Author Topic: Progecitor's summary  (Read 2530 times)

Progecitor

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Progecitor's summary
« on: April 19, 2021, 02:27:16 PM »
For reference I began to masturbate at the age of 11 (1996) and the first symptom I can remember was IBS (in 1996 or 1997). I think I might have overdone masturbation around the age of 12-13 and it could have lead to POIS, although not certain. I realized that many of my symptoms were related to sexual activity (~2000), POIS exacerbated at the age of 17 (2003) and I developed a serious mental problem due to a distinct symptom (not for disclosure). I discovered the name of the disease in 2018. Found the first acceptable treatment (MACA) in 2020. Even though both SSRIs, SNRIs and tryptophan work about the same way I still have a special problem with them.
I have never taken illegal drugs. I have never smoked. I have never had a relationship or sexual contact with anyone whatsoever. I hardly ever drink any alcohol. I think I am a bit addicted to porn. I am definitely hetero. I masturbate around once in 1-2 weeks time.

Symptoms
In the beginning I often had a feverish feeling and was prone to IBS-D. This might had been because I hadn't eaten enough as my POIS seems to be accompanied with a serious energy expenditure. I was probably more prone to dysbacteriosis then, but it can't be proven in my case anymore. As to my current symptoms:
- The burning sensation of excretion I said before. After O I tend to have IBS-C (not by definition).
- Hypothermia or at least a perception of it after the heat of O passes. It is also noticeable at acute-chronic phase turnover after which I don't really feel cold anymore. In the winter I often can't keep my hands warm. Even wearing two gloves can't get it warm, although winters here are quite mild usually.
- Some kind of mild rhinitis is present all the time. The phlegm often contains some blood. My nose is often dry. A burning sensation can often be felt in the nose. Interestingly taking tryptophan or medicinal mushrooms (probably apigenin) makes this go away, but I also tend to sneeze more often, because of them.
- I hardly ever cough, but after talking more then one hour I usually develop a sore throat. I can have some coughing sprees too when I do a lot of physical work.
- Ocular photophobia: It occurs in the mornings. I can't keep my eyes open in the light as I feel as it is burning my eyes out. If I try to force them open I often sneeze. I don't have a skin light sensitivity.
- Bloodshot eyes/Red eyes symptom: I often have a blurry vision linked to brain fog. I am also short sighted with about -3.0 and -4.0 diopter. My sight began to deteriorate around the time I had began masturbating, so there might be a link, but not necessarily. At acute onset I can have quite red bloodshot eyes. It doesn't mean I have full-blown red eyes, but veins seem to leak. It might be due to vasodialation and/or irritation. This symptom can change really fast. It looks like my eye is constantly regenerating, but it can't always keep up with deterioration. In chronic phase my eyes can be really white, but as a low grade POIS is present it can return to some degree intermittently.
- Skin problems: I only have mild skin symptoms. Some slight red dots appear on the chest after O. In the first few days after bathing and drying myself with a towel I can get a very itchy skin for a short time or until dressed. I often have some acne after O even if I have a shower, but it might be normal for the skin to become more oily after O. Very rarely I can develop a really painful red rash besides the anus when I sweat and work a really lot, but with cleaning and rest it disappears by next day. Dandruff is also definitely correlated with acute POIS, but I can manage it quite well with Nizoral.
- Increased hunger right after O: I just have to eat anything even when my stomach is full. I also have a similar experience by eating apple in the chronic phase. I also can't get rid of biting my nails unconsciously because of this and I might be more susceptible to pathogens, although it also seems that they can't really live within me.
- Cognitive problems: I have typical mind fog which is usually strongest in the morning, but can still be present in the evening. Blurry vision and decreased cognition are tightly linked. The more acute POIS is the less I can focus. I can have a psychogenic nausea from any mental activity during a very acute phase. I can usually tolerate passive activity (like watching TV) better then active activity (like reading or playing video games) even if it is fun. I have short term memory problems like forgetting things I have been just told or having a complete block down when speaking about something and I often can't recall words I want to say. I don't seem to have a problem with long term memory otherwise I wouldn't be able to write in English. Actually if I am reminded (like next day) I can even recall a short term memory, so it seems that it is all about the inability to recall short or long term memories. In chronic phase I can recall a lot more things and I can speak much more fluently. I also seem to be much more creative then. I don't know much about this stuff, but there is a distinction of episodic memory related to detail. I often noticed that when I read a book in chronic phase I remembered the details quite vividly, but after an O it is like I had an amnesia in episodic memory. I can still roughly remember what happened, but I simply can't remember the details and they don't really come back even in the next chronic phase unless I learned them. Needless to say how terrible a storyteller I am. When brain fog is heavy in the morning (usually until late afternoon) my train of thoughts often stops completely. I just gaze stupidly at the world and can only have the most primal of thoughts. I actually see that others see that I am stupid, but I just can't do anything about it and it is frustrating. I also found that mental activity can have a lower, but similar effect as tryptophan, and it is no wonder as it actually increases with both mental and physical activity.
- Muscle fatigue: General low-grade muscle fatigue. I can usually overcome it with willpower, but it still hurts while working. The lower leg doesn't really hurt that's why I can stand alright. The thigh hurts more especially when going upstairs. I also feel a weaker pain in my arm, but it is only a problem when I want to lift a heavier weight as even when I develop muscles I simply can't lift things due to increasing pain. It is so good to sit down after work that I don't even want to stand up for at least an hour. I found that applying menthol balsam can really regenerate it by next day, but with physical activity it soon comes back. Physical activity seems to have a dual effect as in some regard it makes my symptoms stronger, but it can also clear up my mind. With a short physical activity red eye problems can get better, but after a while it can even get worse due to exertion.
- Nodules (enlarged lymph nodes) in the breast: I don't even know when I developed this, but I had them for years and they are present almost all the time. After acute POIS onset larger nodules can be felt in the breast tissue. They are mildly painful to the touch. They get smaller as POIS vanes, but can still be present in chronic phase. They are certainly not malignant, but there is a definite link to the chest pain symptom. The breasts are completely normal in appearance otherwise.
- Periodic chest pain: I only have this symptom from my early 20th of age. I think it has a connection with breast nodules as pain usually develops beneath them. This most often occurs right after O and when I manage my POIS badly like eating undesirable food. It is usually present for a few days.
The pain can be very severe. I can lie in the bed without feeling any pain, but for the slightest of movement it feels like being stabbed for a short moment. I think it might be partly because of some physical tension, but it might be some immunological thing too. It can appear on either sides or at both sometimes and it can also go from one side (it can disappear) to the other. At a moderate episode I was at the pediatric clinic and ECG proved negative and radiography also proved negative so it is not apparently a pulmonitis or at least it is not an apparent pulmonitis. Blood test was rather normal and only creatine phosphokinase (CPK) was high with CPK: 1032 IU/L (24-190). CPK was good in other blood tests where it was measured. It might be an allergic case of extrapleural interstitial liquid without pulmonitis, but I might be wrong.
Somewhat contrary to this when riding a bike (weak exertion) and breathing a lot of fresh air symptoms can get better. I also noticed that charcoal can help somewhat while coffee (black list foods too, but coffee did this many times so I am sure of it) can reintensify pain. Actually it is rather lucky that I have never told anyone at my work place about my chest pain as I have it quite frequently. I can usually conceal it quite well and even in those cases I couldn't I always said it was only a heart burn, because of a weak heart, so they don't suspect me of harboring tuberculosis or something. If I had really told about it to others I might have been in trouble due to the pandemic as I would have been suspected frequently even though I had this symptom for a decade now. It is not even like I was lying as even my relatives and my doctors had never believed it. Even at the one time my blood test showed something the doctor said it would go away. I knew that even without being told, but the problem is that it always returns too.
- Periodic kidney pain: at a time it occurred once or twice a year and lasted about two days. Usually the site of the kidney was in pain. I haven't had a medical check-up for this so I don't know more. I am sure this developed due to sit-ups, which can increase my disease the most. I think I even had a pancreatitis once for a few days due to this. When I have a muscle fever I feel really bad for days. At the time I thought it was due to some kind of lactic acidosis, but I am really not sure at this point. I haven't had this symptom since I stopped doing sit-ups and it was years ago.
- Urinary problems: I don't have a problem with holding the urine, but I have a serious problem with the urge of urination. I don't really have to go peeing very frequently, but the urge comes in a few hours. If I don't urinate my symptoms are enhanced. If I urinate the volume is usually small, so it is not like my bladder can't hold any more, but the capsaicin-like, burning compound probably begins to irritate the nerves in the bladder. The kidneys probably also reach a threshold where they can force this compound into the urine and so its level begins to elevate in my whole body aggravating symptoms. It is often a bit hard to let go as at the end of the penis it actually creates a slight pain which wants to stop my body from letting go. I could sleep through a night when I was younger, but since a few years ago (when I was 28-29) I almost always wake up at night sometimes very precisely in 6 hours from going to sleep. Although when I am in the chronic phase I can often sleep through the night without waking up.
- Slight tachycardia: My blood pressure seems to be normal usually, but it seems I can have some problems with my pulse. There are times when I suddenly wake up at night even when I didn't have any bad dreams. My tinnitus can be especially loud. When measuring it the blood pressure seems to be good, but pulse can be 90-100. After I go and urinate (decrease the capsaicin-like compound) and drink a bit of water I can go to bed again and slowly I feel relaxed again.
- Conjunctivitis: I am not sure the medical terms I use are correct, but I often have dry eyes which is of course in some relation to bloodshot eyes (maybe uveitis). This symptom can occur anytime and especially when I am in front of the monitor. It also tends to increase at late night when I am getting tired. If I still force them I tend to have more pronounced bloodshot eyes.
- Sleeping problems: Often I can only get myself to sleep when I am on my belly. At the first time I heard about COVID-19 patients being better lying on their belly-side I immediately associated to my disease and always thought that there must be an association between the two and now it seems especially likely. I usually get quite tired right after O, but not to a degree that I can't stay awake, just that my body really desires it. I can have a disturbed sleep on the first sleep after an O, but on the following days I can usually rest quite well unless I wake up because of the urge to urinate or the loud tinnitus. What I also noticed that in acute POIS I don't really have any dreams. I am not exactly sure if I don't have them or just can't remember them. As chronic POIS follows I begin to have more dreams or at least I can remember them. The problem with vivid dreams is however that they can often be erotic and my unconscious ego tends to realize the consequences too late. :)
I also noticed that I can get a very refreshing sleep without a blanket even if I have a pajama on, but I can only do this in the summer when there is a relatively warm air, especially due to my hypothermia.
- Headache: Of course I can also have headaches, but I can pretty well control the appearance of this symptom, so they don't pose such a threat anymore. At the beginning of my severe POIS development (around the age of 17, but I had symptoms beforehand too) I had some very serious headaches. At one time I clearly remember that I was lying in bed for two days as I had a very bad headache (unresponsive to painkillers) and sometime I opened the window to get some fresh air and then miraculously only an hour later there was hardly any pain. Since then I always try to get as much fresh air as I can and keep a window slightly open even during winter. I haven't really tested many painkillers, but Quarelin (400 mg metamizol sodium, 60 mg caffeine, 40 mg drotaverine hydrochloride) can surely get rid of it and often even a half is enough if the pain is not severe. It is rather strange that it contains caffeine as drinking a coffee can often elevate (there are cases when it lowers it) a head-ache as well as my other symptoms. I suspect that other components play a role in this and caffeine just might be good. Another thing that can cause a headache is if I can't go to the toilet in the morning and have to do a lot of physical work. A headache that develops this way usually doesn't react well to painkillers and often only going to the loo can solve the problem after which the pain can slowly subside. Mainly this is the reason that I still keep drinking coffee in the morning, although it can surely cause bloodshot eyes and enhance chest pain, but can reduce brain-fog and clear me out. Head-ache also has a connection to bloodshot eyes. When bloodshot eyes are very severe I can develop a head-ache in response, but it can also happen the other way around.
Other less frequent symptoms: transient joint pain (There was a time when I actually developed it for a few days or weeks while I was taking glucosamine-sulfate), transient muscle twitches (usually resolves with position change. I think it might be connected to the blood veins, but I was not even aware that this could be a POIS specific symptom and haven't really cared about it.)

