Author Topic: Milnacipran - completely stopping my brain fog  (Read 98581 times)

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #200 on: November 01, 2020, 01:35:31 PM »
It still works for me.

Have you tried the new brand.

Not yet, certainly. I'll try it soon and post a report.

Laotzu1980

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Re: Milnacipran - completely stopping my brain fog
« Reply #201 on: November 03, 2020, 02:50:22 AM »
I am about to order Savella (Milnacipran) from AIPCT online pharmacy. Highly skeptical, but at least a few of you have tried them and received your order.

I wonder if other members are trying it too and can report back with their results...

Cheers

Laotzu1980

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Re: Milnacipran - completely stopping my brain fog
« Reply #202 on: November 03, 2020, 03:01:39 AM »
Hurray, are you able to test the one from AIPCT?

If you don't test it until you run out of this box, you may find it doesn't work, and you will be stuck with no option? Isn't it better to find out now so you can pre-order a new box from elsewhere if it doesn't work and receive it in time before your current box which works, runs out.

That pharmacy seems sketchy, their phone number doesn't work, he emailed me back instantly though with decent English which is comforting - but there are so many counterfeit drugs around, who knows... Somehow you have had luck with that other place. Glad it's still working for you. :-)

Laotzu1980

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Re: Milnacipran - completely stopping my brain fog
« Reply #203 on: November 03, 2020, 03:10:30 AM »
I have written 2 posts above and don't want to bombard anyone, but a quick question whenever you have time Hurray... :-)

These kinds of (anti-depressent) drugs normally take days, or weeks to kick-in. Yet, didn't you say that the very first time you took it, and O'd an hour or so afterwards, that it worked for you? That means the drug worked almost immediately for you, like a Diazepam/Valium. Had you taken it for a few days in a row before you tried to O, or you just took it the first time, O'd, and it worked like magic?

Lastly, if you are open to share, otherwise no need, but what purpose was that drug prescribed for, and if it was prescribed, the assumption is that the drug would be available in the country that the doctor prescribed it - but you had to buy it in India? A bit confused about that.

Thanks again for all the info.

Quantum

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Re: Milnacipran - completely stopping my brain fog
« Reply #204 on: November 03, 2020, 09:43:38 PM »
I have written 2 posts above and don't want to bombard anyone, but a quick question whenever you have time Hurray... :-)

These kinds of (anti-depressent) drugs normally take days, or weeks to kick-in. Yet, didn't you say that the very first time you took it, and O'd an hour or so afterwards, that it worked for you? That means the drug worked almost immediately for you, like a Diazepam/Valium. Had you taken it for a few days in a row before you tried to O, or you just took it the first time, O'd, and it worked like magic?

Lastly, if you are open to share, otherwise no need, but what purpose was that drug prescribed for, and if it was prescribed, the assumption is that the drug would be available in the country that the doctor prescribed it - but you had to buy it in India? A bit confused about that.

Thanks again for all the info.

Hi Laotzu,
I do not take milnacipran, and will not neither, but just a comment about your question above.  The anti-depressant drugs effect, as you say, may take weeks to fully develop.  But it is not known, up to now, what in this drug may be beneficial in POIS.  So, its benefits may not be linked to the anti-depressant effect.  Other effects show more rapidly.  For example, gastrointestinal side-effects of many anti-depressant will start within hours of the first dose, which is not surprising, because 90% of the serotonin in the body is in the guts - just a small portion is in the brain.  So, some unknown effect could be beneficial against POIS and brain fog, and this effect could theoretically start right away, just like some side effects do. 

Maybe, eventually, a POIS study will try some specific medication in POIS, and see when, and hopefully, how, they are useful in POIS.  Milnacipran may be one day tested in such a study.  Till then, we have to stay open to anecdotal results, and try to learn from them as much as possible.
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swell

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Re: Milnacipran - completely stopping my brain fog
« Reply #205 on: November 03, 2020, 09:44:50 PM »
I think it makes sense for an SNRI to be helpful for POIS, specially if symptoms are mental and behavioral only.  I think at the root of POIS is emotionally harmful memories as a child (specific to ejaculation), those memories may it be abuse, event(s), accident(s), painful episode(s), over a period of time, hard-wire neural circuits atypically, and as child grows they manifest into various disorders, POIS being one - a disorder centered on ejaculation. 

