Progecitor's summary

[Progecitor]

For reference I began to masturbate at the age of 11 (1996) and the first symptom I can remember was IBS (in 1996 or 1997). I think I might have overdone masturbation around the age of 12-13 and it could have lead to POIS, although not certain. I realized that many of my symptoms were related to sexual activity (~2000), POIS exacerbated at the age of 17 (2003) and I developed a serious mental problem due to a distinct symptom (not for disclosure). I discovered the name of the disease in 2018. Found the first acceptable treatment (MACA) in 2020. Even though both SSRIs, SNRIs and tryptophan work about the same way I still have a special problem with them.
I have never taken illegal drugs. I have never smoked. I have never had a relationship or sexual contact with anyone whatsoever. I hardly ever drink any alcohol. I think I am a bit addicted to porn. I am definitely hetero. I masturbate around once in 1-2 weeks time.

Symptoms
In the beginning I often had a feverish feeling and was prone to IBS-D. This might had been because I hadn't eaten enough as my POIS seems to be accompanied with a serious energy expenditure. I was probably more prone to dysbacteriosis then, but it can't be proven in my case anymore. As to my current symptoms:
- The burning sensation of excretion I said before. After O I tend to have IBS-C (not by definition).
- Hypothermia or at least a perception of it after the heat of O passes. It is also noticeable at acute-chronic phase turnover after which I don't really feel cold anymore. In the winter I often can't keep my hands warm. Even wearing two gloves can't get it warm, although winters here are quite mild usually.
- Some kind of mild rhinitis is present all the time. The phlegm often contains some blood. My nose is often dry. A burning sensation can often be felt in the nose. Interestingly taking tryptophan or medicinal mushrooms (probably apigenin) makes this go away, but I also tend to sneeze more often, because of them.
- I hardly ever cough, but after talking more then one hour I usually develop a sore throat. I can have some coughing sprees too when I do a lot of physical work.
- Ocular photophobia: It occurs in the mornings. I can't keep my eyes open in the light as I feel as it is burning my eyes out. If I try to force them open I often sneeze. I don't have a skin light sensitivity.
- Bloodshot eyes/Red eyes symptom: I often have a blurry vision linked to brain fog. I am also short sighted with about -3.0 and -4.0 diopter. My sight began to deteriorate around the time I had began masturbating, so there might be a link, but not necessarily. At acute onset I can have quite red bloodshot eyes. It doesn't mean I have full-blown red eyes, but veins seem to leak. It might be due to vasodialation and/or irritation. This symptom can change really fast. It looks like my eye is constantly regenerating, but it can't always keep up with deterioration. In chronic phase my eyes can be really white, but as a low grade POIS is present it can return to some degree intermittently.
- Skin problems: I only have mild skin symptoms. Some slight red dots appear on the chest after O. In the first few days after bathing and drying myself with a towel I can get a very itchy skin for a short time or until dressed. I often have some acne after O even if I have a shower, but it might be normal for the skin to become more oily after O. Very rarely I can develop a really painful red rash besides the anus when I sweat and work a really lot, but with cleaning and rest it disappears by next day. Dandruff is also definitely correlated with acute POIS, but I can manage it quite well with Nizoral.
- Increased hunger right after O: I just have to eat anything even when my stomach is full. I also have a similar experience by eating apple in the chronic phase. I also can't get rid of biting my nails unconsciously because of this and I might be more susceptible to pathogens, although it also seems that they can't really live within me.
- Cognitive problems: I have typical mind fog which is usually strongest in the morning, but can still be present in the evening. Blurry vision and decreased cognition are tightly linked. The more acute POIS is the less I can focus. I can have a psychogenic nausea from any mental activity during a very acute phase. I can usually tolerate passive activity (like watching TV) better then active activity (like reading or playing video games) even if it is fun. I have short term memory problems like forgetting things I have been just told or having a complete block down when speaking about something and I often can't recall words I want to say. I don't seem to have a problem with long term memory otherwise I wouldn't be able to write in English. Actually if I am reminded (like next day) I can even recall a short term memory, so it seems that it is all about the inability to recall short or long term memories. In chronic phase I can recall a lot more things and I can speak much more fluently. I also seem to be much more creative then. I don't know much about this stuff, but there is a distinction of episodic memory related to detail. I often noticed that when I read a book in chronic phase I remembered the details quite vividly, but after an O it is like I had an amnesia in episodic memory. I can still roughly remember what happened, but I simply can't remember the details and they don't really come back even in the next chronic phase unless I learned them. Needless to say how terrible a storyteller I am. When brain fog is heavy in the morning (usually until late afternoon) my train of thoughts often stops completely. I just gaze stupidly at the world and can only have the most primal of thoughts. I actually see that others see that I am stupid, but I just can't do anything about it and it is frustrating. I also found that mental activity can have a lower, but similar effect as tryptophan, and it is no wonder as it actually increases with both mental and physical activity.
- Muscle fatigue: General low-grade muscle fatigue. I can usually overcome it with willpower, but it still hurts while working. The lower leg doesn't really hurt that's why I can stand alright. The thigh hurts more especially when going upstairs. I also feel a weaker pain in my arm, but it is only a problem when I want to lift a heavier weight as even when I develop muscles I simply can't lift things due to increasing pain. It is so good to sit down after work that I don't even want to stand up for at least an hour. I found that applying menthol balsam can really regenerate it by next day, but with physical activity it soon comes back. Physical activity seems to have a dual effect as in some regard it makes my symptoms stronger, but it can also clear up my mind. With a short physical activity red eye problems can get better, but after a while it can even get worse due to exertion.
- Nodules (enlarged lymph nodes) in the breast: I don't even know when I developed this, but I had them for years and they are present almost all the time. After acute POIS onset larger nodules can be felt in the breast tissue. They are mildly painful to the touch. They get smaller as POIS vanes, but can still be present in chronic phase. They are certainly not malignant, but there is a definite link to the chest pain symptom. The breasts are completely normal in appearance otherwise.
- Periodic chest pain: I only have this symptom from my early 20th of age. I think it has a connection with breast nodules as pain usually develops beneath them. This most often occurs right after O and when I manage my POIS badly like eating undesirable food. It is usually present for a few days.
The pain can be very severe. I can lie in the bed without feeling any pain, but for the slightest of movement it feels like being stabbed for a short moment. I think it might be partly because of some physical tension, but it might be some immunological thing too. It can appear on either sides or at both sometimes and it can also go from one side (it can disappear) to the other. At a moderate episode I was at the pediatric clinic and ECG proved negative and radiography also proved negative so it is not apparently a pulmonitis or at least it is not an apparent pulmonitis. Blood test was rather normal and only creatine phosphokinase (CPK) was high with CPK: 1032 IU/L (24-190). CPK was good in other blood tests where it was measured. It might be an allergic case of extrapleural interstitial liquid without pulmonitis, but I might be wrong.
Somewhat contrary to this when riding a bike (weak exertion) and breathing a lot of fresh air symptoms can get better. I also noticed that charcoal can help somewhat while coffee (black list foods too, but coffee did this many times so I am sure of it) can reintensify pain. Actually it is rather lucky that I have never told anyone at my work place about my chest pain as I have it quite frequently. I can usually conceal it quite well and even in those cases I couldn't I always said it was only a heart burn, because of a weak heart, so they don't suspect me of harboring tuberculosis or something. If I had really told about it to others I might have been in trouble due to the pandemic as I would have been suspected frequently even though I had this symptom for a decade now. It is not even like I was lying as even my relatives and my doctors had never believed it. Even at the one time my blood test showed something the doctor said it would go away. I knew that even without being told, but the problem is that it always returns too.
- Periodic kidney pain: at a time it occurred once or twice a year and lasted about two days. Usually the site of the kidney was in pain. I haven't had a medical check-up for this so I don't know more. I am sure this developed due to sit-ups, which can increase my disease the most. I think I even had a pancreatitis once for a few days due to this. When I have a muscle fever I feel really bad for days. At the time I thought it was due to some kind of lactic acidosis, but I am really not sure at this point. I haven't had this symptom since I stopped doing sit-ups and it was years ago.
- Urinary problems: I don't have a problem with holding the urine, but I have a serious problem with the urge of urination. I don't really have to go peeing very frequently, but the urge comes in a few hours. If I don't urinate my symptoms are enhanced. If I urinate the volume is usually small, so it is not like my bladder can't hold any more, but the capsaicin-like, burning compound probably begins to irritate the nerves in the bladder. The kidneys probably also reach a threshold where they can force this compound into the urine and so its level begins to elevate in my whole body aggravating symptoms. It is often a bit hard to let go as at the end of the penis it actually creates a slight pain which wants to stop my body from letting go. I could sleep through a night when I was younger, but since a few years ago (when I was 28-29) I almost always wake up at night sometimes very precisely in 6 hours from going to sleep. Although when I am in the chronic phase I can often sleep through the night without waking up.
- Slight tachycardia: My blood pressure seems to be normal usually, but it seems I can have some problems with my pulse. There are times when I suddenly wake up at night even when I didn't have any bad dreams. My tinnitus can be especially loud. When measuring it the blood pressure seems to be good, but pulse can be 90-100. After I go and urinate (decrease the capsaicin-like compound) and drink a bit of water I can go to bed again and slowly I feel relaxed again.
- Conjunctivitis: I am not sure the medical terms I use are correct, but I often have dry eyes which is of course in some relation to bloodshot eyes (maybe uveitis). This symptom can occur anytime and especially when I am in front of the monitor. It also tends to increase at late night when I am getting tired. If I still force them I tend to have more pronounced bloodshot eyes.
- Sleeping problems: Often I can only get myself to sleep when I am on my belly. At the first time I heard about COVID-19 patients being better lying on their belly-side I immediately associated to my disease and always thought that there must be an association between the two and now it seems especially likely. I usually get quite tired right after O, but not to a degree that I can't stay awake, just that my body really desires it. I can have a disturbed sleep on the first sleep after an O, but on the following days I can usually rest quite well unless I wake up because of the urge to urinate or the loud tinnitus. What I also noticed that in acute POIS I don't really have any dreams. I am not exactly sure if I don't have them or just can't remember them. As chronic POIS follows I begin to have more dreams or at least I can remember them. The problem with vivid dreams is however that they can often be erotic and my unconscious ego tends to realize the consequences too late.
I also noticed that I can get a very refreshing sleep without a blanket even if I have a pajama on, but I can only do this in the summer when there is a relatively warm air, especially due to my hypothermia.
- Headache: Of course I can also have headaches, but I can pretty well control the appearance of this symptom, so they don't pose such a threat anymore. At the beginning of my severe POIS development (around the age of 17, but I had symptoms beforehand too) I had some very serious headaches. At one time I clearly remember that I was lying in bed for two days as I had a very bad headache (unresponsive to painkillers) and sometime I opened the window to get some fresh air and then miraculously only an hour later there was hardly any pain. Since then I always try to get as much fresh air as I can and keep a window slightly open even during winter. I haven't really tested many painkillers, but Quarelin (400 mg metamizol sodium, 60 mg caffeine, 40 mg drotaverine hydrochloride) can surely get rid of it and often even a half is enough if the pain is not severe. It is rather strange that it contains caffeine as drinking a coffee can often elevate (there are cases when it lowers it) a head-ache as well as my other symptoms. I suspect that other components play a role in this and caffeine just might be good. Another thing that can cause a headache is if I can't go to the toilet in the morning and have to do a lot of physical work. A headache that develops this way usually doesn't react well to painkillers and often only going to the loo can solve the problem after which the pain can slowly subside. Mainly this is the reason that I still keep drinking coffee in the morning, although it can surely cause bloodshot eyes and enhance chest pain, but can reduce brain-fog and clear me out. Head-ache also has a connection to bloodshot eyes. When bloodshot eyes are very severe I can develop a head-ache in response, but it can also happen the other way around.
Other less frequent symptoms: transient joint pain (There was a time when I actually developed it for a few days or weeks while I was taking glucosamine-sulfate), transient muscle twitches (usually resolves with position change. I think it might be connected to the blood veins, but I was not even aware that this could be a POIS specific symptom and haven't really cared about it.)