The following may not have a relation to POIS:
- Sensory neuropathy: Around 2010 I had about 4 or 5 episodes (with a few month to a year in between) of neuropathic pain which had lasted for about one or two month. It either started from my big toes on both of my legs and day by day slowly crawled up to my waist. Or it started from the fingers on one of my arm and crawled to my chest. It felt like constantly being stabbed by tiny needles on the skin surface which was a hellish pain without seeming of an end. I could move, but I didn't want to stand on any of my soles because of the pain or couldn't easily hold a pen in case of my fingers. There was a time when I was lying in the bed in the morning when it was warm under the blanket, but I felt like freezing. It seems my receptors had ran haywire on my skin. The first time was the worst though as I thought that it would never go away. At the first episode I went to see the doctor after a week where the GP prescribed meloxicam, which did nothing to the pain. I also went to Rheumatology where they told me I have no muscle, but they didn't give me the correct diagnosis (it was dorsalgia and muscle pain). As the pain somehow disappeared on its own after quite a few weeks I didn't even seek medical knowledge in the following episodes. I was quite disappointed in doctors by this time. I have only found out that I had actually had sensory neuropathic pain a few years ago while I was searching for POIS. I really have to question how competent they were at Rheumatology or if they just didn't want to bother with me. Fortunately this kind of pain hasn't returned for years, but even if it had now I at least know its name.
I had some O during these episodes and it had never changed the normal POIS episode. Still I think the actual initiation of the episodes were linked to times when I did sit-ups more often, and since I realized this I have never done sit-ups anymore. It really might have been the nerves in my backbone in this case, but who knows for sure.
- Enlarged lymph nodes on the backside of the neck somewhat under the ears. I developed this a few years ago. Once or a few times in a year either of them can get inflamed for a few days, but then the pain disappears. It doesn't react to acute phase, but it seems somewhat similar to the chest pain.
- Epigastrial discomfort: It also only developed a few years ago. It might have been the result of eating too much all the time. I often felt my stomach was full even when I was hungry. A mild pain was present almost all the time. I didn't have a medical check-up for this but I also never had reflux.
- Ass muscle pain/inflammation: It also developed only a few years ago. The origin of the pain is deep in the muscle somewhere close to the rectum, but it doesn't seem I can feel any nodules there. It resembles very much to the chest pain. It usually lasts a few days. The pain can be present on only one side, but can also move to the other. It has the same stabbing kind of pain with movement. Only a kind of inflammation can be felt when I am not in motion. As pain becomes very severe I practically become lame and can hardly move. Now the most perplexing thing in this regard is that this symptom most often occurs at the beginning of the chronic phase and the only really thing that can actually stop its build-up is having a release by O. If I don't release just masturbate it can enhance the pain. Even O doesn't make it regress right away, but it seems to be a turning point in its course. Two years ago I very often had this pain and interestingly chest pain occurred less often although I masturbated with about the same frequency.
- Left ear tinnitus: Developed it around 2010. Maybe it was due to an infection. I can hear the pulse constantly which can be a pain when I am reading a book in the silent room. Sometimes it gets louder, but measuring my blood pressure and pulse often proves normal. Sometimes I had acute POIS related sleep disorder when I suddenly woke up in the middle of the night with a very loud tinnitus. When I measured the blood pressure it was often completely normal, but pulse was often around 100 what I wouldn't have expected while sleeping.

Other considerations:
- Chronic sleep deprivation generally makes me feel more ill.
- After acute sleep deprivation (about 22 hours) I develop a kind of superPOIS state. I begin feeling very unwell. I get a constant tingling sensation in my belly. My anus is constantly itching. At a time I also felt like freezing, although it was a warm summer day. It was hard to stop the shaking under the blanket, but a good sleep solved the problem every time. I only had this state a few times and not in the last ten years, because I am not stupid to stay awake to wait for it anymore. I should recheck this state, but I can't really get myself to do it.

Things that enhance my POIS:
1. ejaculation: Make no mistake I have a chronic phase and O just enhances it in my (s)experience.
2. sleep deprivation: either chronic or acute
3. diet: It doesn’t really matter what I eat I still have POIS, but some food can seriously enhance it.
4. physical and mental exertion: usually dual effect: some symptoms strengthen while others weaken.
5. medicine and supplementation: Can go both ways. Many things are under trial.

Psychological effects that can enhance my POIS (probably due to parasympathetic enhancement):
- Having a cathartic experience while watching a good movie.
- Crying (sometimes because of my sorrow)
- Reading a lot has a dual effect (probably tryptophan)
What actually weakens my POIS is psychological stress, but only for a short time and it also doesn't make it disappear.

I usually have brain fog and ocular photophobia in the morning and by evening my mind tends to clear up somewhat. I also tend to have a burning urine in the evenings.
« Last Edit: April 20, 2021, 01:38:32 AM by Progecitor »

Progecitor

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Re: Progecitor's summary
« Reply #1 on: April 19, 2021, 03:33:20 PM »
Diet
Some foods evidently enhance POIS, but this is not an actual food allergy. They also act the same in the chronic phase, but in the acute phase the impact is more severe. There are foods that act quickly (like in an hour), but others act only by next day or as long as it is in my body. Unfortunately I couldn't get myself into a rigorous selective diet and also haven't documented all separate symptom enhancement in detail, but they all generally make me feel more ill. Medical tests didn't prove lactose or gluten intolerance.

Black list:
- paprika/ sweet pepper: Sweet pepper contains non-pungent capsiate and could be a reason for TRPV1 activation. Of course hot pepper with capsaicin is twice as worse. Also any food made from sweet pepper even if cooked or fried has a negative effect, except if it is pickled.
- tomato: First it makes me better. Minutes after consuming it the blurry vision clears up and I can think more straight. As it moves along digestion it makes me a bit worse, but nowhere near as paprika.
- apple: same as paprika, but also makes me very hungry just as an acute pois onset. Apple makes the stool looser, but the burning pain is also intensified.
A few years ago I often drank some diluted apple cider vinegar before going to sleep and I usually woke up much fresher without the pronounced brain fog. The reason I stopped using it is that somehow I tend to forget about good methods. :) It seems likely that fermented apple only contains the good components of apple (most probably quercetin) and not the ones that make me ill.
- apricot: the fruit and jam also, the bloodshot eyes are especially bad which is usually accompanied by morning ocular photophobia.
- cherry: Bloodshot eyes. It also contains melatonin, but not sure of its involvement.
- banana: Bloodshot eyes by next morning even though banana contains tryptophan which would theoretically lessen this symptom.
- peach: usually needs a greater amount for an effect.
- strawberry: seems to have a very mild, but negative effect
- poppy seed: acts quickly and long, same burning effect. Needless to say that eating poppy seed cake with cherry as one would usually do makes me very ill. Cetirizine may only have a mild effect on POIS, but it may greatly reduce the effect of some foods. I haven't tested this idea extensively, but I ate poppy seed a few times without any problems while taking MACA and Cetirizine.
- walnut: generally feel bad, interestingly has a slighter effect when eating continuously, but not eating it for a time, then starting again has the same severe effect. Certainly increases the burning pain just like poppy seed does.
- sour cabbage/sauerkraut: It induces POIS quite severely, but interestingly normal cooked cabbage doesn't really have an effect, although it seems I can lose weight overnight by gorging myself with (meat and rice) stuffed cabbage, which is funny. It is hard to believe that other POISers have such a good experience with it. Well we usually eat the home-made kind and the starting culture could be different.
- whole bread / graham bread: Enhances POIS symptoms. Especially if eaten with foods like paprika/sweet pepper. Stool is sticky and burning which I think is a sign of dysbacteriosis and dysfermentation. I also can't eat normal bread as I get constipated and my gut aches. I found that I can at least eat rye bread and German wheat/spelt in moderation without problems. German wheat has a high tryptophan content which might have something to do with it. I also don't have any problem with soft buns or croissant, so I don't think it is a gluten matter at all.
- red wine: Really the only thing I can drink, but this also makes me the worst. Consuming a greater amount (I don't remember, but maybe half a bottle or a whole bottle) can cause a burning diarrhea.
Its strange that it contains serotonin and I still feel bad.
- coffee: Clearly enhances the disease, especially the bloodshot eyes and the chest pain when it occurs at the time. Without sugar or with milk (even if sugar is added) has a slighter effect. It seems a controversy, but I still drink it as it helps bowel clearance. I noticed if I can't go to the toilet in the morning and do physical activity at work I often develop a serious headache supposedly because high toxin concentration in the bowel. There were several cases when I really regretted that I had drank coffee during work even though my gut was normal at the time. At home I only drink it with a lot of milk while also eating something, but at work it is usually not available. So several times I drank it in itself and it often induced an unavoidable diarrhea. Interestingly often there wasn't any stool, but only some clear, white mucus with a lot of flatulence. First I wasn't even sure what it was so once I took a sample to parasitology, but they only said that it was negative. I have to guess it is really mucus either due to erosion or a clear apoptopic event. When I drank pure coffee without added sugar it happened less often, so I have to guess that bacteria are also involved (maybe SIBO).
- cinnamon: there is no stomach ache as in allergy, it just enhances POIS. Red eye symptom can be bad.
- clove (I mean the one that is used with biscuits and not garlic): like cinnamon
- thyme: like cinnamon
- milk: I don't have a noticable problem with it (I don't drink more than a liter daily). Yogurt can have a dual effect. Although lactase ensyme (5000 FCCU) has a minimal positive effect, I wouldn't say it is worth serious consideration. Contrary to this after going home from the negative lactulose test it gave me a severe itchiness at the bottom, but without diarrhea, so disbacteriosis still must have occured. This is one of the reasons that I think that lactic acid must be involved.
- soy beans
- egg-plant: I am defenitely ill of it (gut ache), but I also don't think it is a POIS related thing. As many of us have problems with nightshades it is probably a bad thing indeed.
- hemp seeds: I ate them a few times and they possibly increased the burning pain, but symptoms were not awful, so it only has a weak effect.
- chicory coffee: It doesn't contain caffeine, however it still produces a similar effect as coffee. Eyes are noticeably more bloodshot and the burning pain is increased.
- instant coffees: These are usually even worse than coffee even when I drink them with milk, so I try to avoid them as much as possible.
- dried mango fruit: I ate quite a few at one time and the burning pain was considerably worse the following day.



In my experience if it gives a burning feeling or a red eye symptom or a morning ocular photophobia or enhanced blurriness than it is surely a POIS enhancing food.
Morning ocular photophobia can occur with normal acute POIS, but can be especially bad after some food. Photophobia has a slight relationship with bloodshot eyes and a certain one with light induced sneezing. The more serious cases can be accompanied with serious eye pain. This can also have a head-ache inducing effect.
An approximate intensity enhancing order would be apricot=sour cabbage > cherry = banana > apple > peach > strawberry

Based on FODMAP the polyol group may have to be considered, although I have good items on the red list and bad ones on the green list also.

Maybe list:
- pears seem to have a cleaning effect even if it creates a severe flatulence, but it can also make things worse if taken with another enhancing food. At once I had a very severe illness (POIS episode) when I ate pear, banana and grape together.
- tangerine: it seems to cause severe flatulence, but doesn't really have an effect on POIS, although it makes me a bit less foggy, but I rather avoid it. (In retrospect it could be good).
- watermelon: Can be both good and bad. If consumed in consideration it has a good effect, but too much can cause severe sometimes burning diarrhea. As of late I tried to eat the inner hard side of the shell as it supposedly contains citrullin. I found that it might be a little good, but needs further testing.
- grape: I am not sure. It sometimes make me feel much worse, while sometimes nothing happens. I still need to test this more. I seem to have a problem with raisin too, but mainly flatulence. (probably help - needs rechecking)
- egg barley (pastry): I have a suspicion that it can induce inflammation, but not confirmed. Also other pastry don't have any effect.
- tea: teas are very controversial. I haven't had the time to sort it all out. Some good quality black tea without anything added can surely help sore throat. I also consume medicinal teas, but usually mixed. Some tea can make me better, while others rather worse, but it is also not always evident. So far I think that lemon-balm actually helps.
- cheese: I am not sure as I only consume small amounts, but it doesn't seem to have an effect. One thing I found is that it can make me prone (not always, but seemingly more often) to nocturnal emission, which is quite bad itself. Maybe no wonder it is called an aphrodisiac.
- cauliflower: gives me a severe flatulence, but I don't think it actually does anything to POIS. (probably helps - needs rechecking)
- mushrooms: I am often ill of it (gut ache), but not always. I also don't think it is POIS related.
- chestnut: gut ache, not POIS I think
- household biscuit: gut-ache, not POIS related
- plum: It probably has a weak mixed effect. If I eat it raw I have a lot of flatulence which is often a good thing in regard of POIS, however it probably also induces the burning pain somehat like many other fruits, especially if it is not ripe enough. I don't usually eat it raw, but we make a lot of home-made plum jam and although this has no major effect on POIS at least it helps with gut motility, so rather safe to consume.

