Author Topic: Muon's Case  (Read 24596 times)

Muon

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Re: Muon's Case
« Reply #135 on: March 09, 2021, 12:43:34 PM »
Observed this several times, time to take a note:
Eating late, at the end of the day >9 pm, increases the chance to encounter the following scenario:

Abruptly waking up at night due to a bowel movement. Food traveling through gut could be felt. Accompanied by activity at an area close to or at the brainstem. Feeling hot. Irregular respiratory rate. Impaired blood circulation body/brain. Sections of limbs getting tense.

Positive scenario I encountered not related to the above:

Out of nowhere it felt like I was getting proper (blood?) supply to the brain. Felt activity in center of head. Accompanied by fatigue.

On a regular basis:
Impression that circulation body and brain are not in-phase.
When respiratory rate is irregular I get the impression that the ANS uncouples or slips slightly and subtle out of phase from the body.

Weird event:
Sweating on my upper left leg when washing my hands briefly with warm water. This happened a few times in the past when washing my hands but the sweating location was isolated on my upper back instead of leg.

Something similar might be going on:
ME/CFS at the Intersection of the Nervous & Immune Systems (Lecture) - Michael VanElzakker, PhD

Scenario at the top of this post is clearly gut/brain communication. Something could be wrong with a section of my gut. Nimodipine could be trialed to increase blood flow to the brain(stem) in case of potential vagus nerve dysfunction.

I did try to get an orgasm while the condition below was present:
"When respiratory rate is irregular I get the impression that the ANS uncouples or slips slightly and subtle out of phase from the body."
Orgasm and ejaculation were not timed properly as it should be, as in matched. There was some lag between the onset of both. I remember another event in the past where I experienced ANS related symptoms while getting an O and had anorgasmia (POIS symptoms were worse btw and onset was faster).

Extremely rare event: I had an O without POIS symptoms in the past when I experienced no other symptoms and was relaxed while getting an O.

Dumping this here:
Some parts of the body (mainly parts of limbs) cannot get supplied by sufficient blood supply for exercise, feels tense as well (i think it's blood supply but could be wrong though) while other parts are gettting more supply, there is asymmetry. 
« Last Edit: March 09, 2021, 01:30:36 PM by Muon »

Muon

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Re: Muon's Case
« Reply #136 on: March 11, 2021, 09:25:47 AM »
Abruptly waking up at night due to a bowel movement. Food traveling through gut could be felt. Accompanied by activity at an area close to or at the brainstem. Feeling hot. Irregular respiratory rate. Impaired blood circulation body/brain. Sections of limbs getting tense.

Could be a section of the gut with mucosal degradation or pro-inflammatory environment which is extra sensitive to friction (due to dysbiosis?). The vagus nerve is involved here, since symptoms are autonomic in nature. POIS could share similar mechanics, semen traveling through sections of the male genital tract that are innervated by vagal afferents, starting abnormal mucosal/brainstem communication mediated by the vagus nerve. Also the vagus nerve influences mucosal mast cells and might mimmick allergy. It may lead to altered inflammatory relfexes by the vagus nerve firing to other body parts which seems unrelated.

Muon

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Re: Muon's Case
« Reply #137 on: March 12, 2021, 09:41:41 AM »
Is postural orthostatic tachycardia syndrome (POTS) a central nervous system disorder? (2021)

Abstract

Postural orthostatic tachycardia syndrome (POTS), a disorder of the autonomic nervous system characterized by a rise in heart rate of at least 30 bpm from supine to standing position, has been traditionally viewed as a dysfunction of the peripheral nervous system. However, recent studies and evidence from overlapping conditions suggest that in addition to being considered a disorder of the peripheral nervous system, POTS should be viewed also as a central nervous system (CNS) disorder given

(1) significant CNS symptom burden in patients with POTS;
(2) structural and functional differences found on neuroimaging in patients with POTS and other forms of orthostatic intolerance;
(3) evidence of cerebral hypoperfusion and possible alteration in cerebrospinal fluid volume, and
(4) positive response to medications targeting the CNS and non-pharmacologic CNS therapies.

This review outlines existing evidence of POTS as a CNS disorder and proposes a hypothetical model combining key mechanisms in the pathophysiology of POTS. Redefining POTS as a CNS disorder can lead to new possibilities in pharmacotherapy and non-pharmacologic therapeutic interventions in patents affected by this disabling syndrome.

