As you aware, POIS is a such a kind that, the medicines work initially, but afterwords the same medicine fails to fight against POIS.
Not true for me.
Testosterone is working _better_ now than when I started TRT (testosterone replacement therapy) 3 years ago!
Finally to say, wonderful life after 7 years.
Congratulations!
I think what happens is that we THINK (really want) the medicines to work, so they seem to. And it depends so much on "chance". POIS has it's ups and downs, weather, amount of sleep, nutritional condition, so many factors, and so many of them we don't related directly to POIS, maybe because we don't take detailed notice of all the factors.
So one day, we have all the stars lined up, and by chance, also try some remedy. WOW, it seems to work! How many times have I said that! Then the bottoms falls out when the weather changes or some other factor that I haven't been keeping track of, changes.
Tests of remedies is complex! We can't realistically do it without a step by step protocol. Note all initial conditions, limit items being tested, not all changes outside of the testing parameters, and then perhaps even do blind tests with cross-checks.
Sounds like a pain in the butt, and so that's why we don't dedicate a little more time to it. But we're just fooling ourselves if we don't.
The idea is not to be critical or reprimanding, but to bring attention to what it really take to do a test that has any use.
Your testosterone worked because it was administered and controlled by a doctor. You didn't just try it for the heck of it! Or if at least you did, it was still under the control of a doctor who could say, "today it didn't work because of such and such but lets change the dose a bit and keep it up for a bit..." or whatever. At least more control, and entered with a plan and evaluated with understanding.
"A success is not a success without the data and a failure is not a failure with the data!"
This would have to be our motto!