Author Topic: Milnacipran - completely stopping my brain fog  (Read 6489 times)

demografx

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Re: Milnacipran - completely stopping my brain fog
« Reply #165 on: September 23, 2020, 03:17:15 PM »
Link doesn't work Demo. It redirects me to the login screen.

Yes, Muon, that’s the NSF login screen. In my preceding post, I’m suggesting the search can be done

• at Naked Science Forum as a member (many POISCenter members are also NSF members)

• at Google

Sorry for the confusion.
« Last Edit: September 23, 2020, 03:20:10 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #166 on: September 23, 2020, 03:55:19 PM »
Role of inflammation in the pathogenesis and treatment of fibromyalgia

" Milnacipran, a dual reuptake inhibitor, acts its therapeutic effect partly by targeting glial activation and thereby inhibiting neuroinflammation."

Glial cells

Thanks for that Muon, that's more evidence showing that milnacipran can play an anti-inflammatory role.

"Mast cells, glia and neuroinflammation: partners in crime?"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930370/

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #167 on: September 23, 2020, 04:13:27 PM »

If anyone is interested in my pre-POIS-treatment testosterone results, I posted 5,000 times @ https://www.thenakedscientists.com/forum/index.php?action=pm;f=outbox
so the results might be found there or with Google.

There's a lot of really useful information on the old forum  :) It takes a bit more digging to find things, but it's worth it.

Here's page 1:

https://www.thenakedscientists.com/forum/index.php?topic=6576.0

demografx

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Re: Milnacipran - completely stopping my brain fog
« Reply #168 on: September 23, 2020, 04:14:51 PM »
Thanks, hurray!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: Milnacipran - completely stopping my brain fog
« Reply #169 on: September 24, 2020, 09:13:45 AM »
You could test this hurray:

Glia and Mast Cells as Targets for Palmitoylethanolamide, an Anti-inflammatory and Neuroprotective Lipid Mediator

Clinical studies demonstrating efficacy of palmitoylethanolamide:

Ref

I bet fibromyalgia is probably mast cell and/or glia driven low grade chronic inflammation.
« Last Edit: September 24, 2020, 10:04:46 AM by Muon »

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #170 on: September 25, 2020, 07:48:12 AM »
Palmitoylethanolamide sounds like it has good potential, Muon. However, to see if it worked for POIS, I would have to stop taking milnacipran temporarily, otherwise I would have no way of know if palmitoylethanolamide was effective or not.

I'm not keen on risking another POIS episode  :)


Muon

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Re: Milnacipran - completely stopping my brain fog
« Reply #171 on: September 25, 2020, 08:51:31 AM »
Fair enough hurray.

LookingForACure

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Re: Milnacipran - completely stopping my brain fog
« Reply #172 on: October 02, 2020, 06:13:08 PM »
I recently started seeing a psychiatrist and I asked him about milnacipran. He said that it could be a good option for me down the line as an adjunct to my current medication bupropion, which has helped my depression but done nothing for my POIS. So I expect to be able to trial milnacipran in a few months and add some more data here!  I have had fairly good responses to various drugs in the past, namely adderall, caffeine, and nicotine, so it seems fairly plausible that the medication route is promising for me.

Hurray, I have looked through your history and think our POIS cases are almost identical, which is one reason I am so interested in trying this medication. I too have predominantly cognitive symptoms - my sole physical symptom is hives during sex/masturbation (and possibly slight muscle weakness) - and struggle with social situations during POIS. My social issues were what led to me identifying my POIS, and would probably be my most debilitating symptoms if I wasn't in a particularly intellectually demanding job.

I find it interesting that the effects of milnacipran on your POIS are acute - most antidepressants take weeks to months to take effect. Milnacipran, from my research seems to be faster-acting (on the order of one week). This is still a far cry from most drugs taken for acute effects, like adderall. Pharmacology is weird though, and we barely understand how any of these drugs work. So maybe we shoudn't overthink things  :). I wonder if daily milnacipran use would nullify the effects on POIS? I still have moderate brain fog some of the time outside of POIS, so I may have to try this.
« Last Edit: October 02, 2020, 06:35:35 PM by LookingForACure »

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #173 on: October 03, 2020, 02:24:30 PM »
I recently started seeing a psychiatrist and I asked him about milnacipran. He said that it could be a good option for me down the line as an adjunct to my current medication bupropion, which has helped my depression but done nothing for my POIS. So I expect to be able to trial milnacipran in a few months and add some more data here!  I have had fairly good responses to various drugs in the past, namely adderall, caffeine, and nicotine, so it seems fairly plausible that the medication route is promising for me.

Hurray, I have looked through your history and think our POIS cases are almost identical, which is one reason I am so interested in trying this medication. I too have predominantly cognitive symptoms - my sole physical symptom is hives during sex/masturbation (and possibly slight muscle weakness) - and struggle with social situations during POIS. My social issues were what led to me identifying my POIS, and would probably be my most debilitating symptoms if I wasn't in a particularly intellectually demanding job.

I find it interesting that the effects of milnacipran on your POIS are acute - most antidepressants take weeks to months to take effect. Milnacipran, from my research seems to be faster-acting (on the order of one week). This is still a far cry from most drugs taken for acute effects, like adderall. Pharmacology is weird though, and we barely understand how any of these drugs work. So maybe we shoudn't overthink things  :). I wonder if daily milnacipran use would nullify the effects on POIS? I still have moderate brain fog some of the time outside of POIS, so I may have to try this.