The following may not have a relation to POIS:
- Sensory neuropathy: Around 2010 I had about 4 or 5 episodes (with a few month to a year in between) of neuropathic pain which had lasted for about one or two month. It either started from my big toes on both of my legs and day by day slowly crawled up to my waist. Or it started from the fingers on one of my arm and crawled to my chest. It felt like constantly being stabbed by tiny needles on the skin surface which was a hellish pain without seeming of an end. I could move, but I didn't want to stand on any of my soles because of the pain or couldn't easily hold a pen in case of my fingers. There was a time when I was lying in the bed in the morning when it was warm under the blanket, but I felt like freezing. It seems my receptors had ran haywire on my skin. The first time was the worst though as I thought that it would never go away. At the first episode I went to see the doctor after a week where the GP prescribed meloxicam, which did nothing to the pain. I also went to Rheumatology where they told me I have no muscle, but they didn't give me the correct diagnosis (it was dorsalgia and muscle pain). As the pain somehow disappeared on its own after quite a few weeks I didn't even seek medical knowledge in the following episodes. I was quite disappointed in doctors by this time. I have only found out that I had actually had sensory neuropathic pain a few years ago while I was searching for POIS. I really have to question how competent they were at Rheumatology or if they just didn't want to bother with me. Fortunately this kind of pain hasn't returned for years, but even if it had now I at least know its name.
I had some O during these episodes and it had never changed the normal POIS episode. Still I think the actual initiation of the episodes were linked to times when I did sit-ups more often, and since I realized this I have never done sit-ups anymore. It really might have been the nerves in my backbone in this case, but who knows for sure.
- Enlarged lymph nodes on the backside of the neck somewhat under the ears. I developed this a few years ago. Once or a few times in a year either of them can get inflamed for a few days, but then the pain disappears. It doesn't react to acute phase, but it seems somewhat similar to the chest pain.
- Epigastrial discomfort: It also only developed a few years ago. It might have been the result of eating too much all the time. I often felt my stomach was full even when I was hungry. A mild pain was present almost all the time. I didn't have a medical check-up for this but I also never had reflux.
- Ass muscle pain/inflammation: It also developed only a few years ago. The origin of the pain is deep in the muscle somewhere close to the rectum, but it doesn't seem I can feel any nodules there. It resembles very much to the chest pain. It usually lasts a few days. The pain can be present on only one side, but can also move to the other. It has the same stabbing kind of pain with movement. Only a kind of inflammation can be felt when I am not in motion. As pain becomes very severe I practically become lame and can hardly move. Now the most perplexing thing in this regard is that this symptom most often occurs at the beginning of the chronic phase and the only really thing that can actually stop its build-up is having a release by O. If I don't release just masturbate it can enhance the pain. Even O doesn't make it regress right away, but it seems to be a turning point in its course. Two years ago I very often had this pain and interestingly chest pain occurred less often although I masturbated with about the same frequency.
- Left ear tinnitus: Developed it around 2010. Maybe it was due to an infection. I can hear the pulse constantly which can be a pain when I am reading a book in the silent room. Sometimes it gets louder, but measuring my blood pressure and pulse often proves normal. Sometimes I had acute POIS related sleep disorder when I suddenly woke up in the middle of the night with a very loud tinnitus. When I measured the blood pressure it was often completely normal, but pulse was often around 100 what I wouldn't have expected while sleeping.

