blood circulation issues
- Palpitations
- Multiple brief moments of activity around the Thyroid area
- My sex drive increased when I maintained an erection
I suspect POIS affects neuroendocrine cells. When looking at neuropeptides which controls food intake I see some interesting candidates: https://en.wikipedia.org/wiki/Hypothalamus#Control_of_food_intake
Like Leptin (https://en.wikipedia.org/wiki/Leptin)
I think there might be some change in certain neurohormone levels/signaling or inflammation of neuroendocrine glands due to POIS.
Have you tried L-Arginine? I know it's bad for people with Herpes Simplex infections but it seems to help me with gut motility. I think it builds the gut mucosal lining, it is also involved in heart health and it boosts blood flow so it can cause erections.
Have you tried L-Arginine? I know it's bad for people with Herpes Simplex infections but it seems to help me with gut motility. I think it builds the gut mucosal lining, it is also involved in heart health and it boosts blood flow so it can cause erections.I have tried L-Arganine or L-Citruline, can't remember which one it was. Anyway it did nothing. Took this because of NO theories.
Dumping some info here:
''IL-10 checks the inducible form of Cyclo-oxygenase, Cyclo-oxygenase-2 (COX-2). Lack of IL-10 has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice.''
https://en.wikipedia.org/wiki/Interleukin_10
Combine that with Nanna's theories about COX and my IL-10 Data (https://poiscenter.com/forums/index.php?topic=2891.0). IL-10 seem to dip right after orgasm this could lead to COX activation. Timing of COX inhibitor intake seem to be crucial. IL-10 is anti-inflammatory and if IL-10 is the main inducer of COX activation then IL-10 upregulators could be used for therapy.
Tregs could be tested. Treg pool can be increased by testosterone and IL-2 therapy. IL-10 can be upregulated by testosterone as well.
Naltrexone, blocking TLR-4 (also mu-opoid), decreasing IL-8 https://www.tandfonline.com/doi/abs/10.3109/10520295.2014.903299
Targeting TLR-9 for IL-8: https://www.ncbi.nlm.nih.gov/pubmed/21968713
Ways to increase IL-10: https://selfhacked.com/blog/il-10/
Calorie restriction, which is beneficial to me, seem to decrease IL-8 and increase IL-10. IL-8 test has been taken in the morning, it could increase by meals (testing later on day?).
Wim Hof's, the Iceman, breathing meditation seem to be beneficial.
People complaining about high/low temperature sensitivity, pressure, friction. Sensory neuropathy?
Yes and I forget what I'm currently doing. These episodes happen more frequent during hot weather conditions and also hot weather seems to synergize with POIS as in POIS being more reactive.My brain seems to react clearly to pois. Summer plays a role in this as well. I'm thinking about testing some obscure hormones. My GP was thinking about sending me to an endocrinologist but most docs are not taking POIS seriously.
I also tried to get some testing for osteoporosis done but this was being refused because of my age and normal bone markers. I'm getting these blackouts lately where i can't remember what i were doing. If this keeps going on in this manner i will be having full blast alzheimer/parkinson in 10-15 years.
is your "amnesia" like, you thought about doing something next but as you finish what you are currently doing you forget what you are suppose to do next.
Is it something different.
what do you mean by summer plays a role
Example 1: I want to go to the supermarket and prepare myself. Putting on my coat. Suddenly I stand in the hallway and forget what I'm doing and what I suppose to do next. At that moment I do not know why I am wearing a coat.
Example 2: I have no appetite and need to remind myself to make a meal. At the moment just before I'm getting up to make a meal I forget what I'm going to do next. I can't remember. So I skip the meal.
I also got breathing rithm problems, so perhaps this is due to a lack of oxygen. I can feel that blood flow to the brain isn't optimal anyways.
Yesterday I ejaculated a large amount of sperm. POIS symptoms did build up very slowly, almost unnoticable. 5 hours later it accelerated. I became feverish and nauseous, I almost threw up. Just before this acceleration I ate my evening meal. It's weird because these were not my typical POIS symptoms. I'm thinking about getting a test for a complete blood count and time it exactly when it accelerates.
Today I ate some watermelon. It induced a runny nose immediately after ingestion followed up by a wave of fatigue and did not feel well. I could feel parts of tissue inside my body react where the juices made contact. I suspect it's the same mechanism as POIS.
Intresting, i am trying resarching again connection on histamine intolerance, 80% of this symptomes fit in histamine sensitivity, histamine
- A complete loss of appetite and hunger
- Low GI motility
- Poor digestion
- A complete loss of the sense of smell
- A complete loss of thirst
- Major disruption of breathing rithm (frequency cannot be maintained)
- Blood circulation issues
- Palpitations
- Multiple brief moments of activity around the Thyroid area
- My sex drive increased when I maintained an erection
intolerance.
Is it posible that , during arousing (ejaculation specialy) trigger in us a storm of
histamine,on wich we are hipersensitive?
Pros:
Symptomes match
Linked to orgasm
Can be linked to microbiota
Can be linked to hormones, stress, exercice...
CONS :
No blood test showed high hista levels
Some guys improved with anti-hitamine (benadryl, loratadine) but few
WAldinger said no
Timing is not good : it appears after some minutes BUT it mostly disappears quickly, in several hours
No/few Poisers seems sensible to histamine food release : cheese red wine, seafood...
Alcohol decrease Diamine oxidase activity and then alcohol may increase Pois symptoms but it doesn't.
Diamine oxidase is the key hormone.
Histamine is elimintaed by Diamine oxidase but if its levels is low, too much histamine can be present in blood, causing symptoms after a trigger.
I fully agree b_jim.
Well it is not that simple,
histamine intolerance fit nicely
in pois symptomes(only 1%) the same like chronic lyme.
Not even chr- lyme or hist- intolerance are not recognized by medicine.
But when you resarch POIS
symptomes -neuro, CFG, ME,
POTS... you will always find there lyme disiese, try it :) .
From mayo clinic to...
Appropriate methylation is also essential for proper histamine catabolism. Histamine N-methyltransferase (HNMT) is an enzyme required for breakdown of histamine in the intracellular pathway.
(people cured pois with this)
This alsou afeect pois:
Histamine, in its role as a neurotransmitter, works to control the sleep-wake cycle. It may decrease GABA levels and increase norepinephrine and epinephrine levels. Histamine may cause increased permeability of the blood-brain barrier. It also significantly influences neuroendocrine control including behavioral state, biological rhythms, energy metabolism, thermoregulation, fluid balance, stress, and reproduction. Elevated histamine may affect thyroid function. Histamine may play a role in neurocognitive function as well. (Haas, 2008)
Read few treeds here and you will see that is not that simple.
DAO, MAO, diet, non diet...stress,
infections, genetics...
https://healthygut.com/articles/how-to-get-relief-from-a-histamine-intolerance/
https://www.medicalnewstoday.com/articles/322543.php
https://www.diagnosisdiet.com/histamine-intolerance-science/
http://www.diagnosisdiet.com/histamine-intolerance/
https://www.medicalnewstoday.com/articles/322543.php
diarrhea
chronic headache
flushing, especially of the head and chest
irritable bowel syndrome or IBS
congested, runny, or itchy nose
red, itchy, or watery eyes
sneezing
shortness of breath
hives or red, raised, itchy, burning bumps
very itchy skin
unexplained anxiety
stomach cramps or pain
chronic constipation
nausea and vomiting
gas or bloating
unexplained exhaustion
dizziness
very dry, patchy, or scaly skin (eczema)
irregular or increased heart rate
What if mast cells are infected? It could mimmick a mast cell activation disorder by a change in their function.
Mast Cells and Natural Killer Cells?A Potentially Critical Interaction (https://www.mdpi.com/1999-4915/11/6/514/htm)
Now virus-infected mast cells seem to release IL-8. This is upregulated in my case as well.
They recruit NK cells via IL-8. This could be drawn from the peripheral blood lowering their numbers. My NK cells are low as well.
IFN-gamma seems to increase by this infection which is also elevated in my case.
I wonder whether gastrointestinal candida colonisation promotes sensitisation against components of human sperm. Could it depend on the location of colonization? Perhaps at the part where Vitamin D is absorbed, since low vit D numbers can be low in poisers.
Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice. (https://www.ncbi.nlm.nih.gov/pubmed/16423887)
The wax and wane behaviour of my symptoms is strange. POIS switches emphasis on symptoms. Periods with higher intensity of symptom A which can fade in intensity after a while and emphasis switches to other symptoms/body locations. Smoldering behaviour.
Another thing is when in POIS I can feel something flowing/crawling very slowly in my lower legs (if I am interpreting this correctly). The speed is in the order of ~mm/sec, it's close to the surface of the skin.
Muon before desensitization did you make Cytokines test?
Muon before desensitization did you make Cytokines test?No
This is a very interesting paper. I was looking at the sensitivity difference between urinary vs serum light chain testing and stumbled upon this paper:
Polyclonal free light chains: a biomarker of inflammatory disease or treatment target? (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564472/)
So for eosinophil activity I can use ECP and for B cell activity I can use free light chains. Even when there are (auto-)antibodies involved why hunting for them when you can measure their breakdown products? FLCs can be deposited in organs. IL-8 appears to be involved as well.
I asked this question Muon because there is a chance you developed your immune response after desensitization.
I think whoever did not undergo desensitization should do these tests.
