Muon's Case

[Muon]

https://en.wikipedia.org/wiki/Histamine_N-methyltransferase#Genetic_variants

"Although the relationship between histamine and IL-8 has not been fully studied as of 2020, it is known that histamine can increase the expression of IL-8 through H1 receptors in vitro and enhance the release of IL-8 in different cell types."

Histamine induces interleukin-8 secretion by endothelial cells

"These data suggest that histamine may be involved in the control of the late inflammatory reaction associated to allergic disorders through IL-8 secretion by EC."

Role of interleukin 8 in depression and other psychiatric disorders

IL-8 is produced early in the inflammatory response, possibly persisting for days or weeks, unlike most other inflammatory cytokines that are produced and cleared within a few hours (Remick, 2005). Thus, IL-8 might be specific for more chronic inflammatory changes in neurodegenerative and neuropsychological alterations in the brain.

[Muon]

This is something that helped my brother, best thing he tried:

https://nextvalley.nl/shop/noopept/

https://en.m.wikipedia.org/wiki/N-Phenylacetyl-L-prolylglycine_ethyl_ester

[Muon]

If exposure to high ambient temperatures lasts too long it will build up to state where it is on the brink of some sort of systemic breakdown. That's how I developed POTS 10 years ago. It was a combination of heat and stress that pushed it over the red line.

I do think POIS en POTS are symptoms of something else.

[Muon]

(delayed) weakness has become the dominant POIS symptom for me. Not because it worsened but because it didn't improve as much as other symptoms did.

[Warrior]

(delayed) weakness has become the dominant POIS symptom for me. Not because it worsened but because it didn't improve as much as other symptoms did.

I noticed red meat & eggs helped a lot with improving my weakness symptoms, addition to cutting plant inflammatory foods.

[Muon]

https://en.wikipedia.org/wiki/Eicosanoid

"Redness - An insect's sting will trigger the classic inflammatory response. Short acting vasoconstrictors - TXA2 - are released quickly after the injury. The site may momentarily turn pale. Then TXA2 mediates the release of the vasodilators PGE2 and LTB4. The blood vessels engorge and the injury reddens.

Swelling - LTB4 makes the blood vessels more permeable. Plasma leaks out into the connective tissues, and they swell. The process also loses pro-inflammatory cytokines."

Orgasm ---> increased blood vessel permeability/leaky vessels ----> temporary loss of (pro-inflammatory) cytokines

[berlin1984]

Pale

What about our Indian POIS friends?
Or Southern Chinese?
Or African ancestry?

BTW, I have

Gene: OCA2
Variant: c.1441G>A  (CT)
This variant is associated with lower melanin production and may result in less pigmentation in skin or eyes. The variant is suggested to play a role in oculocutaneous albinism when combined with more severe variants, but these findings lack statistical significance.
 Freq: 0.7987% rare

[Muon]

Why have I never been questioned about Central Sensitization by a medical professional?

"To recognize CS, question the patient for hypersensitivity to touch, bright light, sound, smell, hot or cold sensations, mechanical loading of musculoskeletal tissues, and all kinds of physical, mental and emotional stressors."

[Muon]

Ate a new product, coconut yoghurt (high fat), which induced exploding Diarrhoea. Food sensitivities are mild in general at this moment and suddenly getting an extreme reaction from a certain product. Didn’t feel sick before or after eating it.

[Muon]

The middle of my head seem to be coupled to my heart (and cardiovascular system). If I feel changes in my head I feel something going on with the heart. Sexual triggers affect middle of my head and thus affects heart.

I once ate L-Dopa (Mucuna Pruriens) + L-Tyrosine. A few pills, dose was unkown. I felt it affected the middle of my head briefly and affected my cardiovascular system, felt much lighter systemically (better circulation?). I was never able to replicate this effect.

[Muon]

Ate a new product, coconut yoghurt (high fat), which induced exploding Diarrhoea. Food sensitivities are mild in general at this moment and suddenly getting an extreme reaction from a certain product. Didn’t feel sick before or after eating it.

Had watery diarrhea today. Ate some grass fed cow butter. It seems there is a limit to the amount of butter I can handle. Is there a fat absorption or lipid metabolism problem in the GI tract?

[Frank]

Sometimes going from 0-100 can cause these kind of problems. You could try a more gradual introduction to see where your limit is.

Have you investigated your stomach acidity?

The duodenum which comes after the stomach mixes together the food + acid + bile and this processes causes the food to be pulverised.

A lack of bile or acid can cause  undigested food to pass through causing an upset stomach.

[Muon]

Sometimes going from 0-100 can cause these kind of problems. You could try a more gradual introduction to see where your limit is.

Indeed

Have you investigated your stomach acidity?

No, I had moments, especially in 2013 when POTS peaked, that food felt like a brick sitting in stomach doing nothing. I expect it to be on the lower side.

The first symptom arose during breast feeding at age 2 days. Cardiac Pulse faded until it was gone. They gave me smaller portions and it didn't happen again.

My guess: I think that neural networks were overloaded. I have this problem to this day, portion size puts a load on my brain and on some systemic network. Digestion in stomach can affect my respiratory rate for example. It feels like the body has to work harder, as in, providing/directing power but at the cost of other functions. That's why the cardiac pulse probably went weaker when I were a baby.

My uncle, as a baby, had a reaction to porridge (gut). Had to be taken to the intensive care unit.

Then you have POIS. Orgasm can make me feel weak (nervous system?). Add that digestive effect on top of it when eating during POIS mode and it will be even more difficult to digest stuff. There is also a local contact reaction going on between food and stomach for some type of foods, but I think that is immune related.

Large meal size can also be more demanding (on my neural networks?) when relatively powerfull peristaltic movement of gut is necessary.