As you aware, POIS is a such a kind that, the medicines work initially, but afterwords the same medicine fails to fight against POIS.
Not true for me.
Testosterone is working _better_ now than when I started TRT (testosterone replacement therapy) 3 years ago!
Your testosterone worked because it was administered and controlled by a doctor. You didn't just try it for the heck of it! Or if at least you did, it was still under the control of a doctor who could say, "today it didn't work because of such and such but lets change the dose a bit and keep it up for a bit..." or whatever. At least more control, and entered with a plan and evaluated with understanding.
Not only that, Dave, but it was a 10-year process for me since the 1st POIS paper came out. I contacted whoever I thought would have a clue, worldwide, in the US, and in Europe. Mostly well known sexologists, most notably Jane Thomas at Johns Hopkins University.
In the 7th year, I finally decided to "pull out all guns" and "shoot" this evil, hideous creature-thing called POIS. I contacted my Harvard biotech pioneer friend and he suggested a major teaching university and world class laboratory. I was reluctant, but desperate enough to follow his advice and the forum's advice - which was to get a full range of hormonal blood tests, which led to a brain MRI -- and many more formalized blood tests. My endocrinologist doctor is a fully tenured top University Professor in Endocrinology and is in a RESEARCH environment because of the university.
My daily (365X) testosterone patches are the result of THOROUGH testing, consultation, and re-testing,
with a sympathetic, top ranked,senior endocrinologist-physician and a world class medical laboratory. It did not happen overnight by ANY stretch of the imagination.
No snap of the finger here.
Careful, methodical, validated, adjusted, constantly monitored, and it will continue that way.
And even with all that - in our primitive pre-NORD Grant period - I was lucky.