White list:
- spirits: I don't have much experience as I don't like them, but small amounts don't have an effect.
- sugar: At acute disease onset my energy craving is so enormous that I often eat a lot of sweet stuff. It might not be good for my health, but it is also a wonder I haven't developed diabetes yet.
- sunflower seed (raw) and its derivatives like oil and margarine doesn't do anything to POIS.
- cocoa: I actually feel a bit better after consuming. Might be its serotonin content.
- potatoes
- rice: in itself not, although consuming it with cinnamon or paprika might have a slight enhancing effect. Maybe pectin is involved.
- corn
- cucumber: neither raw nor if pickled has an effect. If it is sour I feel worse, but I don't think it is a POIS effect.
- bean and lentils: although flatulence is not a good feeling at acute POIS onset, but they also contain tryptophan and they can seemingly shorten the acute state.
- meat: I haven't found any meat type that I am worse of, but I am not really fond of meat. I eat it if there is, but I can also do well without it. I also don't have a problem with sausages which makes me wonder about histamine.
It seems to me that I don't tolerate fat so well, as sometimes eating a bit of beacon can cause a slight, but prolonged (few hours) heartburn. The strange thing is that POIS or ejaculation for that matter can alleviate this problem. As I get very hungry after O, it seems to me that energy reserves are used up at an accelerated rate which also causes a kind of clearance even if a foggy hell is its substitution.
- ginger: First I was suspicious because of its burning taste, but I thought it helped a bit. Its positive effect became very clear when consumed it after (MACA+Cetirizine) as it gave a clear benefit.
- pea: a little suspicious, but not in regard of POIS I think
- carrots
- vegetable (root)
- radish
- beetroot
- lettuce
- rumex
- spinach
- pumpkin
- onion: raw and cooked, but I have a suspicion that raw onion can make me susceptible to tonsillitis. I had it every year for at least thrice with a duration of 1-3 weeks sometimes only 1 clear week between and I think I often ate raw onion before it happened. I wanted to verify this by stopping to eat it. Actually I haven't had it for more than a year now, but as coronavirus struck we also wear mask almost every time so it could be only that as well.
Actually I feel better from raw onion, but I somehow forgot about it as I have a somewhat paranoid fear of tonsilitis. Maybe I should pickle some red onions and see how it works.
- garlic: I didn't notice any effect, although I haven't really tested it extensively. Although I have a suspicion that garlic scent is more prolonged for me than others for the same amount consumed.
At a time someone brought us pickled garlic and it didn't cause this all permeating odor. Recently my mother got this bottle called apple cider vinegar fermented on garlic bed. Sometimes I add a little to my usual tea and it seems like it gives a real extra kick to it. Most probably because it is loaded with quercetin from both apple and garlic.
- eggs: I didn't notice any effect, although I don't eat it frequently.
- broccoli: it can make me feel better
- coconut: no effect
- raspberry: I don't think I have a problem with it or not perceptible.
- blueberry: I think I feel better because of it.
- honey-dew melon
- nut, hazel-nut
- lemon: It certainly helps reduce brain fog.
- orange: It helps with POIS.
- zucchini: I ate it a few times during last summer and I think it actually helped with POIS as I was always feeling a bit better on the following days.

Also of note that eating only from the white list won't make POIS disappear as I also had POIS with a clear bowel.
Another consideration that should be taken is that some foods may contain compounds with both good and bad effect.
This list is a good approximation, but I wouldn't say that everything is 100 % tested out. Recently I have gained so much new knowledge on POIS that I think I should retest everything and do a serious revaluation retrospectively and document everything before I forget it. This might also take years especially if I have to stop now working medicine in order to have a clear "foggy" view.
It is very important to note that I view POIS based on my personal theory and I see it subjectively.

It is rather strange that fermentation could take away the POIS enhancing capability of both apple and sweet pepper (paprika), but it can add it to cabbage. This may worth further investigation.
« Last Edit: October 04, 2021, 02:01:00 AM by Progecitor »

Progecitor

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Re: Progecitor's summary
« Reply #2 on: April 20, 2021, 01:36:03 AM »
Complete medical background

Laboratory blood tests
The marked ones are highlighted. During the years the reference values also changed making unmarked values marked or the opposite way. Tests were mostly in the acute phase, although not all, still I have symptoms even in the chronic phase.
1990. 02. (Hydrocele sclerotisation): blood markers: HCT: 0.35, Hgb: 7.0 mmol/l, RBC: 3.9 T/l, WBC: 5.8 G/l, Thromb. 220 G/l, weight: 20 kg, blood pressure: 110/70 Hgmm, ESR: 10 mm/h, blood glucose: 6.0 mmol/l, Blood type "0" Rh neg., ECG: SR, centrum Alignment, Regular Curved, Serum-Na: 138 mmol/l, Se-K: 4.2 mmol/l, Se-CN: 3.8 mmol/l, Se-creat.: 55 umol/l, Se-bilir.: 12 umol/l, bleeding time: 2'14", clotting time: 5'22", urine pH: acidic, protein: neg., glucose: neg., acetone: neg., ubg: normal, sediment: 3-4,
2001. 07. Hgb: 147, WBC: 6.79, HCT: 0.44 (0.45-0.51), glucose: 5.3, Na: 139, Cl: 104, K: 5.0, KN: 4.4, ALT: 13 U/l (<60), AST: 17 U/l (<50), otherwise normal.
2004. 03. (Psychiatry 1.) RR: 120/80 P: 72, neutrophil: 0.48, monocyte: 0.11, eosinophil: 0.05, total bilirubin.: 17.4, otherwise normal.
2004. 09. (Hernitomia sec. Bassini ingu. l.d.): ALT: 17 U/l, AST: 23 U/l, total bilirubin: 27.1 umol/l (<17), WBC: 13.8 G/l, NEU: 11.80 g/l, NEU%: 0.86, LYM: 0.96 g/l, LYM%: 0.07, MONO: 0.98 g/l, MONO%: 0.07, EOS: 0.00 g/l, EOS%: 0.00, BASO: 0.05 g/l, BASO%: 0.00
2005. 07. (Psychiatry 2.) monocyte: 0.11, cholesterol: 5.5, triglyceride: 1.89, otherwise normal
2007. 12. (at a time of the regular chest inflammation, radiography and ECG were negative the same day): calcium: 2.35 mmol/l (2.1-2.6) ALT: 22 U/l, AST: 43 U/l, total bilirubin: 27.6 umol/l (<17), CPK: 1032 U/l (24-190), cholesterol: 5.1 mmol/l (3.9-5.2), LDL: 3.44 mmol/l (<3.36), HDL: 1.35 mmol/l (1.45-5.20), ESR: 6 mm/h (<20), reticulocytes: 0.008 (0.008-0.020). WBC: 6.65 G/l (4.0-10.0), neutrophil: 0.53 (0.50-0.70), lymphocyte: 0.37 (0.20-0.40), monocyte: 0.09 (0.03-0.10), eosinophil: 0.02 (0.01-0.04), basophil: 0.00 (<0.01), abs. neutrophil: 3.53 G/l, abs. lymphocyte: 2.44 G/l, abs. monocyte: 0.57 G/l, abs. eosinophil: 0.10 G/l, abs. basophil: 0.01 G/l, urine: specific gravity: 1025 (1001-1040), pH: 6.0 (4.5-7.8 ).
2010. 10. (during a case of sensory neuropathy): ALT: 8 U/l, AST: 12 U/l, total bilirubin: NA, CPK: 96 U/l, reticulocytes: 0.005 (0.008-0.020), neutrophil%: 56 (50-70), lymphocyte%: 35 (20-40), EOS%: 1 (1-4), CRP: 7.1 mg/l (<5.0), urine: NA, stool blood: negative
2012. 05. (a paid checkup during an acute phase): CRP: 2.4 mg/L (0.0-10.0), anti streptolysin: 53 IU/ml (0-200), WBC: 6.08 G/L (4.0-9.0), neutrophil%: 46 (50-70), lymphocyte%: 43.1 (25.0-40.0), monocyte%: 7.5 (0.0-8.0), eosinophil%: 3.0 (0.0-5.0), basophil%: 0.4 (0.0-1.0), abs. neutrophil: 2.80 G/L (1.80-6.30), abs. lymphocyte: 2.62 G/L (1.00-4.10), abs. monocyte: 0.46 G/L (0.00-0.70), abs. eosinophil: 0.18 G/L (0.00-0.40), abs. basophil: 0.02 G/L (0.00-0.10), urine: specific gravity: 1030g/l (1003-1029), pH: 6.0
2016. 02. (acute phase – around the time I developed two small lesions on the neck which are still present): ALT: 13 U/l, AST: 19 U/l, total bilirubin: 20.6 umol/l, WBC: 6.45 G/l, NEU: 43.0% (40.0-74.0), lymphocyte%: 44.6 (19-39), MONO%: 9.9 (3.0-10.0), EOS%: 2.3 (0.1-5.0), BASO%: 0.02 (0.1-2.0), NEU: 2.77 G/l (1.68-8.00), LYM: 2.88 G/l (0.84-4.32), MONO: 0.64 G/l (0.12-1.08), EOS: 0.15 G/l (0.04-0.54), abs. basophil: 0.02 G/l (0.04-0.21), RDW: 10.7 %CV (11.5-14.5), urine: specific gravity: 1020, pH: 5.0.
2018. 06. (acute phase) ALT: 11 U/l, AST: 17 U/l, total bilirubin: 22.7 umol/l (1.7-21.0), WBC: 5.16 G/l, NEU%: 41.9 (40.0-74.0), lymphocyte%: 43.9 (19.0-39.0), MONO%: 9.7 (3.0-10.0), EOS%: 3.9 (0.1-5.0), BASO%: 0.6 (0.1-2.0), NEU: 2.16 G/l, LYM: 2.27 G/l, MONO: 0.50 G/l, EOS: 0.20 G/l, abs. Basophil: 0.03 g/l (0.04-0.21), RDW: 10.9 %CV (11.5-14.5), urine: specific gravity: 1015, pH: 6.0, urine sediment: 12/view (<6)

Commentary:
Although I think I have some kind of sepsis it certainly doesn't show in liver function represented by ALT and AST.
The elevated total bilirubin is supposed to be due to my Gilbert-disease.
RDW is a parameter to describe the morphology of the red blood cell.
As an elevated RDW value is an indicator of chronic inflammation I simply can't comprehend how it could be low.  It is true that a lower RDW value was only present in the last two tests, so I am not sure if it is really in connection with my POIS which I had for more than 20 years.
Abs. Basophil was always around 0.01-0.03 G/l which is a low value and it only became marked as the reference interval increased to 0.04 G/l at the low end. This isn't very interesting in itself, but a high basophil count is in connection with chronic allergic diseases which raises some questions.
The hernia I suffered in 2004 was due to the fact I gained 20 kg in half a year even though I was very skinny before. The most probable culprit was Zyprexa and that is why it was switched to Zeldox. The intestine became blocked and I vomited a lot before the surgery so it is not indicative of POIS.
I had a few cases of two-sided kidney pain, but these symptoms disappear in a few days and it is almost impossible to get an appointment in such a short order. I was really "lucky" that I had a chest pain long enough that I managed to get it "diagnosed".