Other considerations:
- Chronic sleep deprivation generally makes me feel more ill.
- After acute sleep deprivation (about 22 hours) I develop a kind of superPOIS state. I begin feeling very unwell. I get a constant tingling sensation in my belly. My anus is constantly itching. At a time I also felt like freezing, although it was a warm summer day. It was hard to stop the shaking under the blanket, but a good sleep solved the problem every time. I only had this state a few times and not in the last ten years, because I am not stupid to stay awake to wait for it anymore. I should recheck this state, but I can't really get myself to do it.

Things that enhance my POIS:
1. ejaculation: Make no mistake I have a chronic phase and O just enhances it in my (s)experience.
2. sleep deprivation: either chronic or acute
3. diet: It doesn’t really matter what I eat I still have POIS, but some food can seriously enhance it.
4. physical and mental exertion: usually dual effect: some symptoms strengthen while others weaken.
5. medicine and supplementation: Can go both ways. Many things are under trial.

Psychological effects that can enhance my POIS (probably due to parasympathetic enhancement):
- Having a cathartic experience while watching a good movie.
- Crying (sometimes because of my sorrow)
- Reading a lot has a dual effect (probably tryptophan)
What actually weakens my POIS is psychological stress, but only for a short time and it also doesn't make it disappear.

I usually have brain fog and ocular photophobia in the morning and by evening my mind tends to clear up somewhat. I also tend to have a burning urine in the evenings.

[Progecitor]

Diet
Some foods evidently enhance POIS, but this is not an actual food allergy. They also act the same in the chronic phase, but in the acute phase the impact is more severe. There are foods that act quickly (like in an hour), but others act only by next day or as long as it is in my body. Unfortunately I couldn't get myself into a rigorous selective diet and also haven't documented all separate symptom enhancement in detail, but they all generally make me feel more ill. Medical tests didn't prove lactose or gluten intolerance.

Black list:
- paprika/pepper: I mean the normal, sweet variety. Even though it doesn't contain capsaicin it still gives a burning feeling at the exit. Of course hot paprika is twice as worse. Also any food made from paprika even if cooked or fried has a negative effect, except if it is pickled.
- tomato: First it makes me better. Shortly after (minutes) consuming it my blurry vision clears up and I can think more straight. As it moves along digestion it makes me a bit worse, but nowhere near as paprika.
- apple: same as paprika, but also makes me very hungry just as an acute pois onset. Apple makes the stool looser, but the burning pain is also intensified.
A few years ago I often drank some diluted apple cider vinegar before going to sleep and I usually woke up much fresher without the pronounced brain fog. The reason I stopped using it is that somehow I tend to forget about good methods. It seems likely that fermented apple only contains the good components of apple (most probably quercetin) and not the ones that make me ill.
- apricot: the fruit and jam also, the bloodshot eyes are especially bad which is usually accompanied by morning ocular photophobia.
- cherry: Bloodshot eyes. It also contains melatonin, but not sure of its involvement.
- banana: Bloodshot eyes by next morning even though banana contains tryptophan which would theoretically lessen this symptom.
- peach: usually needs a greater amount for an effect.
- strawberry: seems to have a very mild, but negative effect
- poppy seed: acts quickly and long, same burning effect. Needless to say that eating poppy seed cake with cherry as one would usually do makes me very ill. Cetirizine may only have a mild effect on POIS, but it may greatly reduce the effect of some foods. I haven't tested this idea extensively, but I ate poppy seed a few times without any problems while taking MACA and Cetirizine.
- walnut: generally feel bad, interestingly has a slighter effect when eating continuously, but not eating it for a time, then starting again has the same severe effect. Certainly increases the burning pain just like poppy seed does.
- sour (pickled?) cabbage: quite severe, but interestingly normal cooked cabbage doesn't really have an effect, although it seems I can lose weight overnight by gorging myself with (meat and rice) stuffed cabbage, which is funny.
- whole bread / graham bread: Enhances POIS symptoms. Especially if eaten with foods like paprika/pepper. Stool is sticky and burning which I think is a sign of dysbacteriosis and dysfermentation. I also can't eat normal bread as I get constipated and my gut aches. I found that I can at least eat rye bread and German wheat/spelt in moderation without problems. German wheat has a high tryptophan content which might have something to do with it. I also don't have any problem with soft buns or croissant, so I don't think it is a gluten matter at all.
- red wine: Really the only thing I can drink, but this also makes me the worst. Consuming a greater amount (I don't remember, but maybe half a bottle or a whole bottle) can cause a burning diarrhea.
Its strange that it contains serotonin and I still feel bad.
- coffee: Clearly enhances the disease, especially the bloodshot eyes and the chest pain when it occurs at the time. Without sugar or with milk (even if sugar is added) has a slighter effect. It seems a controversy, but I still drink it as it helps bowel clearance. I noticed if I can't go to the toilet in the morning and do physical activity at work I often develop a serious headache supposedly because high toxin concentration in the bowel. There were several cases when I really regretted that I had drank coffee during work even though my gut was normal at the time. At home I only drink it with a lot of milk while also eating something, but at work it is usually not available. So several times I drank it in itself and it often induced an unavoidable diarrhea. Interestingly often there wasn't any stool, but only some clear, white mucus with a lot of flatulence. First I wasn't even sure what it was so once I took a sample to parasitology, but they only said that it was negative. I have to guess it is really mucus either due to erosion or a clear apoptopic event. When I drank pure coffee without added sugar it happened less often, so I have to guess that bacteria are also involved (maybe SIBO).
- cinnamon: there is no stomach ache as in allergy, it just enhances POIS. Red eye symptom can be bad.
- clove (I mean the one that is used with biscuits and not garlic): like cinnamon
- thyme: like cinnamon
- milk: I don't have a noticable problem with it (I don't drink more than a liter daily). Yogurt can have a dual effect. Although lactase ensyme (5000 FCCU) has a minimal positive effect, I wouldn't say it is worth serious consideration. Contrary to this after going home from the negative lactulose test it gave me a severe itchiness at the bottom, but without diarrhea, so disbacteriosis still must have occured. This is one of the reasons that I think that lactic acid must be involved.

