Chart of POIS Types and Their Possible Relief Methods (ongoing project)

[Quantum]

This thread is intended the be a work in progress, with progressive updating of the chart.

SEE THE COMPLETE POIS TYPES CHART IN THE POST JUST AFTER THIS ONE , at https://poiscenter.com/forums/index.php?topic=2338.msg19448#msg19448

 ( following is an intro to the chart itself)

POIS is not exactly the same for every POIS sufferers, and it is clearer now that POIS is a group of similar syndromes having a common trigger ( ejaculation), a common pattern, but may cause different physiological events, thus different symptoms, even if similar, from one POIS sufferer to another .  As a sign that POIS is not fully identical in every case, something helping one POISer can worsen the symptoms of another, or have no effect at all, pointing clearly to the fact that POIS is not a unique and identical syndrome in all sufferers.  Niacin can help one, and have no effects for another.  Like in diabetes, where you have Type I and Type II, it seems to me that there is more than just one type of POIS.

Since one of the best kind of information obtained from the forum is from members who have found something efficient for the relief of their symptoms, then I have chosen to base my POIS types on relief method.  The rational behind this choice is that if two POIS sufferers get consistent relief for a long enough period of time from the same method or product, then at the physiological level, chances are their POIS are similar, even if their symptoms are not exactly the same.  If two members that are both relieved by niacin, chances are they have the same type of POIS.  Methods have to be effective for at least some months, and bring 70% to 100% relief, to be included in my chart.

From there, I hope to detect some patterns, so it would become possible, for example, to make some predictions, like if one has this kind of symptoms and his POIS is worsen by so and so, than this type of relief method could be efficient for him.  I know this will take time to reach this, and will never be 100% accurate, but I sure want to give a shot at it. 

Each type is named after the method or product that brought the relief ( Example: POIS type responding to niacin, meaning that this type of POIS is relieved when using the niacin protocol detialed in that section).  For each type, I hope to identify some possible mechanism about how it brings relief, identify some reference members ( at least one, of course !), level of relief obtained, and so on.  Than,  if there is more than one known member for a particular POIS type, it will be interesting to try and see what they have specifically in common, like things that worsen their POIS, or their type of symptoms.  Needless to say this will be a long process.

I know there will be numerous types of POIS at the start, but some may reveal later to be the same type and be fused.

All input from all members will be welcomed.  For example, if you think you are a member of a type and wish to be listed as reference member, and add useful comments for that type, that go ahead.  But this will imply that you had at least 2 to 3 months of consistent relief with the specific substance or method.  If you find some common points with some other members of your type, something that is not common to all POISers, than that would be very, very interesting, and could become a predictive factor.  For example, if members of a particular type have their symptoms worsen by a hot shower, and not the other types of POIS, that would be a specific parameter.  I can make up some hypothesis here, to illustrate the potential usefulness of the chart:  if all POISers who have their symptoms worsen by a hot shower have no relief with, let's say, niacin, and have relief with let's say, magnesium ( I made that up), than a new member having his symptoms worsen by a hot shower could think he is of this same type, and try magnesium ( after checking with a health professional, as usual).  This will be no guarantee, but with time, this chart may become useful.

Of course, if you do not want to be listed as a reference member for a type of POIS, let me know by PM and I will remove your member name of the chart.

If you want another type to be added, let me know as well.

I will post the current version of the chart just after this post, and will update on that same post, rather than re-posting multiple versions of the chart.

[Quantum]

POIS Types Chart
and Their Possible Relief Methods


Pois types in this chart are named and classified according to the treatment or method they are positively responding to.   If symptoms of two different members are relieved by the same method or treatment, they are considered, in this chart, to have the same POIS type.

1- POIS type: Responding to treatment with Niacin   
Reference member(s)   Daveman, Limejuice, Observer, Poisperson, Bluesbrother, victor.kons, Gino,...   
Relief method description: Niacin taken on empty stomach, waiting for the flush to happen before ejaculation.  Usually doses from 100mg to 300mg, but varies. 
Effect on severity and duration of POIS: 50% to 90%
Possible reason for effectiveness: data to be added
POIS symptoms ( mainly):   brain fog (difficulty thinking and slow response time), impaired memory, headache, physical fatigue (low energy level), runny nose, insomnia, stiffness and pain in muscles and joints
POIS worsened by: hot showers, starches and simple carbs, long sleeping time, active physical training,  Any ingestion, food, alcohol, anything but water, closer than 8 hours from orgasm, multivitamins daily (cancelling the niacin effect). smoking marijuana before O.  (all these not confirmed by all ref. members, but by one at least ).
No relief with : data to be added
Other comments and information:
- Some members had success with non-flush type ( niacinamide). 
- Also used: Xantinol Nicotinate in tablets 450 mg. 
-  Method of member Gino includes Matcha powdered tea (just before O) in addition to Niacin (within 2-6 hours before O), see his method at https://poiscenter.com/forums/index.php?topic=3746.msg39754#msg39754


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2 - POIS type: Responding to TRT
Reference member(s)   Demografx, Green
Relief method description   Testosterone Replacement Therapy  ( warning, needs medical supervision) See detailed protocols below
Effect on severity and duration of POIS: 70% to 80%
Possible reason for effectiveness:  TRT possibly offsets severe drop in testosterone [depletion?]
POIS symptoms ( mainly): after ejaculation/at POIS onset.severe fatigue: emotional, physical, cognitive -- plus, all 10 fingertips dry up, feel like they're "burning", yet simultaneously "drained", and there persists a strange sensation/high anxiety about this weird short-term (4 days) dermatitis condition -- resulting in much inexplicable psychic pain/anguish ( Demo).
POIS worsened by: hot showers ( to be confirmed with other members of this POIS type)
No relief with : progesterone
Other comments and information: TRT can cause infertility, by decreasing sperm production; major family planning implications. Medical supervision - especially for young POISers - is critical.

In early 2022, Demografx added tadalafil 10mg ( Cialis) to his anti-POIS regimen.   Recovery with TRT alone was 2 days, and when using TRT+taladafil, recovery is less than a day.  Also, the intensity of symptoms is less with TRT + taladafil. ( note: considering that the duration of effect of tadalafil is around 36 hours, the timing of this medication intake is not a concern).