Higher environmental temperature upregulates Leptin. Also duration of exposure to a higher temperature will lead to increased leptin. Duration of exposure to higher or lower temperatures has a significant effect on my health. Feels like higher temperature induces low grade inflammation and the length of exposure will amplify this. My earlier thoughts were that temperature effects had something to do with mast cell activation, endothelial dysfunction, sensory nerves or dysautonomia. I can add upregulation of leptin to that list of possibilities. Digestion is also improved during winter compared to summer time, leptin could play a role in this.
https://www.ncbi.nlm.nih.gov/pubmed/22279186
https://www.sciencedirect.com/science/article/abs/pii/S0026049500800013
https://link.springer.com/article/10.1007/s00421-004-1084-7
''Leptin promotes T cell activation and shifts the T-cell cytokine production towards a Th1 response''
''recent reports have indicated an ability of leptin to negatively influence the proliferation of naturally occurring human CD4+CD25+FoxP3+ regulatory T cells''
Leptin and Inflammation (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829991/#S7title)
It seems I'm getting bubbly urine after a period of symptoms including and especially muscle stifness. These bubbles seem quite large like 1 cm in diameter on average, I wouldn't classify this as foam. I'm certain this isn't caused by the high velocity of the urine stream.
Something else came to mind was the candida albicans LTT testing. What if there is a hightened permeability of the intestinal barrier somewhere. The species which are already present may able to come into contact with the immune system. There could be a specific immune response where memory T cells against candida are produced. But what if these are not specific at all? What if a molecule from the seminal fluid fits onto the same receptor as candida albicans? These memory T cells might be activated by release of seminal fluid, while they are created to suppress C. Albicans in the first place. I'm not talking about infection or colonization.
Candida Albicans LTT (https://www.dropbox.com/s/oovb5fk9hzlpnkz/Muon%204-2%20LTT%20Candida%20Albicans%2014-08-2015.pdf?dl=0)
I got testicle pain at the moment. It's like they are being squeezed.
Yes my testicles also hurt when in POIS. Most of the time the left one. My urine is darker and smells very bad. I got my urine tested twice at my family doctor, but there was nothing to see.
Yes indeed it's the left one most of the time. It's smoldering with a wax and wane behaviour. Also the pressure at the lower part of the spinal cord leading to weakness in my legs impairs my daily living big time...I can't even do the dishes at the moment. Standing on weak legs is so exhausting.
I had this in the past that this pressure continued to buid up. At a certain treshold the pressure drops completely and a leg jolt happens at the same time. It's like lightning shooting through my leg. I get only one shock through my leg and only one leg is involved. The pressure build up takes tens of minutes. Sometimes I could prevent this build up by moving around. POIS triggers this behaviour.
A moment of arousal today has put me in a tense state for almost a whole day, especially in my limbs. I suspect this is a vasospasm, it's tightened up. Legs are weaker as well which I think stems from decreased blood supply. I think there isn't sufficient blood being supplied to muscles causing exercise intolerance. The ANS might be responding abnormally to arousal or release of pre-ejaculate. My brain felt tense as well.
Pressure in my back is getting worse. As soon as I stand up my legs are getting weaker and keep getting worse with prolonged standing. It's exhausting. I get relief by bending forward or laying down. POIS is also a trigger for this pressure in my lower spine. Lumbar spinal stenosis? https://en.wikipedia.org/wiki/Lumbar_spinal_stenosis
A moment of arousal today has put me in a tense state for almost a whole day, especially in my limbs. I suspect this is a vasospasm, it's tightened up. Legs are weaker as well which I think stems from decreased blood supply. I think there isn't sufficient blood being supplied to muscles causing exercise intolerance. The ANS might be responding abnormally to arousal or release of pre-ejaculate. My brain felt tense as well.
Pressure in my back is getting worse. As soon as I stand up my legs are getting weaker and keep getting worse with prolonged standing. It's exhausting. I get relief by bending forward or laying down. POIS is also a trigger for this pressure in my lower spine. Lumbar spinal stenosis? https://en.wikipedia.org/wiki/Lumbar_spinal_stenosis
Blood flow issues should be treatable with L-Arginine, it is a vasodilator.
Problems right now is extremely tense muscles, rigidity of joints my shoulders are completely
****** up , my right eye like vision is reduced 50% and hypersexuality. Hypersexuality is excruciating i cannot focus. When i get aroused my muscles tense up...
Language, please
and hypersexuality. Hypersexuality is excruciating i cannot focus. When i get aroused my muscles tense up...
I'm using Metoprolol succinate Ret T 50 mg (slow releasing) for the last 8 days for cardiac issues and it seems to neutralize the hypersexuality spikes. I already knew this from the one time I used the 25 mg tartrate once but I found that form too intense. It also reverses the weakness in the legs a bit, It feels like more blood is flowing through my legs, knee joints feel better and I feel that my feet get more resistance against the ongoing fungal creep. It also does something to my brain, I get the impression that my brain is locked into a different state. My GP proposed to up the dose to 75 mg because it doesn't have a constant effect to leg weakness, it seems to come in waves/bursts.
Alot of beta blockers lower testosteron
Testosteron is needef for tissue repair
Summer has come to an end and it's getting colder. I just took a walk outside when it was cold and felt so much better. The effect is insane. I have my central heating turned off and feeling better when night falls inside my apartment as well.
- Increased muscle strength, especially in lower limbs. I can stand on my legs without much problem (major difference compared to summer).
- Increased stability of heart rate
- Less intense POIS symptoms in general
- Faster recovery period of POIS symptoms
- Less brain fog
- Better metabolism/digestion
- Decreased food sensitivities
- Less joint pain (knees and spine)
Did some googling and found this: Immune Responses to Exercising in a Cold Environment (https://www.sciencedirect.com/science/article/abs/pii/S1080603211002018)
''Even brief exposure to cold leads to increased levels of norepinephrine and cortisol, lymphocytosis, decreased lymphoproliferative responses, decreased levels of TH1 cytokines and salivary IgA, and increased lactate levels during exercise.''
Perhaps I should move to a country with an (sub)arctic climate.
(https://aws1.discourse-cdn.com/business4/uploads/electroneum/original/2X/b/bece0b1a70f2e926a797b221ffd124c9b534a584.jpeg)
It's the same with me , the heat is "killer" for me.
But ... when winter is tough, I can't handle it the same,
due to muscle stiffness, asthma like symptomes, MG symptomes, lower immunity etc ...
Pois in winter make my extremities very cold, poor circulation.
In summer,it is the opposite ,
i get POTS.. dubled fatigue, hard heart pumping,
and many other symptomes.
If really it helps you, I recommand derivative bath.
I tried it without real effect on my Pois but why not.
The idea is to cold the center of body which is the center of body (pubis, Perineum) temp regulation (if we except hypothalamus) to generate "positive effects" (like less inflammation).
The old method was to wash and make a massage of theses areas with cold water ("fresh water" not too cold).
The modern method is to put an "ice pack" to cool the Perineum area.
Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP (https://www.nature.com/articles/ni805)
''TSLP-activated DCs primed naive TH cells to produce the proallergic cytokines interleukin 4 (IL-4), IL-5, IL-13 and tumor necrosis factor-α, while down-regulating IL-10 and interferon-γ.''
Thymic stromal lymphopoietin: master switch for allergic inflammation (http://jem.rupress.org/content/jem/203/2/269.full.pdf)
(https://rup.silverchair-cdn.com/rup/content_public/journal/jem/203/2/10.1084_jem.20051745/3/269fig2.jpeg?Expires=1579563377&Signature=YLLAFoAwM~Rip-SsNZcNx6ZzFEvc9wdWVDWNIeTV3GX7pdfNGiKuGRAFmgOlect48m9SH8zb47a-LKmDluYb9808Y3iXVARgzr2ZGNSFuLuZuDRKBp46UExRyahhOozOZXOMuuaRM21FbAfKrjeHqKxxhOOSjALfjL1oUjMADqOoBYM9E7Lj2t2TBDY9FohBTEB-PPB3zepyMsJkzQY5LgkbDH~-mWDGtUM~MzsrKYaqmiMAQ2RDov5UvnXaWzZs8NXUN7RNDNuJsYJPpValh3Jl7UhUW9NJvqZrfdALx7VlpY2qS~ov-G7z1wZDUoawTiAhe69hW4gBliGDHrav7A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The B-cell side of Allergy and Chronic Inflammatory Disease: Studies on the source of IgE and IgG4 (https://repub.eur.nl/pub/111750/)
Click on Free full text at the right side of the page. See chapter 6.
''Concluding, our data provides evidence for long lasting effects of sublingual immunotherapy on the memory compartment of the immune system. Increased numbers of regulatory T-cells lead to a higher frequency of IgG4+ memory B-cells and a beneficial shift in the IgG4+/IgE+ memory B-cell ratio, reflecting the increased IgG4/IgE antibody fraction in serum, which results in a favorable outcome.''
So the SCIT might have increased my IgG4 levels (my brother did not receive any immunotherapy). These levels may indicate that there was an increase in Tregs. We could be dealing with low Treg numbers here. They are also mentioning that Treg numbers at mucosal surfaces especially might be altered. I personally got problems with food reactions at mucosal surfaces. So Treg numbers in POIS patients is something that can be investigated especially at mucosal surfaces.
Sometimes when I wake up my oral mucosal layer can be thick, smooth and developed. As soon as I wake up my mouth gets dry. I first thought it had to do with posturing up or physical activity and didn't bother with it. After that I had a few moments where my oral mucosal layer was thick again and this time I stayed in bed a little longer when I woke up. My mouth still dried up.
It has to do with the wake state. I noticed that my brain switches to a slightly tense state when waking up, my interpretation is that it's in an overactive state. Also low environmental temperatures + a good night of sleep increases the chance of me waking up with a non-dry mouth.
Yes I have this too. When my sleep is bad I wake up with a dry mouth. And I also have a lot of dental plaque. I have this when in POIs. But the latest months also out of PoIS.
This is mostly a case of Mouth breathing. Both you and vandemolen must be breathing through your mouth due to a obstruction happening in your nose while sleeping.
Testicle pain in my left testicle woke me up in the middle of the night. Plus I had problems getting my breathing frequency constant (this is not hyperventilation, it's closer to hypoventilation). I also had the feeling some circulatory system was sluggish. I often get the impression there is a lower volume of blood available or that the body has trouble distributing it properly.
