Muon's Case

[Muon]

Hi Muon,

Have you tried high dose D3, like getting serum to at least 70ng/mL? And have you tried direct glutathione supplementation or NAC?

No I take at least 2000 IU per day. Have tried liposomal NAC 1200 mg plus 500 mg liposomal Glutathione per day for less than 2 weeks. I feel it interferes slightly with middle of brain but does not translate to relieve of other symptoms, I have not tried a long term trial. High dose D3 could be an option.

https://poiscenter.com/forums/index.php?topic=2755.msg49170#msg49170

This helped me 11 years ago with POTS. I needed to induce a pump. Big muscles groups like quadriceps are most effective. Effect starts immediately after session and takes an hour to buildup to almost fully resist gravity again for about half a day. I was prone to injuries because the body didn't recover fast enough. I needed these exercises everyday during a summer, the heat increased POTS symptoms and had to counter it by strength training (with an inflamed and not fully functioning body). At the end of summer I had injuries but survived the summer. Most exercises were done in a horizontal position.

[Warrior]

Hi Muon,

Have you tried high dose D3, like getting serum to at least 70ng/mL? And have you tried direct glutathione supplementation or NAC?

No I take at least 2000 IU per day. Have tried liposomal NAC 1200 mg plus 500 mg liposomal Glutathione per day for less than 2 weeks. I feel it interferes slightly with middle of brain but does not translate to relieve of other symptoms, I have not tried a long term trial. High dose D3 could be an option.

https://poiscenter.com/forums/index.php?topic=2755.msg49170#msg49170

This helped me 11 years ago with POTS. I needed to induce a pump. Big muscles groups like quadriceps are most effective. Effect starts immediately after session and takes an hour to buildup to almost fully resist gravity again for about half a day. I was prone to injuries because the body didn't recover fast enough. I needed these exercises everyday during a summer, the heat increased POTS symptoms and had to counter it by strength training (with an inflamed and not fully functioning body). At the end of summer I had injuries but survived the summer. Most exercises were done in a horizontal position.

You might be interested in exploring high dose D3. This D3 wiki outlines different serum levels that work best for different conditions. The website basically summarises all of the D3 research and plots the different expert recommended serum levels to a graph. Really fascinating stuff. I think if you can control the main safety concerns (magnesium depletion as you mentioned on my thread & hypercalcemia with adequate K2), as well as medical oversight and regular pathology testing, I think it's hugely beneficial and something to look into. I think people largely overlook the importance of the actual serum levels when it comes to D3.

[Muon]

Aspirin and immune system (Hussain, 2012)

[Muon]

I have imported Benadryl. I just noticed that it contains the inactive ingredient D&C red #27 aluminum lake. Safe in small quantities according to the FDA. What about accumulation?

Had one on a day when I had an O. Thought it interfered with orgasm in the brain, was not sure. Wanting to test it further with proper timing and double dose (50mg). But then I noticed aluminum on the label. Not sure if I should continue with this.

[Muon]

I found documents about details of the event which took place two days after birth. Reason for hospital admission: Cyanosis and Apnea during breastfeeding. They also found a heart murmur which could not be detected during a second measurement. Cardiology found no deviations. "Probably caused by too much food".

Birth younger brother, reason for admission mother: postpartum fluxus in anamnesis.
Details upon departure of the maternity caregiver: Right eye (of younger brother) looks a bit inflamed. Treatment with sofamicine 3 times 1 drop per day.

[Muon]

https://www.hollandandbarrett.nl/shop/product/holland-barrett-macuna-pruriens-500mg-bevat-van-nature-25-l-dopa-60-capsules-6100003372

Just testing random stuff here and there out of POIS.
L-Tyrosine had no effect, took as much as 5 g.
Mucuna Pruriens 500 mg: no effect.
Mucuna Pruriens 1500mg: Feeling hot for a short-timed burst, after this it affected systemic tone to a more natural state (It decreased tense feeling at location of brainstem as well). The latter effect does not hold up that long (maybe less than an hour?). Need to use it more often to check for consistency.

[Muon]

Mucuna Pruriens 1500mg: Feeling hot for a short-timed burst, after this it affected systemic tone to a more natural state (It decreased tense feeling at location of brainstem as well). The latter effect does not hold up that long (maybe less than an hour?). Need to use it more often to check for consistency.

This effect at this dosage is not reproducable. No consistency.

