Author Topic: Mast Cell Activation Syndrome  (Read 27627 times)

Muon

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Re: Mast Cell Activation Syndrome
« Reply #285 on: September 23, 2020, 08:30:03 AM »
Anatomy and Physiology of Erection, Ejaculation, and Orgasm

"Through activation of specific protein kinases, protein phosphorylation leads to opening of potassium channels, closing of calcium channels".

"While these are similar between genders, in men there is additional activation in the periaqueductal gray matter."

Additional activation may lead to additional activation of glia and may explain bias of gender aside from ejaculate/mast cell dynamics.

Ideas: https://scholar.google.com/scholar?hl=nl&as_sdt=0%2C5&q=+periaqueductal+gray+matter+glial&btnG=
« Last Edit: September 23, 2020, 08:34:19 AM by Muon »

Journey

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Re: Mast Cell Activation Syndrome
« Reply #286 on: September 23, 2020, 11:20:41 AM »
Anatomy and Physiology of Erection, Ejaculation, and Orgasm

"Through activation of specific protein kinases, protein phosphorylation leads to opening of potassium channels, closing of calcium channels".

"While these are similar between genders, in men there is additional activation in the periaqueductal gray matter."

Additional activation may lead to additional activation of glia and may explain bias of gender aside from ejaculate/mast cell dynamics.

Ideas: https://scholar.google.com/scholar?hl=nl&as_sdt=0%2C5&q=+periaqueductal+gray+matter+glial&btnG=
U say it's why more men than women got POIS?
INTP, 19 y.o. aware of POIS since 2019 when realized by abstaining that O/WD gives POIS, likely had it since puberty, fatigue, brainfog, clumsier, slower thinking/processing, voice volume goes down, sometimes harder to look in eyes, lower stamina/strength

Muon

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Re: Mast Cell Activation Syndrome
« Reply #287 on: September 23, 2020, 11:32:36 AM »
U say it's why more men than women got POIS?

Yes that's what I meant with bias of gender. I'm throwing ideas around, don't take them as fact.

hurray

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Re: Mast Cell Activation Syndrome
« Reply #288 on: September 23, 2020, 05:07:58 PM »
Role of inflammation in the pathogenesis and treatment of fibromyalgia

" Milnacipran, a dual reuptake inhibitor, acts its therapeutic effect partly by targeting glial activation and thereby inhibiting neuroinflammation."

Glial cells

"Furthermore, astrocytes release gliotransmitters such as glutamate"
Milnacipran blocks NMDA receptors. Glutamate receptor activation leads to mechanisms related to intracellular calcium concentration. Also I'm not surprised if (micro)glia crosstalk with mast cells in POIS.

Check education and intelligence polls:
"Recent publications have proposed that the number of glial cells in the brain is correlated with the intelligence of a species."

There might be a link with testosterone somewhere in this story. Mast cells respond to T so that may shutdown communication or it affects glia directly somehow. I haven't looked into literature for the neuroendocrinology of glial cells.

That's an interesting chain of thought, Muon. Milnacipran's inhibition of NMDA receptors could help to explain why milnacipran works as it does.

Muon

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Re: Mast Cell Activation Syndrome
« Reply #289 on: September 24, 2020, 06:18:42 AM »
Role of inflammation in the pathogenesis and treatment of fibromyalgia

" Milnacipran, a dual reuptake inhibitor, acts its therapeutic effect partly by targeting glial activation and thereby inhibiting neuroinflammation."

Glial cells

Thanks for that Muon, that's more evidence showing that milnacipran can play an anti-inflammatory role.

"Mast cells, glia and neuroinflammation: partners in crime?"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930370/

More stuff here:
https://scholar.google.nl/scholar?start=0&q=mast+cells+glia&hl=nl&as_sdt=0,5

Muon

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Re: Mast Cell Activation Syndrome
« Reply #290 on: September 24, 2020, 06:39:24 AM »

My excellent doctor found a POIS study using Cromolyn on Pubmed. He said it was only 4 patients and the drug helped only half of them. He prescribed Nalcrom to me to try for a month. I had to have the pharmacy order it because it's not commonly used in Canada. I'll have it in the next day or two to try out and I'll report back. It's very expensive too but luckily my insurance covered it. A 4 week supply was over $400.
My POIS doctor gave me Nalcrom for two months. I hope it will help.
Nalcrom did not help me.

You could try palmitoylethanolamide (PEA) since CBD helped you.