In my experience if it gives a burning feeling or a red eye symptom or a morning ocular photophobia or enhanced blurriness than it is surely a POIS enhancing food.
Morning ocular photophobia can occur with normal acute POIS, but can be especially bad after some food. Photophobia has a slight relationship with bloodshot eyes and a certain one with light induced sneezing. The more serious cases can be accompanied with serious eye pain. This can also have a head-ache inducing effect.
An approximate intensity enhancing order would be apricot=sour cabbage > cherry = banana > apple > peach > strawberry

Based on FODMAP the polyol group may have to be considered, although I have good items on the red list and bad ones on the green list also.

Maybe list:
- pears seem to have a cleaning effect even if it creates a severe flatulence, but it can also make things worse if taken with another enhancing food. At once I had a very severe illness (POIS episode) when I ate pear, banana and grape together.
- tangerine: it seems to cause severe flatulence, but doesn't really have an effect on POIS, although it makes me a bit less foggy, but I rather avoid it. (In retrospect it could be good).
- watermelon: Can be both good and bad. If consumed in consideration it has a good effect, but too much can cause severe sometimes burning diarrhea. As of late I tried to eat the inner hard side of the shell as it supposedly contains citrullin. I found that it might be a little good, but needs further testing.
- grape: I am not sure. It sometimes make me feel much worse, while sometimes nothing happens. I still need to test this more. I seem to have a problem with raisin too, but mainly flatulence. (probably help - needs rechecking)
- egg barley (pastry): I have a suspicion that it can induce inflammation, but not confirmed. Also other pastry don't have any effect.
- tea: teas are very controversial. I haven't had the time to sort it all out. Some good quality black tea without anything added can surely help sore throat. I also consume medicinal teas, but usually mixed. Some tea can make me better, while others rather worse, but it is also not always evident. So far I think that lemon-balm actually helps.
- cheese: I am not sure as I only consume small amounts, but it doesn't seem to have an effect. One thing I found is that it can make me prone (not always, but seemingly more often) to nocturnal emission, which is quite bad itself. Maybe no wonder it is called an aphrodisiac.
- cauliflower: gives me a severe flatulence, but I don't think it actually does anything to POIS. (probably helps - needs rechecking)
- mushrooms: I am often ill of it (gut ache), but not always. I also don't think it is POIS related.
- egg-plant: I am defenitely ill of it (gut ache), but I also don't think it is a POIS related thing.
- chestnut: gut ache, not POIS I think
- household biscuit: gut-ache, not POIS related

White list:
- spirits: I don't have much experience as I don't like them, but small amounts don't have an effect.
- sugar: At acute disease onset my energy craving is so enormous that I often eat a lot of sweet stuff. It might not be good for my health, but it is also a wonder I haven't developed diabetes yet.
- sunflower seed (raw) and its derivatives like oil and margarine doesn't do anything to POIS.
- cocoa: I actually feel a bit better after consuming. Might be its serotonin content.
- potatoes
- rice: in itself not, although consuming it with cinnamon or paprika might have a slight enhancing effect. Maybe pectin is involved.
- corn
- cucumber: neither raw nor if pickled has an effect. If it is sour I feel worse, but I don't think it is a POIS effect.
- bean and lentils: although flatulence is not a good feeling at acute POIS onset, but they also contain tryptophan and they can seemingly shorten the acute state.
- meat: I haven't found any meat type that I am worse of, but I am not really fond of meat. I eat it if there is, but I can also do well without it. I also don't have a problem with sausages which makes me wonder about histamine.
It seems to me that I don't tolerate fat so well, as sometimes eating a bit of beacon can cause a slight, but prolonged (few hours) heartburn. The strange thing is that POIS or ejaculation for that matter can alleviate this problem. As I get very hungry after O, it seems to me that energy reserves are used up at an accelerated rate which also causes a kind of clearance even if a foggy hell is its substitution.
- ginger: First I was suspicious because of its burning taste, but I thought it helped a bit. Its positive effect became very clear when consumed it after (MACA+Cetirizine) as it gave a clear benefit.
- pea: a little suspicious, but not in regard of POIS I think
- carrots
- vegetable (root)
- radish
- beetroot
- lettuce
- rumex
- spinach
- pumpkin
- onion: raw and cooked, but I have a suspicion that raw onion can make me susceptible to tonsillitis. I had it every year for at least thrice with a duration of 1-3 weeks sometimes only 1 clear week between and I think I often ate raw onion before it happened. I wanted to verify this by stopping to eat it. Actually I haven't had it for more than a year now, but as coronavirus struck we also wear mask almost every time so it could be only that as well.
Actually I feel better from raw onion, but I somehow forgot about it as I have a somewhat paranoid fear of tonsilitis. Maybe I should pickle some red onions and see how it works.
- garlic: I didn't notice any effect, although I haven't really tested it extensively. Although I have a suspicion that garlic scent is more prolonged for me than others for the same amount consumed.
At a time someone brought us pickled garlic and it didn't cause this all permeating odor. Recently my mother got this bottle called apple cider vinegar fermented on garlic bed. Sometimes I add a little to my usual tea and it seems like it gives a real extra kick to it. Most probably because it is loaded with quercetin from both apple and garlic.
- eggs: I didn't notice any effect, although I don't eat it frequently.
- broccoli: it can make me feel better
- coconut: no effect
- raspberry: I don't think I have a problem with it or not perceptible.
- blueberry: I think I feel better because of it.
- honey-dew melon
- nut, hazel-nut
- lemon: It certainly helps reduce brain fog.
- orange: It helps with POIS.

Also of note that eating only from the white list won't make POIS disappear as I also had POIS with a clear bowel.
Another consideration that should be taken is that some foods may contain compounds with both good and bad effect.
This list is a good approximation, but I wouldn't say that everything is 100 % tested out. Recently I have gained so much new knowledge on POIS that I think I should retest everything and do a serious revaluation retrospectively and document everything before I forget it. This might also take years especially if I have to stop now working medicine in order to have a clear "foggy" view.
It is very important to note that I view POIS based on my personal theory and I see it subjectively.

It is rather strange that fermentation could take away the POIS enhancing capability of both apple and pepper (paprika), but it can add it to cabbage. This may worth further investigation.

