I can say that I have a very similar problem as Igy. My POIS is definitely directly related to the gallbladder, its condition and bile acids, but I still cannot fully understand how.
According to the analysis of my shit, I have a little indigestion of fats and according to the ultrasound of the gallbladder, I have a polyp of unknown genesis there (in the area of the biliary neck), I was diagnosed with biliary hypotension.
On the Russian forum there are 2-3 people who have cured their pois by curing the gallbladder (2 people vigorously drove bile, and 1, on the contrary, chose a diet so as not to disturb the gallbladder as much as possible).
I have digestive problems such as
-large gases
- going to the toilet every 3-4 days
and any drugs that at least somehow touch the gallbladder in a special way affect the POIS
-Artishok 30 minutes before meals definitely does better
-If I add milk thistle, my autistic symptoms seem to increase
-If I start adding a handful of nuts 30 minutes before a meal, my stool improves sharply, one day it becomes much better than my illness, sociality improves, brain fog improves, but after 48 hours it gets worse
- if I do not add chips, milk, any unhealthy food to my food - I feel better
- if I drink drugs that relax the muscles of the gallbladder (hymecromone), my POIS becomes much worse and the digestive symptoms intensify, the right side begins to hurt
I also tried a gentle diet for gall, it got a little better, and then immediately a little worse.
If I stop eating foods that stimulate the gall completely, I get worse.
In general, I cannot say what exactly is wrong with my gall and how it affects the POIS, but this is directly related
Apparently, somehow the lack of bile acids kills the intestines.
In general, reading this forum for several years, most of the cure stories are related to the effect on the intestines. That is, there are many conditions that affect the gut and cause POIS. SIBO, MCAS, food allergies, bile problems, acid problems, etc.
I can say that over the course of a year I established a lot of correlations with my gut, a month I ate apples and chicken, then just chicken, food with low histamine, food with low FODMAP, food with low lectins, and I can say with certainty what the condition gallbladder correlates with my POIS.
I'm a little bit stumped because I don't know what to experiment with next. Obviously, I have hypotension and I need to stimulate the flow of bile, but the power of the artichoke is not enough for me, it gets worse on milk thistle, from nuts before eating too, that is, most likely, my intestines cannot withstand pure fatty foods, then how can I to stimulate my gallbladder to test further?
I also tried bile acids, but it seemed to me that it got worse and I stopped the experiment, apparently, I need to carry it out again.
If it is still clear why nuts before meals make it worse (indigestion of fats), but why stimulation with pure bile acids and milk thistle makes it worse, it is completely incomprehensible. Maybe I have an inflamed gallbladder and any injury to it makes it worse, but why then didn't a gentle diet make me better?
And what could be a polyp?
Thanks for reading, good luck everyone.
P.S. I have a polyp of the gallbladder near the duct and on a broad base, but 3 years ago I did not have a polyp, there was a bend of the gallbladder in the same place where the polyp + hypotension, but there was a POIS.
But POIS got worse during this time.
My pois is getting MUCH worse if i smoking right quickly after inhaling(cigarette or e-cig, doesnot matter)