In 2023, Demografx changed his protocol in a significant manner:
Iinjections of Depo testosterone, 150mg/once a week
Cialis 5mg daily
L-Citrulline 3,000mg daily
CPAP nightly  ( seems to help too)
Result (From Demografx): "1. My symptoms have changed to a different form of one that is much less agonizing and shorter in duration. 2. My new weekly-injection-based TRT  (plus daily Cialis) treatment for POIS is a ‘dramatic improvement’ over my previous 10-year implementation of a daily transdermal 8mg TRT patch (no ED drug) protocol."

Alternate, personalized, regimen ( member: Green):
Testosterone 83mg per week
Fexafenodine on the day of orgasm
Paroxitine daily (20mg - 40mg)
Tramadol  4 caps (50mg)
Niacin 1000mg an hour prior to sex/O


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3 - POIS type: Responding to fenugreek and garlic
Reference member(s) Vincent M, hurray, Vanker, Observer, Warrior, others...
Relief method description: fenugreek, one or two 550mg capsules just before or just after ejaculation, garlic daily (?). Some take Fenugreek on a daily basis.  Some take Fenugreek with tea rather than with garlic.  Warrioronthetrot method initially included lectin-free diet, but fenugreek and garlic eventually proved to be the essential elements ( see details at https://poiscenter.com/forums/index.php?topic=3964.msg42080#msg42080  and https://poiscenter.com/forums/index.php?topic=3964.msg43952#msg43952  ).  Warrior updated solution in 2023 includes a animal-based diet ( gluten-free and grains-free - Paul Saladino diet) and a complex B supplement in addition to fenugreek and garlic, for improved effectiveness, see the details at https://poiscenter.com/forums/index.php?topic=3964.msg42080#msg42080 .
Effect on severity and duration of POIS: up to 90% in some cases
Possible reason for effectiveness: data to be added
POIS symptoms ( mainly): very dry skin and straw hair seem to be more common in this group than others.  Brain fog seems severe,in general , in this group, and social anxiety too.
POIS worsened by: hot showers ? ( to be confirmed)
No relief with : data to be added
Other comments and information: It is possible that this type is similar to the Mytelase/Lecithin type, because fenugreek is a good source of choline, and some members having relief with fenugreek ( ex: hurray) have also their symptoms worsened by hot shower.   Also, fenugreek seems to be useful even if taken way after ejaculation, like 2 days after ( still provides some relief).
For a detailed experiment by Warrior about the respective effects of fenugreek and of garlic on his POIS symptoms, see https://poiscenter.com/forums/index.php?topic=3964.msg44360#msg44360


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4 - POIS type: Responding to cholinergic supplements/drugs
Reference member(s) POISse, Outsider, Floppy Banana , ( For eggs:  Bulbo), ThisType
Relief method description: for Floppy Banana, Outsider :  Mytelase ( 20mg) and lecithin, just before or after orgasm ( warning: taking Mytelase needs medical supervision), or Lecithin/choline/eggs intake before and during POIS.  Also, see ThisType regimen at http://poiscenter.com/forums/index.php?topic=2486.msg22620#msg22620 ( no Mytelase)
Effect on severity and duration of POIS: up to 90% relief
Possible reason for effectiveness: In this POIS type, main physiological effect would be a cholinergic deficit, corrected by cholinergic agents like Mytelase, or sources of choline like lecithin, choline itself, eggs, fenugreek, or else.
POIS symptoms ( mainly): fatigue, brain fog, insomnia, cognitive problems, speech problems
POIS worsened by: Hot showers ( confirmed by 3 members), and, depending on members: sports (increased insomnia, fatigue, brain-fog - POIse), milk and wheat products (POISse)
No relief with : claritin, zyrtec, niacin ( POISse)
Other comments and information: Could be included in this type the relief obtained in the long term by eating eggs daily, if we consider eggs as a good source of lecithin ( reference member: Bulbo).  Also, there is a possible link between this type and the fenugreek type, because fenugreek is a good source of choline. 


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5 - POIS type: Responding to Taurine
Reference member(s) b_jim
Relief method description: 600mg taurine each day ( and no sugar in diet )
Effect on severity and duration of POIS: 90% relief on severity, duration reduced to 1/3 or less of usual duration ( if no sugar in diet)
Possible reason for effectiveness: possible correction of a Gaba or Dopamine imbalance ?  Support of taurine hepatic detoxification pathway ?
POIS symptoms ( mainly): brain fog, muscle weakness, muscle twitching, fatigue, ...
POIS worsened by: refined sugar ( increased duration and severity)
No relief with : B3 (niacin), garlic, fenugreek, olive oil, gluten-free diet, antihistaminics
Other comments and information: associated with skinny type, general anxiety, premature ejaculation, bad alcohol resistance, sluggish liver.   
Note: for pattern detection, more than one reference member would be needed


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6 - POIS type name: Responding to pre-pack with  IDO/TDO/NMDAr blockers+ anti-oxidants
Reference member(s) Quantum, G-man, romies, fsol, Michael218, Psy's husband
Relief method description: pre-pack taken 20 to 75 minutes before ejaculation, composed of IDO and TDO inhibitors  ( Rosemary extract, peppered curcuma, quercetin ) , NMDAr blockers ( L-theanine, magnesium), Antioxidants ( lycopene, green tea extract, flaxseed oil), and some others ( for complete description of the pre-pack and the dosage of each element in it, see in this thread: http://poiscenter.com/forums/index.php?topic=2090.msg16604#msg16604 ).  Some members have customized their pre-pack and have a different composition  ( Michael218 pre-pack based on Complex-B vitamins and other components like antioxidants such as Vit C and E, see at http://poiscenter.com/forums/index.php?topic=2338.msg21433#msg21433 and http://poiscenter.com/forums/index.php?topic=2338.msg21438#msg21438  for complete composition of his pre-pack )
Effect on severity and duration of POIS: 80% to 100% relief
Possible reason for effectiveness: block of toxic kynurenine metabolites production, and block of pro-inflammatory cytokines
POIS symptoms ( mainly): Fatigue, hypotension and exercise intolerance, marked emotional symptoms - irritability, anxiety, mood swings, ... (Quantum). Brain fog, fatigue, physical and emotional symptoms ( romies, fsol), Physical and cognitive symptoms ( G-man) 
POIS worsened by: too much exercise/sports before or after ejaculation ( Quantum, romies ) ;   caffeine crash after effect ends (fsol); refined sugars in diet/unhealthy diet
No relief with : level of relief not high enough if only some elements of the pack taken and not the whole.
Other comments and information: No worsening with hot showers; recovery after sport or physical training is longer than normal, regardless of POIS or any sexual activity, and seems to trigger symptoms similar to POIS but milder and for a shorter duration ( Quantum, romies, fsol )
more detailed information about this method at http://poiscenter.com/forums/index.php?topic=2090.msg16604#msg16604 
simplified pre-pack with post-pack ( romies):  http://poiscenter.com/forums/index.php?topic=2090.msg19833#msg19833
For Psy's husband's pre-pack and method: https://poiscenter.com/forums/index.php?topic=2090.msg45741#msg45741 