Sometimes I can feel the liver flaring up when these type of symptoms show up. I think the liver gets less blood volume per unit time. Antoher example is when I eat a meal I can have the feeling some circulation slowing down and start to get problems with my breathing frequency. What I think happens is that the stomach at that moment draws more blood towards itself for digestion and it draws it from places where it's needed.
Something different; The tightness or squeezing feeling during POIS that last for hours to days. My wild guess is that this is vasoconstriction (smooth muscle contraction?). Autonomic signaling? Endothelial problems? Or slow reacting substances of anaphylaxis(SRS-A) that play a role in hypersensitivity reactions but minus the anaphylaxis part?
Have you experimented with individual B vitamins? I've read that B1 (Thiamine) can affect breathing at night.
I've tried a B complex and had a bad reaction. I am looking at individual B vitamins now.
Have you experimented with individual B vitamins? I've read that B1 (Thiamine) can affect breathing at night.Yep same here vitamine B complex gives me a bad reaction as well, tested this multiple times. I haven't tried testing them separately for long periods. I'm trying some niacin again but lower dose 100 mg (non flushing dose). The first few tries had some minor positive effect on circulation (against the feeling of circulatory stagnation). But it isn't long lasting and is only noticeable when this symptom intensity is low, it doesn't do anything for my pois.
I've tried a B complex and had a bad reaction. I am looking at individual B vitamins now.
I have tried some CBD oil of 10% not pharma quality as purity goes, just from the store. My initial impression is that it suppresses my POIS to some extent now and then (the stuff isn't distributed evenly in the jar as far as density goes) but quit using it because I had some bad reactions to it, like suddenly feeling susceptible to infection and inducing intense sore throat. It works actually better outside POIS against inflammatory flares. I will need higher dose, higher purity, higher frequency intake per day and a longer period of intake in combination with POIS to conclude this actually works.
Bad posture gives me autonomic instability. I'm starting to leak some drops of fluid (urine/prostate fluid?) when I'm in an inclined positions (semi supine) which is a new symptom. Quick transition from supine to upright gives me a sudden urge to urinate lately, which is an old symptom. It feels like the upright position activates the SNS, there is also some pressure in the lower part of the spine especially when standing still.
Got stress from sitting still. This led to a light burning sensation below the surface of my skin around the upper body. Most noticable in my arms especially forearms. Also had problems of forgetting to breath. Zero sense of thirst and appetite. Need to remind myself to drink. Impaired sense of smell. Increased frequency of urination and some spills of droplets from my urinary tract. Can't get warm when I'm cold. Nasal drip and runny noses from stress. Avoiding triggers especially stress is an impossible balancing act before you know it you are slowly sliding into a downward spiral.
The day before there was a sudden focal activity at a spot around the centre of my brain. Shortly after that my body started to get hot. It wasn't fever, I wasn't glowing or sweating.
I think POIS is majorly a limbic system dysfunction leading to imbalance in the HPA axis leading to the abnormal immune activity.
I think this is as close towards understanding POIS as I will ever get.
You’ve certainly given it much extensive thought
It never occurred to me to test IL-8 in seminal plasma. Perhaps the serum level is an indication of elevated sIL-8. Very interesting and information dense paper. There is even a link with premature ejaculation. I haven't read all of it yet, will comment later.
Interleukin 8 and the male genital tract (https://sci-hub.se/https://www.sciencedirect.com/science/article/pii/S0165037813000466)
''Of importance, in both murine and human systems, b2-AR agonists inhibit IFN-g production by Th1 cells, but do not affect IL-4 production by Th2 cells.'' page 616
The Sympathetic Nerve - An Integrative Interface between Two Supersystems: The Brain and the Immune System (https://sci-hub.se/http://pharmrev.aspetjournals.org/content/52/4/595)
Did the doctors say anything about your very high CMV and VZV titres?No. The VZV memory antibodies are literally off the chart btw.
Did you try to treat itNot sure what to do. I did get treated 15 years ago with, I believe it was, acyclovir and prednisone for 14 days.
or retest it?Nope
Do you think this might be the cause of your issues?I have no idea Simon. I'm triggering activity in my body by certain triggers, also in a slow smoldering and lingering way. You could make a case for viral reactivation but I'm leaning more towards mast cell activation. I'm not jumping on any potential cause for the full 100% though.
Do you get acne or other skin infections?On my shoulders and back there is something that resembles acne but dermatologists are not 100% sure it's acne. It's seems to show up together with symptoms. They say it might come from overactive sebaceous glands.
No. The only hormones that have been measured are thyroid hormones. Somehow nobody took the effort testing for other hormones.
Strange I had an orgasm with almost zero POIS symptoms.
3 Grams L-Arginine
4 Grams L-Lysine
14.4 Grams Lecithin
25 mg Zinc
Multi Vitamin Pack
This combo works great for me. The only drawback is when I dump my load that’s it. My orgasm is so intense and voluminous I am expended and don’t want to go round two.
Source : https://www.thundersplace.org/male-supplements/l-arginine.v3.html
Standing an sitting puts pressure on my lower spine resulting in weakness of upper legs and gives me stress which triggers symptoms in other parts of the body. I can't function due to this symptom. My spine triggered too frequently last year which increased its reactivity. POIS/arousal and stress affect that same area paving the way for increased sensitivty to spinal pressure. Joints in spine feel stiff and it feels like something is stuck in lower back.
I get relieve by laying down, bending forward, pulling legs towards my chest or doing a spinal decrompression exercise but relieve is only for a few minutes. Also starting to get problems with pressure on neck joints which can result in a headache in centre of brain.
Synovial Mast Cells: Role in Acute and Chronic Arthritis (https://pubmed.ncbi.nlm.nih.gov/17498049/)
Pressure--->Synovial mast cell activation--->joint inflammation?
My doctor doesn't even take a serious look at this while it affects me 24/7 every day in a major way. I'm so angry and frustrated.
Also had a brief moment of arousal which brought my brain into a different state. It took hours before it returned to the state prior to arousal. Something in my brain didn't stabilize.
The spinal problems are worse than POIS at this point in time.
I get a bit of "stuck feeling" and tightness in lower back too when stressed.
A potential candidate responsible for my elevated IgG4:
Nerve growth factor specifically induces human IgG4 production (https://onlinelibrary.wiley.com/doi/10.1002/eji.1830210121)
Nerve growth factor: a neuroimmune crosstalk mediator for all seasons (https://onlinelibrary.wiley.com/doi/full/10.1111/imm.12717)
IL-13 and NGF are now on my radar for selective increase in IgG4.
My grandma did feel better in general and recovered to some extent after they injected something in her throat via the oral way. The substance is unknown. A friend of her recommended to go to that doctor because he helped that friend with getting fertile again. So the oral cavity was being skipped, the question is what was the substance involved? Was it a hormone?Clomid?
Hey man,Translation:
Ik zit jouw case door te nemen: https://poiscenter.com/forums/index.php?topic=2545.0
Er zitten zo onwijs veel gelijkenissen bij. Zelfs de gekke dingen zoals dat over-flexibel zijn.
Je hebt er misschien niet veel aan dit te weten, behalve een schrale troost. Toch wilde ik het even zeggen.
Not fully translated from Dutch: Took 2 Kurkuma capsules with black pepper ~ 10 min post O on an empty stomach in the morning and it started to have an effect ~10 min after intake.
Active ingredients 1 capsule:
Kurkuma 100mg
Including curcumine 3000 ug
Black pepper extract 10 mg
Including piperine 9,5 mg
Vitamine D 5 ug (100% RI)
Vitamine C 12 mg (15% RI)
Ingredients: Kurkuma (curcuma Longa L), vulstof (microkristallijne cellulose), Gelatine(rund/varken), Vitamine, Black pepper extract (Piper Nigrum), stabilisatoren (magnesium salts from fatty acids, siliciumdioxide)
Brand: Trekpleister
I get the impression it affected cardiovascular symptoms (inflammation?). Needs further testing could be a fluke, I have tested this before in the past with black pepper and it had no effect, could be the empty stomach thing or difference in formula.
For nasal symptoms: Using minimum dose of disodiumcromoglycate for about 14 days now. Concentration= 40 mg/ml, spraying once in both nostrils twice a day. Going to bump up dose soon.
Last months increased breathing problems. Low respiratory rate ~6 (once every 10 seconds) and sometimes it stalls and have to remind myself to breath, respiratory muscle are slightly weak (need force). This leads to Arrhythmia (not the other way around). One of these days I will get a heart attack. If I force myself to maintain a normal RR my body feels better instantly, brain and extremities ,especially the feet. Healtcare doesn't monitor these things, what a joke.
Summer has come to an end and it's getting colder. I just took a walk outside when it was cold and felt so much better. The effect is insane. I have my central heating turned off and feeling better when night falls inside my apartment as well.
- Increased muscle strength, especially in lower limbs. I can stand on my legs without much problem (major difference compared to summer).
- Increased stability of heart rate
- Less intense POIS symptoms in general
- Faster recovery period of POIS symptoms
- Less brain fog
- Better metabolism/digestion
- Decreased food sensitivities
- Less joint pain (knees and spine)
Did some googling and found this: Immune Responses to Exercising in a Cold Environment (https://www.sciencedirect.com/science/article/abs/pii/S1080603211002018)
''Even brief exposure to cold leads to increased levels of norepinephrine and cortisol, lymphocytosis, decreased lymphoproliferative responses, decreased levels of TH1 cytokines and salivary IgA, and increased lactate levels during exercise.''
The pro-inflammation hormonal substances cannot leak as easy accross constricted blood vessels.
Candida can also suppress the production of serotonin, crucial in depression. Candida also down regulates IL-17, perhaps as a defense mechanism, as IL-17 is very important in removing Candida. Recent research suggests that it might directly bind to Candida and induce nutrient starvation conditions in the organism. Candida down regulates IL-17 by shifting the Kynurenine pathway the opposite direction that POIS does, which may support its proliferation in our bodies as a way to counter this effect. Coincidentally, Staph. A infections counter the inflammatory effects of Candida, and a few years ago I had a antibiotic resistant Staph A. infection (MRSA).
