Author Topic: Free Flow Discussion about POIS  (Read 1013019 times)

lauracostis

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Re: This may seem like a familiar place.
« Reply #1080 on: January 17, 2014, 08:24:28 PM »
Daveman and I had a Skype conference today with Barry and Pooja.

Went well, I thought. It was an introduction to understanding POIS and how best to study it with Forum Volunteers (Defsync already has his bags packed :)

There will be a 1-2 month delay to get Rutgers' official approval to do fMRI's on POISers.


I think FMRI is a good first step, if we can prove that there are physiological changes in the brain of poisers, than trying to find the cause can be the next step.


Laurac, you're a longtime member and one of our most medically sophisticated members, so...THAT'S GOOD NEWS!! :)

This is fantastic!
I am actually part of a research team right now that is studying diabetic foot care/ulcers. Although, I would rather be researching POIS!

demografx

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Re: This may seem like a familiar place.
« Reply #1081 on: January 17, 2014, 08:55:35 PM »
Thanks again, Laurac!!

It's been an honor and pleasure to team with you all these years!

Demo
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: This may seem like a familiar place.
« Reply #1082 on: January 17, 2014, 09:28:55 PM »


I'm not too sure if POISCenter wholeheartedly agrees with this
sentiment mistake!





« Last Edit: January 21, 2014, 12:32:39 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

lauracostis

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Re: This may seem like a familiar place.
« Reply #1083 on: January 25, 2014, 04:06:05 PM »
Thanks again, Laurac!!

It's been an honor and pleasure to team with you all these years!

Demo
THE SAME TO YOU DEMO!

demografx

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Re: This may seem like a familiar place.
« Reply #1084 on: February 02, 2014, 09:41:47 PM »


For most of us, this means....PAIN/AGONY!

 :)



« Last Edit: February 02, 2014, 10:15:24 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Colm

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Re: This may seem like a familiar place.
« Reply #1085 on: February 06, 2014, 12:05:53 PM »
Support or advice - Niacin Flush.

I'm one of the community here continuing a trial of Niacin. This is having had some initial very positive impacts.

I am still hoping that it may continue to help me and others, and for the research to clearly identify how it's action is related to POIS. The theories around vasoconstriction people speak about here and at NSF is interesting.

I don't want to abandon Niacin, but want to be sure there isn't any harm to Immune system or other organs, using it for POIS in limited dosage.

I had been taking the 100 MG of Flush Niacin just once a week, whether with or without an Orgasm.

Up toward the year end, I felt comfortable using it. However, I am wondering if there are some side effects (I have been getting), that others may have advice on. I'd like to continue safe treatments only and use Niacin safely to limit POIS impacts. Am sure others think the same with what they also experiment with.

Here's what happened.
I was off for 2 weeks over the holiday period in December, so I decided to take Niacin more often, I took the Flush 100 MG every two to three days for a week.

Usually, about an hour after taking Niacin, (even without O) experiencing the flush, I feel quite well and some symptoms recede, and in particular I usually feel more open and energised. The next day, I usually feel really wrecked, run down, tired, my body runs cold, and then these symptoms kind of clear away on the following day, which leaves me a bit better (than pre-Niacin dose) and fairly stable for a few days.

A month back however, after a week of taking the 3 doses of Niacin in succession, I got a very bad flu for three weeks (worst in years) with a really heightened over-sensitivity to being cold, even when others around me were warm.

Maybe I just got the flu, and it was nothing at all to do with Niacin. Three weeks later, with the flu gone, on Friday two weeks back, I decided to go back to the once a week Niacin approach. Initially on taking, I felt really the positive impacts, but on the Saturday I felt totally wrecked, with heightened sinus problems and my body experienced the extreme sensitivity to cold.

The Sunday, I felt much better, like something cleared, and the shock reaction from Niacin was gone, but I have now yesterday again come down with another flu. I am self employed, so this is a real pain. In my worst years of my POIS, over a decade back, I did experience a lot of colds with low immune system and sinus problems.

My core question on Niacin.
My question is, has anyone of our Niacin folks had any similar experiences with this shock or reaction to Niacin, 12-18 Hours post flush.

Anyone know if it can it mess around with immune system or something? Did you personally experience any negative side effects?

Only thing I can think of is maybe because I usually take it 6/7 hours after food, and then don't eat for an hour. Maybe that approach is too hard on my system, and I need to take it a bit closer to food and less than 100 MG.