I found documents about details of the event which took place two days after birth. Reason for hospital admission: Cyanosis and Apnea during breastfeeding. They also found a heart murmur which could not be detected during a second measurement. Cardiology found no deviations. "Probably caused by too much food".

https://en.wikipedia.org/wiki/Prostaglandin_E2
"In babies there may be decreased breathing and low blood pressure"

Central apnoea and endogenous prostaglandins in neonates
https://sci-hub.se/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1651-2227.2000.tb00766.x

"Although it is thought that the pathophysiology of central apnoeas is linked to immaturity of the respiratory system (2), the exact mechanisms leading to central apnoeas in neonates are as yet poorly understood. Central apnoea is defined as recurrent respiratory pauses of 10–20 sec duration, or shorter pauses associated with oxygen desaturation, cyanosis or hypotonia (2–4). Apnoea occurs in 23% of all premature infants (5). Up to 24% of normal full-term infants show apnoeas 10 sec in the first 4 mo of life (6)."

"Pharmacotherapy of central apnoea in neonates includes methylxanthines theophylline and caffeine (7) or doxapram. In contrast to these ventilationenhancing drugs, opioids such as fentanyl, prostaglandin E1 (PGE1) and prostaglandin E2 (PGE2) lead to central apnoeas."

"Inhibition of prostaglandin synthesis by indomethacin causes stimulation of respiratory activity "

https://en.wikipedia.org/wiki/Apnea_of_prematurity
"Apnea of prematurity can be readily identified from other forms of infant apnea such as obstructive apnea, hypoventilation syndromes, breathing regulation issues during feeding, and reflux associated apnea with an infant pneumogram or infant apnea/sleep study."

POTS
https://www.scivisionpub.com/pdfs/new-insight-into-the-understanding-of-the-pathophysiology-of-the-postural-orthostatic-tachycardia-syndrome-pots-and-a-description--3119.pdf
"At least one form of POTS can have a good response to dopaminergic drugs e.g., dextroamphetamine, which also corrected other associated conditions"

"The model suggests that progesterone blocks dopamine"

Female POISer:

I first managed it with Dextroamphetamine which is used for ADHD but now not even that helps and i will feel like crap for up to 10 days after sex or stressful days and exercise. I also have severe heat sensitivity after sex and feel like crap for a long time after with very little motivation.

Im a female so my progesterone naturally fluctates, but i notice during the 2 weeks that my progesterone rises i feel almost constant POIS with flu-like symptoms and fatigue. When my period starts and the 2 weeks before ovulation i feel pretty much normal with no flu symptoms and energy is pretty good most of the time.

I have posted about the relation between brain injury and elevated progesterone in the past. There is a report about omega3 treatment for POIS in the pois paper archive. Now I wonder if pois patients with high progesterone are Omega3 defficient.

TBI and sex: Crucial role of progesterone protecting the brain in an omega ? 3 deficient condition: https://www.sciencedirect.com/science/article/abs/pii/S0014488613003701

[Muon]

Did a blood test for 11 omega fatty acids, expecting results within 25 days. I have started taking arctic fish oil, which is send to me directly from the factory in Norway to minimalize oxidation time. I have been told it takes 4 months to replenish fatty acids within red blood cells. Will take a second PUFA test in the fifth month for comparison.

[Muon]

Personal interest in TSLP + IL-8. Cordyceps:

It behaves as a mast cell inhibitor. Using the copy function of perplexity AI:
https://www.perplexity.ai/search/how-does-cordyceps-interacts-w-VBEeYReZRgm0UK7thnu2vA

[Muon]

I could be wrong here but I get the impression that there is a master modulator that regulates multisystem hypersensitivities. Many hypersensitivity symptoms including POIS can decrease in (trigger)sensitivity at the same time and think is related to the brain (middle of head). Increased mechanical stress acts on mentioned area of brain and this seem to increase mucosal reactivity to food/acidity/friction. I also suspect potential suboptimal blood flow in brainstem at times, feeling something slowly oscillates in that area from time to time.

Current supplements (have to look at dosage later):
Core (I do always take this):
Vitamine D3 + K2
Zinc Glycinate
Sodium vitamine C

On top of this at the moment:
Pregnenolone
Magnesium Glycinate
Boron
Taurine
Kaempferol (still taking it since the first time mentioning in this thread)
Arctic Fish oil (6 month program)
Adding L-Lysine and Collagen powders to the Sodium vitC powder

Switched to organic meat, buying it directly from a farm.
I drink only spring water. 1,5 L bottles are loaded with coarse himalaya salt (I will never go back to tapwater again).
I don't eat grains or seed oils.
Cooking with coconut oil.
Trying to eat 1 fresh pomegranate every day but they are not always available. Deep red colored acid ones are the best, can react with mucosal (throat) but is beneficial once absorbed into the system. Diet consists mostly of meat, fruit and occasionally vegetables and dairy.

Where I fail (points of potential improvement):

Unable to manage mechanical stress (mostly posture related)
Unable to proper dedust environment.
Fail to exercise daily.
Decreasing screen time

[Muon]

This should counter Gustatory rhinitis, I wonder when applied systemically one can counter POIS. People that use first generation H1 blockers successfully against POIS could try atropine to rule out anticholinergic effects.