The more I read about Candida, the more convinced I am that it is causing POIS.
Pityrosporum folliculitis is a fungal ‘acne’. Could it be PF? My doctor said that I have it. Ketonazole cream helps me.You mentioned Daktarin earlier. That one in gel form got me rid of oral fungal outbreak (there were literally fungal wires appearing in my mouth). There was a problem. Normally you would swallow the substance. When I did that I got literally flattened by it, my legs got weak and I collapsed to the ground and my immune system felt extremely weak, never experienced something like this. So I called the doc and she said it never happened before, she contacted the producer and they told her I was the first case that experienced something like this. They advised me not to swallow it just flush the mouth. I still don't know why I reacted so extreme to it (herxheimer?). If that was a herxheimer reaction then perhaps I should take it again.
What's your diet like anyway?
I don't eat any refined grains or sugars, though I do eat fruit and plenty of whole grains. My last IGG4 test showed a pretty strong candida response, which my physician said means I had an overgrowth at some point.
Hi Colm,
I think all the things you mention can be also beneficial ,
I tried them all, but did not find any significant relief, but perhaps in combination with alcohol, I mean in wine, they work better ?
But in my case I can?t figure out anything else but the alcohol (ethanol) is what makes the difference. Also because in the past I had experieces with beer and stronger liquor which also gave relief.
In someway or another the alcohol blocks the outbreak of POIS or stimulates something which outcompete the pois-outbreak.
1. I think Sam-e and Choline supplement has done wonders for me. My face paresis (post car accident) has disappeared since last 2 weeks. I'd say safely 90% improvement (for the first time in my life)
Another weird thing is - I've had, and still have, a weird symptom that consists in shaking or trembling as a result of any physical effort. It feels as if my nerves were malfunctioning and unable to transmit signals like they should....
During sex there is increased blood pressure, body movement, blood flow to large muscles, deep breathing leading to activation of vagus nerve activity and consequent relaxation of this nerve ....I believe there is a blood volume redistribution present as a response to POIS in conjunction with vasoconstriction, that's also a reason why I think you will get a pale skin. I'm not exactly sure whether it goes to skeletal muscles, organs or large muscles. It's possible my exercise intolerance stems from this phenomena besides inflammation. The vagus nerve could be involved.
Btw I found out that the level of Sam-e in the body modulates the release of IL-10 and IL-35
- when I was a kid - Staphylococcus aureus (not many symptoms, mainly in throat)
- since I was 19 ? symptoms like in inflammation of the prostate gland (I take no drugs for it because symptoms 1-2 times in month for 1-3 hours, from time to time control visit by urologist); I have not often prostate symptoms till today (also weak urine stream, but it could be worse)
...Sounds like an 'abnormal' endogenous process due to orgasm that can be triggered by an exogenous substance, in this case semen...I think it's the prostaglandins in the semen that cause this. Or it could be caused by the polyamines (spermine, spermidine).
...From second paper:
"Human seminal plasma contains very high concentrations of prostaglandins when compared to other bodily secretions. It is now apparent that PGE2 (https://en.wikipedia.org/wiki/Prostaglandin_E2), 19-hydroxyprostaglandin E1 and 19-hydroxyprostaglandin E2 are the three major prostaglandins in human seminal plasma, each being present in millimolar concentrations..."
Hmmm...https://en.wikipedia.org/wiki/Transcortin (also known as corticosteroid-binding globulin (CBG) or serpin A6)I was born through a c-section so I maybe didn't get these bacteria that in the image are said to be given to the offspring through the natural delivery Muon do you know if those strains mentioned which don't transfer through csection can lack of them increase chances of POIS and Aspergers and such things I was breastfed though so I got the ones from that but not from natural birth due to being born through a csection.
""Hepatic synthesis of corticosteroid-binding globulin more than doubles in pregnancy; that is, bound plasma cortisol in term pregnancy is approximately 2 to 3 times that of nonpregnant women"
Microbial Changes during Pregnancy, Birth, and Infancy (https://www.frontiersin.org/articles/10.3389/fmicb.2016.01031/full?gclid=Cj0KCQjw9fntBRCGARIsAGjFq5FgiqzCqFJTYidtBQFx44wczUpQRgXDWo4KO8oANYVSpk5V3YhYYDwaApojEALw_wcB)
What if the females in my family with health issues felt better during pregnancy due to changes in their microbiome? Are the strains, that change during pregnancy, responsible for my POIS? Mothers give part of their microbiome to their children if I'm not mistaken. Could these strains be targeted? Questions....
(https://www.frontiersin.org/files/Articles/204716/fmicb-07-01031-HTML/image_m/fmicb-07-01031-g001.jpg)
(https://www.frontiersin.org/files/Articles/204716/fmicb-07-01031-HTML/image_m/fmicb-07-01031-g002.jpg)
Intens (heavy weights) body building exercises (most of them in flat or inclined position). Short powerful movements, almost explosive with Reps between 3-5. The trick is you need to induce a pump. Need to add more details.
So, now, whenever I get symptoms, I run on a treadmill or lift weights or do whatever kind of intense physical exercise I feel like doing until I'm exhausted and drenched in sweat, and while sometimes symptoms take a few hours or even a day to resolve after that, it's nothing compared to the minimum of a week that they usually last.
1 question, did you check your liver and bile production?
You can have fatty liver even with in range results. Read my post, maybe it helps, i got better when dealing with bile production and fatty liver. But fatty liver is not mandatory to have low bile production, it can be hereditary.
https://poiscenter.com/forums/index.php?topic=3203.105
I also have diagnosed fatty liver.
...it's like these pills are helping liver to detox and to produce bile and clean toxic stuff from blood.
Bile regulates good/bad bacteria, it prevents SIBO, if the colon has bad bacteria i get POIS due to undigested food get to colon and bad bacteria making gasses like methane and hydrogen sulfide, which is getting to blood and into brain and then i get POIS symptoms.
wow I never read this thread till today and was frozen while reading. Moun's your symptom match mine. Thank you for sharing these links. Not to badger you, but the link you posted: Impairment of microcirculation of the facial nerves catches my attention, talks about: Endothelin, which has potent vasoconstrictive effects, may contribute to the pathogenesis of the microcirculatory impairment that occurs in patients with Bell palsy, mainly by promoting secondary ischemia. I dont follow since we POISers have low BP and Endothelin constrict vessels raising BP. During POIS, I get severe burning in my Palsy areas, as if nerves are trying to fire up but unable to. When I take vasodilatory things (specially a med, gabapentin) that burning sensation stops but I dont know if vasodilatory is the key or its something else the key that helps. But I know that POIS creates a burning sensation also across all distal peripherals, like ankles, wrists, exact symptoms of Raynaud syndrome.
Did some googling and found this: Immune Responses to Exercising in a Cold Environment (https://www.sciencedirect.com/science/article/abs/pii/S1080603211002018)
''Even brief exposure to cold leads to increased levels of norepinephrine and cortisol, lymphocytosis, decreased lymphoproliferative responses, decreased levels of TH1 cytokines and salivary IgA, and increased lactate levels during exercise.''
Past Events
Januari 2020
A few times tingling sensation at the glans penis and became very sensitive to any friction (not sexual related just limp penis).
Februari 2020
I ate some liver and suddenly became feverish and nauseous for less than 30 sec of duration immediately after ingestion. Perhaps 5-10 mins after there were migratory colds traveling over my body and turned into systemic cold (shivering) after the migratory cold ended.
October 2020
Washing the glans penis during shower led to activation in lower back at the spinal area (which is already sensitive), no pain, just activation of something and it isn't muscle, no feeling of contraction. Activation stops when friction stops. Applying friction again flares up activity in my lower spine again.
Washing the glans penis during shower led to activation in lower back at the spinal area (which is already sensitive), no pain, just activation of something and it isn't muscle, no feeling of contraction. Activation stops when friction stops. Applying friction again flares up activity in my lower spine again.When I rub my glans/forehead exactly on the top area for example against the palm I feel this interesting kind of tingly kind of pulling feeling in the lower back area too either in nerves or something like that if I did that for many minutes it would feel way too intense and I would have to stop and once I do not rub anymore it just stops I already recall noticing that when I was a teenager.
I spent 4 months with colitis and lost half of my weight until thankfully my mother deduced that soy was the culprit. So I believe that, if it was a true allergy, I'd have had a more intense reaction. And yes, I've never tolerated soy well, and I've had that problem for as long as I can remember.
I have had similar symptoms, where if I get incidentally aroused by something (which happens unfortunately often during abstinence), the arousal chemicals seem to be stuck in my brain for many hours afterwards. To your point this is not pleasurable at all and is frankly a gross feeling. I haven't figured out any way to get rid of it other than waiting it out and trying to distract myself.
Vibration excites something in my body. Something drops to the floor makes sound and it feels like it excites a cloud of particles in a domino's-like fashion, its net-momentum going one-way (it branches out as wel) only once, mostly in my lower torso (Most of the time it is traveling upward). It's like a wave.
Another scenario:
Glans penis (limp state and is not sexual related) becomes sensitive while walking or riding a bike that I have to stop walking for a few mins or stop riding the bicycle (I stop because the sensitivity increases with duration of movement up to the point that it hurts). The little friction it makes with my clothing seems to get amplified after repetitive motion. It gets better once I pause. (very mild tingling involved)
"Many, if not most, of the symptoms related to neurosomatic disorders are caused by autonomic dysfunction which may be a result of inappropriate endothelin secretion. Blocking endothelin receptors may be an important way to treat neurosomatic disorders in the future"
"Both adenosine and gabapentin decrease pain in many patients with FMS by decreasing hyperactive neuronal activity. Gabapentin selectively opens KATP channels."