Physiological anamnesis:
Vaccinations in childhood: 1985: BCG, Di-Per-Te I/a, I/b, I/c, Polio, 1986: Polio, Morbilli 1987: Polio, 1988: Di-Per-Te II., 1990: Rubeola, 1997. 05. 09.: BCG – Mtx 5TU negative, Re BCG: "973", 1997. 09. 09.: Scar: positive. 1999-2000: H-B-VAX II (3 times), 2001: 5TU
1990. 03. – Op: Hydrocele sclerotisatio Testicle seems to be normal to the touch, some liquid can be felt. Inflammatory pattern is not present.
~1991 – chickenpox, also known as varicella
~1993 – mumps
~1996-1999 – correction for teeth
I had a few tick bites in childhood, but they were safely removed and I had never developed a skin patter.
I had other insect bites as well such as ant, flea, wasp, bee, but there wasn't any allergic reactions to them only the local inflammation.
2004. 03-04. Hospitalization – Psychiatric department – severe POIS onset at the age of 17.
Abdominal and pelvic ultrasonography (USG): normal although the cavities of the left kidney are bigger and contain liquid. Therapy: Zyprexa, Rivotril, Zoloft.
Gastroscopy - negative
CT of brain: negative
2004. 09. Urology: Checkup: everything is normal.
2004. 09. Inguinal hernia  – Chest radiography: negative
2005. 07. Hospitalization at Psychiatric Dep. to set new medication. Therapy: Zeldox 40 mg, Rivotril, Imovane, Dicetel, Zoloft.
2007. 12. regular chest pain – It was one of the first cases and it became regular afterwards (one occasion per 2 weeks – 2 month, but actually very irregular in appearance and intensity): radiography and ECG were negative
2008. 12. Ophthalmology: Shortsightedness that slowly deteriorates. Eyes are normal, eye Ultrasound: negative
2009. 03. Dermatology: control examination with smaller problems.
2010. 07. Ophthalmology: Normal findings.
2010. 10. Abdominal USG: negative
2010. 10. Spinal radioscopy 1: Dorsal kyphosis is standard. Small degree left convex scoliosis is seen. The angle of the lumbar and the sacrum is pronounced. Pronounced right convex scoliosis is seen.
LV rests low, the LS gap is narrower, LV backside arc is slightly open.
2010. 11. Proctology: Mild dermatitis, otherwise normal.
2010. 11. Gastroenterology: consultation – diagnosis: dyspepsia, IBS without diarrhea (Refluxon 30 mg, Dicetel 50 mg)
2011. 02. Thyroid examination - negative – SH: 1.81 uIU/ml (0.35 – 4.94).
2011. 04. Gastroenterology: negative partial colonoscopy.
2011. 04. Irrigoscopy with double contrast: polypus in the right flexure? - Inadequate preparation!
2011. 06. Gastroenterology: Successful endoscopy with negative result.
2011. 06. Parasite test 1 (stool sample): Protozoan negative, helminth egg negative.
2011. 06. Bacteriology test (stool sample) 1: Aside from normal E.coli count Klebsiella sp. was in great number. Pathogenic role is in question.
2011. 07. Bacteriology test 2: Normal E.coli were not present altogether (I clearly remember that I had an O the day before! Most of the bacteriological tests were in the acute phase, but I also had normal findings in such cases even though the burning feeling was usually present).
2011. 08. Bacteriology test 3: Normal flora is present in very small number. Aside from normal E.coli count Klebsiella sp. was in great number. Dysbacteriosis?
2011. 09. Bacteriology test 4: Salmonella, Shigella, E.coli O124, Yersinia enterocolitica and Campylobacter were not present. (Normal findings.)
2011. 11. imlaat autoantibodies: EMA IgA negative, EMA IgG negative, Transglea IgA: 1.2 U/ml (0.0-5.0), GSE serology negative (Gluten intolerance)
2012. 01. Lactose intolerance H2 breath test negative. I didn’t have a diarrhea, but lactulose still induced a heavy burning feeling when I went home. Lactase ensyme slightly helps in reducing the depression felt after eating. However milk actually helps to reduce the negative effects of coffee.
2012. 01. Bacteriology test 5: Salmonella, Shigella, E.coli O124, Yersinia enterocolitica and Campylobacter were not present. (Normal findings.)
2012. 01. Parasite test 2: Protozoan negative, helminth egg negative.
2012. 02. Dermatology: control examination.
2012. 03. Parasite test 3: Protozoan negative, helminth egg negative.
2012. 04. Parasite test 4: Helminth identification: negative
2012. 06. Ophthalmology – Everything is as usual. USG of the eyes due to floaters: negative
2012. 08. Bacteriology test 6: Salmonella, Shigella, E.coli O124, Yersinia enterocolitica and Campylobacter were not present also Salmonella Typhi negative, Salmonella Paratyphi negative. (Normal findings.)
2013. 02. Immunochemistry: sTSH: 4.080 mU/L (0.300-4.200 mU/L), FT4: 16.1 pmol/L (12.0-22.0 pmol/L), FT3: 5.9 pmol/L (2.4-6.3 pmol/L)
2013. 06. Otorhinolaryngology: Ear inflammation
2014. 04. Spinal radioscopy 2: Cervical rib can't be seen. The arc of the cervical lordosis is straightened. Height of the centrum is normal. Lamellas are smooth. Margins are intact. Cartilage gaps are not tighter. (Sensory neuropathy)
2014. 06. Reumathology: Dorsalgia, uncategorized (I had sensory neuropathy!)
2015. 08. Otorhinolaryngology: On the backside of the neck I developed two smaller lymph nodes on both sides that once or twice a year can get inflamed. They said it is not their department.
2015. 08. Dermatology: They couldn't do anything with it. They said to be on the lookout if it gets worse, but it hasn't so far fortunately.
2016. 11. USG: normal kidney, testicle USG: bilaterally normal echo structure of the testicles and epididymis.
2016. 12. Urology: manual prostate examination: normal, urine: normal – bacteria or fungi are not present. Uroflow: unsuccesful.
2018. 08. 14. Abdominal USG: negative (I had a constant abdominal discomfort for about three years, but one of the supplements made it disappear although I am not sure which.)
2018. 10. Otorhinolaryngology: Control
2019 spring:  The local Rare Disease Department: The professor have never heard about POIS, but checked on the net and confirmed. However he told me that he can't do anything as it is an andrological disease and not for his department.
2019 spring: Local Andrology: The doctor had heard about POIS, but he probably didn't know much. He asked me what I wanted, but I was not prepared for the question. In retrospect I should have asked for a hormonal screening. Nevertheless he told me they can't really do anything and I should seek help at the capital. Well I planned to go, but I am not very mobile and then came the pandemic so I couldn't since then.
2019. 04. (chronic phase) Parasite test 5: Protozoan negative, helminth egg negative.
2019. 04. (chronic phase) Bacteriology test 7: Salmonella, Shigella, E.coli O124, Yersinia enterocolitica and Campylobacter were not present. (Normal finding.)

Psychological anamnesis:
I took every medication regularly even when I didn't believe in their effectiveness. Unfortunately I hadn't documented the effects of the medication at the time and can't really remember much about the details.
2003. 12. It all started with a peculiar OCD onset that was driven by panic.
2004. 01. fluvoxamin [SSRI] (Fevarin 50 mg) – Based on the medical documentation I felt somewhat better from this.
2004. 03. paroxetine [SSRI] (Rexetin 20 mg) – I think I didn't take this or only a few as I had to go to the hospital (voluntarily of course) and there they gave me a lot of other pills.
2004. 03. olanzapine (Zyprexa 5 mg x 1), sertraline [SSRI] (Zoloft x 1), clonazepam [benzodiazepin] (Rivotril 0.5 mg x 3)
Zyprexa, Zeldox: In retrospect I don't believe they did much good to me.  I shouldn't had taken Rivotril for such a long time, but it was the only thing that could manage my panic. I don't remember every detail, but it certainly enhanced my mental depression and made me even more forgetful. Actually it was for the best because it made me so ill that I couldn't concentrate on my panic.
Taking Zyprexa led me to gain 20 kg in half a year and it resulted in an almost fatal hernia with a blockage. Thanks to surgery I survived. It was a "real experience" when the doctor tried to feel out the position of my intestines through the testicle.
2005. Zyprexa –> ziprazidon Zeldox 40 mg
Zoloft worked really well, but I only discovered it after I stopped taking Zyprexa. Zoloft could shorten my POIS days, but it never occurred to me to time it to O. I only took it as I was told to.
2007. 01. Zeldox 40 mg, Rivotril 0.5 mg 3 x 1, Zoloft ? Sertwin 50 mg, then 100 mg.
Zoloft worked really well, but I didn't have any income at the time so I wanted to switch to a cheaper medication.
I was in the acute phase of POIS when I had no Zoloft medication left and that is when I developed a serotonin deprivation syndrome.  I had never felt so well in the previous years so it struck me quite profoundly. My mind worked so well compared to when I feel like I am a dead weight in a dead body. I had some pain and a slightly bloody stool as a side effect and no burning feeling at all. Unfortunately symptoms reappeared in the following days and POIS reestablished itself.
I tried to tell at the psychiatry that this was something important, but they didn't even document this. Well I can hardly blame them as why should they had cared about an imaginary disease that disappeared for a short time due to a regular withdrawal symptom.
2007. 08. Zeldox 40 mg, Rivotril 0.5 mg 3 x 1, sertraline (Sertwin 100 mg) (based on the documentation I was agitated, but this could had been a life issue) –> citalopram [SSRI] (Citagen 20 mg): my mood was better from this
2008. 02. Zeldox, Rivotril, Citagen ? tiaprid (Tiapridal 100 mg) 3 x half pill: First I felt better, but later it enhanced my OCD.
2008. 03. Zeldox, Rivotril, Tiapridal ? Citagen 20 mg
2009. 01. Rivotril 0,5 mg x 3, Citagen 20 mg, Zeldox –> clozapin (Leponex 25 mg) Morning: half + Evening: one and a half.
Stopping Zeldox was especially hard. Its withdrawal symptom was that I couldn't sleep for a month.
Well technically I slept, but it was like I shut my eyes then opened it a moment later to realize that it was morning. At other times it felt like a restless half-sleep/awake. Even though I slept I didn't feel rested. After a few weeks the tiredness accumulated and I felt like I was going to die if I don't take Zeldox again. Fortunately there came a day when my sleeping became a bit more restful and it got better with every day.
2009. 02. Rivotril + Citalopram, Leponex. I couldn't take Leponex as it hypotonised me.
2009. 10. Rivotril + Citalopram (I took it in a smaller dose as it made me tired, but it might had been Rivotril actually –> venlafaxin [SNRI] (Velaxin 75 mg Retard)
2009. 11. Rivotril + Venlafaxin Sandoz 150 mg Retard (I didn't report any side effects and my mood was quite good.)
My POIS wasn't cured otherwise I would have reported it and so the doctor kept switching the medication so that we might find a better one. I also forgot about it as I was not checking the papers and only recently realized that it could be worth to recheck it and probably other SNRIs as well.
My OCD also resolved around 2010, but I don't exactly remember when. It was probably due to a resignation towards panic to which I got attenuated. However I also developed a kind of profound self loathing. This hate was not directed towards my mind, but rather my body. I think this is why I developed a kind of pseudoschizophrenia where I felt a profound alienation from my body, while I simply couldn't blame my mind for it. Nevertheless I have never had any suicidal thoughts.
2010. 02. Venlafaxin  –> quetiapin (Seroquel Xr 200 mg retard) – At first I felt myself better, but later I had enhanced anxiety. I said my thinking was better, but the doctor considered it too vivid.
2010. 03. Rivotril + Seroquel Xr 300 mg retard – As I remember it made me sleep 10+ hours daily (at times even 15 hours) and I still felt sleepy all the time. It is possible that sleeping a lot had a good effect on my POIS as my body was recuperating more. However I practically had no life left besides sleeping.
2010. 05. Rivotril + Seroquel –> quetiapin (Nantarid 25 mg) 2x1+ paroxetin (Parogen 20 mg)
I didn't take any of these as this was the point I got fed up of antipsychotics and decided to stop them altogether.
2011. 04. I went to the doctor for control, but I only took Rivotril in a small dosage.
2011. 09. I told the doctor that I wanted to stop Rivotril as well.
It may sound hard to believe, but it was really hard to stop with the last pill. I had to cut up the 0.5 mg pill and taking one eight less each day. I still had withdrawal symptoms like feeling unwell, sleeping badly and strange pain effects. For a time after this I felt really good as the light gain a new shine and I was feeling a bit euphoric.
2013. 02. I was at the hospital for a psychological checkup. My physiological symptoms were not considered as I had no proof to back up anything. I also couldn't masturbate at the time so I actually felt better. The final diagnosis was schizophrenia although the doctor said I was an especially difficult case and they discussed my case a lot. They had a hard time deciding as some of my symptoms were very typical of schizophrenia while other were totally not.
They also gave me some pills while I was in: klomipramin (Anafranil Sr 75 mg retard) and amisulprid (Amisulprid-Ratiopharm 200 mg). I don't really know what amisulprid does as I only continued to take Anafranil when I came out. Anafranil greatly reduced my sexual desire. When I masturbated I had a really hard time achieving orgasm, but when I finally managed POIS came in full force.
I also stopped taking it and only went for control to the psychiatry. Even then I usually only talked with the assistant about my daily problems for a few minutes, but I refused medication. A few years ago my doctor retired and I didn't want to explain everything again to a new doctor so I simply stopped going.
In the last few years I was fixed on repaying my tuition debt and couldn't spend on supplements. Actually I thought it was futile and doctors and family confirmed this. I haven't even tried to find the disease as I thought I was the only one who had such a problem on the whole world.