In my view SNRI would counter the symptoms to an extend, however if your POIS has manifested into a lot more systemic effects all over your body, SNRI's efficacy would have certain limitations. But I think SNRI is a good Rx medical approach to detach you from trauma provided you continue the medication daily, and you take certain precautions (which sometimes docs forget) i.e. monitoring your heart-rate, BP, temps, and weight.
« Last Edit: November 03, 2020, 09:48:30 PM by swell »
POIS Free, 2+ yrs (occasional/predictive lapses)
Pois symptoms: Peripheral (Skin: Urticaria, dryness, pale blotchy skin), Exasperation of: [Nerve weakness, Muscle weakness + Mental (CNS: Brain Fog, Irritation, Isolation, Speech lethargy, Anxiety)].
Other conditions: ASD, ADD, GA

Journey

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Re: Milnacipran - completely stopping my brain fog
« Reply #206 on: November 04, 2020, 05:22:42 AM »
I think it makes sense for an SNRI to be helpful for POIS, specially if symptoms are mental and behavioral only.  I think at the root of POIS is emotionally harmful memories as a child (specific to ejaculation), those memories may it be abuse, event(s), accident(s), painful episode(s), over a period of time, hard-wire neural circuits atypically, and as child grows they manifest into various disorders, POIS being one - a disorder centered on ejaculation. 

In my view SNRI would counter the symptoms to an extend, however if your POIS has manifested into a lot more systemic effects all over your body, SNRI's efficacy would have certain limitations. But I think SNRI is a good Rx medical approach to detach you from trauma provided you continue the medication daily, and you take certain precautions (which sometimes docs forget) i.e. monitoring your heart-rate, BP, temps, and weight.
Interesting theory can you elaborate more on the POIS painful childhood memory theory have you had one you think may have caused POIS and have you heard other cases, is it possible to rewire the underlaying traumatic memories completely fixing POIS and getting your state of being to what it was before that, I don't remember what could have been traumatic memory that could've caused POIS I think POIS began as my body started producing semen before I don't recall having it. I got mostly cognitive type of symptoms but there are some physical too like different muscle tension in some areas making my walk sort of odd and slowing my reflexes.

swell

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Re: Milnacipran - completely stopping my brain fog
« Reply #207 on: November 04, 2020, 03:16:27 PM »
I would, if you could get me your waking up temperature, fasting glucose, peak glucose, and BP readings.  Though in advance, answering (and I have discussed it in other threads too), in my case I think my painful memories have been due to my own limitations.  I have been very sensitive as a child, severe speech issues, extreme fear, emotionally numb, and big blind spots in thinking i.e. unable to understand certain very basic things, unable to let go of things.  During growing up, I all of sudden one day discovered I had the ejaculatory organ p, and I viewed it as some spider crawling up on me.  I was gripped in intense fear, and I think my family, and doctors tried to allay my fear.  I am not certain of details, but I think it was circumcision procedure after which big thick stitches are put on the p, and somehow I only noticed that I had a penis organ, and those stitches appeared to me as a spider.  All I remember is my ordeals (on the p organ) never ended.  I remember myself yelling in fear as threads from my clothes used to get stuck inside or around the p.  Then I became frightened from the nocturnal emissions.  And all I remember, I used to turn very pale and sick, severe nasal congestion (that was intolerable).  Nasal congestants, steroids, they used to stop working. 

Thanks goodness I did not have much awareness of many things in life, otherwise I would have killed myself instantly as a no brainer, since inability to breath discomfort was intense.  I feared ejaculation and symptoms that ensued.  As years passed, my symptoms became tolerable and I accepted the reality as nobody believed me anyways.  I did not give up my search though, and just few years ago, I found this forum and learnt most importantly that what I was experiencing was real, more people like me.  I have experimenting with various approaches since.  Almost all approaches that Quantum lists in of the pinned threads, I tried them.  nanna1's approach I think is very effective.  My transformational breakthrough happened though after I tried 'bovine naturally dissected thyroid', but since I have been trying so many things, so its foolhardy for me to say that it was x that did it. My research on it, was intriguing, I felt there was a concerted effort (or maybe it was legitimate, I dont know) but I felt a concerted effort to portray it negatively by modern medicine that is pharma influenced. 