Hi, LookingForACure.

When I have taken sertraline (an SSRI) in the past, the effects gradually increased for about 2 weeks before stabilizing. Milnacipran, however, acts very quickly for me, and I think the same is true for drop247 who has posted some detailed reports of his own milnacipran use in this thread. As you say, there are a lot of unknowns regarding the pharmacology of certain drugs  :)

It's encouraging that your symptoms are close to mine - it would hopefully increase the probability that milnacipran would help with your POIS too. Like you, I really struggle socially when I am in POIS. It is a tremendous relief to not have to deal with that any more.

Milnacipran is quite difficult to get hold of in most countries - if you are in the US, you may be able to get Savella on prescription (but it's expensive!), and some European countries prescribe Ixel. I use an Indian generic version of milnacipran called Milza.

LookingForACure

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Re: Milnacipran - completely stopping my brain fog
« Reply #174 on: October 03, 2020, 10:58:10 PM »

Hi, LookingForACure.

When I have taken sertraline (an SSRI) in the past, the effects gradually increased for about 2 weeks before stabilizing. Milnacipran, however, acts very quickly for me, and I think the same is true for drop247 who has posted some detailed reports of his own milnacipran use in this thread. As you say, there are a lot of unknowns regarding the pharmacology of certain drugs  :)

It's encouraging that your symptoms are close to mine - it would hopefully increase the probability that milnacipran would help with your POIS too. Like you, I really struggle socially when I am in POIS. It is a tremendous relief to not have to deal with that any more.

Milnacipran is quite difficult to get hold of in most countries - if you are in the US, you may be able to get Savella on prescription (but it's expensive!), and some European countries prescribe Ixel. I use an Indian generic version of milnacipran called Milza.

I am hopeful! Milnacipran is expensive, and does not seem to be FDA approved for depression, which is my diagnosis. As a result, insurance likely will not cover it. However, I will pay any amount of money for relief from POIS. My lost earning potential alone from this disease is staggering, even ignoring the misery of dealing with it.

Drop247, I see that you have experienced significant but not complete relief from your POIS - have you considered trying a higher dose, such as 50 mg?


Iwillbeatthis

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Re: Milnacipran - completely stopping my brain fog
« Reply #175 on: October 07, 2020, 03:11:12 PM »
Don't order from https://aipctshop.com/ its been six weeks now and still haven't received, the tracking never worked at all and they said it could be lost and now have reshipped a new package for me but I don't know if this is true or not... Either way its pretty frustrating

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #176 on: October 07, 2020, 04:13:05 PM »
Don't order from https://aipctshop.com/ its been six weeks now and still haven't received, the tracking never worked at all and they said it could be lost and now have reshipped a new package for me but I don't know if this is true or not... Either way its pretty frustrating

That's pretty disappointing, Iwillbeatthis, sorry to hear about your experience.

I placed a first order with that pharmacy last month to see if they were any good. My usual pharmacy was out of stock of milnacipran. A week later, I got a letter from Parcelforce asking me to pay a customs charge. I was very surprised that it arrived so quickly, other orders have taken considerably longer. The pharmacy charged me $30 for "Express Mail", so maybe that's why.

I wasn't very happy about the customs charge, but I logged onto Parcelforce's site and paid it, and the parcel arrived shortly afterwards. I haven't tried the milnacipran they sent me yet, so I can't comment on that.

I'd guess that they will send a second parcel out as promised. I had a parcel from a different pharmacy take 2 months earlier this year - however, I had a proper tracking number from them, so I knew what was happening. The best case scenario is that you may end up with two parcels  :)
« Last Edit: October 07, 2020, 05:23:10 PM by hurray »

Nas

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Re: Milnacipran - completely stopping my brain fog
« Reply #177 on: October 07, 2020, 06:02:38 PM »
Don't order from https://aipctshop.com/ its been six weeks now and still haven't received, the tracking never worked at all and they said it could be lost and now have reshipped a new package for me but I don't know if this is true or not... Either way its pretty frustrating
Yup, another cargo company totally xxxxxxx up an important delivery and you can't even get your money back.
« Last Edit: October 07, 2020, 07:42:37 PM by demografx »

certainlypois2

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Re: Milnacipran - completely stopping my brain fog
« Reply #178 on: October 07, 2020, 09:35:51 PM »
Don't order from https://aipctshop.com/ its been six weeks now and still haven't received, the tracking never worked at all and they said it could be lost and now have reshipped a new package for me but I don't know if this is true or not... Either way its pretty frustrating
My tracking from them through USPS says its in newyork going through customs. My order was about three weeks ago. I ordered two months worth I hope customs don't get suspicious.  There is insurance in the shipping pay, did they give you new tracking.  It was a pain trying to use bitcoin to pay them.
When they did not send my order right away, they were pretty responsive in telling me that they can send it right away if I converted my order to all 50 mg, since there was a shortage of 25 mg.
« Last Edit: October 07, 2020, 09:41:15 PM by certainlypois2 »

certainlypois2

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Re: Milnacipran - completely stopping my brain fog
« Reply #179 on: October 07, 2020, 09:38:07 PM »
Hurray, what is the name of the pharmacy they sent you.
« Last Edit: October 07, 2020, 09:41:34 PM by certainlypois2 »