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7 - POIS type : Responding to gluten-free diet  ( and other diets)
Reference member(s) Going less crazy, jacksonsean, Vincent M  (wheat-free diet), bbd2501 ( AIP diet ), bletzer ( AIP diet ) mike_sweden ( paleo), BuckarooBanzai88 ( gluten-free and nightshades-free diet ), Spartak
Relief method description: strict gluten free diet, dairy also avoided for GoingLessCrazy (
jacksonsean still have non-pasteurized dairies), or AIP diet
Effect on severity and duration of POIS: 80% and more relief
Possible reason for effectiveness: reduce inflammatory reaction in the body due to food intolerance (?)
POIS symptoms ( mainly): Brain fog, fatigue, irritability, redness in the eyes, inability to communicate effectively or to concentrate ( presence of bloating in the bowels is more present in this type than other types of POIS )
POIS worsened by: anything with gluten in it ( or simply any grain, for GoingLessCrazy), additives like Carrageenan , eggs, dairies, or else, depending on the diet.
No relief with : data to be added
Other comments and information:For more info about the complete Going Less Crazy method and food list, see http://poiscenter.com/forums/index.php?topic=2275.msg18450#msg18450  ;   for more info about complete jacksonsean method: http://poiscenter.com/forums/index.php?topic=1240.msg11486#msg11486.  About bbd2501 diet: http://poiscenter.com/forums/index.php?topic=2275.msg21620#msg21620 ; For more info on BuckarooBenzai88 diet: https://poiscenter.com/forums/index.php?topic=2805.msg26099#msg26099 and https://poiscenter.com/forums/index.php?topic=2805.msg25371#msg25371 .   For Spartak diet, see https://poiscenter.com/forums/index.php?topic=2275.msg45409#msg45409


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8 - POIS type: Responding to antihistamines
Reference member(s) Happy2, Certainlypois2, Nico, Wolf, eccentricbipois, mike_sweden
Relief method description: Zyrtec ( cetirizine) 10mg daily ( 6 pm), and Benadryl ( diphenydramine)  just before or just after ejaculation ( 2 x 25mg ). Two other Benadryl 25mg capsules if another ejaculation later the same day   Alternate method: Claritin ( 10mg of loratadine) daily, and Benadryl ( diphenydramine)  just before or just after ejaculation ( member happy2 notes that Zyrtec/Benadryl combo far more effective for him than Claritin/Benadryl combo).  For eccentricbipois :  25mg of hydroxyzine, 30 mins to 1 hour before orgasm, just before going to sleep.  For mike_sweden: 12mg of promethazine ( Lergigan, Phenergan), suspension form, at bedtime, every day.
Effect on severity and duration of POIS: 70% to 100% , but possible drowsiness/hangover from Benadryl/diphenhydramine or hydroxyzine the following day
Possible reason for effectiveness: Blocks the effects of a massive histamine release ? Neurological effects in the brain, like brain fog, caused by histamine ?
POIS symptoms ( mainly): brain fog, fatigue, concentration/attention occasional symptoms; flu-like symptoms, burning sensation in lower back, physical fatigue, insomnia, bad mood, isolation from other people, depression
POIS worsened by: coming down from caffeine high ( would need confirmation by more than one member), mental or physical exertion on first days of POIS ( POIS symptoms will last a few more days), carbohydrates/sugars ( Happy2)
No relief with : Niacin, L-Tyrosine, Zinc, Acupuncture (eccentribipois)
Other comments and information: more info on antihistamines use in POIS at http://poiscenter.com/forums/index.php?topic=1060.msg9574#msg9574.
For eccentricbipois use of hydrozyzine, see https://poiscenter.com/forums/index.php?topic=3317
For mike_sweden thread about promethazine, see https://poiscenter.com/forums/index.php?topic=4552.0


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9- POIS type: Responding to methylation support and diet 
Reference member(s) Kurtosis, nanna1, CuriousCharacter 
Relief method description: use of methylation support supplement, and healthy diet ( lots of fruits and veggies, and so on)
Effect on severity and duration of POIS: 100% relief 
Possible reason for effectiveness: data to be added   
POIS symptoms ( mainly): data to be added
POIS worsened by: data to be added
No relief with : data to be added
Other comments and information:
- Member Kurtosis no longer active on this forum or elsewhere about POIS, but you can find the final recap of his method at https://www.reddit.com/r/POIS/comments/35rh8o/kurtosis_explains_to_the_best_of_his_knowledge/
- For nanna1 method see http://poiscenter.com/forums/index.php?topic=2502.msg21497#msg21497 .
- For CuriousCharacter daily stack and pre-pack descriptions, see https://poiscenter.com/forums/index.php?topic=2831.msg27282#msg27282 ( a modified version is also described later in the thread.  Note:  not clear if diet changes are part of his method ) 