Self-tests:
Alcoholic probe: As POIS somewhat feels like having a hang-over I thought that it may show something, however it certainly didn't.
Stool pH was 8, semen pH was 8.
11 component urinary rapid test: pH is usually around 5-6. Specific gravity is always a bright yellow which is the highest value (1030) according to the test. Ascorbic acid is somewhat elevated when I do a lot of physical work, but this is supposed to be normal. The other parameters that are always negative: urobilinogen, glucose, bilirubin, ketones, blood, protein, nitrite, leukocytes.
The rapid test for Clostridium difficile toxin A and B from stool sample proved to be negative (2019).
« Last Edit: August 11, 2021, 11:21:05 AM by Progecitor »

BoneBroth

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Re: Progecitor's summary
« Reply #3 on: April 20, 2021, 02:18:42 AM »
Hi Progecitor!

Thanks for your great documentation! I have an almost identical symptom-history. I will take some time to analyse it. I'm planning to do a organ/symptom/analyse value list that helps us understand what organ is causing each symptom. I belive that the POIS related inflammation (caused by some hormonal inbalance) is comproimising organs in the whole body - specifically organs that has a high blood flow: blood vessels, heart, liver, kidney, brain and intestines. This explains why we experience so many diffrent symptoms.

Each organ gives it own symptom when function is decreased (or in chain reactions). Depending on what organ is the weakest link the symptoms appears diffrently on diffrent people. Some examples:

  • Kidney -> Low blood pressure, POTS, headache, varicose veins, slow intestines/constipation. I'm staring to belive the kidneys might be the most important organs relating to POIS symptoms since they are regulating the blood pressure - an adequate blood supply is everything for a good health
  • Liver/gall bladder - > Acne, varicose veins, yellowish stools, headache, blood pooling, thick blood, liver spots, low bilirubin levels and alcohol sensitivity.
  • Intestines - > Bloating, gas, candida, leaky gut, skin issues, coated tounge which leads to vitamin deficiency, advanced hormonal imblances, SIBO, auto-immune disorders (that cause damage on the same organ as POIS inflammation) and headache
  • Brain -> Headache, depression, no motivation and a long list of symptoms because of decreased function in hypothalamus/pitutary
  • Thyroid -> Temperature regulation, hotflash, difficulty sleeping, muscle weakness, hyperactivity.
  • Adrenal -> Cortisol excess followed by cortisol decline -> inflammation, testosterone deficiency. Cushing's syndrome, Addison's disease.
  • CNS (Central Nervous System) - > tingeling, difficult to breath, sudden urge to urinate
  • Blood vessels/blood - > varicose veins, blood pooling (thick blood) because of clumping platelets
  • Gonads  -> Testosterone deficiency, slow healing process, aggregated inflammation
 
When the intestinal function is damaged it will in time lead to similar symptoms as POIS, because the process is the same: A leaky gut will leak substances into the blood stream and when those substances attach to organs the immune system will send lymphocyes to the site and cause inflammation. But instead of inflammatory hormones and hormonal break down products, this inflammation is caused by substances iike proteins, bacterias, fungus etcetera that should not normally escape from the walls of the intestines. 

This came clear to me as I fixed my acne issue after doing a liver cleanse (I dont get as severe acne after POIS now). I still get the other symptoms on POIS, but not so much the liver related, since the liver is now somewhat restored (with nutrition/detox). On POIS the liver might be so inflamed that might be working on only 5-30% of its normal rate (this is not easy to analyse due to the complexity of the livers detoxification stages, the stage 1 detoxificaiton pathway might work, but the path 2 pathway might halt. This leads to accumulated toxins in the whole body (headache). Some hormonal breakdown products are 10 times more toxic/inflammatry then the hormones itself. A compromised liver is very damaging for your health in th elong run, however the liver has a tremendously capability to heal, even in a very bad stage.

With this view it might be more easy to plan mesures for the restoration phase. But you cant scoop water from a sinking ship forever. Although restoration is essential for the healing process the cause of POIS still must be solved. The main measure would be stress management and restraining from orgasm for at least a year. I get into more detail in my info below.
« Last Edit: April 20, 2021, 06:11:47 AM by BoneBroth »

Progecitor

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Re: Progecitor's summary
« Reply #4 on: May 17, 2021, 02:29:15 PM »
A list of the supplements, herbal teas, exotic spices and medications that have worked so far.
I tried to make an approximate intensity comparison, however it is not necessarily correct. The order from left to right also represents a subjective scale. I may reevaluate some of them with more testing.
Please don't consider the order in the average and weak list as it would take years of rigorous testing to provide a more accurate list. The ones that I put in the good category have a noticeable effect, while the ones I put in the best have a considerable positive effect on symptoms.
It is important to note that when I talk about a weak or moderate reduction in POIS it usually means that they don't actually reduce depression or bloodshot eyes, but rather that they ameliorate the burning pain and as such can probably prevent symptom aggravation, which in a way is a positive effect in itself. I could say they have a general anti-inflammatory effect, but I am not sure if this was a correct term as even POIS seems to have a kind of anti-inflammatory property.
If anyone wanted to check if he or maybe she has a similar POIS as mine, I would first recommend trying MACA and saffron as they have a considerable positive effect without any major side effects.

Rd = Recommended dosage per day
se: considerable side effects

The best: lucerne (alfalfa), saffron, MACA, Ecdysterone, Mexican Wild Yam Root (se), Resveratrol, licorice (se), drotaverine (No-Spa), astaxanthin, lungwort tea (Pulmonaria officinalis), L-Tryptophan (se), charcoal capsules (se)

The good: Medicinal mushroom mix (se), seven mushroom mix, Tongkat Ali, Lion’s mane, Tribulus terrestris, Reishi Ganoderma powder, Berberine, SNRI (Venlafaxine), SSRIs (serotonin deprivation syndrome due to Zoloft was better), Beta-1,3/1,6-D-Glucan, Cordyceps, Echinacea + Beta glucan, lavender tea, Diosmin + Hesperidin, raspberry leaves tea

The average: niacinamide (Vitamin B3), Echinacea drops, melatonin,  ibuprofen, ginkgo biloba, tea tree oil, Ashwagandha, papaya pills, lansoprazole (Refluxon), Gotu Kola, bitter gourd, Garcinia cambogia, Nutrisan RespiCalm, Vitamin C-1000+, safflower oil

The weak: chamomile extract capsule, ginger, lemon balm tea, linden tea (Tilia), chamomile tea, Cetirizine, soy lecithin, Sulforaphan, NAC, Vitamin B12, Vitamin B6 (se), GABA, chia seeds, black tea, artichoke tea, common centaury tea, Galega tea, anise tea (se), rosemary tea, safflower spice tea, hops tea, Physalis, grape seed extract, fenugreek, Naproxen, Testosterol 250, charcoal pills, magnesium, beta-sitosterol (se), red clover, garlic gelcapsules, spirulina, Shatavari, jasmine infused green tea, nutmeg, Pygeum, passionflower, Creatine HCl (se), Cascara sagrada, Bacopa, Artemizia, Yohimbe, selenium, alpha lipoic acid (ALA), milk thistle (sylimarin), coenzyme Q10, flaxseed/linseed oil, feverfew tincture, siberian ginseng, Zembrin - Kanna (se)

The controversial:  oregano, Tricolor Maca

The ineffective: zinc (se), chasteberry (Vitex agnus-castus) (se), matcha powder tea, green tea capsules, CLA, evening primrose oil, zinc (se), Aspirin (se), cod fish oil (DHA/EPA) (se), acai berry, Fo-ti (Polygonum multiflorum), beta alanine

The bad:
biotin (Vitamin B7), paracetamol, taurine, turmeric, black pepper, lemongrass tea, sage tea, Kudzu, Pregnenolone, canola oil, synephrine

I will add more details later, but most of the information can be found in my research thread:
https://poiscenter.com/forums/index.php?topic=3733.0

Details:
Licorice - Glycyrrhiza glabra [400 mg per capsule from which 16 mg is glycyrrhetinic acid]:
I had one capsule the previous morning and one in the morning. About 8 hours later I took another one and 3 hours later I had an O. Right after it I took another one (18 h). So on that day I took 1200 mg of licorice of which 48 mg was glycyrrhetinic acid.
It reduced POIS somewhat at its onset, but I still had symptoms like weakly bloodshot eyes. I measured it several times and my blood pressure didn't seem to change, but I had other side-effects. In the first hours I felt transient slight pain sensations all over the body and developed some mild headache or discomfort, although it is hard to tell if the latter was not due to POIS itself. Another worrisome symptom was a recurring weak heart ache or cramping that I felt from time to time even in the next morning. I think licorice only has side-effects at first. It was around the time I went to bed when I began to feel myself somewhat better. It was 8 hours after I took the second capsule and I mean the first one in the afternoon. I got up after three hours of sleep to take a leak and I definitely felt better at the time. In the morning I generally felt better, but I still had a weak level of POIS. I still had some depression, but the eyes were relatively well. The nodules in the breast were moderately reduced. The burning feeling noticeably reduced and the quality of the stool was better. The best was that I could walk relatively easily without feeling the fatigue-like burden on my muscles. So licorice really has a beneficial effect on my POIS, but its side-effects prevent me from using a higher dose.
Licorice also contains phytoestrogens, so I am not even sure if its beneficial effects are really due to glycyrrhetinic acid.

Chamomile extract capsule: 1 capsule containing 250 mg chamomile extract with 2.5 mg apigenin.
1 capsule doesn't seem to do anything noticeable, however consuming 2 x 2 capsules with a few hours of difference surely has a weak-moderate effect on the burning pain and thus somewhat reduces all POIS symptoms. So all in all it was 1000 mg chamomile extract containing 10 mg apigenin. By the way it was also equivalent with 10 g chamomile flower. The medicinal mushroom capsule I mentioned previously contained 9 mg apigenin, but it had a better effect, so apigenin really seems to help, but it is better if it is combined with other things as well.

Turmeric: I tried it three times by consuming about one tablespoon cooking grade turmeric powder mixed in some water. It doesn't have any rapid effect, but every time I had bloodshot eyes in the next morning and the burning sensation was also enhanced. On the last occasion I also added some black pepper and everything was about the same. I have tried to avoid black pepper for years as I have already suspected it to be bad for my POIS. Still I need to test it a bit further and maybe with higher doses for a definite conclusion.

Chasteberry [400 mg per capsule]: It is supposed to increase progesteron in women. Well it may not do so in man. The first time I took one it unexpectedly induced a weak-moderate ass muscle inflammation (probably not a POIS symptom), but this disappeared in a few hours (after consumption from 2 o 6 hours). At another day I took one in the morning and one in the afternoon. However this kind of inflammation only appeared very weakly.
In regard of POIS symptoms it didn't reduce depression and I still had bloodshot eyes. It may have reduced the burning feeling a bit, but I am not really sure without a more extensive testing. Another thing I noticed was a weak bulging of some blood vessels a few hours after consumption, however blood pressure was alright. All-in-all I could also say that it had practically no effect.
The product doesn't specify what part of the plant was used, but it is probably the leaves or the fruit. The seeds are sold separately and they are said to be antiaphrodisiac, so I will have to test them too.

Melatonin: I have only tested a lower dose (2 mg) so far. It makes me somewhat sleepy, but this passes after a short time. There are no rapid effects, but it can somewhat reduce the burning feeling. I will try higher doses, but I don't want to mess up the circadian rhythm. It may serve well in an evening stack, especially if I wanted to do "sex" in the morning.

Anise tea [about 1 liter]: As it is another estrogen receptor modulator I thought it could be interesting to test. It doesn’t seem like it does anything particular to my POIS symptoms, however it can give me a headache. Could this be something similar as what I experienced with Kudzu?