I have not Muon. I only recently seen a doc, and they hesitantly did some blood tests, and wrote some negative comments on my medical records, for bringing a huge list to them, and the doc making me understand :) that you dont get tests because you are 'curious' to find. I did get a heart echo-cardio though (by jumping through some hoops).
My cardiac fitness came excellent, 105% of Maximal heart rate. I do have a incomplete right bundle branch block (that I think turns to complete when stressed) though doc says its all normal. I would be curious if you have had echo cardio, or other folks can share their insights.
That said, my small fiber neuropathy, I think, is resolved now.Swell, have you done any test for small fiber neuropathy yet?
Muon! If you haven't found this already you might be interested in this article as it seems to be related to your relatives at least if my theory holds true.
"All the females who got health problems felt better during their pregnancies and felt worse during their menstrual cycle."
AEA is low during pregnancy, but is high during menstruation, especially in the follicular phase.
The low levels in postmenopausal women and the high levels in the follicular phase suggest that steroid hormones primarily regulate AEA levels, with estradiol increasing the levels and progesterone suppressing them. The effect of progesterone could result from regulation of the degradation of peripheral AEA by peripheral blood mononuclear cells given that the levels of FAAH, the principal enzyme involved in AEA degradation, in these cells are regulated by progesterone. The induction of high AEA levels by estradiol could be mediated by its effect upon endothelial cells given that it has been reported that estradiol increases the release of AEA from these cells into the circulation.
https://academic.oup.com/jcem/article/89/11/5482/2844400?login=true
My mums autistic behaviours are increasing everyday and same with her high anxiety and low mood, she will not take any supplements now when I offer them to her. She keeps telling me she is fine and to leave her alone but she clearly isn't, its pretty frustrating. Her mum died of motor neurone disease and I worry about her developing something similar as her body clearly isn't functioning properly. Its likely she has many of the same gene mutations I do, if only she listened to me it probably would be cheaper to fix her health now rather than wait for a disease to develop down the line.
She helped her friend move out of a very moldy apartment the other day when she got back she had a butterfly rash on her face which I had never seen on her before which is quite concerning.
My mother gets these flares of butterfly rash on her face, mostly when stressed. You see this symptom in Lupus which is autoimmune. HOD's mother got Hashimoto's disease. Keep observing her behaviour, my brother got psychosis recently. I thought she liked the supplement? What was the name of the motor neuron disease?
I believe lupus is a food/stress/gut related issue. You should listen what Pharmacist Ben Fuchs has to say about it here (https://benfuchsarchives.com/?s=lupus).
I believe lupus is a food/stress/gut related issue.
Tried a bit of a green smoothie containing pineapple and spinach, pineapple gives me diarrhea, spinach does other things. Haven't touch those ingredients for years.
I had to run to the toilet in ~ 1 hour after ingestion and had solid brown stool (yesterday's food) covered in green diarrhea. It was tolerable after ingestion until it hit a particular spot in my intestines. I won't touch that stuff anymore. Still highly sensitive to those ingredients especially pineapple. IBS.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609577/ :Very good find. Dumping this here:
"In addition, we characterize two CD38 inhibitors: quercetin and apigenin"
You have to try to rebalance your whole body.
If you work only the lumbar part, you will not have the expected result.
A bad posture requires a lot of energy from our body. I believe that the vagus nerve works hard to try to return the correct posture.
A wrong tension in our muscles ends up causing a stress on the body that activates defense systems that are related to inflammation. Try to do the work of improving posture throughout the body, I believe it will be of great value to achieve the target (cause of the problem).
Abruptly waking up at night due to a bowel movement. Food traveling through gut could be felt. Accompanied by activity at an area close to or at the brainstem. Feeling hot. Irregular respiratory rate. Impaired blood circulation body/brain. Sections of limbs getting tense.
Muon, way back when I started my Magical TRT Mystery Tour, I had an MRI of the brain ordered by my endocrinologist, resulting in a find of Empy Sella Syndrome. Not sure if/where to post...https://rarediseases.org/rare-diseases/empty-sella-syndrome/#general-discussion
1 hour is also the timing that I start to feel bad after ingestion of foods like certain brands of chocolate (where other foods can start triggering local symptoms in oral cavitiy or stomach upon contact for example).
Food curve:(https://i.imgur.com/IgsOqT2.jpg)
Food curve:(https://i.imgur.com/IgsOqT2.jpg)
Could you explain this graph?
Does this mean dopeamine stays elevated DURING the process of maturbation..
Or even AFTER?
Could you explain this graph?
Does this mean dopeamine stays elevated DURING the process of maturbation..Or even AFTER?
Abruptly waking up at night due to a bowel movement. Food traveling through gut could be felt. Accompanied by activity at an area close to or at the brainstem. Feeling hot. Irregular respiratory rate. Impaired blood circulation body/brain. Sections of limbs getting tense.Probably POTS, drawing blood towards intestines from somewhere else like brain/limbs. Happens often at other body parts, waterbed effect.
Strange I had an orgasm with almost zero POIS symptoms. A small area close to the center of the brain stabilized within a few minutes (rough estimate, could be a bit longer) after orgasm. I thought there was no problem in that area at that specific moment until the quick transition to a more 'normal' like state happened, the 'normal' state feels less active, much calmer. My libido also made a big change during the last 1.5 months from high to low and POIS symptoms have slightly improved, probably due to prolonged cold weather conditions.
Edit: forgot to mention that my body as a whole was relaxed, other symptoms were barely present and it was past midnight.
I was able to get luteolin in the product Neuroprotek. I have tried this supplement and am experiencing significant improvement, enough to believe there is serious weight to this theory.
I can already feel the effects of Neuroprotek within ~15 min, it acts on my brain, adressing brain fog. Perhaps I should build it up first instead of starting with 3x2. Hmmm when it comes down to mast cells it shouldn't work that fast from what I've been reading, it probably does something else.
0 side effects from cromolyn. It mainly affects my gut, it attenuates IBS-like symptoms but not completely. It doesn't seem to do anything else. I find it too pricey at what it does though, not impressed, maybe I need to take it a little longer.
With regards to neuroprotek, too soon to tell, but the changes are a bit too fast in my opinion (chucked away 2x2 capsules and will call it a day for now). Luteolin is the least phenolic compound of the flavonoids. It's almost bedtime for me over here and I'm alert as hell, cognitive speaking.
Some POISes report low and extreme low levels of vasopressin (made in the hypothalamus) and Aldosterone (made in the kidneys). Those substances regulate blood pressure.
Here you can do dr Hertoghes selftest for aldosterone deficiency (https://www.hertoghe.eu/wp-content/uploads/Test-yourself-for-Aldosterone-Deficiency-1.pdf):
Some POISes report low and extreme low levels of vasopressin (made in the hypothalamus)
Wrong of me, I cant find any analyse reports of low vasopressin but many POIS:ers report symptoms of low aldosterone and vasopressin (also known as antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin): Dehydration, dry skin, wrinkles, decrease in saliva and dry eyes.Some POISes report low and extreme low levels of vasopressin (made in the hypothalamus)Where did you read this?
It's a very confusing feeling to describe: almost as if my body "didn?t need to breathe", or forgot how to regulate the breathing pattern. I could hold my breath and feel no need to breathe in a long time. I had to "breathe manually", which led to hyperventilation and panicking. I had a few attacks like this during the next weeks, but after that it resolved spontaneously, even though it happened a few times in the next years, especially on very hot days in the summer (my favorite weather). I learned to live with it and not panic if it happened, and that was it. Now, considering the evolution of my POIS, I believe exercise was the trigger.Does this have any relation with the info given above inside this post?
I ingested my own semen. All of it. Nothing happened.When I was a teenager I ingested my own semen and afterwards my stomach and digestion completely shat down just like when sick with a stomach bug but except it was like a 100% stomach shutdown and I literally felt like I was dying until I vomited it all out which instantly relieved it but that is the only time I have done it and doing it again for the sake of experimenting feels very weird to me but I remember that one episode very clearly
Edit: Had gut/belly pain later on that same day (ingested at mid-day) and flatulence but that could have been due to food as well.
I ingested my own semen. All of it. Nothing happened.
Edit: Had gut/belly pain later on that same day (ingested at mid-day) and flatulence but that could have been due to food as well.
Weirdly I have this same thing happen the first night of POIS episodes: when falling asleep it is like my brain forgets to tell my body to breathe, and I keep half falling asleep, realize I?m not breathing, and then get up gasping.Once upon a time, in my worst pois episodes, I had sleep paralysis.
Generally if I just get up and read a book I?m fine, but if I try to sleep it continues on and off through most of the night. Other nights I am fine.
I ingested my own semen. All of it. Nothing happened.
Edit: Had gut/belly pain later on that same day (ingested at mid-day) and flatulence but that could have been due to food as well.
Pure science in action ;D
Guys , cheers..
(https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcSuKoJdOLieyF5_EgjcGzNPXGRWt_LGRx-tzCBb3Tl3wM_hFGU65BvJTbAEp74U0oSltMk&usqp=CAU)
Ah, wait . Edit , belly pain .. delayed alergic reaction ???
Here you can do dr Hertoghes selftest for aldosterone deficiency (https://www.hertoghe.eu/wp-content/uploads/Test-yourself-for-Aldosterone-Deficiency-1.pdf):
My endo says one adrenal gland is producing way too much aldosterone. She prescribed something similar to (but not the same as) spironalactone.
If I were younger, doc would recommend surgery to remove adrenal gland.