About how to re-wire the neural circuits which control mental, behavioral and systemic processes in body (immune system, gut, etc) I think is close to impossible as they get hard-wired as you grow, effectively changing your various 'metabolic' pathways, hormones, neurotransmitters, gene expressions, enzymes, etc.  I do am intrigued about Psylocybin research that claims to successfully reverse underlying causes, but that's a very expensive therapy to try. 

Interesting theory can you elaborate more on the POIS painful childhood memory theory have you had one you think may have caused POIS and have you heard other cases, is it possible to rewire the underlaying traumatic memories completely fixing POIS and getting your state of being to what it was before that, I don't remember what could have been traumatic memory that could've caused POIS I think POIS began as my body started producing semen before I don't recall having it. I got mostly cognitive type of symptoms but there are some physical too like different muscle tension in some areas making my walk sort of odd and slowing my reflexes.
POIS Free, 2+ yrs (occasional/predictive lapses)
Pois symptoms: Peripheral (Skin: Urticaria, dryness, pale blotchy skin), Exasperation of: [Nerve weakness, Muscle weakness + Mental (CNS: Brain Fog, Irritation, Isolation, Speech lethargy, Anxiety)].
Other conditions: ASD, ADD, GA

Iwillbeatthis

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Re: Milnacipran - completely stopping my brain fog
« Reply #208 on: November 04, 2020, 05:30:08 PM »
I would, if you could get me your waking up temperature, fasting glucose, peak glucose, and BP readings.  Though in advance, answering (and I have discussed it in other threads too), in my case I think my painful memories have been due to my own limitations.  I have been very sensitive as a child, severe speech issues, extreme fear, emotionally numb, and big blind spots in thinking i.e. unable to understand certain very basic things, unable to let go of things.  During growing up, I all of sudden one day discovered I had the ejaculatory organ p, and I viewed it as some spider crawling up on me.  I was gripped in intense fear, and I think my family, and doctors tried to allay my fear.  I am not certain of details, but I think it was circumcision procedure after which big thick stitches are put on the p, and somehow I only noticed that I had a penis organ, and those stitches appeared to me as a spider.  All I remember is my ordeals (on the p organ) never ended.  I remember myself yelling in fear as threads from my clothes used to get stuck inside or around the p.  Then I became frightened from the nocturnal emissions.  And all I remember, I used to turn very pale and sick, severe nasal congestion (that was intolerable).  Nasal congestants, steroids, they used to stop working. 

Thanks goodness I did not have much awareness of many things in life, otherwise I would have killed myself instantly as a no brainer, since inability to breath discomfort was intense.  I feared ejaculation and symptoms that ensued.  As years passed, my symptoms became tolerable and I accepted the reality as nobody believed me anyways.  I did not give up my search though, and just few years ago, I found this forum and learnt most importantly that what I was experiencing was real, more people like me.  I have experimenting with various approaches since.  Almost all approaches that Quantum lists in of the pinned threads, I tried them.  nanna1's approach I think is very effective.  My transformational breakthrough happened though after I tried 'bovine naturally dissected thyroid', but since I have been trying so many things, so its foolhardy for me to say that it was x that did it. My research on it, was intriguing, I felt there was a concerted effort (or maybe it was legitimate, I dont know) but I felt a concerted effort to portray it negatively by modern medicine that is pharma influenced. 

About how to re-wire the neural circuits which control mental, behavioral and systemic processes in body (immune system, gut, etc) I think is close to impossible as they get hard-wired as you grow, effectively changing your various 'metabolic' pathways, hormones, neurotransmitters, gene expressions, enzymes, etc.  I do am intrigued about Psylocybin research that claims to successfully reverse underlying causes, but that's a very expensive therapy to try. 

Interesting theory can you elaborate more on the POIS painful childhood memory theory have you had one you think may have caused POIS and have you heard other cases, is it possible to rewire the underlaying traumatic memories completely fixing POIS and getting your state of being to what it was before that, I don't remember what could have been traumatic memory that could've caused POIS I think POIS began as my body started producing semen before I don't recall having it. I got mostly cognitive type of symptoms but there are some physical too like different muscle tension in some areas making my walk sort of odd and slowing my reflexes.

If I were you I would try the Dynamic Neural Retraining System its for retraining the limbic system I think it would help and then maybe also eye desensitization therapy

swell

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Re: Milnacipran - completely stopping my brain fog
« Reply #209 on: November 05, 2020, 02:36:25 PM »
That is actually a very good advice.  I wish they made the knowledge of it free on the internet.


