Muon's Case

[Muon]

Sodium Naproxen lowest available over the counter dose gave me significant side effects right away in particular stomach problems (pain). It did something to the throat as well, can't describe with words what it did. Awful stuff.

[Muon]

There is clearly communication between the middle of my head and the heart and gut (gut is more stable at the moment compared to brain/heart communication). That spot is too susceptible to things like stress and sexual arousal. I wonder if the vagus nerve is involved and if so, is it just a mediator of signaling and the cause somewhere else or is the nerve itself dysfunctional.

There is also interaction between fluid from sexual organs and tissue in urinary tract. I can feel things like burning so there must be some kind of signaling involved in that area as well.

Brain/neural network/immune axis?

[Muon]

I get the impression that the nervous system is hypersensitive, weak and easily overloaded. Eating a meal right after a shower isn't a good idea. The body took a hit during shower and digestion burdens a similar system. Though, there is some slightly increased (nervous system?) resistance against certain triggers like sexual arousal since the last couple of months.

[less_fogged]

I get the impression that the nervous system is hypersensitive,

The other day I visited one of my doctors and I used the same wording...nervous system is hypersensitive
Adding to that within my long explanation I was first saying that I feel like I have a dysregulated nervous system and then mentioning, hypersensitive nervous system and/or overactive nervous system, which leads to all my day and night time symptoms.....

[Muon]

I have more days where I need less sleep. I was sleeping at my parents house for a week and they noticed it as well. Could be a good sign or bad. At peak dysautonomia symptoms in the past I experienced a summer where I woke up at 5 AM every day while my body needed more sleep, it was wrecking me.

[Muon]

I'm stuck with some kind of fibromyalgia syndrome outside POIS.
First part of the problem I suspect is a brainstem dysfunction which is affected by stress and sexual arousal/orgasm.
Sensory and autonomic networks are probably involved.

2nd part I suspect is immune related like MCAD.

[Muon]

And then there are events where you feel systemically drained after orgasm including brain (I think the cause is located in the middle of my head) even if inflammation is mild or barely present. Body is very heavy, constant urge to sit or lay down, loss of power. Libido is killed in this state and has a difficulty to build up (which I don't mind). Standing upright postpones the build up of any libido. Now...I wonder if this state can be reversed rapidly by an adrenaline injection.

[demografx]

…Libido is killed in this state and has a difficulty to build up (which I don't mind)…

Just the opposite in my case. I do mind, as I believe libido is tied to my refractory period. A sluggish build up means sluggish semen re-generation which in turn increases POIS, in my opinion.

[demografx]

…I wonder if this state can be reversed rapidly by an
adrenaline injection.

CAUTION!

 “…common [adrenaline shot] side effects include tachycardia, hypertension, headache, anxiety, apprehension, palpitations, diaphoresis, nausea, vomiting, weakness, and tremors.” May 1, 2023

https://tinyurl.com/4pkssw8v

[Muon]

I was never able to get my hands on SAM-e to test the stack of Nanna1 properly, only half baked. I managed to get SAM, it turns out the stuff is blacklisted for my country, getting a warning when ordering over seas. Got all of his stuff anyway but it will have to wait until I have tested Methylene Blue thoroughly. I wonder why this is blacklisted.

[Muon]

I found an old strip with tablets of 500 mg Asperin. Used 1 post ejaculation. It behaves the same as Exedrin meaning acetylsalicylic acid (ASA) is the active component. I suspect I need to take this pre + post ejaculation with multiple tablets spread over the day during post ejaculatory period to better inhibit POIS inertia compared to a single tablet post orgasm. 1 tablet brings significantly relieve (physical plus cognitive) and it is reliable (experience from exedrin). Downside: it causes stomach irritation (probably the reason I stopped using it after 1 tablet, stomach was more sensitive in the past). My grandma used Enterosalicyl which has a similar structure, probably some genetic component involved.

It is useless for prophylactic use against sexual arousal though considering the side effect.

[Warrior]

I was never able to get my hands on SAM-e to test the stack of Nanna1 properly, only half baked. I managed to get SAM, it turns out the stuff is blacklisted for my country, getting a warning when ordering over seas. Got all of his stuff anyway but it will have to wait until I have tested Methylene Blue thoroughly. I wonder why this is blacklisted.

There are some concerns with SAM-e, you can search those up, maybe thats why it's blacklisted, idk. Have B vitamins or choline ever had an improvement on your POIS?

