Author Topic: The root couse of POIS Mercury intolerance))leaky gut))Mercury retention))POIS  (Read 28575 times)

Hopeoneday

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« Last Edit: July 10, 2021, 11:49:21 AM by Hopeoneday »
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Igy78

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Re: The root couse of POIS Mercury intolerance))leaky gut))Mercury retention))POIS
« Reply #181 on: September 28, 2021, 01:12:00 PM »
Did not give feedback for a long time, was in hospital in march for 4 days due to eating to much paprika in powder/spice, and i inflamed my pancreas, stomach and liver again. I was on endoscopy and long story short they found chronic erosive gastritis, acute pancreatitis and fatty liver,  was healing from march with gastritis diet and i feel better, here and there orgasms with improvement, but still had spikes of anxiety and depression, but only if i eat carbs. Well recently i cut out all of the carbs and i feel amazing, only when i'm really really hungry i eat bread but after 4-6 hours symptoms slowly coming back,  so carbs are obviously depleting some B vitamins, or pancreas has problems with amylase or liver can not replenish needed vitamins, or stomach is to sensitive for acidic foods, i am on ppi and i sense it , if my stomach is better i have more energy, here and there i fuck up with nutella and kinder bueno, one or two days feeling like shit but it passes. Anyway it will be long journey to heal all that without carbs. But i'm really glad that i am on right track and i do not wasting energy on searhing what is wrong with me and spending a lot of moeny for suplements that did not work. So if you did not visited a gastroenterologist or had an endoscopy my advice is to do all that.
« Last Edit: September 28, 2021, 01:14:20 PM by Igy78 »

BoneBroth

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Re: The root couse of POIS Mercury intolerance))leaky gut))Mercury retention))POIS
« Reply #182 on: September 28, 2021, 01:59:52 PM »
Igy78: Where exactly was the endoscopy done, in the large intestine only? I also made an endoscopy there, but they said it look just fine. I think my problems are in the small intestine (SIBO), but they never look there.
« Last Edit: September 28, 2021, 04:02:40 PM by BoneBroth »

demografx

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Re: The root couse of POIS Mercury intolerance))leaky gut))Mercury retention))POIS
« Reply #183 on: September 28, 2021, 02:27:22 PM »
I had a diverticulitis attack that nearly killed me (inflammation of the intestines).
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

BoneBroth

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Re: The root couse of POIS Mercury intolerance))leaky gut))Mercury retention))POIS
« Reply #184 on: September 28, 2021, 04:07:06 PM »
I just met a guy on a fair last week who showed me before-and-after photograps on the large intestine after some months drinking something called "structured water" made by a machine from Japan. The results were amazing. The intestinal pockets that were showing on the before pictures were gone after some months on the water and the intestine looked like getting in to a young state again.

Igy78

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Re: The root couse of POIS Mercury intolerance))leaky gut))Mercury retention))POIS
« Reply #185 on: September 28, 2021, 04:32:08 PM »
Igy78: Where exactly was the endoscopy done, in the large intestine only? I also made an endoscopy there, but they said it look just fine. I think my problems are in the small intestine (SIBO), but they never look there.

Endoscopy of the stomach, i also did 1 year before that endoscopy of intestines, everything was ok in colon, but in stomach was/is world war 3.

Hopeoneday

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https://pubmed.ncbi.nlm.nih.gov/24898714/
Perspectives in endocrine toxicity of heavy metals--a review

Abstract
An attempt has been made to review the endocrine/hormonal implications of a few environmentally significant metals, viz, lead, mercury, cadmium, copper, arsenic and nickel, in man and animals. Special emphasis has been given to the adrenals, thyroid, testis, ovary and pancreas. Toxic metals can cause structural and functional changes in the adrenal glands. Their effects on steroidogenesis have been reviewed. It has been reported that thyroid hormone kinetics are affected by a number of metallic compounds. Occupational exposure to a few of these metals can cause testicular injury and sex hormone disturbances. Protective effects of a few antioxidants on their reproductive toxicity have also been discussed. Information gathered on female reproductive toxicity of heavy metals shows that exposure to these metals can lead to disturbances in reproductive performance in exposed subjects. Certain metals can cause injury to the endocrine pancreas. Exposure to them can cause diabetes mellitus and disturb insulin homeostasis. The need to develop molecular markers of endocrine toxicity of heavy metals has been suggested. Overall information described in this review is expected to be helpful in planning future studies on endocrine toxicity of heavy metals.
« Last Edit: November 08, 2021, 04:48:33 PM by Hopeoneday »
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Hopeoneday

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I wonder could one poiser be positive on antifibrilin antibodies?