Galega/goat's-rue/French lilac tea (Galega officinalis) [about 1 liter]: It raised my interest as it is another traditional antidiabetic tea and it contains some compounds that formed the basis for the development for metformin. I expected it to potentially modulate POIS, however this proved to be in vain. It seems to have some beneficial effect on POIS, however this effect is quite subdued.

Garlic pills [10 mg per gelcapsule]: I took garlic capsules from the morning with 3-4 hours of difference. It definitely reduces the burning feeling moderately. After taking the third I had an O two and a half hour later, after which I took another garlic capsule and three hours later a last one before going to sleep. When I got up in the middle of the night to take a leak I also took a garlic capsule. This way garlic couldn't definitely prevent POIS as I still had bloodshot eyes, however besides the reduced burning sensation I had reduced rhinitis. In the morning I felt that I had more energy. So garlic is definitely helpful, however on its own it is not an adequate treatment.

CLA [2000 mg per gelcapsule]: It has some effect on POIS, but its quality seems to be mixed and weak, so it doesn't really do anything to symptoms or only weakly enhances POIS. Nevertheless it is not a supplement I am going to incorporate in my regime.

Evening primrose oil [500 mg per gelcapsule of which 45 mg is gamma-linolenic acid]: It has mixed effects just like CLA. I took four capsules in a day. Although primrose oil can reduce the burning pain, it doesn't make a real difference. It also induces bloodshot eyes almost every time I take it, which is a no good for me. 

Ayurveda tea: The most indicated ingredients are Withania somnifera and Centella asiatica, but it also contains cymbopogon citratus, glycyrrhiza glabra, pterocarpus marsupium, zingeber officinale, ocimum sanctum, cinnamomum tamala, cinnamomum zeylanicum. I had some negative experience with it. I only drank it three times, but as I remember it gave me a headache every time. I even developed a chest inflammation after one occasion, although it was possibly not due to the tea. Due to this I was a bit skeptical about Ashwagandha and Gotu Kola.

Ashwagandha (Withania somnifera) [240 mg per capsule of which 12 mg is Withanolid]: I took one capsule in the morning and one another five hours later. I took a third one six hours later and had an O two and a half hours after that. To my wonder this partially managed to prevent POIS onset as I didn't really develop bloodshot eyes and the burning sensation was also reduced. In the morning I had a somewhat reduced fatigue and depression, however I had bloodshot eyes and the burning pain was moderate. After testing it some more I realize that at first I overestimated Ashwagandha’s benefit as it didn't prove to be that effective on acute days. At best it may be as good as berberine, however I need to take at least four capsules for this and there could be adverse side-effects if I used such an amount regularly.

Gotu Kola (Centella asiatica aerial parts) [435 mg per capsule]: Another suspicious one that proved to the contrary. I took one in the morning then another in the afternoon and a third one in the evening after which I had an O one hour later. I didn't develop bloodshot eyes right after O, but I had some cramping intestinal pain. In the morning I generally felt somewhat better, than I would usually expect, however I still had a moderate burning pain and thus POIS symptoms as well.

Mexican Wild Yam Root [425 mg per capsule; Rd: 2]: Another great one! This one considerably reduces POIS symptoms, however serious side effects may make it difficult to use effectively. It also has a rather rapid effect. Shortly after the first capsule I began to feel a reduction in my chronic symptoms, so I decided to test it more seriously and had an O two hours later. POIS onset was rather mild (e.g. only mild bloodshot eyes). Four hours later I took another one before going to sleep. My eyes were rather clear at this time which means that the first one was still in effect. In the morning I felt rather great. I could best compare the degree of its effect to licorice.
However my joy proved short lived as shortly after taking the third one in the morning I developed a serious back pain. The pain seemed to originate from around the left lung and radiated to my back. I could breathe well though, but any movement induced a sharp pain. This lasted for about one and a half day then it disappeared. Of course I had similar cases in the past, but it is more usual that the pain radiates to the front and that is why I call it chest pain. This whole episode reminded me to my experiences with medicinal mushrooms which can also induce a similar effect when I use them as a singular treatment in high dose.
At another occasion I only took one capsule 3 and a half hours before an O although I also drank some saffron tea. At least this proved to be safe. It has yet to be determined if two capsules are safe or not. By the way I think wild yam capsules are best taken about 2-3 hours before an O.
As wild yam is marketed as a traditional women's health support it makes me think that a hormonal imbalance theory seems even more probable as the origin of POIS.

Red clover (Trifolium pratense) [Red clover flower tops 375 mg per capsule including 76 mg isoflavanoids; Rd: 1-2]: It has a beneficial effect, although not to a great degree. I took 3 capsules per day and even had an O with it, however it was only about as effective as garlic pills. Side effects were short sporadic pain effects at different places, but it was only a nuisance.

Naproxen [220 mg Naproxen Sodium which equals 200 mg of Naproxen; Rd: 1-2 or 3 at max]: At most I took 3 and a half pills. I haven't had an O with it, but it reduced the burning pain weakly.

Matcha tea: When I first tried matcha tea it seemed to be good, but now I have to reconsider this after I tested it a bit more. The conclusion I made that it is only weakly beneficial or not at all. I drank one teaspoon (about 4 g x 3) of matcha tea three times a day. I couldn't really notice any change in symptoms during the acute period. The only notable thing is that the lymph nodes in my breasts got inflamed which doesn't occur frequently otherwise, but this may have been a coincidence only.

Green tea capsules [500 mg per capsule: 80% polyphenols, 60% catechins, EGCG: 225 mg, caffein: 10 mg, Rd: 1]: I took two capsules in a day, but I couldn't perceive any change whatsoever. Later I will try it in some combinations, however I can't believe that prolonged use would make it any more effective for me.

Black tea: I discovered it last year that it has a certain positive effect when consumed in greater amounts (about 1-2 l). It helped in some POIS recovery cases. I also noticed that sucking on the used filter can rapidly alleviate a sore throat, although only for a few minutes. I also realize that different brands have considerably different effectiveness. Unfortunately I couldn't find the brand that worked well before and my current one is not the best.

Niacinamide: I also tested combinations of matcha tea and black tea with niacinamide separately, however I couldn't see any great difference compared to their base effects. I didn't have an O, but I was on acute days and exercise intolerance is an everyday issue nowadays, so there was place for improvement. I also think that niacinamide is most effective about 8-10 hours after consumption. This doesn't mean that taking another one before an O would be a bad idea or that other POIS types would react with the same timing.

Testosterol 250 [In one capsule it contains 250mg plant sterol, 15 mg inuline and some more, Rd: 1]:
This one is marketed as a popular testosterone booster. I really hoped it would work, however I had to be disappointed. It had a weak positive effect after an O when I took three capsules in a day, but I simply don't see any point in further raising the dosage.

Pregnenolone [50 mg per capsule Rd:1]: It seemed to be an interesting one to try, so I did. Unfortunately it proved to be of no use. I think it actually makes my symptoms worse, although not very apparently. The bloodshot eyes were especially bad on the days when I used it and depression hadn't changed whatsoever. I think the stool had a burning quality more so than usual, however this is rather difficult to judge accurately. Two times I wanted to take another capsule for a greater effect, however after looking at my eyes in the mirror I just didn't dare to.

Grape seed extract (Vitis Vinifera) [200 mg extract in 4 pills of which 190 mg is proanthocyanidine; Rd: 4]: I took 4 to 6 on consecutive days. As far as I could judge it only has a weak beneficial effect, but nothing considerable.

Hops tea [about 1L]: I think it has a weak beneficial effect, but nothing considerable.

Beta-1,3/1,6-D-Glucan [100 mg Beta-1,3/1,6-D-Glucan powder and 160 mg Maitake Mushroom powder; Rd: 1]: I took 3 in a day and it definitely has a good effect on POIS. I also had an O with it and I could perceive an antidepressive effect, however I still had bloodshot eyes to a degree and didn't feel exactly well. It may have about the same effectiveness as Cordyceps, although I would need a consecutive test to be able to judge this.
I also bought several other types of mushroom supplements and I am really interested in trying those as well.

Soy beans (bio, cooked for one hour with only a little added salt): I ate about 80-100 g of it at two separate days. To cut it short I think it is actually bad for me. Like other beans it also causes a lot of flatulence, which in a way causes a bump in POIS, but also accelerates POIS disappearance usually. In the past I had some positive experience with beans (especially bean soup), however soy bean seems to have a mixed effect instead. The bloodshot eyes and depression haven't changed. However the burning pain was certainly enhanced and at the second time I got up in the morning feeling especially weak.

Beta-sitosterol [400 mg of plant sterols per capsule including 200 mg beta-sitosterol; Rd: 2]: I only took one capsule that gave me a rather great headache which lasted throughout the day. Interestingly though I think it actually reduced POIS to a weak-moderate degree, however the testing circumstances were not ideal. Later I will try smaller doses to see if this is any better that way.

Rhaponticum Tribulus [500 mg Tribulus terrestris and 100 mg Rhaponticum carth. per capsule]: It was on sale so I bought a supplement that combines Tribulus and Ecdysteron. I haven't tested it much, but it certainly makes me feel better, so ecdysterone is really a good find.

Tea tree oil: I tested it some more, although without an O. However it certainly seems to have a beneficial effect as it considerably reduces the burning pain. I think it has a solid moderate effect and I will try to have an O with it to be able to judge it more accurately.

GABA [500 mg gamma-aminobutyric acid per capsule; Rd: 2]: So far I have only taken one at different times as it has some worrying side effects. Most importantly it didn't change depression. However it somewhat reduced the burning pain and had a good effect on stool quality.
A very peculiar side effect I experienced is that GABA can cause a sharp pain in the brain at a specific site. However this is nothing like any headache I have ever experienced before. I am not sure if I should be worried about this phenomena if I decided to take it in a greater dose or for a prolonged time.

Spirulina [One pill contains 300 mg spirulina algae powder, 0.45 mg beta carotine, 75 ug (daily intake reference: 9.38%) vitamin A provitamin; Rd: 1-8]: I took 9 pills (3x3) for two days, however there weren't any considerable effects. Although it definitely had a good effect on stool quality and the burning pain was somewhat reduced which means that it is a little effective at least.

Common centaury tea: I haven't tried this again, but I forgot to mention a side-effect I experienced.
There occurred a weak pulsating feeling on the top of the head. This was reminiscent to the feeling when I overdosed tryptophan, but it was much weaker and orthostatic intolerance was not present at all. I am really not sure if this could be considered some kind of cleaning effect or something bad tough.
« Last Edit: November 17, 2021, 08:13:04 AM by Progecitor »

Progecitor

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Re: Progecitor's summary
« Reply #5 on: September 06, 2021, 10:21:48 AM »
Some additional trials:
Acai berry [75 mg acai berry extract per softgel capsules; Rd:2]: I took 3-4 per day. I think it has a weak mixed effect. It reduced the burning pain, however I almost constantly had weak-moderate degree bloodshot eyes while I used it. I will put this in the ineffective group due to this. By the way I often pass the (safer) ineffective supplements to my mom and she told me that after taking acai berry and green tea capsules in combination for a week her high blood pressure normalized and this made her happy. I don't know whether this is true, but it could be a good thing to test for those who have high blood pressure problem.

Shatavari powder (Asparagus) [Rd: 2 tsp]: First of all shatavari must be taken with milk. Whenever I drank it with water it greatly irritated my throat. However drinking it with milk greatly diminishes this side-effect. I tested shatavari by taking 2-3 tsp for some days and even had an O with it. I think it has a weak-moderate efficacy as it is good for my gut, but doesn't actually make a real difference. It is considered an adaptogen and is actually recommended to be taken with Ashwagandha for a greater effect. On the last day I did just that (3+3 teaspoon of Shatavari + Ashwagandha powder during the day) and it seems to have a solid moderate effect, although even Ashwagandha may have that if used alone, so the combination doesn't necessarily make them better.

Jasmine infused green tea [about 2 liters; made tea two times using a teabag containing 2 g of jasmine tea and drank it throughout the day]: At first I thought it works quite well, so I even had an O, but in the next morning my symptoms were quite average. Nevertheless jasmine tea was at least weakly beneficial considering how it reduced the burning pain. As jasmine tea is based on green tea I may still need to reevaluate green tea, although even if it has a benefit it is surely not considerable. It is also possible that jasmine infused black tea would work better, but I am not sure if I can obtain such.