[Progecitor]

Complete medical background

Laboratory blood tests
The marked ones are highlighted. During the years the reference values also changed making unmarked values marked or the opposite way. Tests were mostly in the acute phase, although not all, still I have symptoms even in the chronic phase.
1990. 02. (Hydrocele sclerotisation): blood markers: HCT: 0.35, Hgb: 7.0 mmol/l, RBC: 3.9 T/l, WBC: 5.8 G/l, Thromb. 220 G/l, weight: 20 kg, blood pressure: 110/70 Hgmm, ESR: 10 mm/h, blood glucose: 6.0 mmol/l, Blood type "0" Rh neg., ECG: SR, centrum Alignment, Regular Curved, Serum-Na: 138 mmol/l, Se-K: 4.2 mmol/l, Se-CN: 3.8 mmol/l, Se-creat.: 55 umol/l, Se-bilir.: 12 umol/l, bleeding time: 2'14", clotting time: 5'22", urine pH: acidic, protein: neg., glucose: neg., acetone: neg., ubg: normal, sediment: 3-4,
2001. 07. Hgb: 147, WBC: 6.79, HCT: 0.44 (0.45-0.51), glucose: 5.3, Na: 139, Cl: 104, K: 5.0, KN: 4.4, ALT: 13 U/l (<60), AST: 17 U/l (<50), otherwise normal.
2004. 03. (Psychiatry 1.) RR: 120/80 P: 72, neutrophil: 0.48, monocyte: 0.11, eosinophil: 0.05, total bilirubin.: 17.4, otherwise normal.
2004. 09. (Hernitomia sec. Bassini ingu. l.d.): ALT: 17 U/l, AST: 23 U/l, total bilirubin: 27.1 umol/l (<17), WBC: 13.8 G/l, NEU: 11.80 g/l, NEU%: 0.86, LYM: 0.96 g/l, LYM%: 0.07, MONO: 0.98 g/l, MONO%: 0.07, EOS: 0.00 g/l, EOS%: 0.00, BASO: 0.05 g/l, BASO%: 0.00
2005. 07. (Psychiatry 2.) monocyte: 0.11, cholesterol: 5.5, triglyceride: 1.89, otherwise normal
2007. 12. (at a time of the regular chest inflammation, radiography and ECG were negative the same day): calcium: 2.35 mmol/l (2.1-2.6) ALT: 22 U/l, AST: 43 U/l, total bilirubin: 27.6 umol/l (<17), CPK: 1032 U/l (24-190), cholesterol: 5.1 mmol/l (3.9-5.2), LDL: 3.44 mmol/l (<3.36), HDL: 1.35 mmol/l (1.45-5.20), ESR: 6 mm/h (<20), reticulocytes: 0.008 (0.008-0.020). WBC: 6.65 G/l (4.0-10.0), neutrophil: 0.53 (0.50-0.70), lymphocyte: 0.37 (0.20-0.40), monocyte: 0.09 (0.03-0.10), eosinophil: 0.02 (0.01-0.04), basophil: 0.00 (<0.01), abs. neutrophil: 3.53 G/l, abs. lymphocyte: 2.44 G/l, abs. monocyte: 0.57 G/l, abs. eosinophil: 0.10 G/l, abs. basophil: 0.01 G/l, urine: specific gravity: 1025 (1001-1040), pH: 6.0 (4.5-7.8 ).
2010. 10. (during a case of sensory neuropathy): ALT: 8 U/l, AST: 12 U/l, total bilirubin: NA, CPK: 96 U/l, reticulocytes: 0.005 (0.008-0.020), neutrophil%: 56 (50-70), lymphocyte%: 35 (20-40), EOS%: 1 (1-4), CRP: 7.1 mg/l (<5.0), urine: NA, stool blood: negative
2012. 05. (a paid checkup during an acute phase): CRP: 2.4 mg/L (0.0-10.0), anti streptolysin: 53 IU/ml (0-200), WBC: 6.08 G/L (4.0-9.0), neutrophil%: 46 (50-70), lymphocyte%: 43.1 (25.0-40.0), monocyte%: 7.5 (0.0-8.0), eosinophil%: 3.0 (0.0-5.0), basophil%: 0.4 (0.0-1.0), abs. neutrophil: 2.80 G/L (1.80-6.30), abs. lymphocyte: 2.62 G/L (1.00-4.10), abs. monocyte: 0.46 G/L (0.00-0.70), abs. eosinophil: 0.18 G/L (0.00-0.40), abs. basophil: 0.02 G/L (0.00-0.10), urine: specific gravity: 1030g/l (1003-1029), pH: 6.0
2016. 02. (acute phase – around the time I developed two small lesions on the neck which are still present): ALT: 13 U/l, AST: 19 U/l, total bilirubin: 20.6 umol/l, WBC: 6.45 G/l, NEU: 43.0% (40.0-74.0), lymphocyte%: 44.6 (19-39), MONO%: 9.9 (3.0-10.0), EOS%: 2.3 (0.1-5.0), BASO%: 0.02 (0.1-2.0), NEU: 2.77 G/l (1.68-8.00), LYM: 2.88 G/l (0.84-4.32), MONO: 0.64 G/l (0.12-1.08), EOS: 0.15 G/l (0.04-0.54), abs. basophil: 0.02 G/l (0.04-0.21), RDW: 10.7 %CV (11.5-14.5), urine: specific gravity: 1020, pH: 5.0.
2018. 06. (acute phase) ALT: 11 U/l, AST: 17 U/l, total bilirubin: 22.7 umol/l (1.7-21.0), WBC: 5.16 G/l, NEU%: 41.9 (40.0-74.0), lymphocyte%: 43.9 (19.0-39.0), MONO%: 9.7 (3.0-10.0), EOS%: 3.9 (0.1-5.0), BASO%: 0.6 (0.1-2.0), NEU: 2.16 G/l, LYM: 2.27 G/l, MONO: 0.50 G/l, EOS: 0.20 G/l, abs. Basophil: 0.03 g/l (0.04-0.21), RDW: 10.9 %CV (11.5-14.5), urine: specific gravity: 1015, pH: 6.0, urine sediment: 12/view (<6)

Commentary:
Although I think I have some kind of sepsis it certainly doesn't show in liver function represented by ALT and AST.
The elevated total bilirubin is supposed to be due to my Gilbert-disease.
RDW is a parameter to describe the morphology of the red blood cell.
As an elevated RDW value is an indicator of chronic inflammation I simply can't comprehend how it could be low.  It is true that a lower RDW value was only present in the last two tests, so I am not sure if it is really in connection with my POIS which I had for more than 20 years.
Abs. Basophil was always around 0.01-0.03 G/l which is a low value and it only became marked as the reference interval increased to 0.04 G/l at the low end. This isn't very interesting in itself, but a high basophil count is in connection with chronic allergic diseases which raises some questions.
The hernia I suffered in 2004 was due to the fact I gained 20 kg in half a year even though I was very skinny before. The most probable culprit was Zyprexa and that is why it was switched to Zeldox. The intestine became blocked and I vomited a lot before the surgery so it is not indicative of POIS.
I had a few cases of two-sided kidney pain, but these symptoms disappear in a few days and it is almost impossible to get an appointment in such a short order. I was really "lucky" that I had a chest pain long enough that I managed to get it "diagnosed".