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10 - POIS type: Responding to Beta-blockers/ Propranolol
Reference member(s) Arun, Laotzu1980, OpiesDad
Relief method description: For Arun: 10mg of propranolol just before or after ejaculation (warning, taking this medication needs medical supervision).  For Laotzu:  40mg when in POIS wipes out cognitive symptoms and anxiety for a few hours. For OpiesDad, 60mg extended-release tablets, 2 times a day regularly.
Effect on severity and duration of POIS: 75% relief.   For Laotzu, 100% relief of cognitive symptoms for a few hours. OpiesDad 80% relief ( completed at 100% with other measures, see OpiesDad detailed method at https://poiscenter.com/forums/index.php?topic=2335.msg44937#msg44937 )
Possible reason for effectiveness: data to be added
POIS symptoms ( mainly): Arun: faster and stronger heartbeat, muscle stiffness and pain, and others.  For Laotzu: cognitive symptoms,  Brain fog even outside of POIS, tiredness, insomnia, weakness, anxiety.  For OpiesDad:  red eye, fatigue, racing heart, difficulty speaking correctly, not being able to maintain a normal conversation, loss of focus and other cognitive symptoms, skin problems, aching joints, anxiety, painful testes, nausea, photophobia, headaches.
POIS worsened by:  For Arun, Niacin, Antihistamines, sometimes made POIS worse  (For OpiesDad, not worsened by niacin, and helped by antihistamines)
No relief with : For Arun, Niacin, Garlic, fenugreek, Antihistamines ) Saw Palmetto, Relora, For OpiesDad, niacin
Other comments and information: for more details about Laotzu method, see https://poiscenter.com/forums/index.php?topic=2335.msg41030#msg41030 and https://poiscenter.com/forums/index.php?topic=3578.msg41276#msg41276.  For OpiesDad method, see https://poiscenter.com/forums/index.php?topic=2335.msg44937#msg44937


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11- POIS: Responding to NSAID ( non-steroidal anti-inflammatory drugs)
Reference member(s) Dirkstar, Suppertime, nabrajjj, and other members
Relief method description: 400-800mg Ibuprofen 20 minutes before significant arousal (much earlier if not on an empty stomach).  Suppertime protocol:  400mf of Ibuprofen just after orgasm, with lots of water ( see http://poiscenter.com/forums/index.php?topic=2358.msg19679#msg19679 ). nabrajjj method:  400mg of ibuprofen before release, but taken daily at night to avoid POIS from nocturnal emissions.
Effect on severity and duration of POIS: 80-90% on severity, unclear effect on duration
Possible reason for effectiveness: high amounts of prostaglandins created in the prostate and released internally during ejaculation, which bind to spinal neurons causing hypersensitivity and non-focal CNS stress ( hypothesis of prostaglandins production by prostate irritating spinal nerves comes from the neurologist who prescribed the NSAIDs to Dirkstar ).  COX inhibition in the whole body, as an alternative explanation.
POIS symptoms ( mainly): Severe brain fog including short and long term amnesia, slurring of speech, hypersensitivity particularly to sound, thrumming of middle ear muscles, headache, nausea, head "stuffiness", fatigue, light sleep, sleeplessness, vivid dreams, scalp pimples w/in one day of orgasm then disappearing, crawling sensations on scalp and face; onset noticed w/in 30 minutes of orgasm or limited ejaculation near orgasm (though to a lesser degree), gradual increases in severity over 3 days then gradually disappears over next 5-7 days
POIS worsened by: Effects are cumulative with each ejaculation, intensity of orgasms
No relief with :  Antihistamines, Niacin (need to revisit), B-12, Vitamin C, multi-vitamins, Tylenol before orgasm, good diet, exercise, alcohol
Other comments and information: Tylenol helps with hypersensitivity and sleep if taken before bedtime; Dirkstar also has developed early onset Parkinson's Disease possibly secondary to POIS via excitotoxicity of dopaminergic neurons; Dirkstar also had (self-diagnosed) hypoglycemia when younger and possibly lessened with fitness when older possibly contributing to excitotoxicity aspect of PD; Coffee might decrease duration of symptoms (but may have further stressed CNS leading to PD); May be related to hypersexuality and/or lengthy periods of arousal (intense dopaminergic stress); Dirkstar also seems to be prone to inflammatory disorders such as tendonitis, bursitis, and sinusitis; Dirkstar also has non-pattern hair loss since 15 yrs old implying a hormonal or auto-immune problem linked to puberty/sexual activity; Dirkstar diagnosed with restless legs syndrome which seems to correlate with POIS symptoms


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12 - POIS type: Responding to psychotherapy/sex therapy
Reference member(s) carmack97, lw
Relief method description: Carmack: 1year and a half of consulting a sexologist ( see more details at http://poiscenter.com/forums/index.php?topic=2627.msg23025#msg23025 ).  Lw: many months of psychotherapy and the use of self-help books ( see https://poiscenter.com/forums/index.php?topic=2993.msg47354#msg47354 )
Effect on severity and duration of POIS: 100% relief
Possible reason for effectiveness: strong psycho-somatic cause / psychologic blockage have been treated/re-programmed
POIS symptoms ( mainly): Carmack: lasted 4 days every time: depression (feeling low, people hating me, feeling like having no friends, losing interest in life, low self-esteem, suicidal fought), fatigue (especially on the first 3 days, feeling tired during the afternoon usually), brain fog, anxiety, difficulty concentrating, increased shyness.  Lw: described as "5 days of hell" ( anxiety, depression, confused thinking, gastro-intestinal discomfort, etc)
POIS worsened by: data to be added
No relief with : data to be added
Other comments and information: data to be added


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13 - POIS type: Responding to CBD oil  ( Cannabidiol hemp oil)
Reference member(s) : Vandemolen, Olaf
Relief method description: purified 20% cbd oil. Started with 1 drop before going to sleep. The next morning 1 drop and at night 1 drop. The next morning 2 drops and the at night 2 drops. The cbd oil worked after 2 weeks.  For Olaf, 2 drops of 5% CBD oil at bedtime ( see https://poiscenter.com/forums/index.php?topic=3283.msg34098#msg34098 )
Effect on severity and duration of POIS: 100% POIS-free
Possible reason for effectiveness: data to be added
POIS symptoms ( mainly): flu-like symptoms, feeling cold, extreme fatigue, exhausted, palpitations, problems finding words, incoherent speech, dysarthria, concentration difficulties, quickly irritated, can not stand noise, photophobia, depressed mood, headache, itching eyes, painful eye, congestion nose, watery, runny nose, sneezing, white tongue, dirty taste in mouth, dry mouth, sore throat, muscle tension in back and neck, muscle weakness, pain muscles, stiffness muscles. Symptoms for 1 day, used to be 4 days.  Also:  No NE, no PE.
POIS worsened by: Symptoms worse if don’t ejaculate after sexual activity.
No relief with : data to be added
Other comments and information: comment from Vandemolen : "There is a guy who has been successfully treated by over the counter 3,5% cbd oil, but it didn’t help me"

Also, Vandemolen developed an allergy to CBD oil and had to stop using it .  His comment on it: "after 2 months I was out of CBD oil. A few months later I get new cbd oil. But when I started I used 4 drops in just a few hours. I got allergic and got sick. After 6 months (last week) I started with 1 drop. It went well. Two days later again 1 drop. But I got sick again. So my allergy for cbd oil isn’t still over."

