Author Topic: POIS Paper Archive - a list of scientific articles about POIS  (Read 33659 times)

Eliasjoelrivera

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Re: POIS Paper Archive
« Reply #20 on: November 28, 2019, 07:35:23 AM »
New paper:

Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin

interesting article. I think I will be happy to seek treatment to put it into practice. At some point I thought about using testosterone patches. But this method seems more effective. I will start consulting an endocrinologist. thanks for the info.

demografx

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Re: POIS Paper Archive
« Reply #21 on: November 28, 2019, 07:35:58 AM »
Can we know exactly the guy's symptoms?
Email the author?
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS Paper Archive
« Reply #22 on: November 28, 2019, 07:40:19 AM »
I will start consulting an endocrinologist.
An endocrinologist is the *only* physician/medical specialist I consulted who actually helped me.

Ten years ago, I was advised by a Harvard biophysicist friend who pioneered & then developed some successful AIDS treatment, to seek out a *university* based endocrinologist because they are more research-oriented and thus likely to be more open to POIS evaluation & treatment. So I did.
« Last Edit: November 29, 2019, 05:28:09 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: POIS Paper Archive
« Reply #23 on: November 28, 2019, 07:43:22 AM »
Can we know exactly the guy's symptoms?
Email the author?
Sorry I didn't read the full article, yes the patient seems to be suffering from POIS evident by his social withdrawal.

demografx

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Re: POIS Paper Archive
« Reply #24 on: November 28, 2019, 07:52:36 AM »
Thanks, Nas
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: POIS Paper Archive
« Reply #25 on: November 28, 2019, 08:02:49 AM »
So can we suppose that gonadotropin treatment is similar to TRT or should we consider it as a novel treatment with a different mechanism of action?

demografx

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Re: POIS Paper Archive
« Reply #26 on: November 28, 2019, 08:02:56 AM »
Keep in mind that Dr. Waldinger’s first co-author is an endocrinologist. Even 10 years ago, I was successful in persuading my endocrinologist to take me seriously by pointing this out.

As Quantum often suggests, I showed him the Waldinger+endocrinologist article from 2002.
« Last Edit: November 28, 2019, 11:37:42 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS Paper Archive
« Reply #27 on: November 28, 2019, 08:04:03 AM »
So can we suppose that gonadotropin treatment is similar to TRT or should we consider it as a novel treatment with a different mechanism of action?
I would ask an endocrinologist.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS Paper Archive
« Reply #28 on: November 28, 2019, 08:10:36 AM »
I don’t know anything about them (NYU docs sound promising), but I considered a similar online chat with an endocrinologist:
Chat with an endocrinologist:
https://tinyurl.com/rq28vrt
« Last Edit: November 29, 2019, 05:33:31 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: POIS Paper Archive
« Reply #29 on: November 28, 2019, 04:08:45 PM »
My mother, her sister and my grandmother who got health problems all felt better during pregnancy. Take a look at this:
https://en.wikipedia.org/wiki/Human_chorionic_gonadotropin#Reference_levels_in_normal_pregnancy

Theoretically, both desensitization and TRT are able to stabilize mast cells:
https://poiscenter.com/forums/index.php?topic=2301.msg31643#msg31643

By applying hCG they could have expanded his Treg pool by stimulation of androgen receptors. See links about androgens and Tregs inside this thread: https://poiscenter.com/forums/index.php?topic=2891.0

It would be of interest to know what his FOXP3+Treg numbers were before and after hCG treatment. The outcome of this 'treatment' is very encouraging but don't forget that this is only a case report so far and his POIS has not been completely reversed from what I understand despite having a high T level after application.

Some other papers which might be of interest:

Serotonin secretion from rat Leydig cells

Human adrenal cortex hyperfunction due to LH/hCG
« Last Edit: November 28, 2019, 04:39:04 PM by Muon »

Nas

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Re: POIS Paper Archive
« Reply #30 on: November 28, 2019, 04:37:27 PM »
I just want to know what's the difference between hCG and TRT. Because the former is very rare and difficult to obtain and the other is easier but potentially more dangerous for cardiac issues.

Muon

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Re: POIS Paper Archive
« Reply #31 on: November 28, 2019, 04:47:50 PM »
I just want to know what's the difference between hCG and TRT. Because the former is very rare and difficult to obtain and the other is easier but potentially more dangerous for cardiac issues.
In addition to that, what else did it do besides cranking up T?

Nas

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Re: POIS Paper Archive
« Reply #32 on: November 28, 2019, 05:04:38 PM »
I just want to know what's the difference between hCG and TRT. Because the former is very rare and difficult to obtain and the other is easier but potentially more dangerous for cardiac issues.
In addition to that, what else did it do besides cranking up T?
I suspect the mechanism of POIS lies somewhere in their. For example there are many people who suffer from low testosterone but they don't have POIS. So it must be that in the mechanism of testosterone regeneration POIS occurs. Maybe androgen receptors in the brain or the testies.

Eliasjoelrivera

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Re: POIS Paper Archive
« Reply #33 on: November 28, 2019, 05:24:29 PM »
I just took a turn with an endocrinologist, I will present my case with documents taken from poiscenter. I hope to get a successful response and possible treatment. I'm sure he'll send me studies and so on.

demografx

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Re: POIS Paper Archive
« Reply #34 on: November 28, 2019, 05:26:54 PM »
TRT...is...potentially more dangerous for cardiac issues.
Depressing! I had 5-way bypass, open heart surgery...but I won’t blame you for ruining my Thanksgiving, my previous doctor agrees with you. No, that’s not why I fired him ;D
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS Paper Archive
« Reply #35 on: November 28, 2019, 05:28:00 PM »
I just took a turn with an endocrinologist, I will present my case with documents taken from poiscenter. I hope to get a successful response and possible treatment. I'm sure he'll send me studies and so on.
Elias, excellent! Best wishes!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: POIS Paper Archive
« Reply #36 on: November 28, 2019, 05:36:31 PM »
TRT...is...potentially more dangerous for cardiac issues.
Depressing! I had 5-way bypass, open heart surgery...but I won’t blame you for ruining my Thanksgiving, my previous doctor agrees with you. No, that’s not why I fired him ;D
You would love my Egyptian doctor he doesn't seem to think that TRT is bad for you ;D

Muon

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Re: POIS Paper Archive
« Reply #37 on: November 28, 2019, 05:48:34 PM »
I had 5-way bypass, open heart surgery...
What kind of cardiac symptom(s) led up to this surgery? 

demografx

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Re: POIS Paper Archive
« Reply #38 on: November 28, 2019, 05:57:34 PM »
Clogged arteries, arrhythmia, chest pain.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS Paper Archive
« Reply #39 on: November 28, 2019, 05:58:37 PM »
TRT...is...potentially more dangerous for cardiac issues.
Depressing! I had 5-way bypass, open heart surgery...but I won’t blame you for ruining my Thanksgiving, my previous doctor agrees with you. No, that’s not why I fired him ;D
You would love my Egyptian doctor he doesn't seem to think that TRT is bad for you ;D
Yes!!!! What’s his phone number? Hurry!!!!!            ;D
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business