Physiological anamnesis:
Vaccinations in childhood: 1985: BCG, Di-Per-Te I/a, I/b, I/c, Polio, 1986: Polio, Morbilli 1987: Polio, 1988: Di-Per-Te II., 1990: Rubeola, 1997: BCG – Mtx 5TE neg, Re RCG: 973, Scar: pos. 1999-2000: H-B-VAX II (3 times), 2001: 5TE
1990. 03. – Op: Hydrocele sclerotisatio Testicle seems to be normal to the touch, some liquid can be felt. Inflammatory pattern is not present.
~1991 – chickenpox, also known as varicella
~1993 – mumps
~1996-1999 – correction for teeth
I had a few tick bites in childhood, but they were safely removed and I had never developed a skin patter.
I had other insect bites as well such as ant, flea, wasp, bee, but there wasn't any allergic reactions to them only the local inflammation.
2004. 03-04. Hospitalization – Psychiatric department – severe POIS onset at the age of 17.
Abdominal and pelvic ultrasonography (USG): normal although the cavities of the left kidney are bigger and contain liquid. Therapy: Zyprexa, Rivotril, Zoloft.
Gastroscopy - negative
CT of brain: negative
2004. 09. Urology: Checkup: everything is normal.
2004. 09. Inguinal hernia  – Chest radiography: negative
2005. 07. Hospitalization at Psychiatric Dep. to set new medication. Therapy: Zeldox 40 mg, Rivotril, Imovane, Dicetel, Zoloft.
2007. 12. regular chest pain – It was one of the first cases and it became regular afterwards (one occasion per 2 weeks – 2 month, but actually very irregular in appearance and intensity): radiography and ECG were negative
2008. 12. Ophthalmology: Shortsightedness that slowly deteriorates. Eyes are normal, eye Ultrasound: negative
2009. 03. Dermatology: control examination with smaller problems.
2010. 07. Ophthalmology: Normal findings.
2010. 10. Abdominal USG: negative
2010. 10. Spinal radioscopy 1: Dorsal kyphosis is standard. Small degree left convex scoliosis is seen. The angle of the lumbar and the sacrum is pronounced. Pronounced right convex scoliosis is seen.
LV rests low, the LS gap is narrower, LV backside arc is slightly open.
2010. 11. Proctology: Mild dermatitis, otherwise normal.
2010. 11. Gastroenterology: consultation – diagnosis: dyspepsia, IBS without diarrhea (Refluxon 30 mg, Dicetel 50 mg)
2011. 02. Thyroid examination - negative – SH: 1.81 uIU/ml (0.35 – 4.94).
2011. 04. Gastroenterology: negative partial colonoscopy.
2011. 04. Irrigoscopy with double contrast: polypus in the right flexure? - Inadequate preparation!
2011. 06. Gastroenterology: Successful endoscopy with negative result.
2011. 06. Parasite test 1 (stool sample): Protozoan negative, helminth egg negative.
2011. 06. Bacteriology test (stool sample) 1: Aside from normal E.coli count Klebsiella sp. was in great number. Pathogenic role is in question.
2011. 07. Bacteriology test 2: Normal E.coli were not present altogether (I clearly remember that I had an O the day before! Most of the bacteriological tests were in the acute phase, but I also had normal findings in such cases even though the burning feeling was usually present).
2011. 08. Bacteriology test 3: Normal flora is present in very small number. Aside from normal E.coli count Klebsiella sp. was in great number. Dysbacteriosis?
2011. 09. Bacteriology test 4: Salmonella, Shigella, E.coli O124, Yersinia enterocolitica and Campylobacter were not present. (Normal findings.)
2011. 11. imlaat autoantibodies: EMA IgA negative, EMA IgG negative, Transglea IgA: 1.2 U/ml (0.0-5.0), GSE serology negative (Gluten intolerance)
2012. 01. Lactose intolerance H2 breath test negative. I didn’t have a diarrhea, but lactulose still induced a heavy burning feeling when I went home. Lactase ensyme slightly helps in reducing the depression felt after eating. However milk actually helps to reduce the negative effects of coffee.
2012. 01. Bacteriology test 5: Salmonella, Shigella, E.coli O124, Yersinia enterocolitica and Campylobacter were not present. (Normal findings.)
2012. 01. Parasite test 2: Protozoan negative, helminth egg negative.
2012. 02. Dermatology: control examination.
2012. 03. Parasite test 3: Protozoan negative, helminth egg negative.
2012. 04. Parasite test 4: Helminth identification: negative
2012. 06. Ophthalmology – Everything is as usual. USG of the eyes due to floaters: negative
2012. 08. Bacteriology test 6: Salmonella, Shigella, E.coli O124, Yersinia enterocolitica and Campylobacter were not present also Salmonella Typhi negative, Salmonella Paratyphi negative. (Normal findings.)
2013. 02. Immunochemistry: sTSH: 4.080 mU/L (0.300-4.200 mU/L), FT4: 16.1 pmol/L (12.0-22.0 pmol/L), FT3: 5.9 pmol/L (2.4-6.3 pmol/L)
2013. 06. Otorhinolaryngology: Ear inflammation
2014. 04. Spinal radioscopy 2: Cervical rib can't be seen. The arc of the cervical lordosis is straightened. Height of the centrum is normal. Lamellas are smooth. Margins are intact. Cartilage gaps are not tighter. (Sensory neuropathy)
2014. 06. Reumathology: Dorsalgia, uncategorized (I had sensory neuropathy!)
2015. 08. Otorhinolaryngology: On the backside of the neck I developed two smaller lymph nodes on both sides that once or twice a year can get inflamed. They said it is not their department.
2015. 08. Dermatology: They couldn't do anything with it. They said to be on the lookout if it gets worse, but it hasn't so far fortunately.
2016. 11. USG: normal kidney, testicle USG: bilaterally normal echo structure of the testicles and epididymis.
2016. 12. Urology: manual prostate examination: normal, urine: normal – bacteria or fungi are not present. Uroflow: unsuccesful.
2018. 08. 14. Abdominal USG: negative (I had a constant abdominal discomfort for about three years, but one of the supplements made it disappear although I am not sure which.)
2018. 10. Otorhinolaryngology: Control
2019 spring:  The local Rare Disease Department: The professor have never heard about POIS, but checked on the net and confirmed. However he told me that he can't do anything as it is an andrological disease and not for his department.
2019 spring: Local Andrology: The doctor had heard about POIS, but he probably didn't know much. He asked me what I wanted, but I was not prepared for the question. In retrospect I should have asked for a hormonal screening. Nevertheless he told me they can't really do anything and I should seek help at the capital. Well I planned to go, but I am not very mobile and then came the pandemic so I couldn't since then.
2019. 04. (chronic phase) Parasite test 5: Protozoan negative, helminth egg negative.
2019. 04. (chronic phase) Bacteriology test 7: Salmonella, Shigella, E.coli O124, Yersinia enterocolitica and Campylobacter were not present. (Normal finding.)