[Progecitor]

I found an old strip with tablets of 500 mg Asperin. Used 1 post ejaculation. It behaves the same as Exedrin meaning acetylsalicylic acid (ASA) is the active component. I suspect I need to take this pre + post ejaculation with multiple tablets spread over the day during post ejaculatory period to better inhibit POIS inertia compared to a single tablet post orgasm. 1 tablet brings significantly relieve (physical plus cognitive) and it is reliable (experience from exedrin). Downside: it causes stomach irritation (probably the reason I stopped using it after 1 tablet, stomach was more sensitive in the past). My grandma used Enterosalicyl which has a similar structure, probably some genetic component involved.

It is useless for prophylactic use against sexual arousal though considering the side effect.

Aspirin can really help even in my case, though it loses its effectiveness rather rapidly. At least it provides a partial benefit in an amount of 200 mg daily. 500 mg seems the be a rather high dose, though I see that in case of Rheumatoid Arthritis or Systemic Lupus Erythematosus even 3000 mg is accepted as an initial dosage.
https://www.drugs.com/dosage/aspirin.html
In the past I also found willow bark tea to provide some benefit. Of course the latter my induce more side-effects long term. As an alternative you could try buying the gastric acid resistant protected form if it is available in your country. It is interesting to note that aspirin may be also available in suppository form. I wonder if it could be actually more useful for us considering the focal point of the inflammation. Unfortunately such a form is unavailable in my county, thus I cannot test it.
Another interesting experiment could be the combination of Aspirin and Tadalafil. Some people on the reddit prostatitis site found this combination to be very useful.
https://www.reddit.com/r/Prostatitis/comments/qm2bk6/found_the_golden_combination/
As POIS appears to be at least partly at the intersection of CP/CPPS and ME/CFS, we could potentially benefit from their treatment strategies. 

[demografx]

…Another interesting experiment could be the combination of Aspirin and Tadalafil [Cialis]…

Interesting, Progecitor!

Can you say more? (I take a nightly dose of 81mg aspirin per my cardiologist).

[Muon]

Note/caution: At 500 mg I can feel my liver. No pain, but I can feel it.

(I take a nightly dose of 81mg aspirin per my cardiologist).

I was looking at the side effects and it turned out this dose (81mg) is actually beneficial to the liver.

Have B vitamins or choline ever had an improvement on your POIS?

I didn't feel well on unmethylated vit B complex in the past. IDK about choline.

[ThuNd3rZ]

have you tried PEA?

https://www.dropbox.com/sh/r0ggay2szphqfgq/AAATpXbA-Q50N9LPiQG1wkGta?dl=0&preview=PEA+(palmitoylethanolamide).pdf

https://youtu.be/G9ATjbb3cdQ?feature=shared&t=3565

[Muon]

have you tried PEA?

No, it is on my list of things to try.

[ThuNd3rZ]

I'm giving it a shot right now, My symptoms are similar to yours.  I'll let you know if it helps, I think on the reddit CFS/Fibro some people report big improvements, while others report nothing.   my symptoms are kind of similiar to you, where I was diagnosed with CFS/ME due to the primary neuro symptoms (weakness/tingling/myoclonus) but i came to realize later  after abstaining for a while I was deep in to a continual POIS flare up and when I abstain it improves significantly, but it can take a while like 4 weeks to recover.  If i had to guess brain stem has some degenerative changes that makes it super vulnerable and then when you pour neuroinflammation on top of it you can get some nasty symptoms. It might be that we are more susceptable and  or lived a life of chronic stress that lead to the brain degeneration.  Unless you can really do a full lifestyle to limit stress to the max, SSRI like Lexapro might be only choice to force the relaxation and help promote neurogenesis to repair some of the damage enough to become more resilient but  with long term SSRI side effects it is a tough call need a very calculated plan to transition on and off them to not get caught taking them too long and becoming worse off.

[Muon]

Started introducing dairy a while ago (I'm still gluten free). When I do get symptoms I'm getting a mild sore throat as if I'm developing flu but doesn't fully develop into a flu like state unlike POIS in the past, just from cheese alone interacting with surface of throat. And sometimes light/minor pain in joints of fingers. I'm not always getting symptoms though, also depends on the amount. A2 products are better tolerable. The body is handling these poducts better than in the past. I think I will stick to kefir and maybe drop the cheese.

[Muon]

I once needed crutches for a period of two weeks because sexual arousal flares fiercly attacked my knee joints. I couldn't withstand pressure from my weight and turning corners was difficult.

https://www.reddit.com/r/POIS/comments/1bthzfv/osteoarthritis_due_to_pois/

Three weeks ago i had second mri and xray of my hip, knee and shoulde joints. According to my doc, I lost significant amount of cartilage in these joints. Every time i orgasm or get aroused, i get burning feeling in my joints along with all other symptoms.

Pois is damaging my joints and i have no choice but to see my body rotting away with time. All the time my joints make clicking sounds and pain is unbearable in hip joint# especially.