Study: POIS and Delayed Onset Muscle Soreness (DOMS)

[demografx]

Google Alert
Postorgasmic Illness Syndrome
As-it-happens update July 23, 2021
WEB   
Cells | Free Full-Text | Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle ...
MDPI
Post orgasmic illness syndrome is a rare, mysterious condition with an unknown pathomechanism and uncertain treatment. The symptoms of post ...

https://www.mdpi.com/2073-4409/10/8/1867

[Muon]

Amazing find Demo.

[Bob Morane]

Thanks for posting this Demo!

This is actually a really interesting read with a different take. And it offers avenues less explored such as Spermidine supplements to compensate for spermidine depletion after ejaculation. A diet high in spermidine rich foods is an option too.

"The spermidine depletion-induced differences are as follows: modulation of
the acute stress response, flu-like symptoms, opioid-like withdrawal and enhanced deregulation of
the autonomic nervous system. The longitudinal dimension of delayed onset muscle soreness, in the
form of post orgasmic illness syndrome and the repeated bout effect, have cognitive and memory
consequences, since the primary injury is learning and memory-related."

Sounds familiar. They also mentioned Heart Rate Variation going lower which is something I have noticed for myself since I monitor my HRV daily.
They mention "cardiac autonomic full recovery" happening after POIS has passed. My HRV clearly goes down by several points during POIS.

I hope they will build up therapeutic interventions following this hypothesis.

Google   
Postorgasmic Illness Syndrome
As-it-happens update July 23, 2021
WEB   
Cells | Free Full-Text | Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle ...
MDPI
Post orgasmic illness syndrome is a rare, mysterious condition with an unknown pathomechanism and uncertain treatment. The symptoms of post ...

https://www.mdpi.com/2073-4409/10/8/1867

[demografx]

Thanks for posting this Demo!

My pleasure! Often Google Alerts only dig up POIS “hype”, so I am delighted that you - - and Muon - - liked it!!

[drop247]

That study probably deserves its own thread. Myself and others on this forum experience terrible DOMS in the days after exercise, as well as a POIS-like episode. What the authors might be missing is that the discomfort and pain of DOMS, even in normal people, is largely caused by histamine. Normal people can even take a antihistamine drug before exercise in order to avoid DOMS in the days after. I will try the high spermidine diet they suggest but I can't help but wonder if histamine is still the issue. Thanks for the article Demo, it really made me think of some things I haven't considered before, like how much exercise is involved in my POIS.

[demografx]

Thanks, drop247, best wishes.

[Muon]

You could make a thread about it in the article, references and links category drop247.

[demografx]

That study probably deserves its own thread.

Feel free to start one for DOMS!

[berlin1984]

Maybe
https://poiscenter.com/forums/index.php?topic=2373.0
https://poiscenter.com/forums/index.php?topic=3609.0

There is additional (overlapping) terms in the CFS community like Post-exertional malaise and Exercise Intolerance

[berlin1984]

Admin Note: Split this off from https://poiscenter.com/forums/index.php?topic=3933

[jon1_reclaim]

Anyone tried this supplement yet ? Sperminide ?? What a name !

[demografx]

…Sperminide ?? What a name !

[demografx]

Admin Note: Split this off from https://poiscenter.com/forums/index.php?topic=3933

Thanks, Berlin!

[Mushnikk]

I for one seem to be an exception here: I dont seem to experience significant excertional malaise. I can ride my bike for 50km per day and feel largely fine. Exercise even benefits my POIS after O.

Sperminidine seems also to be produced by certain gut bacteria. Perhaps those helped by changing their microbiome and feeling better were helped via this route.

[berlin1984]

Yes I had thought about the same possibility. Messed up microbiome not producing certain vitamins anymore and also not producing spermidine anymore.

My single one day trial for spermidine: https://poiscenter.com/forums/index.php?topic=3652.msg41646#msg41646

[Prospero]

An opinion on this article, by a friend in pm:
"Thanks for the article. I disagree with a lot of statements made there. First of all, theoretical studies without any experiments on mouse or human  models (gene expression, not readily available blood tests etc.) are the pathway to nowhere. With the same success, I could attribute every POIS symptom to the loss of zinc in sperm. Pseudoscience seeks to prove a hypothesis correct whereas science seeks to prove it wrong. Moreover, I highly dislike the approach where they try to explain all POIS cases. This theory could be easily declined by simply providing cases where people experience POIS-symptoms just from arousal, and all that spermidine stuff goes into nowhere. This theory can't explain how so many people experience symptomatic relief from such substances as SSRIs, benzos, etc., neither how people were cured by specific dietary protocols. That said, I do not disregard the theory, but this study is completely inappropriate and can't be taken seriously. From my perspective, it is a bro-science anecdote."

I agree with the methodological criticisms, though I still welcome new ideas which can bring about further reflection.

[M.F.M]

My Personal Experience  disagrees to the basis of this hypothesis thats POIS  related to muscle contractions during erection and ejaculation , for the simple reason that me and i remember other fellow POIS sufferers as well has stated  that we discovered masturbation before puberty (which is more  normal than you think because children are curious) and we experienced orgasm as well but of course it was dry   , that orgasm before puberty ?dry orgasm? didnt result in POIS symptoms at all

Unless there is different muscles that are involved in orgasm after puberty , i highly doubt that this hypothesis has solid grounds to be true 

[Rollo]

Dry orgasms are totally possible as an adult aswell....and in my case they do not cause POIS either

[Journey]

Dry orgasms are totally possible as an adult aswell....and in my case they do not cause POIS either

That means the ejaculatory mechanism that develops during puberty is involved in POIS

[Rollo]

So probably the sperm itself since the contraction that causes the release should hardly cause anything else on it's own, right?