Psychological anamnesis:
I took every medication regularly even when I didn't believe in their effectiveness. Unfortunately I hadn't documented the effects of the medication at the time and can't really remember much about the details.
2003. 12. It all started with a peculiar OCD onset that was driven by panic.
2004. 01. fluvoxamin [SSRI] (Fevarin 50 mg) – Based on the medical documentation I felt somewhat better from this.
2004. 03. paroxetine [SSRI] (Rexetin 20 mg) – I think I didn't take this or only a few as I had to go to the hospital (voluntarily of course) and there they gave me a lot of other pills.
2004. 03. olanzapine (Zyprexa 5 mg x 1), sertraline [SSRI] (Zoloft x 1), clonazepam [benzodiazepin] (Rivotril 0.5 mg x 3)
Zyprexa, Zeldox: In retrospect I don't believe they did much good to me.  I shouldn't had taken Rivotril for such a long time, but it was the only thing that could manage my panic. I don't remember every detail, but it certainly enhanced my mental depression and made me even more forgetful. Actually it was for the best because it made me so ill that I couldn't concentrate on my panic.
Taking Zyprexa led me to gain 20 kg in half a year and it resulted in an almost fatal hernia with a blockage. Thanks to surgery I survived. It was a "real experience" when the doctor tried to feel out the position of my intestines through the testicle.
2005. Zyprexa –> ziprazidon Zeldox 40 mg
Zoloft worked really well, but I only discovered it after I stopped taking Zyprexa. Zoloft could shorten my POIS days, but it never occurred to me to time it to O. I only took it as I was told to.
2007. 01. Zeldox 40 mg, Rivotril 0.5 mg 3 x 1, Zoloft ? Sertwin 50 mg, then 100 mg.
Zoloft worked really well, but I didn't have any income at the time so I wanted to switch to a cheaper medication.
I was in the acute phase of POIS when I had no Zoloft medication left and that is when I developed a serotonin deprivation syndrome.  I had never felt so well in the previous years so it struck me quite profoundly. My mind worked so well compared to when I feel like I am a dead weight in a dead body. I had some pain and a slightly bloody stool as a side effect and no burning feeling at all. Unfortunately symptoms reappeared in the following days and POIS reestablished itself.
I tried to tell at the psychiatry that this was something important, but they didn't even document this. Well I can hardly blame them as why should they had cared about an imaginary disease that disappeared for a short time due to a regular withdrawal symptom.
2007. 08. Zeldox 40 mg, Rivotril 0.5 mg 3 x 1, sertraline (Sertwin 100 mg) (based on the documentation I was agitated, but this could had been a life issue) –> citalopram [SSRI] (Citagen 20 mg): my mood was better from this
2008. 02. Zeldox, Rivotril, Citagen ? tiaprid (Tiapridal 100 mg) 3 x half pill: First I felt better, but later it enhanced my OCD.
2008. 03. Zeldox, Rivotril, Tiapridal ? Citagen 20 mg
2009. 01. Rivotril 0,5 mg x 3, Citagen 20 mg, Zeldox –> clozapin (Leponex 25 mg) Morning: half + Evening: one and a half.
Stopping Zeldox was especially hard. Its withdrawal symptom was that I couldn't sleep for a month.
Well technically I slept, but it was like I shut my eyes then opened it a moment later to realize that it was morning. At other times it felt like a restless half-sleep/awake. Even though I slept I didn't feel rested. After a few weeks the tiredness accumulated and I felt like I was going to die if I don't take Zeldox again. Fortunately there came a day when my sleeping became a bit more restful and it got better with every day.
2009. 02. Rivotril + Citalopram, Leponex. I couldn't take Leponex as it hypotonised me.
2009. 10. Rivotril + Citalopram (I took it in a smaller dose as it made me tired, but it might had been Rivotril actually –> venlafaxin [SNRI] (Velaxin 75 mg Retard)
2009. 11. Rivotril + Venlafaxin Sandoz 150 mg Retard (I didn't report any side effects and my mood was quite good.)
My POIS wasn't cured otherwise I would have reported it and so the doctor kept switching the medication so that we might find a better one. I also forgot about it as I was not checking the papers and only recently realized that it could be worth to recheck it and probably other SNRIs as well.
My OCD also resolved around 2010, but I don't exactly remember when. It was probably due to a resignation towards panic to which I got attenuated. However I also developed a kind of profound self loathing. This hate was not directed towards my mind, but rather my body. I think this is why I developed a kind of pseudoschizophrenia where I felt a profound alienation from my body, while I simply couldn't blame my mind for it. Nevertheless I have never had any suicidal thoughts.
2010. 02. Venlafaxin  –> quetiapin (Seroquel Xr 200 mg retard) – At first I felt myself better, but later I had enhanced anxiety. I said my thinking was better, but the doctor considered it too vivid.
2010. 03. Rivotril + Seroquel Xr 300 mg retard – As I remember it made me sleep 10+ hours daily (at times even 15 hours) and I still felt sleepy all the time. It is possible that sleeping a lot had a good effect on my POIS as my body was recuperating more. However I practically had no life left besides sleeping.
2010. 05. Rivotril + Seroquel –> quetiapin (Nantarid 25 mg) 2x1+ paroxetin (Parogen 20 mg)
I didn't take any of these as this was the point I got fed up of antipsychotics and decided to stop them altogether.
2011. 04. I went to the doctor for control, but I only took Rivotril in a small dosage.
2011. 09. I told the doctor that I wanted to stop Rivotril as well.
It may sound hard to believe, but it was really hard to stop with the last pill. I had to cut up the 0.5 mg pill and taking one eight less each day. I still had withdrawal symptoms like feeling unwell, sleeping badly and strange pain effects. For a time after this I felt really good as the light gain a new shine and I was feeling a bit euphoric.
2013. 02. I was at the hospital for a psychological checkup. My physiological symptoms were not considered as I had no proof to back up anything. I also couldn't masturbate at the time so I actually felt better. The final diagnosis was schizophrenia although the doctor said I was an especially difficult case and they discussed my case a lot. They had a hard time deciding as some of my symptoms were very typical of schizophrenia while other were totally not.
They also gave me some pills while I was in: klomipramin (Anafranil Sr 75 mg retard) and amisulprid (Amisulprid-Ratiopharm 200 mg). I don't really know what amisulprid does as I only continued to take Anafranil when I came out. Anafranil greatly reduced my sexual desire. When I masturbated I had a really hard time achieving orgasm, but when I finally managed POIS came in full force.
I also stopped taking it and only went for control to the psychiatry. Even then I usually only talked with the assistant about my daily problems for a few minutes, but I refused medication. A few years ago my doctor retired and I didn't want to explain everything again to a new doctor so I simply stopped going.
In the last few years I was fixed on repaying my tuition debt and couldn't spend on supplements. Actually I thought it was futile and doctors and family confirmed this. I haven't even tried to find the disease as I thought I was the only one who had such a problem on the whole world.

Self-tests:
Alcoholic probe: As POIS somewhat feels like having a hang-over I thought that it may show something, however it certainly didn't.
Stool pH was 8, semen pH was 8.
11 component urinary rapid test: pH is usually around 5-6. Specific gravity is always a bright yellow which is the highest value (1030) according to the test. Ascorbic acid is somewhat elevated when I do a lot of physical work, but this is supposed to be normal. The other parameters that are always negative: urobilinogen, glucose, bilirubin, ketones, blood, protein, nitrite, leukocytes.
The rapid test for Clostridium difficile toxin A and B from stool sample proved to be negative (2019).

[BoneBroth]

Hi Progecitor!

Thanks for your great documentation! I have an almost identical symptom-history. I will take some time to analyse it. I'm planning to do a organ/symptom/analyse value list that helps us understand what organ is causing each symptom. I belive that the POIS related inflammation (caused by some hormonal inbalance) is comproimising organs in the whole body - specifically organs that has a high blood flow: blood vessels, heart, liver, kidney, brain and intestines. This explains why we experience so many diffrent symptoms.