If I were you I would try the Dynamic Neural Retraining System its for retraining the limbic system I think it would help and then maybe also eye desensitization therapy
POIS Free, 2+ yrs (occasional/predictive lapses)
Pois symptoms: Peripheral (Skin: Urticaria, dryness, pale blotchy skin), Exasperation of: [Nerve weakness, Muscle weakness + Mental (CNS: Brain Fog, Irritation, Isolation, Speech lethargy, Anxiety)].
Other conditions: ASD, ADD, GA

Laotzu1980

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Re: Milnacipran - completely stopping my brain fog
« Reply #210 on: November 06, 2020, 07:51:05 AM »
Interesting Quantum. Thank you for that information.

Laotzu1980

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Re: Milnacipran - completely stopping my brain fog
« Reply #211 on: November 07, 2020, 09:01:39 AM »
Interesting, I was watching CNN and I saw an advertisement for Fibromyalgia Tests which listed bullet points of all the symptoms of Fibromyalgia which included: brain fog, poor sleep, anxiety, fatigue and tiredness. These are my exact symptoms, so I am not surprised Milnacipran has helped Hurray with his POIS.

Based on my long battle with extreme POIS I will share one major observation. Quantum has expressed this as well. I have noticed, and this is no exaggeration, that during periods of higher anxiety levels, my POIS is much, much worse. What's really interesting though, is that during periods where I experience no anxiety, and am in a very healthy routine, which includes meditation several times a day, my POIS has periodically been reduced by up to 70-90% (with a prepack of vitamins which I always take) and instead of lasting a few days symptoms may disappear during the first day. This may seem ridiculous, because my POIS is one of the worst here. I literally cannot socialise while in a bad POIS episode, and like clockwork it lasts 2 full days (3 night's sleep).

I imagine that the high cortisol or chemicals released into the body due to stress and anxiety are a primary contributer to my highly sensitive body being unable to deal with its response to orgasm.

Just a thought.
« Last Edit: November 07, 2020, 09:08:51 AM by Laotzu1980 »

Iwillbeatthis

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Re: Milnacipran - completely stopping my brain fog
« Reply #212 on: December 04, 2020, 04:44:36 PM »
I did another test with Milnacipran just now taking it one hour before O, strangely this time it made me on edge and feeling bad for the hour before O, after I had the O I felt much better but this time I had a strange stinging sensation in the prostate during the O and I never had this before. O wasn't pleasurable either more just like a release. Semen also smelt chemically which also never happens probably due to the supplements I'm on.

Iwillbeatthis

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Re: Milnacipran - completely stopping my brain fog
« Reply #213 on: December 04, 2020, 04:59:12 PM »
Another thing to add about Milnacipran is that it makes me always go flacid after the first O, when usually I could go for one or two more. Probably thats a good thing for POISers lol

If you're gonna take Milnacipran I would advise to take only as a one off treatment rather than daily, when I went daily thats when I started to feel much worse from taking it
« Last Edit: December 04, 2020, 05:00:57 PM by Iwillbeatthis »

Iwillbeatthis

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Re: Milnacipran - completely stopping my brain fog
« Reply #214 on: December 05, 2020, 10:15:11 AM »
I did another test with Milnacipran just now taking it one hour before O, strangely this time it made me on edge and feeling bad for the hour before O, after I had the O I felt much better but this time I had a strange stinging sensation in the prostate during the O and I never had this before. O wasn't pleasurable either more just like a release. Semen also smelt chemically which also never happens probably due to the supplements I'm on.

While trying to go to bed I experience some uncomfortable constricted feeling in my head, I have rashes on my chest and face and some veins appear on my forehead. I wake up feeling fine then at 1-30pm then a little stress activates my symptoms a bit but it doesn't feel too overwhleming, I go to buy food and I'm not feeling great but still can speak some what. Now i get home and took two NACS and a drop of oregano oil with olive oil and I'm feeling better.

Either way I recommend this treatment to be tried by everyone as it should probably reduce your symptoms at the least. However for me I will not take it again as I didn't like this latest experience on it and I feel like I react slightly to the drug itself, plus my POIS is already much better than it used to be.