================================================================================

Neuroinflammation: https://poiscenter.com/forums/index.php?topic=2545.msg39297#msg39297

Reduced cerebral spinal fluid volume?:
Muon, way back when I started my Magical TRT Mystery Tour, I had an MRI of the brain ordered by my endocrinologist, resulting in a find of Empy Sella Syndrome. Not sure if/where to post...https://rarediseases.org/rare-diseases/empty-sella-syndrome/#general-discussion

Replace Fibromyalgia and CFS by POIS and put question marks behind those sentences:
"fibromyalgia is considered a neurosensory disorder with central sensitization as the main mechanism [13, 14], and chronic fatigue syndrome is being reframed as a central nervous system disorder of neuroinflammation and abnormal neurovascular coupling"

Some POISers can induce POIS symptoms by physical triggers like pressure or temperature--->Neurosensory disorder? Signaling mismatch between input and output of brain?
Pathophysiology of POTS: proposed model

Thread on Phoenix Rising forum

Thread on Dinet forum
« Last Edit: March 12, 2021, 10:00:00 AM by Muon »

Muon

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Re: Muon's Case
« Reply #138 on: March 17, 2021, 08:02:20 AM »
1 hour is also the timing that I start to feel bad after ingestion of foods like certain brands of chocolate (where other foods can start triggering local symptoms in oral cavitiy or stomach upon contact for example).

Food curve:

berlin1984

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Re: Muon's Case
« Reply #139 on: March 17, 2021, 02:11:56 PM »
Food curve:

Could you explain this graph?
Does this mean dopeamine stays elevated DURING the process of maturbation..
Or even AFTER?
My Protocol with adaoptogens, neurotransmitter precursors, energy production supplements helps with 80% of the symptoms with intercourse, 50% with masturbation.

Charles_b

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Re: Muon's Case
« Reply #140 on: March 17, 2021, 03:03:11 PM »
Food curve:

Could you explain this graph?
Does this mean dopeamine stays elevated DURING the process of maturbation..
Or even AFTER?

I second this question, also a source would be helpful.  My first thought was, ?Wow, that is one hell of a porn session?   ;D

Muon

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Re: Muon's Case
« Reply #141 on: March 17, 2021, 03:03:41 PM »
Could you explain this graph?
Does this mean dopeamine stays elevated DURING the process of maturbation..Or even AFTER?

I stole the picture from nanna's thread. The 1 hour peak regarding food caught my eye.
https://poiscenter.com/forums/index.php?topic=2900.msg26942#msg26942
« Last Edit: March 17, 2021, 03:24:30 PM by Muon »

Muon

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Re: Muon's Case
« Reply #142 on: March 20, 2021, 08:28:57 AM »
Abruptly waking up at night due to a bowel movement. Food traveling through gut could be felt. Accompanied by activity at an area close to or at the brainstem. Feeling hot. Irregular respiratory rate. Impaired blood circulation body/brain. Sections of limbs getting tense.
Probably POTS, drawing blood towards intestines from somewhere else like brain/limbs. Happens often at other body parts, waterbed effect.

Muon

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Re: Muon's Case
« Reply #143 on: March 21, 2021, 07:25:17 AM »
I suspect that POIS triggers hypovolemia. Could be a central mechanism: https://en.wikipedia.org/wiki/Vasopressin

Muon

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Re: Muon's Case
« Reply #144 on: March 22, 2021, 07:18:57 AM »
5+ weeks on 4x200mg/day Cromolyn. It started to calm down my gut after 2 weeks, less triggery, better shaped stool (not sure it's worth $100/month). I feel that my lower back is damaged from all the inflammation + poor blood flow over the years. POIS symptoms attenuated somewhat but this was already trending before I started cromolyn, changes happened in the brain at age 35 (frequent fluctuations). Orgasm is different in the brain now, before that it seemed that some change in the brain during orgasm gets out of bound and your brain gets submerged in something (chemicals hanging around?) while now it returns faster and closer to "baseline" while it doesn't affect the remainder of the brain that much. Libido is different at this point in time, lower. Perhaps symptoms will get worse again when libido rises. Basically some hybrid form of worst case POIS and POIS free state below:

Strange I had an orgasm with almost zero POIS symptoms. A small area close to the center of the brain stabilized within a few minutes (rough estimate, could be a bit longer) after orgasm. I thought there was no problem in that area at that specific moment until the quick transition to a more 'normal' like state happened, the 'normal' state feels less active, much calmer. My libido also made a big change during the last 1.5 months from high to low and POIS symptoms have slightly improved, probably due to prolonged cold weather conditions.

Edit: forgot to mention that my body as a whole was relaxed, other symptoms were barely present and it was past midnight.