POIS - bringing generations together under a common cause :D
I get the suspicion that the Groin problem (one of my first symptoms before hell broke loose) could be related to a regional vasomotor dysfunction of a main artery, same as lower back. Feels like something is getting blocked (or change of tension) upon triggers like exercise, stress, heat, light pressure on affected area or body positions that put pressure on these (my mother who find it difficult to sit at a 90 degrees angle might have a similar issue, pinched tissue + weak vessels?), and POIS, like it doesn't respond properly, leads to weakness, fague minor pain and uncomfortable sensation. Plus veins on bicep did not respond well to blood pressure measurement lately with air cuff. Some pain in the body could be vascular related. I can also feel friction of blood flow in legs every now and then. The spasm in body, especially prevalent in legs, could be vasospasms.When sitting on some surfaces or putting one leg over another the leg that is held over the other always gets numbish tingly and I feel like there is something going on in the left hip area I also had around that area but in the back side some sort of weird pain in 2018/2019 winter when being outside a lot
Side note: I don't get these events anymore:
During POIS, pressure builds up in low part of spine, process could take tens of minutes. Moving around may delay this, unable to prevent this while asleep. Up to a threshold point that pressure is getting released and at the same time one leg shocks as if lightning shoots through it. Depolarization? Polarization builds up due to demyelination? (inflammation?). Or sympathetic outlfow issues in spine? Still have pressure in lower spine upon triggers but it doesn't keep building up, it doesn't reach the former mentioned threshold level.
I ingested my own semen. All of it. Nothing happened.When I was a teenager I ingested my own semen and afterwards my stomach and digestion completely shat down just like when sick with a stomach bug but except it was like a 100% stomach shutdown...
Edit: Had gut/belly pain later on that same day (ingested at mid-day) and flatulence but that could have been due to food as well.
Upon orgasm something gets amplified and/or doesn't get back to baseline in time. Similar behaviour for arousal, it peaks at the centre of my head, thereafter the arousal flare affects other parts of the brain--> impression that chemicals keeps hanging around in brain ('submerged'/'engulfed') after arousal flare. (Does orgasm affect microglia or blood flow in rest of brain?)
Anyway I'm stuck with low grade lingering inflammation troughout the body out of POIS. Starting to add 3x2 capsules/day of Neuroprotek to cromolyn (allergoval) as of this day.
Horizontal_Hero:
"My first lab abnormalities in 13 years have came back after ordering Dr Shoemakers tests. MSH ADH hla acth/cortisol tgfb1 c4a c3a vegf mmp9 to name the major ones. All but mmp9 for me was quite abnormal, indicating a chronically unregulated inflammatory state, caused most likely by the water damaged home I lived in for 30 years and possible repeat exposure to toxic algae blooms or an undiagnosed lyme infection." Ref (https://forums.phoenixrising.me/threads/postorgasmic-illness-syndrome-pois.81982/page-2#post-2329133)
Well I don't have 2 heads (thank God because headaches on 1 head is enough!!!) But I am one that gets severe headaches after sex. It is all over my head. It is not in one spot. In the past it would start out like my head felt deprived of oxygen or something and was very dull achey brain foggy confused feeling. It almost felt as if my brain was burning. I do not sleep well when it is like this. I am very aware of my head the whole time as it feels injured. Normally I sleep like a rock. After a few days of this my headache moves into a more classic headache where it's just painful like a really bad headache. Oddly enough I welcome that because I know I'm out of the first stage and will be better in a few more days. I have to say though since starting testosterone I am not experiencing these kind of severe headaches. My hormone doctor is being extremely conservative with my medication and I'm not to happy about that. My testosterone level is still only testing at 4. She has me on such a light dose. I'm going to see my OBGYN on Thursday to discuss my hormone levels with her.https://poiscenter.com/forums/index.php?topic=2755.msg36770#msg36770
My younger brother:Also had burning feeling in brain in the past. OCD-like behaviour during psychosis.
2020 Dec: Episode of schizophrenia/depersonalization, psychosis, whole body weakness, breathing difficulties. All together and went on for days. He told me he had the impression that there was a lack of oxygen in the brain and thought he passed out a few times.
I get the suspicion that the Groin problem (one of my first symptoms before hell broke loose) could be related to a regional vasomotor dysfunction of a main artery, same as lower back. Feels like something is getting blocked (or change of tension) upon triggers like exercise, stress, heat, light pressure on affected area or body positions that put pressure on these (my mother who find it difficult to sit at a 90 degrees angle might have a similar issue, pinched tissue + weak vessels?), and POIS, like it doesn't respond properly, leads to weakness, fague minor pain and uncomfortable sensation. Plus veins on bicep did not respond well to blood pressure measurement lately with air cuff. Some pain in the body could be vascular related. I can also feel friction of blood flow in legs every now and then. The spasm in body, especially prevalent in legs, could be vasospasms.When sitting on some surfaces or putting one leg over another the leg that is held over the other always gets numbish tingly and I feel like there is something going on in the left hip area I also had around that area but in the back side some sort of weird pain in 2018/2019 winter when being outside a lot
Side note: I don't get these events anymore:
During POIS, pressure builds up in low part of spine, process could take tens of minutes. Moving around may delay this, unable to prevent this while asleep. Up to a threshold point that pressure is getting released and at the same time one leg shocks as if lightning shoots through it. Depolarization? Polarization builds up due to demyelination? (inflammation?). Or sympathetic outlfow issues in spine? Still have pressure in lower spine upon triggers but it doesn't keep building up, it doesn't reach the former mentioned threshold level.
Are you satisfied from doing desensitization to yourself?Yes, a doctor did the procedure.
Is there any problem for you?No adverse effects from what I know.
Is your pois relapsed at all?No. But note that it didn't cure the pois.
What specialist does this kind of "treatment"Allergologist
Are you sure pois is an allergic disease?No
Can you possibly give me a schedule of injections (dosage,...)I have not written it down. I have asked the doc if he could provide me with his latest scheme but I never got an answer back. There is some information in #5 and #22: https://poiscenter.com/forums/index.php?topic=3551.0
Where of my body should I inject my semen?! No one willing do this to me and i cant live with this conditionForearm. You need a special needle which is thin and flexible (can't remember the name). It's important you don't hit an artery. You inject it just under the skin and the angle of injection is almost parallel to the surface of the skin. The problem is that you need to start at a high level of dilution with saline (1:40.000). If low dilution is used then you can fall into shock, an epipen might be necessary.
how much improvement you got from desensitization?!5 year long desensitization treatment 2010-2015 (permanent improvement, the amount varies with type of symptom. Fatigue is by far the most improved symptom, perhaps 80% reduction. For other symptoms it's harder to estimate how much they have been reduced, for most of them I think maybe around 50% but this is a very rough estimate). My POIS was quite extreme.
I feel it's a supplement for the long term.
Still got problems in area lower back at spine, 24/7. Urge to urinate, even when bladder is empty.
Still got problems in area lower back at spine, 24/7. Urge to urinate, even when bladder is empty.
I just realized I have this too! I never thought of mentioning it in relation to POIS, but it appeared in the last 2-3 years. Sometimes when I go to bed (probably because of the change in position) I have to get up to urinate 4-5 times even though when I get to the bathroom I realize my bladder is empty or almost empty.
Starting today with a calcium channel antagonist; Diltiaz HCL AUR 120MG T RET, 1 per day.
My older brother (not the POIS one, age: 41) starts to develop memory problems and fatigue.Do you think that there is any common genomic link with you and your other brother having POIS, and that in his case, it would be a late-onset, and not related directly to sexual activity?
My older brother (not the POIS one, age: 41) starts to develop memory problems and fatigue.Do you think that there is any common genomic link with you and your other brother having POIS, and that in his case, it would be a late-onset, and not related directly to sexual activity?
Low grade chronic stress affects center of head. Body gets stiffer. Harder to move.
My mother uses it but has no effect on her while neuroprotek did.After 60 days on 500mg QuePhyto a day she noticed a difference. Reduced pain in leg and reduced anxiety.
Have they ever tried resveratrol or astaxanthin?No. What dose of those? ERA/ERB ratio of activity? There is a case who mentions menopause in the women thread plus one with high estrogen level. I feel health benefits out of POIS from fresh Pomegranate fruit. I get tired first after ingestion (i think it’s a mucosal reaction), which disappears quickly then once it’s in my system i feel slightly better. Minor effect though.
hello Muon, have you ever tested your intestinal bacteria or SIBO?No, No.
Why not, various paper and people have shown that it is almost impossible that POIS is caused by endocrine problems, maybe the intestinal problems is the root reason.hello Muon, have you ever tested your intestinal bacteria or SIBO?No, No.
…various paper and people have shown that
it is almost impossible that POIS is caused by endocrine problems…
emphasis above (bold) is mine -Demo
…various paper and people have shown that
it is almost impossible that POIS is caused by endocrine problems…
emphasis above (bold) is mine -Demo
Out of all the many medical specialists I consulted since the 1970’s, endocrinologists are the only medical professionals who have significantly helped my POIS. For the last 11 years. And I am not the only one here.
…various paper and people have shown that
it is almost impossible that POIS is caused by endocrine problems…
emphasis above (bold) is mine -Demo
Out of all the many medical specialists I consulted since the 1970’s, endocrinologists are the only medical professionals who have significantly helped my POIS. For the last 11 years. And I am not the only one here.
almost all of the blood test of POISer have no any problems----vitamin mineral or hormone
…various paper and people have shown that
it is almost impossible that POIS is caused by endocrine problems…
emphasis above (bold) is mine -Demo
Out of all the many medical specialists I consulted since the 1970’s, endocrinologists are the only medical professionals who have significantly helped my POIS. For the last 11 years. And I am not the only one here.
Maybe we havn't done the correct tests yet.Agreed.
Well for me I've found that excess brain glutamate is the thing that causes this neurological pressure feeling in the head. If you have issues with eye contact, autistic symptoms, ocd, then high glutamate low gaba is usually the cause of that.
Insufficient dopamine or norepinephrine could also cause the the head problems you're experiencing:
"Dopamine circulates systemically and has many functions beyond activating post-synaptic neurons. A systemic dopamine deficiency, or insufficient D1 receptor agonism can easily create inflammation via increased NLRP-3.