Update : Started to feel bad again and used TDCS Transcranial direct current stimulation now I feel better I'm going to trial just only TDCS the next time I try an O. Theres a lot of scientific studies backing up TDCS for lots of different things like brain injuries or psychiatric conditions so it is worth testing more for POIS
« Last Edit: December 05, 2020, 11:59:18 AM by Iwillbeatthis »

certainlypois2

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Re: Milnacipran - completely stopping my brain fog
« Reply #215 on: December 06, 2020, 12:09:58 AM »
tdcs sounds interesting.

Iwillbeatthis

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Re: Milnacipran - completely stopping my brain fog
« Reply #216 on: December 06, 2020, 12:40:35 PM »
I did another test with Milnacipran just now taking it one hour before O, strangely this time it made me on edge and feeling bad for the hour before O, after I had the O I felt much better but this time I had a strange stinging sensation in the prostate during the O and I never had this before. O wasn't pleasurable either more just like a release. Semen also smelt chemically which also never happens probably due to the supplements I'm on.

While trying to go to bed I experience some uncomfortable constricted feeling in my head, I have rashes on my chest and face and some veins appear on my forehead. I wake up feeling fine then at 1-30pm then a little stress activates my symptoms a bit but it doesn't feel too overwhleming, I go to buy food and I'm not feeling great but still can speak some what. Now i get home and took two NACS and a drop of oregano oil with olive oil and I'm feeling better.

Either way I recommend this treatment to be tried by everyone as it should probably reduce your symptoms at the least. However for me I will not take it again as I didn't like this latest experience on it and I feel like I react slightly to the drug itself, plus my POIS is already much better than it used to be.

Update : Started to feel bad again and used TDCS Transcranial direct current stimulation now I feel better I'm going to trial just only TDCS the next time I try an O. Theres a lot of scientific studies backing up TDCS for lots of different things like brain injuries or psychiatric conditions so it is worth testing more for POIS

Forget what I said everything was only temporary relief I went to the gym last night and in the second half I started to feel symptoms, when I hung from the pull up bar I could feel pain and a weird feeling in the pelvic area 10cm down from bellow button.

Today I was more active than yesterday and I felt symptoms still, I feel like my prostate didn't empty properly during the O which caused semen to go into the bladder. My pelvic area 10cm bellow from bellow button is still sore when I push down on it, it feels like this every time for POIS. From the beginning of my POIS I have always thought it is probably to do with semen irritating the bladder, which then in turn causes issues with catecholamines norepinephrine etc. I had IC before POIS.

I only did this as an experiment as people keep asking me about Milnacipran and I didn't really monitor the other times I tried it so much. Masturbation is a complete waste of time unless you are at a point where you are feeling worse from not masturbating or have a good treatment for it.

Laotzu1980

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Re: Milnacipran - completely stopping my brain fog
« Reply #217 on: December 22, 2020, 03:39:24 AM »
Hurray - are you still having success with Milza?
Do you only take it before 'o' or more often?
How many O's per week do you use it for?
Thanks 🙂

Laotzu1980

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Re: Milnacipran - completely stopping my brain fog
« Reply #218 on: March 24, 2021, 11:47:50 AM »
I find this strange.

Hurray has found a solution which totally removed his POIS. He only takes it before O.

Why are other members not trying this? Only one other member tested it after him and also had some success.

Shouldn't members be all over this potential miracle drug which is only needed prior to O, and not every day?

I'm overseas and it is not available here, but in Australia it is, and I will try it as soon as I return.

Don't others want to give it a try?
« Last Edit: March 24, 2021, 11:49:54 AM by Laotzu1980 »

Iwillbeatthis

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Re: Milnacipran - completely stopping my brain fog
« Reply #219 on: March 24, 2021, 12:23:31 PM »
I find this strange.

Hurray has found a solution which totally removed his POIS. He only takes it before O.

Why are other members not trying this? Only one other member tested it after him and also had some success.

Shouldn't members be all over this potential miracle drug which is only needed prior to O, and not every day?

I'm overseas and it is not available here, but in Australia it is, and I will try it as soon as I return.

Don't others want to give it a try?

Tried it and it wasn't successful for me, but maybe I'm a unique case as my MAO gene mutations are problematic for antidepressants/psychiatric drugs.

But I get your point I think a lot of people in here are just interested in finding/trying their own treatments rather than trying what works for others which might be better in some cases but worse in others. Also there is an overwhelming amount of info on this forum it took me a few years before I started using it properly and trying out the different advice. So I can understand how it can be confusing on what to do/try.
« Last Edit: March 24, 2021, 12:31:16 PM by Iwillbeatthis »