My take after observing dynamics over the years:
Upon orgasm something gets amplified and/or doesn't get back to baseline in time. Similar behaviour for arousal, it peaks at the centre of my head, thereafter the arousal flare affects other parts of the brain--> impression that chemicals keeps hanging around in brain ('submerged'/'engulfed') after arousal flare. (Does orgasm affect microglia or blood flow in rest of brain?)

Anyway I'm stuck with low grade lingering inflammation troughout the body out of POIS. Starting to add 3x2 capsules/day of Neuroprotek to cromolyn (allergoval) as of this day.
« Last Edit: March 22, 2021, 07:29:38 AM by Muon »

Muon

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Re: Muon's Case
« Reply #145 on: March 22, 2021, 04:58:51 PM »
I can already feel the effects of Neuroprotek within ~15 min, it acts on my brain, adressing brain fog. Perhaps I should build it up first instead of starting with 3x2. Hmmm when it comes down to mast cells it shouldn't work that fast from what I've been reading, it probably does something else.

I was able to get luteolin in the product Neuroprotek. I have tried this supplement and am experiencing significant improvement, enough to believe there is serious weight to this theory.

Iwillbeatthis

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Re: Muon's Case
« Reply #146 on: March 22, 2021, 05:08:54 PM »
Just wanted to ask did you have any issues tolerating the cromolyn as I see a lot of MCAS patients having to start on tiny doses with some being unable to tolerate it completely.

Also was wondering how much has it helped your brainfog?

I went to a specialist allergy dermatology clinic which deals with mast cell issues in January, unfortunately I was unlucky and got the worst reviewed  doctor possible at the clinic by MCAS patients, who seemed completely crazy/mentally handicapped and she also didn't believe MCAS was a real thing. She also was only interested in the dermatological symptoms and I warned my GP about this when he referred me.

Anyway long story short even though the doc wasn't good somehow I managed to get a prescription for Cromolyn so she was helpful in that regard. Prof T said I had heat induced urticaria from showers on my face when I showed him pics. But I asked him before if I should take the cromolyn and he said no because my symptoms aren't primarily allergic.


Iwillbeatthis

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Re: Muon's Case
« Reply #147 on: March 22, 2021, 05:21:09 PM »
I can already feel the effects of Neuroprotek within ~15 min, it acts on my brain, adressing brain fog. Perhaps I should build it up first instead of starting with 3x2. Hmmm when it comes down to mast cells it shouldn't work that fast from what I've been reading, it probably does something else.


I also felt cystoprotek, brain gain work immediately but in the long term they both made me worse. Flavonoids inhibit mao-b and mao-a enzymes which is bad for me with my mutations, really annoying.... I could also be reacting to the olive oil extract as extra virgin olive oil makes me feel really bad because of the phenols I think.

Also maybe you could try taking them sublingually as I felt them work way stronger that way.

Prof T said I should try pure lut small doses but I'm kinda annoyed I wasted money on brain gain and cysto recently, I'm unsure if pure lut would be different or not.

Muon

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Re: Muon's Case
« Reply #148 on: March 22, 2021, 05:30:01 PM »
0 side effects from cromolyn. It mainly affects my gut, it attenuates IBS-like symptoms but not completely. It doesn't seem to do anything else. I find it too pricey at what it does though, not impressed, maybe I need to take it a little longer.

With regards to neuroprotek, too soon to tell, but the changes are a bit too fast in my opinion (chucked away 2x2 capsules and will call it a day for now). Luteolin is the least phenolic compound of the flavonoids. It's almost bedtime for me over here and I'm alert as hell, cognitive speaking.


Iwillbeatthis

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Re: Muon's Case
« Reply #149 on: March 22, 2021, 05:41:09 PM »
0 side effects from cromolyn. It mainly affects my gut, it attenuates IBS-like symptoms but not completely. It doesn't seem to do anything else. I find it too pricey at what it does though, not impressed, maybe I need to take it a little longer.

With regards to neuroprotek, too soon to tell, but the changes are a bit too fast in my opinion (chucked away 2x2 capsules and will call it a day for now). Luteolin is the least phenolic compound of the flavonoids. It's almost bedtime for me over here and I'm alert as hell, cognitive speaking.

Ok thanks, I wonder if the cromolyn would fix my bladder pain/IC as this seems like the epicenter of my POIS reaction. Also I was wondering does cromolyn cure mast cell issues after a while or is something you need to take forever?

Thats good to know about the Luteolin phenol amounts so I'll probably get some. Hope the neuroprotek stays working for you.