The 100MG dose a week is hardly taking an overdose. I think Niacin flush is used safely in patients for cholesterol stabilisation, so it should be safe in theory, if not taken too often or in excessive doses. I know there is potential liver damage (for example) in high regular doses.

What I am really curious about is why I get this "shock" reaction in my body for about 24 hours, which kicks in about 12 hours after the flush. It could be a positive thing, clearing something or resetting something. That is my positive thought and I am continue using Niacin weekly on that basis, because it has been something that has provided one of the best clearing experiences for me, even if that was mainly in my first weeks of using it a few months back.

I am also thinking this could be some overall reaction to the shock of the Flush. The first time I got the flush a few months back after taking 200MG (too much), I got the shakes for 30 minutes, as well as a flush.

Any other similar experiences or thoughts out there? I am so disillusioned with P O I S !!!

demografx

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Re: This may seem like a familiar place.
« Reply #1086 on: February 06, 2014, 03:19:17 PM »

FROM NORD

On Feb 6, 2014, at 12:11 PM, Jason Barron at NORD wrote:

Dear Demo and Daveman,
 
The announcements for 2013 NORD research grant award recipients have been posted on NORD’s website.  For easier navigation and retrieval, I’m including a link to the updated content, here:  https://www.rarediseases.org/medical-professionals/research-grants/recipients.  Please note that the announcement for the POIS category indicates the sponsorship of the POIS Forum.  If you have any other questions or concerns about the grant award and its associated research project, please feel free to contact me at your convenience.
 
Kind regards,
Jason
 
---
Jason Barron
Research Administrator
Associate Director, Medical and Scientific Affairs
National Organization for Rare Disorders (NORD)
1779 Massachusetts Avenue NW, Suite 500
Washington, DC  20036
Email: jbarron@rarediseases.org
T  (202) 588-5700 x109
F  (202) 588-5701
M (203) 482-3398

This e-mail and any attachments may contain confidential and privileged material for the sole use of the intended recipient. Any review, use, distribution or disclosure by others is strictly prohibited. If you are not the intended recipient (or authorized to receive for the recipient), please delete the e-mail, along with any attachments, without copying or disclosing it and notify the sender by reply e-mail immediately. Thank you.
 
 
 
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Ccconfucius

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Re: This may seem like a familiar place.
« Reply #1087 on: February 08, 2014, 03:55:32 PM »

I will add [cost-effective patient travel to Newark]

1. MEGABUS

and

2. SPIRIT AIRLINES

has sweet deals especially when planning ahead.


After looking at spirit airlines, they don't have an option for newwark but they have an option for newyork city which is only 21 min from newwark. There are cheap ways to go from new york to newwark.
A quote on spirit airline has a round trip for los angeles to new york for about 350 dollars. It did list some days where the price was comparable to other airlines, the key is just planning ahead and around the flight.

Megabus does not go to newwark either but it does go to new york city it has many routes coming from east cost states to new york city and a couple in other states.
A round-trip from Knoxville Tennessee to newyork city will go around 150 dollars in February.

Clycos

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Re: This may seem like a familiar place.
« Reply #1088 on: February 08, 2014, 05:47:56 PM »
Hey I can possibly come to Newark, when is this thing happening?

demografx

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Re: This may seem like a familiar place.
« Reply #1089 on: February 09, 2014, 12:41:20 AM »

I will add [cost-effective patient travel to Newark]

1. MEGABUS

and

2. SPIRIT AIRLINES

has sweet deals especially when planning ahead.


After looking at Spirit Airlines, they don't have an option for Newark but they have an option for New York City which is only 21 mins. from Newark. There are cheap ways to go from New York to Newark.
A quote on Spirit Airlines has a round trip for Los Angeles to New York for about 350 dollars. It did list some days where the price was comparable to other airlines, the key is just planning ahead and around the flight.

Megabus does not go to Newark either but it does go to New York City it has many routes coming from East Coast states to New York City and a couple in other states.

A round-trip from Knoxville,Tennessee to New York City will go around 150 dollars in February.


Thank you for all your research, CertainlyPOIS !! :)

« Last Edit: February 09, 2014, 03:11:46 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: This may seem like a familiar place.
« Reply #1090 on: February 09, 2014, 12:52:16 AM »
Hey I can possibly come to Newark, when is this thing happening?

Soon :)
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: This may seem like a familiar place.
« Reply #1091 on: February 09, 2014, 02:48:38 AM »
FROM DR. KOMISARUK YESTERDAY (SATURDAY)

Dear Demo,

Thank you for all your comments.