Each organ gives it own symptom when function is decreased (or in chain reactions). Depending on what organ is the weakest link the symptoms appears diffrently on diffrent people. Some examples:

• Kidney -> Low blood pressure, POTS, headache, varicose veins, slow intestines/constipation. I'm staring to belive the kidneys might be the most important organs relating to POIS symptoms since they are regulating the blood pressure - an adequate blood supply is everything for a good health
• Liver/gall bladder - > Acne, varicose veins, yellowish stools, headache, blood pooling, thick blood, liver spots, low bilirubin levels and alcohol sensitivity.
• Intestines - > Bloating, gas, candida, leaky gut, skin issues, coated tounge which leads to vitamin deficiency, advanced hormonal imblances, SIBO, auto-immune disorders (that cause damage on the same organ as POIS inflammation) and headache
• Brain -> Headache, depression, no motivation and a long list of symptoms because of decreased function in hypothalamus/pitutary
• Thyroid -> Temperature regulation, hotflash, difficulty sleeping, muscle weakness, hyperactivity.
• Adrenal -> Cortisol excess followed by cortisol decline -> inflammation, testosterone deficiency. Cushing's syndrome, Addison's disease.
• CNS (Central Nervous System) - > tingeling, difficult to breath, sudden urge to urinate
• Blood vessels/blood - > varicose veins, blood pooling (thick blood) because of clumping platelets
• Gonads  -> Testosterone deficiency, slow healing process, aggregated inflammation

 
When the intestinal function is damaged it will in time lead to similar symptoms as POIS, because the process is the same: A leaky gut will leak substances into the blood stream and when those substances attach to organs the immune system will send lymphocyes to the site and cause inflammation. But instead of inflammatory hormones and hormonal break down products, this inflammation is caused by substances iike proteins, bacterias, fungus etcetera that should not normally escape from the walls of the intestines. 

This came clear to me as I fixed my acne issue after doing a liver cleanse (I dont get as severe acne after POIS now). I still get the other symptoms on POIS, but not so much the liver related, since the liver is now somewhat restored (with nutrition/detox). On POIS the liver might be so inflamed that might be working on only 5-30% of its normal rate (this is not easy to analyse due to the complexity of the livers detoxification stages, the stage 1 detoxificaiton pathway might work, but the path 2 pathway might halt. This leads to accumulated toxins in the whole body (headache). Some hormonal breakdown products are 10 times more toxic/inflammatry then the hormones itself. A compromised liver is very damaging for your health in th elong run, however the liver has a tremendously capability to heal, even in a very bad stage.

With this view it might be more easy to plan mesures for the restoration phase. But you cant scoop water from a sinking ship forever. Although restoration is essential for the healing process the cause of POIS still must be solved. The main measure would be stress management and restraining from orgasm for at least a year. I get into more detail in my info below.

[Progecitor]

A list of the supplements, herbal teas, exotic spices and medications that have worked so far.
I tried to make an approximate intensity comparison, however it is not necessarily correct. The order from left to right also represents a subjective scale. I may reevaluate some of them with more testing.

The best: lucerne (alfalfa), saffron tea, MACA, lungwort tea (Pulmonaria officinalis)

The good: Tribulus terrestris, licorice, Berberine, Cordyceps and probably some other medicinal mushrooms, Echinacea + Beta glucan, Echinacea drops

The average: lavender tea, niacinamide (Vitamin B3), matcha powder tea, ibuprofen, melatonin

The weak: ginkgo biloba, chamomile extract capsule, ginger, lemon balm tea, linden tea (Tilia), chamomile tea, Cetirizine, Vitamin B12, soy lecithin, Sulforaphan, NAC

The controversial:  L-Tryptophan, SSRIs, SNRI (Venlafaxine), Vitamin B6, oregano, rosemary tea, magnesium, bitter melon

The unconventional: zinc, chasteberry (Vitex agnus-castus)

The bad:
biotin (Vitamin B7), taurine, turmeric, black pepper, lemongrass tea, sage tea, Kudzu, paracetamol

I will add more details later, but most of the information can be found in my research thread:
https://poiscenter.com/forums/index.php?topic=3733.0

Details:
Licorice - Glycyrrhiza glabra [400 mg per capsule from which 16 mg is glycyrrhetinic acid]:
I had one capsule the previous morning and one in the morning. About 8 hours later I took another one and 3 hours later I had an O. Right after it I took another one (18 h). So on that day I took 1200 mg of licorice of which 48 mg was glycyrrhetinic acid.
It reduced POIS somewhat at its onset, but I still had symptoms like weakly bloodshot eyes. I measured it several times and my blood pressure didn't seem to change, but I had other side-effects. In the first hours I felt transient slight pain sensations all over the body and developed some mild headache or discomfort, although it is hard to tell if the latter was not due to POIS itself. Another worrisome symptom was a recurring weak heart ache or cramping that I felt from time to time even in the next morning. I think licorice only has side-effects at first. It was around the time I went to bed when I began to feel myself somewhat better. It was 8 hours after I took the second capsule and I mean the first one in the afternoon. I got up after three hours of sleep to take a leak and I definitely felt better at the time. In the morning I generally felt better, but I still had a weak level of POIS. I still had some depression, but the eyes were relatively well. The nodules in the breast were moderately reduced. The burning feeling noticeably reduced and the quality of the stool was better. The best was that I could walk relatively easily without feeling the fatigue-like burden on my muscles. So licorice really has a beneficial effect on my POIS, but its side-effects prevent me from using a higher dose.
Licorice also contains phytoestrogens, so I am not even sure if its beneficial effects are really due to glycyrrhetinic acid.

Chamomile extract capsule: 1 capsule containing 250 mg chamomile extract with 2.5 mg apigenin.
1 capsule doesn't seem to do anything noticeable, however consuming 2 x 2 capsules with a few hours of difference surely has a weak-moderate effect on the burning pain and thus somewhat reduces all POIS symptoms. So all in all it was 1000 mg chamomile extract containing 10 mg apigenin. By the way it was also equivalent with 10 g chamomile flower. The medicinal mushroom capsule I mentioned previously contained 9 mg apigenin, but it had a better effect, so apigenin really seems to help, but it is better if it is combined with other things as well.

Turmeric: I tried it three times by consuming about one tablespoon cooking grade turmeric powder mixed in some water. It doesn't have any rapid effect, but every time I had bloodshot eyes in the next morning and the burning sensation was also enhanced. On the last occasion I also added some black pepper and everything was about the same. I have tried to avoid black pepper for years as I have already suspected it to be bad for my POIS. Still I need to test it a bit further and maybe with higher doses for a definite conclusion.

Chasteberry [400 mg per capsule]: It is supposed to increase progesteron in women. Well it may not do so in man. The first time I took one it unexpectedly induced a weak-moderate ass muscle inflammation (probably not a POIS symptom), but this disappeared in a few hours (after consumption from 2 o 6 hours). At another day I took one in the morning and one in the afternoon. However this kind of inflammation only appeared very weakly.
In regard of POIS symptoms it didn't reduce depression and I still had bloodshot eyes. It may have reduced the burning feeling a bit, but I am not really sure without a more extensive testing. Another thing I noticed was a weak bulging of some blood vessels a few hours after consumption, however blood pressure was alright. All-in-all I could also say that it had practically no effect.
The product doesn't specify what part of the plant was used, but it is probably the leaves or the fruit. The seeds are sold separately and they are said to be antiaphrodisiac, so I will have to test them too.

Melatonin: I have only tested a lower dose (2 mg) so far. It makes me somewhat sleepy, but this passes after a short time. There are no rapid effects, but it can somewhat reduce the burning feeling. I will try higher doses, but I don't want to mess up the circadian rhythm. It may serve well in an evening stack, especially if I wanted to do "sex" in the morning.