NLRP-3 can cause anxiety, hypertension in a sodium-rich environment and catabolism of norepinephrine. Insufficient dopamine and/or norepinephrine can impair blood flow in key tissues, cause neurological disorders and is well-known for causing debilitating movement disorders / muscle paralysis, including gastrointestinal tissues."
If excessive dopamine metabolism is combined with a DBH deficiency, the subjective experience could resemble the horrible "disulfiram effect" - custodially imposed on some cocaine users - any increase of dopamine and/or alcohol metabolism does not cause pleasure, instead causing anxiety, nausea, potential seizures and/or severe sensory-motor polyneuropathy." - This is what I used to experience; one drink of alcohol would give bad anxiety, bad speech problems, brain fog, really severe pain in head (not typical headache) like I'm about to have a seizure. Tyrosine caused bad brain fog speech problems, and would wake up feeling really rough the next day. Cocaine no pleasure just really bad anxiety and feeling bad, Coffee no pleasure or good feeling just dilated pupils limited speech and vitamin C would also be the same as coffee. Vitamin D also brain fog and anxiety
An imbalanced GABA:glutamate ratio can lead to excessive dopamine metabolism, excitotoxicity and oxidative stress. This can sometimes be caused by insufficient NMDA inhibition (further relating to magnesium and/or zinc deficiency).
The sensation of my heart beating too strongly evolved into a full tachycardia at random times during the day and night, and my usual extrasystoles, that I've had since I was a kid, got worse, more scary and more frequent. I visited a cardiologist, but he couldn't find anything that was wrong with my heart. I felt dizzy and unsteady, with a strange sensation of pressure in the middle of my brain, but it never affected my mental abilities
I also experience the "ballon" feeling inside the head (in POIS) witch feels like there is a very unpleasant pressure behind the nose, deep in the brain. I also believe it might originate from the pitutary/hypothalamus. I've made a poll about signs of decrease pitutary/hypothalamus function. My hypothesis is that a inflamed pitutary/hypothalamus is causing many of the POIS symptoms.
Something is going on near the brainstem (pons/medulla?)The nucleus of the Cranial nerve VII (bell's palsy) is located at the lower part of the pons. https://en.wikipedia.org/wiki/Facial_motor_nucleus
I can't remember now if I asked you this question before, but do you experience a sort of vibration when you tense a muscle? For example, if you extend your arm in front of you, palm down, and press your fingers against your palm, do your fingers and wrist vibrate, as in, being unable to keep a steady contraction? The same thing that usually happens to anyone after absolute exertion to the limit, but all the time and with just light/moderate contraction of the muscles? And if so, did this symptom appear at the same time than your exercise intolerance?
Btw when my brother left psychiatric hospital (including complete isolation) my mom asked him what he felt during his stay. He told her that his brain felt drained.
Interleukin-8 produced by T cells is under the control of dopamine signaling (https://sci-hub.se/https://onlinelibrary.wiley.com/doi/abs/10.1111/cen3.12472) (IL-8 chronically elevated in me and brother).
"Human PBMC react to exposure to Candida albicans Ag through Th1/17 responses. Therefore, IL-8 production might be high under such conditions".
"Neutrophilic inflammation in chronic inflammatory diseases, such as asthma, rheumatoid arthritis, ulcerative colitis and multiple sclerosis, might be suppressed by dopamine D2-like receptor agonists"
My unpleaseant body odour, dating from my teen years but particularly strong after sexual arousalSame here
Yes I had a list with these things but I lost it. Doctor's don't cooperate with IL-8 suppression. I'm aware of ~75% what you have written. I would measure that cytokine in seminal plasma for other POISers. MMP is also on my mind for connective tissue damage and decreased vascular integrity. Nanna suspects I might have an additional increase in GM-CSF. That combination (IL-8+GM-CSF) is being expressed by a type IVd hypersensitivity, T-cell mediated neutrophil inflammation. I get the impression that low grade mucosal inflammation is present, IL-8 might be involved.
Coffee seems to give very minor relieve.
Curcumin+piperine gives more relieve but still minor.
Resveratrol: no effect. Haven't tried high dose.
EPA/DHA: can't say these fishoil capsules do anything. Bottled fishoil however doesn't give me any negative reaction and It's perhaps the best thing that my body is able to digest. It might suppress local stomach inflammation who knows.
I was also unable to read, because reading triggerd very bad symptomes. I stoped having sex for two years, and my Pois is now so better I have only slight pain after orgasem lasting one day. But I never stoped reading, because I have to read in my job and everywhere else. So this trigger "the reading" is still very painfull and making me big truble. I can loose strenght in arms and legs if I read to much, I can get pain so strong in my groin that I can't do anything. Orgasem is not a big problem for me anymore, its reading! And I can't se the conection between semen and reading... I had checked my semen and everything is OK.
I have no clue how to deal with brief moments of sexual arousal. Middle of head lights up which is then followed by systemic symptoms.
The words of this man is cutted in my brain while i was
reasarching orusall pois:
Anyways, a chronic viral infection means that any dopaminergic upregulation will be met with viral insult. It basically conditions the arousal system towards a hypoactive state by sheer immune punishment.
https://forums.phoenixrising.me/threads/why-you-should-be-scared-of-enteroviruses-full-list-of-all-diseases-associated-with-ev.87840/
Brainstem Abnormalities in ME/CFS: A Scoping Review and Evaluation of Magnetic Resonance Imaging Findings (https://forums.phoenixrising.me/threads/brainstem-abnormalities-in-me-cfs-a-scoping-review-and-evaluation-of-magnetic-resonance-imaging-findings-nelson-et-al-2021.86604/)
(https://www.frontiersin.org/files/Articles/769511/fneur-12-769511-HTML-r1/image_m/fneur-12-769511-g003.jpg)POIS/CFS/POTS could be brainstem pathologies as in overlap of affected areas within the brainstem.https://poiscenter.com/forums/index.php?topic=2683.msg23766#msg23766(https://i.imgur.com/z2XLiYy.gif)
I have a problem with large meals it can disrupt the respiratory rate, as in breathing becomes unregular. Happens when food is digested in stomach or at times of bowel movements. I get a sensation at the center of my head at these moments. This can be accompanied by altered general tension and weakness.
These symptoms also show up during sexual arousal/orgasm. The same area within my head gets excited/stimulated during sexual arousal/orgasm.
Heat trigger can do the same. I think the body tries to adjust to heat and create other problems in the body (is there sufficient "power").
I also had some kind of "cramp" in my gut during orgasm in the past, not anymore though. Waldinger said that it was impossible.
I also had some kind of "cramp" in my gut during orgasm in the past, not anymore though. Waldinger said that it was impossible.
gut cramps when I climax,
My boyfriend poiser, has problems with breathing. With or with out pois. He says "he feels bloked breathing" Maybe there is a conexion But I do not know if it is a consecuence of pois or something else
Chapter 2.7: "Although the prevailing view is that FM and related COPCs are not autoimmune disorders, and that classic anti-inflammatory agents are not of benefit in these conditions, there are some data suggesting that the immune system may be playing a role in their pathogenesis. Perhaps the most consistent finding noted to date is a mild elevation in IL-8, which is a cytokine associated with sympathetic function"
Some people who are susceptible to POIS may very well have "sensitive brains" as you said in your previous post, and something other than semen/orgasm may well trigger POIS-like symptoms for them. In my case, I probably have some kind of norepinephrine dysfunction (since milnacipran works for me).
Another scenario:
Glans penis (limp state and is not sexual related) becomes sensitive while walking or riding a bike that I have to stop walking for a few mins or stop riding the bicycle (I stop because the sensitivity increases with duration of movement up to the point that it hurts). The little friction it makes with my clothing seems to get amplified after repetitive motion. It gets better once I pause. (very mild tingling involved)
(delayed) weakness has become the dominant POIS symptom for me. Not because it worsened but because it didn't improve as much as other symptoms did.
Pale
"To recognize CS, question the patient for hypersensitivity to touch, bright light, sound, smell, hot or cold sensations, mechanical loading of musculoskeletal tissues, and all kinds of physical, mental and emotional stressors."
Ate a new product, coconut yoghurt (high fat), which induced exploding Diarrhoea. Food sensitivities are mild in general at this moment and suddenly getting an extreme reaction from a certain product. Didn’t feel sick before or after eating it.
Sometimes going from 0-100 can cause these kind of problems. You could try a more gradual introduction to see where your limit is.Indeed
Have you investigated your stomach acidity?No, I had moments, especially in 2013 when POTS peaked, that food felt like a brick sitting in stomach doing nothing. I expect it to be on the lower side.
Niacin flush gives symptoms
Have you considered a lower dose (e.g. 30mg)? In my case niacin was useful without any apparent flushing.I will take a look at slow release niacin in the future (if that even exist).
https://www.thenakedscientists.com/forum/index.php?topic=14697.msg478002#msg478002
Giggly:
"I truly thought I was the only woman alive experiencing this. For me, this all started AFTER menopause (I'm 53) and no longer had to take birth control pills (I was on those for 20+ years). I thought maybe those two things combined were causing this. After intercourse, I would feel nauseous, dizzy, stuffy nose, sneezing. This lasts for 4-6 hours. I thought I was going crazy. I read somewhere that taking Benadryl 30 minutes before intimacy would help, and it does, but just a bit. Sure would like to find out more info. on this subject for women."
https://en.wikipedia.org/wiki/Combined_oral_contraceptive_pill#Formulations
https://en.wikipedia.org/wiki/Birth_control_pill_formulations
Loperamide, Imodium helped him with POIS (selective peripheral mu-opioid agonist)
https://www.reddit.com/r/POIS/comments/1ah6c15/loperamide_helped_me/
"It's probably been a month since I tried it from pois. This was enough for me to observe that there was a positive effect. An important question regarding the dosage is approximately 2 tablets of 2 mg at a time before lunch and two in the evening. And this is enough for me to feel like a healthy person. I'm still in the process of learning, but I already wanted to share this information. If you take it before orgasm, then the symptoms of pois do not occur, if after orgasm, as soon as you start to feel bad, I drink it and after about 30 minutes everything is fine."