First, while the fMRI does not measure dopamine directly, at orgasm, we do
see activation of the nucleus accumbens of the brain, which is a dopamine
target area.  We also see activation of this brain region in response to
vagus nerve stimulation.  We may be able to see a variation in the typical
pattern of activation of the nucleus accumbens in the men with POIS, which
could indicate altered dopamine function, but this is just a possibility.

Regarding autoimmune function, we are not taking such measurements in this
project.

Regarding travel, we do have a limited travel budget requested.  We have
not yet received our official notice of grant award, nor the budget.  I
expect we will be able to defray travel costs, but probably not
completely.


Thank you kindly.
Sincerely,
Barry

Barry R. Komisaruk, Ph.D.
Distinguished Professor, Dept. Psychology
Adjunct Professor, Dept. Radiology
Board of Governors Distinguished Service Professor
Rutgers University
Smith Hall 327A
101 Warren Street
Newark, NJ 07102

phone (office): 973 353 3941
phone (mobile): 973 462 0178

« Last Edit: February 09, 2014, 03:30:28 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Prancer

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Re: This may seem like a familiar place.
« Reply #1092 on: February 09, 2014, 03:04:13 PM »
Glad I'm not a honey bee, I woulda died thousands of times by now! ;)

demografx

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Re: This may seem like a familiar place.
« Reply #1093 on: February 09, 2014, 06:20:09 PM »
LOL, Prancer! BRK says it is false data, so I deleted it. :)
« Last Edit: February 10, 2014, 08:48:00 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: This may seem like a familiar place.
« Reply #1094 on: February 09, 2014, 08:43:45 PM »
Is this how Rutgers will see us as we fMRI????  ;D
 ;D ;D ;D
 





« Last Edit: February 10, 2014, 03:39:07 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

LAPOISSE

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Re: This may seem like a familiar place.
« Reply #1095 on: February 10, 2014, 03:48:39 AM »
I guess, with the limited budget we have it would be smart to select people who are closed to the research lab or willing to come at their own cost. It's probably better to perform more test with the money that pay plane tickets.

Daveman

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Re: This may seem like a familiar place.
« Reply #1096 on: February 10, 2014, 07:33:26 AM »
I guess, with the limited budget we have it would be smart to select people who are closed to the research lab or willing to come at their own cost. It's probably better to perform more test with the money that pay plane tickets.

Exactly, it would be too easy spend all the money travelling. And since there are organizations that provide low cost or even free travel for these kinds of things, it's better to use them.

Anyways, I don't think the actual budget allows very much for travel. They too want to optimize the research.

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

Stef

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Re: This may seem like a familiar place.
« Reply #1097 on: February 11, 2014, 11:56:07 AM »
Support or advice - Niacin Flush.

I'm one of the community here continuing a trial of Niacin. This is having had some initial very positive impacts.

I am still hoping that it may continue to help me and others, and for the research to clearly identify how it's action is related to POIS. The theories around vasoconstriction people speak about here and at NSF is interesting.

I don't want to abandon Niacin, but want to be sure there isn't any harm to Immune system or other organs, using it for POIS in limited dosage.

I had been taking the 100 MG of Flush Niacin just once a week, whether with or without an Orgasm.

Up toward the year end, I felt comfortable using it. However, I am wondering if there are some side effects (I have been getting), that others may have advice on. I'd like to continue safe treatments only and use Niacin safely to limit POIS impacts. Am sure others think the same with what they also experiment with.

Here's what happened.
I was off for 2 weeks over the holiday period in December, so I decided to take Niacin more often, I took the Flush 100 MG every two to three days for a week.

Usually, about an hour after taking Niacin, (even without O) experiencing the flush, I feel quite well and some symptoms recede, and in particular I usually feel more open and energised. The next day, I usually feel really wrecked, run down, tired, my body runs cold, and then these symptoms kind of clear away on the following day, which leaves me a bit better (than pre-Niacin dose) and fairly stable for a few days.

A month back however, after a week of taking the 3 doses of Niacin in succession, I got a very bad flu for three weeks (worst in years) with a really heightened over-sensitivity to being cold, even when others around me were warm.

Maybe I just got the flu, and it was nothing at all to do with Niacin. Three weeks later, with the flu gone, on Friday two weeks back, I decided to go back to the once a week Niacin approach. Initially on taking, I felt really the positive impacts, but on the Saturday I felt totally wrecked, with heightened sinus problems and my body experienced the extreme sensitivity to cold.