Bitter gourd or melon (Momordica charantia) [500 mg per capsule standardized for 1.8 % charantin, it also contains 15 mcg chromium; Rd: 1-2]: I took 3 splitting it equally during the day. The first time I took a bitter melon capsule it gave me 3 hours of moderate stomach/duodenum pain, however later it seemed to have some positive effect, so I didn't want to give up its trial. Its release from the capsule is probably too concentrated and results in local irritation. I decided to open up the capsules and mix them in water. This way it proved safe for consumption. I tested it vs. an O, but it was only partially effective. It manages to reduce the burning pain significantly, however it is not so good in symptom reduction itself (e.g. regular bloodshot eyes). It certainly helps with POIS recovery, so I would say it has about a moderate efficacy. It also induces more than average flatulence which could be a problem. Besides this my only real problem with bitter gourd is its price tag, which is not the best considering its effectiveness.

Lion's mane [500 mg per capsule; Rd: 1]: Another medicinal mushroom that works really well. It is actually the main component of the medicinal mushroom mix I took earlier. I took 3 capsules in a day and couldn't experience any side-effects. It also had some anti-depressive effect. I even tested it with an O and it had a general positive effect, however this alone can't overcome everything, especially when I eat some POIS enhancing food. It is possibly better than Ganoderma especially if I evaluate the amount I took, but taking both may be even better if I consider my experiences with the medicinal mushroom mix.

Ganoderma lucidum - Reishi powder [Rd: 1-2 tsp]: I took 2-3 tsp per day. This is a really good thing as it makes a noticeable difference in symptoms. Ganoderma gave the distinct odor I experienced with beta-glucan and it actually contains some, however it also has some 5a-reductase inhibitor compounds (e.g. beta sitosterol) as well which could contribute to its overall effect. My subjective feeling is that its effect is comparable to Tribulus terrestris although the amount of powder could be considered a great amount. Reishi just generally makes me better, however it can't overcome everything and using even higher doses doesn't seem safe, although I had no particular side-effects so far. There were some points when it felt like Reishi reduced depression, but I still need to investigate this a bit further.

Branded medicinal mushroom mix: I rechecked the constituents and found that it contains lions's mane (350 mg), chaga (100 mg), ganoderma (30 mg), EGCG (5 mg) and apigenin (9 mg). I haven't tried chaga, but the other two mushrooms surely work and apigenin as well. EGCG (green tea) doesn't seem to work and I am actually a bit suspicious if it could have been the reason why this mix often induced chest inflammation. Nevertheless this medicinal mushroom mix combined with Maca, chamomile tea and some ginger had a very positive effect on POIS, so I have high hopes for a custom combination.

Tongkat Ali [100 mg per capsule; Rd: 1]: Another testosterone booster that makes me noticeably better with some anti-depressive effect. The first time I took Tongkat Ali it caused a headache, however I used it on several other days as well and this hasn't happened again. I have yet to test it with an O, but I am quite sure that it belongs in the good or best category.

Pygeum [500 mg per capsule bark extract, Rd: 2]: I took two capsules for a few days in the acute phase and it certainly has a beneficial effect. It seems to have a weak-moderate effect on burning pain reduction, but it probably can't reduce depression. Pygeum is considered a potent 5a-reductase and aromatase inhibitor, so I believe others should check it as well.

Nutmeg powder: I expected something considerable of nutmeg, however it didn't prove so. I took 1/4-1/2 teaspoon twice per day. It somewhat reduced the burning pain, but symptoms were quite average. Bloodshot eyes may have been a bit worse, although I am not entirely sure in this. Nutmeg also gave a distinct sweetish odor to farts, which is not necessarily a good thing though. :)

Passionflower [250 mg per capsule; Rd: 4]: At most I took 6 in a day and also had an O. It can't prevent POIS onset as I still had bloodshot eyes. Muscle fatigue was also apparent the next day. It weakly reduces the burning pain and has a good effect on stool quality. Depression was not particularly strong however lately I haven't had a real problem with that anyway (probably the effect of summertime).

Tricolor Maca [650 mg per capsule containing yellow, red and black maca; Rd: 2]:  I took a few here and there and sometimes I would get severe bloodshot eyes. This is a bit disappointing, but also a rather surprising discovery. For now I suspect that either black or red maca could be actually detrimental as I have taken yellow maca for quite a while without problems. I also bought yellow maca powder which I had tried a few times without any ill effects. Needless to say this could be a major finding in the search for the root of POIS. In the future I will test tricolor maca some more and also buy some black or red maca if I can to check if such a difference really exists.

berlin1984

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Re: Progecitor's summary
« Reply #6 on: September 06, 2021, 12:53:44 PM »
Awesome you trial so much stuff  :)

Note that some things need to accumulate in the body and don't have an instant effect.

Progecitor

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Re: Progecitor's summary
« Reply #7 on: September 06, 2021, 02:04:33 PM »
Awesome you trial so much stuff  :)

Note that some things need to accumulate in the body and don't have an instant effect.

It is true, however this may be still enough to find out parallelisms and the possible underlying mechanism. If we managed that we could use a more integrated approach in the curative effort. If I wanted to test everything for weeks it would take a lifetime to get anywhere. I believe that preliminary results also portend long-term effects. It is also really interesting that how some of the beneficial things (e.g. saffron, maca, alfalfa) had the most potent and noticeable effect when I first used them (day zero) and later their effect became attenuated. Even more intriguing is the fact that the same seems to be true for bad stuff as well. When I eat any bad food the symptoms usually intensify in only a few hours and can persist for about 1-2 days while it is in my body. Also when I first eat fresh walnuts or poppy seeds in the autumn they can hit me rather severely, but if I keep eating them for days the negative effects become attenuated as well. So the body compensates in both direction.

Progecitor

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Re: Progecitor's summary
« Reply #8 on: October 04, 2021, 02:38:41 AM »
Cascara sagrada bark (not cascara!) [450 mg per capsule; Rd:1]: I took 3 capsules per day and had an O with it. The burning pain was reduced to a weak or maybe weak to moderate level, however not to the degree I hoped for. Symptoms were possibly a bit reduced, but I couldn't see any significant change. A rather inconvenient side effect that cascara sagrada caused is that stools were rather loose and also rather smelly, not to mention farts. Well it may reflect some positive change in the microbiome, however other supplements worked much better without such a problem, so I don't think it is the best choice.

Creatine HCl [800 mg per capsule; Rd: 4]: I took 5-6 capsules daily and also had an O. I think it has a weak to moderate effect on burning pain reduction and symptoms were also not pronounced. At first I was a bit happy that it works so well, however the day after O I continued the supplementation and developed a regular painful lymphoid inflammation on the left side of the neck. I thought it was a coincidence, but I stopped the supplementation. A few days later when the inflammation passed I began to take creatine again, however this time I developed a lymphoid inflammation in the right breast where the pain radiated to the right armpit. So I stopped creatine again and it took the inflammation quite a few days to subside.  So even though creatine was good for POIS I am still not convinced whether it is safe to use. When I am prepared for some more pain I am going to test this again. Another possibility is that I used a too high dose, however studies indicate that in the loading phase one can take even higher amounts without any reported side-effects.

Garcinia cambogia extract (Garcinia gummi-gutta) [500 mg per capsule; Rd: 2]: I took 2-4 capsules daily and had an O with it. Although at first I felt it could be something bad, later it turned out to be actually rather good. It had a moderate effect on the reduction of the burning pain and symptoms were also generally reduced a bit (e.g. only weak bloodshot eyes, weak depression). So on its own it is not particularly effective, however it may be a great addition to some combination. Although I have to note that certain combinations of Garcinia cambogia were found to cause liver toxicity, so one has to be careful. My personal opinion is that the effects of Garcinia cambogia are very similar to that of bitter melon as at first they both felt like something bad, however they actually turned out quite alright.

Fo-ti extract (Polygonum multiflorum) [500 mg per capsule which is equivalent to 5000 mg Fo-Ti]: I took 2-3 daily. I didn't have an O, however it has no considerable effect. It seemed to have reduced the burning pain weakly, however I think I had somewhat more intense bloodshot eyes than usual. Breast lymph nodes were also not reduced.
I also bought dried Fo-ti root separately and made a tea from it, however experiences were not much different as with the capsules. By the way Fo-Ti is indicated to turn hair very strong and so it may be still beneficial, however not for the type of POIS I have.

Bacopa monniera [200 mg leaf extract per capsule]: I took 3-6 per day. I only took it for a few days for now, but it doesn't seem to have a considerable effect. It might had a weak antidepressive effect a few hours after consumption, however I was not especially depressed anyway. However I was also weakly depressed at times, so its effect is certainly not considerable. There was a time when it felt like it warmed me, but this effect was also not consistent so I am not sure if it was only by chance. Bloodshot eyes were consistently weak, but also present. I also had a weak lymphoid inflammation at one day, but I don't think it was due to Bacopa, however it doesn't seem like it helps in this regard either.

Drotaverine (No-Spa) [40 mg per pill; Rd: 3-6]: I took 4-6 pills (160-240 mg) for a few days and it proved to have a considerable effect on POIS. Right on the first day I had an O an hour after taking the first two pills. POIS offset was not too bad, however my timing was possibly off as drotaverine seems to have a slower effect. I think it peaks about 7 hours after consumption as I felt rather well around that time. Drotaverine considerably reduces the burning pain, although I couldn't evaluate it precisely as I ate some bad food on almost all test days and then I simply ran out of pills. On the second morning after O I also experienced a marked reduction in photosensitivity. Its overall effect reminds me of alfalfa, however alfalfa still seems to be better. It is true though that on the last day I took 6 drotaverine pills along with 6 alfalfa pills and I still had POIS symptoms which shows that even the best things can't easily overcome this tenacious disease, but at least I felt considerably better.
So far I couldn't identify any side-effects, however it is possibly not a good idea to take such a high amount on a daily basis, but on days of O it can surely come in handy.
This of course makes the investigation of other PDE4 inhibitor (e.g. luteolin, kanna) worth-while.

Nutrisan RespiCalm [found in 22.5 ml: acacia honey - 13500mg, Grindelia (Grindelia robusta) flower extract - 1350mg, Round sundew (Drosera rotundifolia) aerial parts extract - 405mg, Silver Fir (Abies alba Mill) bud extract - 270mg, Eucalyptus (Eucalyptus globulus Labill.) Leaf Extract - 270mg, Common elder (Sambucus nigra) flower extract - 270mg, Common thyme (Thymus vulgaris L.) leaf extract - 270mg, Eucalyptus (Eucalyptus globulus Labill.) Leaf and Bark Extract - 270mg, Eucalyptus (Eucalyptus globulus Labill.) essential oil - 2.7mg, Mountain pine (Pinus mugo) essential oil - 2.7mg; Rd: 7.5 mg]: This got me interested as it is marketed to be beneficial for breathing issues. I only felt this effect when I first took it, however I have no pronounced breathing problems anyway. I took 3 teaspoons every day (about 15 ml) and I couldn't experience any major side-effects, however it is probably not wise to exceed the recommendation for a longer time. I haven't had an O, but the burning pain reduced noticeably. Symptoms were not major, but still present. For now I would say that it has a moderate effect and certainly seems something good to try especially for those who really have breathing problems. The most active ingredient is likely Eucalyptus as tea tree oil is also beneficial, however the other constituents may contribute too.

Vitamin C-1000 with bioflavonoids [Per pill content: Vitamin-C 1000 mg, Citrus bioflavonoid 50 mg, Acerola 50 mg, rose hip 10 mg; Rd: 1]: I took 2 for a few days. On the second day I took one 8 hours before an O and then another one two hours later. This way POIS onset was surprisingly weak. My eyes were only weakly bloodshot and in the next morning symptoms were generally low grade. I still had noticeable muscle fatigue and rhinitis, but otherwise I felt relatively alright. The stool was relatively loose and only weakly burning. It also managed to ameliorate the effects of some bad foods (e.g. coffee) I ate during the trial. Its overall effectiveness looks to be on par with Ashwagandha, so a solid moderate effect is appropriate for this dosage. There was a time when I drank a lot of lemon juice as it had some good effect, but as I remember I developed some kidney problems, so I stopped drinking it altogether. I also took Vitamin-C pills here and there, but usually no more than a 500 mg pill as I was worried about possible kidney problems.