Muon

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Re: Mast Cell Activation Syndrome
« Reply #291 on: September 24, 2020, 10:05:27 AM »
Food for thought:

Is POIS a subtype of MCAD that activates glia? Or is POIS some sort of glia activation disorder which may be primary or secondary and crosstalk with mast cells leading to secondary MCAD?

https://www.reddit.com/r/POIS/comments/j4jej1/research_papers_and_articles/
« Last Edit: October 04, 2020, 02:34:26 PM by Muon »

Vandemolen

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Re: Mast Cell Activation Syndrome
« Reply #292 on: October 08, 2020, 06:54:05 PM »

You could try palmitoylethanolamide (PEA) since CBD helped you.
I already tried that years ago but it did not help me. But thanks.
POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.

Muon

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Re: Mast Cell Activation Syndrome
« Reply #293 on: October 09, 2020, 07:27:18 AM »
« Last Edit: October 13, 2020, 02:18:43 PM by Muon »

Muon

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Re: Mast Cell Activation Syndrome
« Reply #294 on: October 17, 2020, 10:24:39 AM »
Scroll all the way down to table 1 and 2:
Cardiovascular symptoms in patients with systemic mast cell activation disease

Demografx

Demo's open heart surgery:
Muon:"What kind of cardiac symptom(s) led up to this surgery?"
Clogged arteries, arrhythmia, chest pain.

Using table 2 above to look for potential candidates:

Atherosclerosis: Tryptase, Heparin, IL-8, CCL-5, IL-1b, IL-4, IL-6, CCL2, CCL3, CCL4, TNF-a, VEGF, FGF-2, FGF-7.
Atherosclerosis+heart failure: Tryptase, IL-4, IL-6, TNF-alpha, FGF-2, FGF-7.
Heart failure: Histamine, Tryptase, Chymase, Platelet activating factor, IL-4, IL-6, IL-10, TNF-alpha, FGF-2, FGF-7, TGF-b.

https://academic.oup.com/view-large/127906878
Correlation Between T Level and Inflammatory Markers in Hypogonadal Men, low T:
Adiposity: high CRP, IL-6
Metabolic: high CRP, insulin
Normal pop: high CRP, fibrinogen, oxidative stress
Investigation into cancer: high WBC
Hypogonadism: High TNF-a, CCL3, CCL4
Heart failure: High IL-1b, TNF-a, IL-6

https://academic.oup.com/view-large/127906879
Effect of T Administration on Inflammatory Markers:

Hi there,

I think i have a form of POIS. I can't diagnose it really and this would be a great place to talk about it...  I am a fit bloke, 25years old. I can be feeling energetic and after an erection i can lose all my energy. If i have an orgasm i can feel absolutely debilitated. I slept all through the night and woke up at 7am, had an orgasm and slept until 3pm. even after all that sleep(16+hrs) i feel exhausted and i feel light headed and feint if i exercise. i fear i will have a heart attack.

I try to abstain a lot. I can abstain for a week or 2 and feel great. exercise a lot and then if i have an orgasm i won't be able to play sport safely for a week. my heart feels like its tired all day. my heart rate escalates for the proceeding days(5-7) and i become exhausted so quickly. Mentally i feel ok except tired. a lot of the time after i get sick very easily. My immune system suffers.

i guess im just wanting to know if this is normal or not. my resting heart rate for the days after an orgasm is like 76-82bpm.. and during abstinence its like 72-76bpm..

Guess i just want an explanation and if anyone knows anything i can try to help out

heartPois

Feint if exercising = hypotension? Compensated by increased heart rate?

Two more people with hypotension, check full thread for context, meds could rule out mediators if hypotension is MC driven. If the hypotension isn't immediate then we could be dealing with De-novo formed mediators, which aren't stored but start being generated from scratch upon a trigger.


Do you notice any other health problems besides POIS? (Even with the great lab tests, of course)

Have you tried shaking up your gut around a bit (internet calls it cleanse or detox), for example by doing a 1-2 day fast with only water, coconut oil and minerals? (as an example).

Have you tried for a few days to not eat the eggs and try meat instead?
Or replace wheat grains with rice?
Remove casein/milk products for some time?

I have a tendency of having low blood pressure. I feel my blood pressure drops after an orgasm, which is responsible for my blackouts, headaches, and severe fatigue.

I can't really have meat. I am planning to go on a vegan diet but will continue to have wheat. If I see no improvement then also, I plan on cutting on wheat too. I haven't really tried fasting because I feel that taking more calories helps me reducing general weakness. Also coffee is the only thing which temporarily brings a little relief to me.

Hi Legendary Animal.