The Sunday, I felt much better, like something cleared, and the shock reaction from Niacin was gone, but I have now yesterday again come down with another flu. I am self employed, so this is a real pain. In my worst years of my POIS, over a decade back, I did experience a lot of colds with low immune system and sinus problems.

My core question on Niacin.
My question is, has anyone of our Niacin folks had any similar experiences with this shock or reaction to Niacin, 12-18 Hours post flush.

Anyone know if it can it mess around with immune system or something? Did you personally experience any negative side effects?

Only thing I can think of is maybe because I usually take it 6/7 hours after food, and then don't eat for an hour. Maybe that approach is too hard on my system, and I need to take it a bit closer to food and less than 100 MG.

The 100MG dose a week is hardly taking an overdose. I think Niacin flush is used safely in patients for cholesterol stabilisation, so it should be safe in theory, if not taken too often or in excessive doses. I know there is potential liver damage (for example) in high regular doses.

What I am really curious about is why I get this "shock" reaction in my body for about 24 hours, which kicks in about 12 hours after the flush. It could be a positive thing, clearing something or resetting something. That is my positive thought and I am continue using Niacin weekly on that basis, because it has been something that has provided one of the best clearing experiences for me, even if that was mainly in my first weeks of using it a few months back.

I am also thinking this could be some overall reaction to the shock of the Flush. The first time I got the flush a few months back after taking 200MG (too much), I got the shakes for 30 minutes, as well as a flush.

Any other similar experiences or thoughts out there? I am so disillusioned with P O I S !!!

Hi Colm,

I've just read your post and am hoping that one or more of the men here who use niacin can add some insight, based on their experience.

Your description of the "shock" reaction that occurs ~ 12 hours after taking niacin made me think of some type of temporary re-bound effect. Since niacin causes vasodilation (the niacin "flush" ) -- perhaps your system compensates by temporary vasoconstriction. That could also possibly explain the sudden sensitivity to cold.

I did scan the literature to see if niacin decreases immunity, because of your coming down with some flu-like condition (twice!) after taking it.  I couldn't find anything about niacin leading to altered immunity.

This interpretation of mine might not be even marginally correct!! But the rebound effect did occur to me right away, so I wanted to let you know.

Perhaps others here with niacin experience can chime in? A reply from me on this is nothing compared to hearing from others who are affected by POIS and who might have similar experiences with niacin.

Best wishes to you!

Stef



Daveman

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Re: This may seem like a familiar place.
« Reply #1098 on: February 11, 2014, 01:30:05 PM »
Sorry Colm,

I hadn't even seen the post. The RSS doesn't show all posts, so it got by me.

First I would suggest, that it only be taken before the orgasm. We've known that continual consumption raises the thresholds, and therefore lowers the effectivity.

Also if there ARE any negative effects in some, that these would be amplified by taking the niacin more regularly.


Also when taken before the orgasm, it seems as though a metabolism change consumes the niacin, and therefore doesn't leave "excess niacin" floating around in the system. They say that niacin has a half-life of somewhere around 6 hrs. So I suppose once a day, there won't be much "excess" from day to the next. But, we have a particular condition, and when taken before orgasm, the niacin is "used" for something beneficial. If it is not consumed for that "beneficial thing", then it must be metabolized by some other process.

I have noticed that if I take niacin and don't have an orgasm (if I take 3 or 400 mg and don't get a flush for instance) I feel a lot more sluggish for a day or two. On the other hand, even though at times it might require those 3 or 400 mg to get a flush, as long as I orgasm, there doesn't seem to be any problem.

So although I haven't take very much outside of orgasm, yes, when I do, I usually feel negative effects for a good day.
I ONLY take it before orgasm, unless for some extenuating circumstance.

I think it important to follow these guidlines. Also have your liver checked, at least once, better twice a year. Just in case. Normally this is recommended with high doses (1000mg daily for instance), and shouldn't be a problem at our levels, but each person is different, and it's always better to be safe.

WITHOUT RESEARCH THERE WILL BE NO CURE!
Sessions 5 to 9 days, mostly Flu-like, joints, digestion problems, light cognitive.
Niacin has changed my lif though, now 1 day MAX.
Somewhere in this interaction with Niacin is the answer!

demografx

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Re: This may seem like a familiar place.
« Reply #1099 on: February 11, 2014, 01:46:50 PM »
I guess, with the limited budget we have it would be smart to select people who are closed to the research lab or willing to come at their own cost. It's probably better to perform more test with the money that pay plane tickets.

Excellent point, LAPOISSE.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business