IMPORTANT NOTICE:  CBD oil is not legal everywhere in the world, and, in fact, is still illegal in many countries.


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14 - POIS type: Responding to Physalis/groundcherries
Reference member(s) : Physi  ( see https://poiscenter.com/forums/index.php?topic=3306.msg34401#msg34401 )
Relief method description:   Eating 20 to 25 Physalis ( berries, also called groundcherries or Inca berries or golden berries), 40 minutes to 1 hour before O  ( if taken after O, not wroking)
Effect on severity and duration of POIS: 100% POIS-free
Possible reason for effectiveness: data to be added
POIS symptoms ( mainly): strong brain fog, fatigue, memory loss, difficulties concentrating, lack of social skills, lack of confidence linked to not being in a normal state, lack of tact and humor.  Symptoms last for 3 days when not taking the berries.
POIS worsened by: data to be added
No relief with : data to be added
Other comments and information:
1)   It seems that the more dried the berries are, the more effective they are (you need less berries to get their effect, but member Physi not 100% sure of that hypothesis.)
2)   There may be a peak of efficacy at 45-50 minutes after O, and then a decrease, depending on the number of berries you took. For example, a number of n berries may be effective at 45 minutes after O and not after 1 hour, whereas a quantity of n+10 berries may be effective at 1 hour after O. This, again, is just a hypothesis.
3)   Before reaching the point at which berries start working (around 40 min), physalis are not effective
4)   It doesn't work at all to take them after O. Once you are under POIS, berries are useless. They only work as a preventive treatment.
p.s.:  two other members have reported initial success, but awaiting confirmation of further success/long term success before citing them as reference members.

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15 - POIS type: Responding to Milnacipran
Reference member(s) : Hurray, Jan
Relief method description: Hurray: king 25mg of milnacipran 1 hour before O  ; Jan:  50 mg of milnacipran 1.5 hours before O  ( warning, Milnacipran is a serotonin–norepinephrine reuptake inhibitor used in the clinical treatment of fibromyalgia and depression and needs medical supervision, it is a prescription-only drug in most countries)
Effect on severity and duration of POIS: 100% POIS-free
Possible reason for effectiveness: data to be added
POIS symptoms ( mainly): brain fog, impossibility to socialize, dry skin and scalp, aching articulations. Reference member Hurray had few physical symptoms.
POIS worsened by: data to be added
No relief with : other antidepressants:  duloxetine, venlafaxine
Other comments and information: Hurray had some success in the past with fenugreek, but not possible at this point if this can help predict milnacipran effectiveness.   Also, see notes on nausea and potentially high blood pressure vs dosing, with milnacipran for POIS, at https://poiscenter.com/forums/index.php?topic=3312.msg43848#msg43848 
Jan has 100% effectiveness for over 3 months. He can work, run, do anything that he normally does, and no brain fog or fatigue.  Additional note from Jan: "the combination of pre-pack (vitamins b, c, d, zinc, and calcium) and milnacipran does not seem to work well.  Both times I've done this, I vomited, and milnacipran didn't work ."

For more info, see the milnacipran thread at https://poiscenter.com/forums/index.php?topic=3312.msg34512#msg34512 . Down the thread, Hurray confirms that after 5 months, milnacipran is still effective to prevent his POIS symptoms.   


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16 - POIS type: Responding to oral corticosteroids ( prednisone or dexamethasone)
Reference member(s) : BuckarooBanzai88,  aquantiV (POIS Reddit forum member)   
 Relief method description:  Taking 2,5 prednisone before O ( Buckaroo), or 2,5mg 1 hour before O, and another 2.5mg just after ( aquantiV). (warning, needs medical supervision, it is a prescription-only drug in most countries)Effect on severity and duration of POIS: 85% to 100% Possible reason for effectiveness: data to be added   
POIS symptoms ( mainly): data to be added   
POIS worsened by: data to be added   
No relief with : data to be added   
Other comments and information:
BuckarooBanzai88 thread:  https://poiscenter.com/forums/index.php?topic=3447.msg36311#msg36311  .  Prednisone have been working for over 6 months now.   Used dexamethasone at first, but found out that prednisone start acting more quickly.

AquantiV thread on Reddit:  https://www.reddit.com/r/POIS/comments/43yb2m/pois_treatment_that_has_been_working_for_me/

Also, member Nas had partial relief, mostly form cognitive symptoms, with 1 mg of dexamethasone after O ( see https://poiscenter.com/forums/index.php?topic=73.msg28291#msg28291  and https://poiscenter.com/forums/index.php?topic=2502.msg29425#msg29425).  With dexamethasone, his recovery takes 2 days instead of seven.  However, he mentions that dexamethasone does not stop other POIS symptoms like his psychological and emotional symptoms. 
A short mention of dexamethasone use here, but no follow for long-term effectiveness:  https://poiscenter.com/forums/index.php?topic=31.msg14133#msg14133


--
17 - POIS type: Responding to progestins / norethisterone
Reference member(s) : Reference is a published case report, at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028282/
Relief method description:  Taking 5mg of norethisterone (norethindrone) 30 minutes before sexual activity
Effect on severity and duration of POIS: 95% POIS-free  ( still effective at 10 months follow-up)
Possible reason for effectiveness: data to be added
POIS symptoms : Constant pounding headache, photophobia, increased muscle tension and irritability, increased anxiety and impaired cognitive functioning, mental concentration difficult/difficult to read and retain, frequent nightmares, problem solving difficult (can take three times as long),  absent-minded and disorganized, motivated to avoid social interaction, fatigue and lethargy especially in the mornings, constant urge to go home and sleep.  Condition disappears quickly after 72 h (with return of normal function and confidence).
POIS worsened by: data to be added 
No relief with : data to be added
Other comments and information: In the article, the case is referred to as "Benign coital headache", not as POIS, but from the symptoms list and disappearance after 72h, it really seems to be a POIS case.  However, it is possible that the author, probably a neurologist, didn't know about POIS at the time of publishing