Summary:
The only thing worth mentioning regarding POIS is Excedrin.
I get the impression that the nervous system is hypersensitive,
…Libido is killed in this state and has a difficulty to build up (which I don't mind)…
…I wonder if this state can be reversed rapidly by an
adrenaline injection.
CAUTION!
“…common [adrenaline shot] side effects include tachycardia, hypertension, headache, anxiety, apprehension, palpitations, diaphoresis, nausea, vomiting, weakness, and tremors.” May 1, 2023
https://tinyurl.com/4pkssw8v
I was never able to get my hands on SAM-e to test the stack of Nanna1 properly, only half baked. I managed to get SAM, it turns out the stuff is blacklisted for my country, getting a warning when ordering over seas. Got all of his stuff anyway but it will have to wait until I have tested Methylene Blue thoroughly. I wonder why this is blacklisted.
I found an old strip with tablets of 500 mg Asperin. Used 1 post ejaculation. It behaves the same as Exedrin meaning acetylsalicylic acid (ASA) is the active component. I suspect I need to take this pre + post ejaculation with multiple tablets spread over the day during post ejaculatory period to better inhibit POIS inertia compared to a single tablet post orgasm. 1 tablet brings significantly relieve (physical plus cognitive) and it is reliable (experience from exedrin). Downside: it causes stomach irritation (probably the reason I stopped using it after 1 tablet, stomach was more sensitive in the past). My grandma used Enterosalicyl (https://www.pharmacompass.com/chemistry-chemical-name/enterosalicyl[/url) which has a similar structure, probably some genetic component involved.
It is useless for prophylactic use against sexual arousal though considering the side effect.
…Another interesting experiment could be the combination of Aspirin and Tadalafil [Cialis]…
(I take a nightly dose of 81mg aspirin per my cardiologist).
Have B vitamins or choline ever had an improvement on your POIS?
have you tried PEA?
Three weeks ago i had second mri and xray of my hip, knee and shoulde joints. According to my doc, I lost significant amount of cartilage in these joints. Every time i orgasm or get aroused, i get burning feeling in my joints along with all other symptoms.
Pois is damaging my joints and i have no choice but to see my body rotting away with time. All the time my joints make clicking sounds and pain is unbearable in hip joint# especially.
And then there are events where you feel systemically drained after orgasm including brain (I think the cause is located in the middle of my head) even if inflammation is mild or barely present. Body is very heavy, constant urge to sit or lay down, loss of power. Libido is killed in this state and has a difficulty to build up (which I don't mind). Standing upright postpones the build up of any libido. Now...I wonder if this state can be reversed rapidly by an adrenaline injection.
Something is going on near the brainstem (pons/medulla?)The nucleus of the Cranial nerve VII (bell's palsy) is located at the lower part of the pons. https://en.wikipedia.org/wiki/Facial_motor_nucleus
https://en.wikipedia.org/wiki/Vasomotor_center
…Another interesting experiment could be the combination of Aspirin and Tadalafil [Cialis]…
Interesting, Progecitor!
Can you say more? (I take a nightly dose of 81mg aspirin per my cardiologist).
Is it really working ?
Asprin and tadalafil
I remembered , about a week ago, I had tadalafil 5mg and paracetamol before sex and I didn't get any pois symptoms for 2 days but on 3rd day morning I've experienced heavy pois symptoms
…Another interesting experiment could be the combination of Aspirin and Tadalafil [Cialis]…
Interesting, Progecitor!
Can you say more? (I take a nightly dose of 81mg aspirin per my cardiologist).
Of course I can't claim this combination to be necessarily useful, only that there are some empirical indications that it may be. It is even more difficult to say why it works exactly…
Is it really working ?
Asprin and tadalafil
I remembered , about a week ago, I had tadalafil 5mg and paracetamol before sex and I didn't get any pois symptoms for 2 days but on 3rd day morning I've experienced heavy pois symptoms
…You also need to take into consideration possible side-effects, especially as aspirin and paracetamol could be detrimental for sperm
quality.
Recent testing by ConsumerLab.com of over-the-counter brands of SAMe in the United States found, on average, that for 6 of the 13 brands tested, less than half the amount of SAMe stated on the label was actually present.
SAM-e AND ITS THERAPEUTIC PRINCIPLES (https://jddtonline.info/index.php/jddt/article/download/358/225)
It is from 2013 though.QuoteRecent testing by ConsumerLab.com of over-the-counter brands of SAMe in the United States found, on average, that for 6 of the 13 brands tested, less than half the amount of SAMe stated on the label was actually present.
Does anyone have a membership on this website?:
https://www.consumerlab.com/reviews/sam-e-review-comparisons/same/
https://www.reddit.com/user/esauseasaw/
"The muscle loss, flu-like symptoms, being skinny, and diarrhea all sound like POIS. When I first got POIS, one of the things I was most worried about was my "metabolism being too fast". I was constantly hungry and never gained any weight. It was like food just went right through me without my body absorbing any nutrients. This was in addition to spasms in my face, brain fog, and speech impairment. You may not have these latter symptoms, but I don't anymore either. But that's only because I've learned to manage my POIS to a certain extent."
Lower back support while sitting is important to reduce stress and cope with weakness. I have not found a proper chair yet that perfectly supports my lower back. I also underestimated the importance of this in the past. If I have to sit somewhere then I will use an ergonomic pillow which I carry with me.
I once forgot to flush the toilet after urinating before sleep. Next toilet visit in the morning showed me a layer on the water. You could see the optical refraction (colors like when there is an oil spil on water). Repeated this plenty of times with same results. Water surface physics was altered as well when dripping water on it meaning it was clearly a layer. Quite a consistent effect. Could be normal I don't know.
I have read a story about a woman who has craniocervical instability. She experienced problems with the diaphragm during breathing, causing her breathing to pause. I have the same breathing issue since teenage years.
My upper leg weakness correlates with focal pressure in my lower part of my spine. It is the front and inside of my upper legs. POIS increases the pressure and weakness.
Hi Muon,
Have you tried high dose D3, like getting serum to at least 70ng/mL? And have you tried direct glutathione supplementation or NAC?
Hi Muon,
Have you tried high dose D3, like getting serum to at least 70ng/mL? And have you tried direct glutathione supplementation or NAC?
No I take at least 2000 IU per day. Have tried liposomal NAC 1200 mg plus 500 mg liposomal Glutathione per day for less than 2 weeks. I feel it interferes slightly with middle of brain but does not translate to relieve of other symptoms, I have not tried a long term trial. High dose D3 could be an option.
https://poiscenter.com/forums/index.php?topic=2755.msg49170#msg49170
This helped me 11 years ago with POTS. I needed to induce a pump. Big muscles groups like quadriceps are most effective. Effect starts immediately after session and takes an hour to buildup to almost fully resist gravity again for about half a day. I was prone to injuries because the body didn't recover fast enough. I needed these exercises everyday during a summer, the heat increased POTS symptoms and had to counter it by strength training (with an inflamed and not fully functioning body). At the end of summer I had injuries but survived the summer. Most exercises were done in a horizontal position.
Mucuna Pruriens 1500mg: Feeling hot for a short-timed burst, after this it affected systemic tone to a more natural state (It decreased tense feeling at location of brainstem as well). The latter effect does not hold up that long (maybe less than an hour?). Need to use it more often to check for consistency.
I found documents about details of the event which took place two days after birth. Reason for hospital admission: Cyanosis (https://en.wikipedia.org/wiki/Cyanosis) and Apnea (https://en.wikipedia.org/wiki/Apnea) during breastfeeding. They also found a heart murmur (https://en.wikipedia.org/wiki/Heart_murmur) which could not be detected during a second measurement. Cardiology found no deviations. "Probably caused by too much food".
I first managed it with Dextroamphetamine which is used for ADHD but now not even that helps and i will feel like crap for up to 10 days after sex or stressful days and exercise. I also have severe heat sensitivity after sex and feel like crap for a long time after with very little motivation.
Im a female so my progesterone naturally fluctates, but i notice during the 2 weeks that my progesterone rises i feel almost constant POIS with flu-like symptoms and fatigue. When my period starts and the 2 weeks before ovulation i feel pretty much normal with no flu symptoms and energy is pretty good most of the time.
It behaves as a mast cell inhibitor. Using the copy function of perplexity AI:
https://www.perplexity.ai/search/how-does-cordyceps-interacts-w-VBEeYReZRgm0UK7thnu2vA
- A parasympathetic reflex sensitive to atropine
Dumping these papers for my own case.
CRTH2 was on my radar but never linked it to POTS. Skin pricks might cause abnormal capillary leaks if cells are hypersensitive to prostaglandins (red skin).
Increased CRTH2 Expression in Postural Orthostatic Tachycardia Syndrome (2024)
https://www.medrxiv.org/content/10.1101/2024.11.18.24317517v1
The therapeutic potential of CRTH2/DP2 beyond allergy and asthma (2021)
https://pmc.ncbi.nlm.nih.gov/articles/PMC7612073/
Sex Hormones and Allergies: Exploring the Gender Differences in Immune Responses (2024) https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2024.1483919/abstract
Trying to eat 1 fresh pomegranate every day but they are not always available. Deep red colored acid ones are the best, can react with mucosal (throat) but is beneficial once absorbed into the system. Diet consists mostly of meat, fruit and occasionally vegetables and dairy.
Family members on my mother's side show similar symptoms as I do. All the females who got health problems felt better during their pregnancies and felt worse during their menstrual cycle. My grandma actually looked forward to her pregnancy. My mother has 3 children, my aunt got one and my grandma has 4. They all felt physically better for every single pregnancy.