Artemizia [Ingredients in 5 ml: MCT oil - 4400 mg, artemisinin - 60 mg, vitamin E - 12 mg, chlorophyll - 1 mg, vitamin A - 800 ug, vitamin D - 5 ug; Rd: 1 teaspoon (5 ml)]: I took 1.5 teaspoon per day (3 x 0.5 tsp. - 7.5 ml). It has no noticeable rapid effect, but only a slow one. On the second day I had an O two hours after the second portion for that day. POIS onset was somewhat weaker than usual, but not considerably. In the next morning symptoms were somewhat lighter, but weakly bloodshot eyes and breast lymph nodes were still present. I also experienced a mild depression so it was nothing like saffron. The burning pain was still present, but noticeably reduced. I took one teaspoon in the morning as in the afternoon I had more than usual physical work, but exercise intolerance was rather usual with pronounced bloodshot eyes and a sore throat by the end of the work.
As for side-effects I am really not sure, but it may cause some circulatory issues. I don't usually measure my blood pressure only if something doesn't seem right. So my bp was somewhat lower than usual, but a longer trial would be necessary to clarify this issue. Given the components it is not clear if artemisinin was really the most active agent, but at least the product was beneficial in overall. I would judge the effectiveness as weak to moderate.

Yohimbe bark extract (Pausinystalia johimbe) [500 mg per capsule with 2 % standardized alkaloids content (~ 10 mg). It doesn't specify whether the alkaloid is actually yohimbine.; Rd: 1]: I took daily 2 for a few days, but I didn't have an O. It certainly has a positive effect, however its efficacy is rather poor. It managed to somewhat reduce gut problems, but other symptoms were almost as usual. This was especially apparent when on the third day I had more than usual work and exercise intolerance was  practically the usual with muscle pain/fatigue and bloodshot eyes that were only slightly better than usual. I couldn't experience an increase in libido which is rather low nowadays possibly due to too much work. There are also possible side-effects, although these were not very salient. At times I felt some transient heartaches and some cramping pain at other places, but they were not consistent and bearable. Of course given its low effectiveness and possible adverse effects I don't believe I will add this to a future treatment regime.

Some past experiences: I wanted to retest them before writing about their effects, however I just don't know when I am going to get around to have time for them.
- beta alanine: I took it for two month, but I don't think it was any effective.
- alpha lipoic acid (ALA): I took it for two month partially with beta-alanine and it was possibly weakly effective.
- milk thistle (sylimarin): I took it several years ago and I remember that I had some positive experiences with it. It possibly has a weak or moderate effect.
- coenzyme Q10: I took it a few years ago, but rather sparsely and some vague memory tells me that sometimes I had a noticeably positive experience with it while at other times it was not so useful. Based on recent findings I definitely need to recheck this one.

Some preliminary experiences:
- DHEA: It helped at least weakly, but muscle fatigue may have been worse.
- CBD oil: It helped weakly, but as I increased the dose I experienced nausea and the eyes were also unusually bloody.
- olive leaf extract: I tried this a few month ago by taking three capsules across the day and it certainly reduced the burning pain, however in the third morning the eyes were bloody veined (not bloodshot) and it scared me a bit so I stopped taking it. Maybe I should test it the way Going less Crazy suggested.
- ADEK vitamin: I tried this in the summer with double dose and while it certainly helped at least weakly the following day I sweated like crazy which was rather unusual even for a summer day.
- Allegra: Symptoms were either unchanged or somewhat even worse.

Muon

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Re: Progecitor's summary
« Reply #9 on: November 03, 2021, 09:06:55 AM »
Over-the-Counter Ocular Decongestants in the United States – Mechanisms of Action and Clinical Utility for Management of Ocular Redness
Nasal congestion
Red eyes
Naphazoline eye drops for neurosomatic disorders/neural network disorders are being used but higher concentration like 0.1%, 1 drop in each eye.
« Last Edit: November 03, 2021, 09:14:22 AM by Muon »

Progecitor

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Re: Progecitor's summary
« Reply #10 on: November 17, 2021, 07:57:33 AM »
Astaxanthin [4 mg per capsule; Rd:1]: I took two pills per day and even had an O. Its effect is really great. There is no rapid antidepressive effect, however the reduction in the burning pain is considerable and can be felt in the reduction of other symptoms as well. It has a lesser effect than drotaverine or licorice, but I couldn't perceive any side-effects so far which makes it a really great addition to a stack. More specifically bloodshot eyes were moderately reduced, but I still had morning photophobia. It helped the most with exercise intolerance as even after exhaustive work I had greatly reduced eye problems and also hadn't developed any sore throat. Muscle pain was still present to some degree.
The only problem I see with the product is that it contains too much vitamin E, which makes me hesitant to take more than one each day.

Safflower oil (contains linoleic acid, oleic acid, palmitic acid and stearic acid) [Daily dose is 2 ml (1 coffeespoon) which contains 340 mg of MUFAs from which 340 mg is oleic acid and 1462 mg of PUFAs of which 1462 mg are omega-6 fatty acids]: I took 1.5 (3 x 0.5) teaspoon per day which is about 4-5 times the recommended daily dose. This turned out surprisingly good. The overall effect somehow reminded me to that of passionflower. It doesn't seem like it turns POIS any worse, so it is quite unlikely that linoleic acid would be detrimental. I had an O and while it can't prevent POIS onset the symptoms in the following days were generally weaker, so it helps with recovery. The stool was noticeably yellowish and looser, but the burning pain was still present somewhat. Generally it had about a moderate efficiency in POIS management.

Cold pressed linseed/flaxseed oil [In 10 g it has: 1 g of saturated fatty acids, 2 g of MUFAs and 7 g of PUFAs]: I consumed 3 teaspoons of linseed oil daily which is possibly about 10 grams. It was beneficial for the gut issues, but it had a weak efficiency. Safflower oil was definitely more useful.

Feverfew tincture [In 100 drops it contains the following: feverfew - 83.3 mg, peppermint – 55.5 mg, red raspberry leaves – 55.5 mg, Valeriana – 27.8 mg, lemonbalm – 27.8 mg, ginger – 27.8 mg; Rd: 45-100 drops]: I took 60-100 drops a day and also had an O. It certainly helped with POIS, but only weakly so as symptoms were not much better. The burning pain reduction was somewhat better. It also seemed to have some weak, but short-lived antidepressive effect. My overall estimation would be a weak to moderate efficacy.

Seven mushroom mix [one capsule contains 143 mg from each of the following: ganoderma, chaga, shiitake, maitake, lion's mane, Cordyceps militaris, Tremella fuciformis (snow fungus or snow ear); Rd:2]: I took 4 capsules per day and had an O. At first I was a bit disappointed as POIS onset was only slightly weaker. However it certainly helps with recovery as it is really good for the gut issues. By the second morning I felt much better and the morning photophobia was noticeably reduced. I still had some muscle pain though. Fortunately I had no signs of chest inflammation and the lymphatic nodules in the breasts were actually reduced in size, although they haven't disappeared completely. Its overall efficacy doesn't seem much better than lion's mane alone, but it is still a very good supplement.

Bio Siberian ginseng powder (Eleutherocus senticosus) [Rd: 2-3 g]: I took about 1.5 - 2 teaspoon a day which is about 6-8 g. It doesn't have any considerable effect or side-effect. I masturbated two times without an O and both times symptoms got worse so it couldn't even protect against partial POIS. It seemed to reduce the burning pain a bit, but even flaxseed oil was better in this regard. At least it seemed to help a bit with libido recovery what I consider a good thing.

Diosmin + Hesperidin [One pill contains: Diosmin: 400.5 mg, Hesperidin: 44.5 mg, grape vine leaf extract: 168 mg, grape seed extract: 158 mg, vitamin C: 80 mg; Rd: 1]: I took two daily and had an O. I think it can lighten POIS onset somewhat, but I may need to test it multiple times to verify this. It certainly has a positive effect on gut issues. In this regard it was close to medicinal mushrooms. Depression was so-so and bloodshot eyes were only slightly reduced and it couldn't protect against coffee or food potentiation. Lymphatic issues were quite unchanged or only slightly better. Although bloodshot eyes were close to average, the eye burning that usually occurs as night comes was noticeably reduced. I mention this as I also noticed a similar effect with grapeseed extract alone. However this supplement was better than grapeseed alone, so the other components must also have a beneficial effect. It also lightened morning photophobia a little bit, but the change was not considerable.

Resveratrol (Polygonum cuspidatum root extract) [250 mg per capsule; Rd: 1]: This is another great find. I took 2 capsules daily and had an O. Resveratrol evidently has a considerable effect on my case. Most of my symptoms got better and especially my gut issues. I could move better, felt better, photophobia was noticeably reduced, breast lymph nodes became smaller, but still present. I still had some depression, but it had a really positive effect on my mood as I just generally felt well or normal, which is quite unusual. Resveratrol provided the least help with bloodshot eyes, but even this symptom seemed a bit better. It definitely has a place among my top supplements especially as it had no apparent side-effects so far.

Zembrin - kanna (Sceletium tortuosum aerial parts extract) [25 mg per capsule; Rd: 1]: I took one capsule a day and also had an O. This one proved to be quite elusive. When I first took Zembrin it evidently induced bloodshot eyes and I also became really depressed. The burning feeling also felt somewhat enhanced however stool quality seemed better. Interestingly in the following days the initial reaction became much reduced and the positive effects became more dominant. I also had an O, but unfortunately I took one capsule of MACA that morning and even though POIS was light I am not sure of their individual contributions. Breast lymph nodes were quite unchanged and I was feeling rather average too while taking Zembrin, so my point is that it is neither too good, nor too bad and on the overall I can say that it is weakly beneficial in my case. I also realize that this is not the best supplement to prove any point about opioids due to its PDE4 inhibitory capability. So even though it is not the best supplement for me I can easily imagine that it could prove better for other POISers especially if they had problems with anxiety which is not an issue for me or at least not in a physiological manner.

Canola oil (Premium cold pressed oil without additives): I only tested it one day, by taking one teaspoon in the morning and one in the evening. I spread it on top of bread and ate it that way. I got a similarly bad reaction as I usually experience with eating walnuts. My symptoms were also quite bad in the following few days even though I tried to take several good supplements. I will need to test this at least one more time just to see if the same thing happens, although I have already suspected canola as I had problems with other products that list it as an ingredient. I also don't think the quality or manufacturing could be blamed for any effect as the product seems to be of fine quality.

Synephrine (Citrus aurantium extract) [10 mg per pill; Rd: 2]: I tested synephrine for a few days by taking 2 pills per day. At first it didn't seem so bad, but later I noticed that about 3-5 hours after consumption I would usually develop more pronounced bloodshot eyes. This was not severe though and usually resolved mostly in 1-2 hours. Stool quality seemed better, but the burning pain was unchanged or a bit worse. Breast lymph nodes were also unchanged. All in all synephrine possibly makes POIS a bit worse, however the overall effect is really weak so I don't believe that alpha adrenergic activity is at the core of my problems.

berlin1984

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Re: Progecitor's summary
« Reply #11 on: November 23, 2021, 04:44:58 PM »
Safflower oil (contains linoleic acid, oleic acid, palmitic acid and stearic acid) [Daily dose is 2 ml (1 coffeespoon) which contains 340 mg of MUFAs from which 340 mg is oleic acid and 1462 mg of PUFAs of which 1462 mg are omega-6 fatty acids]: I took 1.5 (3 x 0.5) teaspoon per day which is about 4-5 times the recommended daily dose. This turned out surprisingly good. The overall effect somehow reminded me to that of passionflower. It doesn't seem like it turns POIS any worse, so it is quite unlikely that linoleic acid would be detrimental. I had an O and while it can't prevent POIS onset the symptoms in the following days were generally weaker, so it helps with recovery. The stool was noticeably yellowish and looser, but the burning pain was still present somewhat. Generally it had about a moderate efficiency in POIS management.

What if Safflower oil (= mostly linoleic acid)
"elevates the endocannabinoids 2-AG and anandamide"
which helps you somehow?
Source: http://yelling-stop.blogspot.com/2021/11/does-linoleic-acid-induce-obesity.html "Essentially, we are eating a diet that is giving us the munchies, the effect that marijuana has on those that consume it."

This somehow relates to the thought that I'm self-medicating with Pizza (cheese casomorphin etc) on the day after orgasm.
Others had success with CBD.

But how would this interfact with your caipiscin like theory?