--
18 - POIS type: Responding to Zinc and Iron Supplementation
Reference member(s) :  yousefrouiba
Relief method description:  Daily supplementation with 240 mg of zinc gluconate at night, and 600 mg of ferrous fumarate during the day.  Benefits came after 2 months of this supplementation regime.
Effect on severity and duration of POIS: 100% POIS-free  ( has been for 1 year, as of 2021/10)
Possible reason for effectiveness: correction of iron and zinc deficiency
POIS symptoms : Brain fog,  Digestive problems (bloating), low concentration, low self-esteem, personality changes, depression for several days, acne, inability to gain weight, hair dandruff
POIS worsened by: Choline supplements, lactose and dairy products, Coffee, sleeping for more than 7 hours, eating (except if high protein food, like a piece of meat alone without anything else).
No relief with : Testosterone capsules for one month, Chamomille oil, Lavender oil, Rosmarin, Betahistine, Ginseng, Sulpiride, Licorice, Coconut oil, Glutamine powder, Aspartame, Gelatin, H pylori overgrowth treatment (amoxicilline clarithromycin, omeprazole and metronidazole for 14 days + Saccharomyces boulardii), Ampicillin for 28 days, Candida treatment ( fluconazole 150 mg ), Sulfur bacteria treatment (no thiol no sulfur diet, taking oregano powder )
Other comments and information: Iron supplementation duration depends on iron blood level achieved, so monitoring with blood tests is necessary. Be aware that too much iron can be toxic, so supervision by a health professional is advised.  Zinc supplementation has to be monitored too, to avoid toxic levels - supervision by a health professional is also advised. 

See more details on this method at https://poiscenter.com/forums/index.php?topic=4006.msg42542#msg42542 and https://poiscenter.com/forums/index.php?topic=4006.msg42544#msg42544

--

19 - POIS type: Responding to non-ejaculatory orgasm (Dry orgasm, tantric orgasm)
Reference member(s) Physi, ZombieRehab,
Relief method description: Using contractions of the pelvic floor muscles and/or digital pressure on the baseor urethra to prevent ejaculation during orgasmic spasms.  If pelvic floor muscles are used, previous training of these muscles is required.  Orgasm can still be felt, but no ejaculation occurs.  For a complete explanation on how to achieve a non-ejaculatory orgasm, see this video :  https://www.youtube.com/watch?v=MRflY59PXb0
Effect on severity and duration of POIS: 100% relief if technique is totally successful at preventing ejaculation, but usually around 80% to 90% success rate, because technique is not easy and semen leaks can happen from time to time
Possible reason for effectiveness: POIS caused by ejaculation but not by orgasm ( note: like any method, does not work for every members...some members still have POIS even if they achieve an orgasm without ejaculation). 
POIS symptoms ( mainly): : usual POIS symptoms ( Brain fog, fatigue, etc...) , no pattern detected
POIS worsened by: no particular information
No relief with : info to be added
Other comments and information: ZombieRehab thread:  https://poiscenter.com/forums/index.php?topic=3860.0 .  Physi thread: https://poiscenter.com/forums/index.php?topic=4322.0

--

20 - POIS type: Responding to Xolair (omalizumab)
Reference member(s) Poispilgram
Relief method description:   Personalized dosage of 75mg of Xolair every 6 to 8 weeks with goal of maintaining a blood serum level of 25mg to 100mg.
Effect on severity and duration of POIS: 100% relief
Possible reason for effectiveness: POIS caused by auto-immune reaction following ejaculation ( Xolair is used to treat severe allergic asthma and MCAS.  Also, patient was POIS-free when succeeding with a "dry orgasm" method - see type 19 above for details)
POIS symptoms ( mainly): : usual POIS symptoms ( Brain fog, fatigue, irritalbility, etc...) , no pattern detected
POIS worsened by: no particular information
No relief with : info to be added
Other comments and information: Case report in the scientific literature of a POIS patient treated with Xolair:  https://onlinelibrary.wiley.com/doi/10.1111/imj.80_16230   .   Poispilgrim thread:  https://poiscenter.com/forums/index.php?topic=4581.msg49245#msg49245

--


(General note: as information gathers, it may become possible to fuse some of those POIS types together as it may turn out that they are one and the same, but for now, they seems exclusive in their relief method, suggesting they have some psychophysiological specificity as well. )


--
some other types to eventually add ( not enough information for now):

Responding to tadalafil:  see member wolf post, at http://poiscenter.com/forums/index.php?topic=2369.msg19814#msg19814 ).  Some more info would be needed

Responding to vitamin D supplementation:     many reports from members that vitamin D helps, but more information would be needed.  Vitamin D does not seem to be enough as a stand-alone relief method.  However, it may constitute a useful addition to POIS management, as it is good for the immune system balance ( 1000ui to 2000ui daily are the usual doses mentioned - for higher doses, seek for health professional supervision)
--

 Note about Desensitization:  I didn't include a "POIS type responding to desensitization with sub-cutaneous injection of own semen". There are very few known successes with this method despite the 10 years of experimentation it had been used, and I never heard of more than 30% to 50% relief at best even after years of desensitization ( I usually include methods with providing at least 70% to 80% relief). Moreover, there are no known physician to us that is still using this method.
 