Anti-Fibrillin-1 antibodies are available from several suppliers. In humans, this protein is encoded by the gene FBN1. The protein may also be known as MASS, ACMICD, ECTOL1, FBN, GPHYSD2, asprosin, and epididymis secretory sperm binding protein. The reported amino acid length is 2871 and the expected mass is 312.3 kDa.
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Hopeoneday

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403307/
Glutamate-mediated effects of caffeine and interferon-? on mercury-induced toxicity

(I think that this is the exact mechanism of
how coffe helping me)

Coffee consumption significantly reduced mercury-related toxicity. Of note, caffeine acting through adenosine receptors plays a prominent role in modulating glutamatergic input to various neurons (Fig. 1).

On the other hand, mercury-exposed rats have been shown to exhibit enhanced interferon-? (IFN-?) serum levels as compared to the controls (10). Furthermore, it is claimed that vascular endothelial growth factor and interleukin-6 (IL-6) are released from human mast cells via the stimulation of mercury and disrupt the blood-brain-barrier and permit brain inflammation

Mercury exposure is linked to a shift in the redox status toward oxidative stress. It may enhance lipid peroxidation in all tissues and may have deleterious effects on an organism (1). As MeHg easily crosses the blood-brain barrier, it is highly neurotoxic in exposed human populations (2). Therefore, its cytotoxic effect on neurons is stronger when compared to inorganic HgCl2, even at low levels (3). Eventually, MeHg administration reduces non-enzymatic and enzymatic antioxidants (6).

Mercury has been shown to affect several aspects of glutamatergic signaling (4). In this context, MeHg markedly increases the glutamate concentration at the synaptic cleft by enhancing spontaneous glutamate release from neurons (5). Eventual excitotoxic activity of glutamate resulting from MeHg exposure contributes to neuronal injury. N-methyl-D-aspartate (NMDA) receptor-binding memantine attenuates MeHg-induced neurotoxicity (6). It has also been shown that the HgCl2-induced reduction of cell viability is substantially attenuated by the application of a non-competitive antagonist of NMDA receptors (7). Although mercury-induced neuronal degeneration is suggested to invoke glutamate-mediated excitotoxicity, the underlying mechanisms remain poorly understood

« Last Edit: February 06, 2022, 12:50:51 PM by Hopeoneday »
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Hopeoneday

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Good response from chelation:
https://www.reddit.com/r/POIS_Science/comments/swyndk/pois_is_likely_heavy_metal_intoxication_and/

He had- I got symptoms right off the bat with .25 mg DMPS that went back and forth on round getting better to almost nothing now...
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alerom

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Hi everyone, this is my first post. I have been suffering from POIS for over a year and only connected it to POIS last 4 months.

First of all thank you for everyone that's participated, this forum was a life saver for me. I will write more another time about my story, but quicly i am 33 years old and was perfectly healthy before this happened to me.

I am interested in the mercury/heavy metal theory as this was my first inclin when i got sick. Then 6 months after that I only started getting some relief after taking zeolite which helped with some symptoms. I have for last 2 months implemented a gluten/lectine free diet and have also seen more improvement. Buf i am still not at 100%, i still suffer from fatigue and a pounding heart mainly within 2 days of 0 and the fatigue always lingers with me even outside POIS. But brain-fog has practically dissapeared with the new diet along with fasting.

So I want to try the ACC method, do you guys have a specific brand for ALA? And have you not tried DMSA before or just jumped straight into ALA. I've been on zeolite for 6 months so i reckon that has the same effect as DMSA. I have no amalgam fillings so i'm thinking of just going straight into taking ALA. I obviously don't think the only way to get heavy metal poisoning is through amalgam fillings.

Also apparently there is a liquid zeolite form that penetrates BBB . Thought that could be interesting.

We will get there:)  keeo fighting everyone
« Last Edit: March 03, 2022, 02:52:48 PM by alerom »