I read you have a tendency to hypotension.  This is the first objective symptoms that I have found for my own POIS attacks, years ago !  And not many members report to have it.  So I cannot tell you what to take, but I can share what works for me to normalize my blood pressure in POIS.  It is very important for me, since low blood pressure is one of my worst POIS symptoms - it causes me extreme fatigue, dizziness, severe exercise intolerance, major difficulty to be able to work for 2 or 3 days ( that was a living nightmare !),  heart palpitations, major irritability, and so on.

The first 2 things I have found,  about 25 years ago, were green tea and magnesium.

Green tea is helping me raise my blood pressure (BP) for 4 to 6 hours.  At first, I was drinking commercial iced tea.  But for years now, I use Green Tea extract capsules, because I have now a very healthy diet, which also helps with POIS, so I do not drink sugary drinks anymore. The green tea capsules I take are very effective and high quality, with standardized EGCG and standardized polyphenols, which are the antioxidants in it  ( I use the Jamieson ones - I have no commercial link with them - the one I use are these:  https://www.amazon.ca/Jamieson-Green-Tea-Phytosome-Complex/dp/B001Q8BBFS )  One green tea capsule every 6 hours or so is really helping me to raise my BP. 

Than, the magnesium is also very helping.  I take 50 to 100mg 3 times a day ( still in the jamieson brand - I like their preparation, it is a mix of several natural magnesium salts ).  It helps raise my BP too, and helps with other POIS symptoms too.  With years, I have found that all electrolytes are great to help raise my BP.  .  So I came to use table salt too, which is Sodium chloride. It is very effective to raise BP... I put 2,5 to 3 cc of salt ( 3 cc is the same as 3 ml) in a glass of water and drink it, and take my pressure 20 minutes after... it really helps (  About the salt quantity, here in Canada we use metric measures, and 2,5 to 3 cc, or ml, seems to be the same as 1/4 tbs, but different converters give different results....so I prefer to use ml and cc for accuracy ) .  It is better for me to take less salt, and take more later if needed, than to take too much salt.  But important to note, I have no kidneys issues, and no cardiac issues, and surely not high blood pressure problems, unless I would not take salted water like that, it would be contraindicated, and not safe.

Some potassium, some calcium helps too, but not as much as Sodium chloride and magnesium.  However, when I do physical exercise and sport, I take all of them after, because like in POIS, i get low pressure after, especially when I had sweat a lot.  I lookl like I lose much minerals through sweet ( mine has a very, very salty taste), so I must replenish my electrolytes after.  I take potassium, sodium chloride, magnesium, and calcium, after sport, so I recover much more faster.
During a POIS attack, I aim to get a BP at or over 110/70.   With time, I saw that even at 109/68, I do not feel well and have no energy.  At 112/71,  I am ok.    It usually take 15 to 20 minutes to see the effect of what I have taken on my BP.  I can take some more salty water and other electrolytes after that, if I did not reach my 110/70 mark.
Once my hypotension is under control, I would say that about 75% of my POIS is relieved... and I can live with the rest  ( However, now, my pre-pack take care of 80% to 100% of my symptoms, like explained at https://poiscenter.com/forums/index.php?topic=2090.msg16604#msg16604 )

For 5 years now,, I take my pre-pack before ejaculation, so I do not have hypotension problems anymore.  Green tea, magnesium and potassium are still part of this pre-pack, and I suppose that other components of it, like 5-HTP, helps keep my BP normal, too.

Also, apart from that, I keep in check my B12 and my Iron intake, because a low hemoglobin facilitates hypotension.

See with a health professional if a similar strategy as mine would be safe and useful for yourself.

Hello again. I have POIS with chronic muscle pain, uncomfort in the chest when I swallow food, difficulty tolerating intense exercise, and heat intolerance. All these problems involve palpitations that I can hear.  I’ve passed every blood test my doctor has thrown at me except for the vitamin d 25-hydroxy test. I’ve only gotten referrals for physical therapy and pain management. I requested a referral to see neurology, but my doctor and clinic denied it. It’s been quite difficult to put my focus on each problem individually while focusing on the rest of my life. Does any one know what could be wrong with me chronically aside from POIS?

https://poiscenter.com/forums/index.php?topic=976.0

There are probably more people with cardiovascular symptoms haven't digged much.

Risk of solid cancer:
Risk of solid cancer in patients with mast cell activation syndrome: Results from Germany and USA
« Last Edit: October 17, 2020, 01:41:51 PM by Muon »

Muon

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Re: Mast Cell Activation Syndrome
« Reply #295 on: October 18, 2020, 11:18:04 AM »
This one is interesting, Rupatadine is a PAF antagonist plus antihistamine. Has anyone tried this one?

https://en.wikipedia.org/wiki/Rupatadine
https://en.wikipedia.org/wiki/Platelet-activating_factor