= = = =

• POIS types chart, version 1.0 ( 2016/08/07):  Just a start up version, so don't expect too much. Your input is welcomed for adding to this chart ( adding reference members, adding types, adding any relevant information )
• POIS types chart version 1.01 ( 2016/08/11):  update on Taurine Type and Niacin Type, and other minor changes
• version 1.02 ( 2016/08/19):  update of Fenugreek Type
• version 1.03 ( 2016/09/11):  update of different types according to information provided by members
• version 1.04 ( 2016/09/21):  update of different types according to information provided by members
• version 1.05 ( 2016/10/18):  update of different types according to information provided by members
• version 1.06 ( 2016/11/19):  NSAID type added
• version 1.07 ( 2017/02/11):  update of Gluten-free diet type
• version 1.08 ( 2017/06/21):  update of oral corticosteroids type and other minor updates
• version 1.09 ( 2017/07/14):  update of pre-pack type
• version 1.10 ( 2018/01/03): Cholinergic Deficit Type update
• version 1.11 ( 2018/02/15): renaming of POIS types; addition of POIS type responding to psychotherapy/sex therapy, and to CBD oil
• version 1.12 ( 2018/12/02): updates in section 7 ( gluten-free diets and other diets)
• version 1.13 ( 2020/05/26): section 14 added (POIS responding to Physalis )
• version 1.14 (2021/01/01) : Type 15 ( Milnacipran) and type 16 ( prednisone/dexamethasone) added
• version 1.15 (2021/01/02): Type 17 ( progestins ) added
• version 1.16 (2021/04/14): New reference member with Niacin+Matcha method added to Type 1 ( Niacin
• version 1.17 (2021/06/23):  Propranolol type updated
• version 1.18 (2021/10/09):  Type 18  (Zinc and Iron supplementation) added
• version 1.19 (2022/01/23):  Upgrade of fenugreek type
• version 1.20 (2022/03/22):  Upgrade of milnacipran type
• version 1.21 (2022/08/06):  Upgrade of TRT type (note about Cialis use by Demografx)
• version 1.22 (2023/06/23):  Upgrade of Fenugreek and Garlic section  (Warrior method update )
• version 1.23 (2023/09/22):  Upgrade of TRT section ( Demografx 2023 method update )
• version 1.24 (2024/06/28):  Upgrade of antihistamine type (promethazine) and NSAID Type.  Type 19 added (non-ejaculatory orgasm)
• version 1.25 (2024/06/30):  Upgrade of psychotherapy/sexotherapy type (lw case added
• version 1.25 (2024/09/09):  Type 20 (Xolair) added

[Limejuice]

Thanks for compiling this!  No doubt a large step forward to have this information in one place. Feel free to delete this msg if it muddys the thread.

[POISse]

Hi everyone,

Quantum amazing work here. I am 100% sure people will find it easier to find their pois type and relief with your chart.

As I am mentioned in the chart, I want to add some informations that FloppyB and Outsider may want to comment:

POIS type name: Mytelase and lecithin type

Relief method description: 10mg mythelase + lecithin right after orgasm (within the first minute is the best). Then repeat once a day (during lunch because eating trigger pois symptoms).

Symptoms :
- psychological: concentration, vision problems and insomina (always), memory (3-4 days), social skills (4-5days), bad mood (3-4 days), stress (3)
- physical: red eyes (4-5days), intense fatigue (3-6days), easily fatigue at sport (2 days)

Possible reasons for effectiveness: the vagus nerve is involved for sure but Outsider can probably answer this better than me.

POIS worsen by: hot shower, porn

No relief with: saw palmetto, homeotherapy

Other comment: If you have chrnoicle concentration, vision problems and insomina mytelase might help. Fasting delay the symptoms.

Which everyone a good week,

POISse

[Quantum]

Thanks POISse for your added information !   ( Thanks to Limejuice too for his comment)

POISse, I will try to see if that fits with FB experience, and see if there is some pattern for your small group... but unfortunately, Outsider have been inactive here for some months now.  Maybe FB could comment directly here if he sees some common point with your experience.  In the meantime, I will try to search on forum posts to see what can be confimred from past posts.

I have already done so for the "hot shower" worsening, and it is interesting to note that both Outsider and FB have reported the same as you !  It is not 100% specific, as other POIS sufferers has the same problem, but all have not tried Mytelase and lecithin neither, so let's assume for now, there is a tendency that shows that those who are relieved by Mytelase seems to have their symptoms worsened by hot showers, especially on head and neck region ( as written by Outsider).  This is not the case for all POISers, others have their symptoms worsened by cold showers instead ( ref: Mishlen), or no effect from neither hot or cold ( like myself).  Is that the first pattern my chart would have help to find? Maybe!  Unless some member who has relief with Mytelase share that he never had problems with hot showers.

This hot shower search have helped me to find a possible link between two groups.  Another member, hurray, who has the hot shower problem, says he is relieved by fenugreek, which is a good source of choline.... Choline, lecithin, Mytelase, vagus nerve stimulation, all goes in the direction of increasing the cholinergic side of the nervous system, and for sure is linked to helping muscle functions and cognitive functions.  This would maybe show that the fenugreek group and the Mytelase/lecithin group is the same type of POIS, where the main physiological effect is a cholinergic deficit... more confirmations by members would be needed, but this is possible.  .  I would for sure like to receive feedbacks from members who have relief with fenugreek, that would help to clarify if this could be seen as the same type.

As a counter-example, I have no problem with hot showers, and no cognitive symptoms at all.  I am not part of this type for sure.

Thanks again POISse for your dynamic contribution !

[demografx]

I would for sure like to receive feedbacks from members who have relief with fenugreek, that would help to clarify if this could be seen as the same type.

For fenugreek archived posts @ POISCenter & NSF, put these 2 (separate searches)  in your Google search box:

• fenugreek pois site:http://poiscenter.com

• fenugreek pois site:http://thenakedscientists.com

•• Keep the above spacing intact

[demografx]

Thanks for compiling this!  No doubt a large step forward to have this information in one place. Feel free to delete this msg if it muddys the thread.

Muddy??? It  M A K E S  the thread!

[b_jim]

Amazing job Quantum!

POIS type name: Taurine Type
Reference member(s) b_jim
relief method description: 600mg taurine each day
effect on severity and duration of POIS: 90% (from 3 to 0/1 day if zero sugar)
possible reason for effectiveness: Gaba?Dopamine?
POIS symptoms ( mainly): brain fog, muscle weakness, muscle twitching
POIS worsen by: sugar! (triple duration and severity)
No relief with : B3, garlic, fenugreek, olive oil, gluten free diet, anti-hista…
Other comments and information: type : skinny, general anxiety, premature ejaculation, 0 drugs, no smoke, bad alcohol resistance (only drink few red wine).

[demografx]

Amazing job Quantum!

Agreed!

[Quantum]

Amazing job Quantum!

POIS type name: Taurine Type
Reference member(s) b_jim
relief method description: 600mg taurine each day
effect on severity and duration of POIS: 90% (from 3 to 0/1 day if zero sugar)
possible reason for effectiveness: Gaba?Dopamine?
POIS symptoms ( mainly): brain fog, muscle weakness, muscle twitching
POIS worsen by: sugar! (triple duration and severity)
No relief with : B3, garlic, fenugreek, olive oil, gluten free diet, anti-hista…
Other comments and information: type : skinny, general anxiety, premature ejaculation, 0 drugs, no smoke, bad alcohol resistance (only drink few red wine).

