Muon's Case

[Muon]

https://en.wikipedia.org/wiki/Histamine_N-methyltransferase#Genetic_variants

"Although the relationship between histamine and IL-8 has not been fully studied as of 2020, it is known that histamine can increase the expression of IL-8 through H1 receptors in vitro and enhance the release of IL-8 in different cell types."

Histamine induces interleukin-8 secretion by endothelial cells

"These data suggest that histamine may be involved in the control of the late inflammatory reaction associated to allergic disorders through IL-8 secretion by EC."

Role of interleukin 8 in depression and other psychiatric disorders

IL-8 is produced early in the inflammatory response, possibly persisting for days or weeks, unlike most other inflammatory cytokines that are produced and cleared within a few hours (Remick, 2005). Thus, IL-8 might be specific for more chronic inflammatory changes in neurodegenerative and neuropsychological alterations in the brain.

[Muon]

This is something that helped my brother, best thing he tried:

https://nextvalley.nl/shop/noopept/

https://en.m.wikipedia.org/wiki/N-Phenylacetyl-L-prolylglycine_ethyl_ester

[Muon]

If exposure to high ambient temperatures lasts too long it will build up to state where it is on the brink of some sort of systemic breakdown. That's how I developed POTS 10 years ago. It was a combination of heat and stress that pushed it over the red line.

I do think POIS en POTS are symptoms of something else.

[Muon]

(delayed) weakness has become the dominant POIS symptom for me. Not because it worsened but because it didn't improve as much as other symptoms did.

[Warrior]

(delayed) weakness has become the dominant POIS symptom for me. Not because it worsened but because it didn't improve as much as other symptoms did.

I noticed red meat & eggs helped a lot with improving my weakness symptoms, addition to cutting plant inflammatory foods.

[Muon]

https://en.wikipedia.org/wiki/Eicosanoid

"Redness - An insect's sting will trigger the classic inflammatory response. Short acting vasoconstrictors - TXA2 - are released quickly after the injury. The site may momentarily turn pale. Then TXA2 mediates the release of the vasodilators PGE2 and LTB4. The blood vessels engorge and the injury reddens.

Swelling - LTB4 makes the blood vessels more permeable. Plasma leaks out into the connective tissues, and they swell. The process also loses pro-inflammatory cytokines."

Orgasm ---> increased blood vessel permeability/leaky vessels ----> temporary loss of (pro-inflammatory) cytokines

[berlin1984]

Pale

What about our Indian POIS friends?
Or Southern Chinese?
Or African ancestry?

BTW, I have

Gene: OCA2
Variant: c.1441G>A  (CT)
This variant is associated with lower melanin production and may result in less pigmentation in skin or eyes. The variant is suggested to play a role in oculocutaneous albinism when combined with more severe variants, but these findings lack statistical significance.
 Freq: 0.7987% rare