- A parasympathetic reflex sensitive to atropine

[Muon]

High Temperature: Uhthoffs phenomena
https://en.wikipedia.org/wiki/Uhthoff%27s_phenomenon

https://en.wikipedia.org/wiki/Multiple_sclerosis#Disease_course
Many women with MS who become pregnant experience lower symptoms

Multiple Sclerosis Initially Presenting as Facial Palsy
https://www.ingentaconnect.com/content/asma/asem/2004/00000075/00000011/art00014

[Muon]

I have read enough about Uhthoff's phenomenon to conclude that it is involved in my case excluding vision disturbances (Summer of 2013: heat triggered pain running from eyes into head without optical disturbances, probably inflamed optical nerve). I can imagine having a hard time maintaining posture under warm ambient conditions if it slows down nerve conduction.

It is reversible, and I'm sensitive to this trigger almost 100% of the time just like POIS attacks. Getting stiff muscles by heat is difficult for people to grasp since it is completely the reverse compared to healthy individuals. Saying that I might have MS is a step too far though.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5152601/

To clarify personal experience:

Heat triggers:
Hot Weather
Hot showers
Exercise
Radiators: Doing dishes, cooking, room heating radiator, Sun
Hot Baths (had an intolerance to it as a kid)
Infrared sauna (worst heat trigger, felt dangerous)
Hot foods/drinks (depends on the amount though)

Symptoms:
Stiffness
Systemic/whole body weakness
Exhaustion
Pain
Posture difficulties
Fasciculations
Decreased Concentration

Actually more:
Breathing dysregulation
Decreased digestion

Symptoms are resolved within 24 hours
Best time of the day: Morning and night.

The paper I posted mentions that Aspirin is used as a cooling treatment. Aspirin works for my POIS...

[Muon]

PDF Results of fatty acids in my red blood cell membranes are in the attachments. RBC measurement is more reliable than plasma. Fatty acids in WBC membranes respond non-linear to diet so this one is useless.

Interpretation of results: https://omegaratiotest.com/interpreting-the-results/

RBC and WBC fatty acid composition following consumption of an omega 3 supplement: Lessons for future clinical trials

Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: Implications for clinical utility

Effects of Omega-3 Fatty Acids on Immune Cells

[berlin1984]

Interesting to see those results, also with regards to the anti seed oil movement.

Personally: I'm avoiding seed oils for some time now already (I should check my posts, it is at least 3 years). At home I have only olive oil and coconut oil and Irish butter. If I eat outside or processed/packaged food it will have seed oils obviously.
(At least we're better in EU than in US because EU uses less soy oil and more rapeseed...)

IMHO avoiding omega6 is more important than trying to consume more omega3.

[Muon]

I was an eyewitness of a grand theft auto today. (stressful) Emotion triggered something in the middle of my head plus pressure in the lower part of the spine and upper leg weakness (rubbery legs). POIS isn't able to trigger this intensity of leg weakness anymore, it used to. Emotional trigger is at this moment way stronger than POIS when considering this specific symptom.

[Muon]

Dumping these papers for my own case.
CRTH2 was on my radar but never linked it to POTS. Skin pricks might cause abnormal capillary leaks if cells are hypersensitive to prostaglandins (red skin).

Increased CRTH2 Expression in Postural Orthostatic Tachycardia Syndrome (2024)
https://www.medrxiv.org/content/10.1101/2024.11.18.24317517v1

The therapeutic potential of CRTH2/DP2 beyond allergy and asthma (2021)
https://pmc.ncbi.nlm.nih.gov/articles/PMC7612073/

Sex Hormones and Allergies: Exploring the Gender Differences in Immune Responses (2024) https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2024.1483919/abstract

Finally, we describe hypersensitivity reactions to these hormones.

Interesting, however I do not have access to this paper.

[demografx]

Dumping these papers for my own case.
CRTH2 was on my radar but never linked it to POTS. Skin pricks might cause abnormal capillary leaks if cells are hypersensitive to prostaglandins (red skin).

Increased CRTH2 Expression in Postural Orthostatic Tachycardia Syndrome (2024)
https://www.medrxiv.org/content/10.1101/2024.11.18.24317517v1

The therapeutic potential of CRTH2/DP2 beyond allergy and asthma (2021)
https://pmc.ncbi.nlm.nih.gov/articles/PMC7612073/

Sex Hormones and Allergies: Exploring the Gender Differences in Immune Responses (2024) https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2024.1483919/abstract

Muon, it would help the average reader if you say what this - - and other similar posts - - means for their…..POIS.

[Muon]

Hormone hypersensitivity might be useful info for POIS researchers, I do not know what they have found because it is locked.