Thanks for your kind words, b_jim !

Thanks also for the added data for your POIS type !  I will update my chart accordingly.

I hope that other members cited as reference for a specific type will do the same as you and provide more information on their particular type.

I hope that other members or even non-members reading the forum, that have success with taurine or any other of these type, will share their data so we can refine the chart.

For sure, it is hard to define any trend or pattern if there is only one member in a particular type, but we have to start somewhere, 

[Limejuice]

Here is my information:

POIS type name: Niacin type
Reference member(s)   Limejuice
relief method description: Niacin taken on empty stomach, waiting for the flush to happen before ejaculation.  Usually doses from 100mg to 300mg, but varies. 
effect on severity and duration of POIS: 50%
possible reason for effectiveness: data to be added
POIS symptoms ( mainly): brain fog (difficulty thinking and slow response time), impaired memory, headache, physical fatigue (low energy level), runny nose, insomnia
POIS worsen by: hot showers, starches and simple carbs
No relief with : data to be added
Other comments and information:

[Quantum]

Thank you for your input, Limejuice ! I will add you as a reference member in the Niacin type and mix you information with what is already there.  I will try to see if Daveman share some of these, like the hot shower problem, and the sugar effect, and try to see if it is a "group" effect, present in all those who are relieved by Niacin.

Interesting to note that the worsening by refined sugar is present in more than one type of POIS ( for now, at least in the Niacin type and Taurine type).  It may be common to all types, some more input by members would be needed in order to clarify that.

Considering that Daveman has stiffness and pain in muscles and joints has a major symptom, I would be interested to know, Limejuice, if you have these as well ?

It may happen that the specific symptoms to a particular group may shrink down to a few ones.  For now, I leave more information, and will try to make it more specific if possible.

[Limejuice]

Considering that Daveman has stiffness and pain in muscles and joints has a major symptom, I would be interested to know, Limejuice, if you have these as well ?

It may happen that the specific symptoms to a particular group may shrink down to a few ones.  For now, I leave more information, and will try to make it more specific if possible.

Yes, I do experience joint cracking and mild muscle stiffness. It isn't as severe as the other symptoms but it does occur (as a slight nucence). Thanks!

[Spartak]

Great topic!
Thank you Quantum

[certainlypois2]

for histamine type
my main symptoms; brain fog,fatigue,concentration/attention
occasional symptoms; flu like symptoms, burning sensation in lower back

[Quantum]

for histamine type
my main symptoms; brain fog,fatigue,concentration/attention
occasional symptoms; flu like symptoms, burning sensation in lower back

Thanks, CP2  for the data !   I have added this to the Histamine POIS type.  It would be great to hear from other members of that same type.

Do you have tried anything that made your POIS worst ?  Or any treatment you have tried and that had no effects ?


Eventually, with this chart, I would really love that there would be at least 3 members for all of the POIS types in the chart, so that they can talk together and find what is specific for their type of POIS.  That may take a long time to get there, but, it is better than just sit, doing nothing but waiting.



Thanks to Spartak too for his positive comment !

[certainlypois2]

for histamine type
my main symptoms; brain fog,fatigue,concentration/attention
occasional symptoms; flu like symptoms, burning sensation in lower back

Thanks, CP2  for the data !   I have added this to the Histamine POIS type.  It would be great to hear from other members of that same type.

Do you have tried anything that made your POIS worst ?  Or any treatment you have tried and that had no effects ?


Eventually, with this chart, I would really love that there would be at least 3 members for all of the POIS types in the chart, so that they can talk together and find what is specific for their type of POIS.  That may take a long time to get there, but, it is better than just sit, doing nothing but waiting.



Thanks to Spartak too for his positive comment !

When i was doing dessensitization i remember once my symptoms got worse when i went to a higher concentration.
 i believe it gets worse but i am not sure, when i come down from caffeine high.
Also, i dont use antihistamines(claritin and zyrtec) (10mg or 5mg) every day like happy2 because it gives me memory problems. There were just to manytimes while using those drugs that i couldnt remember something while i was having a conversation. I am currently trying 2.5 mg daily. 

I have not gotten a chance to properly test supplements because my orgasms have been to frequent. I just started really testing supplements, i should be able to update you soon.

[Quantum]

Thansk again CP2 for your active participation!

 Your mention of caffeine si ringing a bell for me - I think many POISers made mention of caffeine, both as helping them or making them worst.  I think it could become a good marker that helps sorting groups apart.  Just like like hot showers/cold showers seems to also be a good marker, and also benefits/no benefits from niacin.   By identifying more and more of those significant markers, we may find similarities and differences between groups. 

As for me, I can say that I am totally intolerant to caffeine, both for stomach acidity, as well as for its amplification of my anxiety symptoms, and somehow, of my aggressive reactions, when in POIS.  This is why, with time, I have found that green tea is better for me - less caffeine, and the L-Theanine that is also contains is calming, tempering the anxiety exacerbation of caffeine.

[Quantum]

If anybody is aware of a member that could be added as a reference member to any of the POIS types of the chart, let me know, along with links to the post(s) on the forum where this member have written about his relief by a particular method ( which define, in my chart, the belonging to a particular group, see initial post of this thread for details about this )


The more members we will have in any specific group, the easier it will be to find the subtle differences that are particular to this group.  That's the first step in trying to see how many POIS types, in fact, there are, and what is the best way to relieve each of these types. 

[victor.kons]

POIS type name: Niacin type
Reference member(s)   victor.kons
relief method description: 0.5 ml of Xanthinol Nictotinate injection and O after 10 mins or 150mg pure Niacin in tablets and O after the flush or Xantinol Nicotinate in tablets 450 mg and O after the flush.
effect on severity and duration of POIS: 100%
possible reason for effectiveness: data to be added
POIS symptoms ( mainly): brain fog (difficulty thinking and slow response time), impaired memory, headache, physical fatigue (low energy level), insomnia
POIS worsen by: long sleeping time, active physical training
No relief with : data to be added
Other comments and information: