Author Topic: Exercise intolerance - please help  (Read 5393 times)

IronFeather

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Exercise intolerance - please help
« on: November 28, 2020, 07:45:17 AM »
Hello! It's been a few months since I was active in this forum, but most people probably don't know me anyway, so I'll introduce myself. I'm a 24-year-old woman from Spain, and have been suffering from POIS since my early teens.

Until March, my POIS was well managed and tolerable, basically because I abstained from all sexual activity and exercised regularly, which for some reason improved my symptoms a lot.

However, due to covid, we started using bleach at home for general cleaning, and I developed some kind of reaction to it. It took me months to figure out that bleach was the cause, and it completely short-circuited everything in my body: I've had tachicardia, a continuous horrible feeling of shortness of breath,  dizziness, loss of appetite, fever... somehow, I know this is all related to POIS, because I'm not allergic to bleach.

My problem is, I've developed exercise intolerance. Now when I exercise, even if it's something as innocent as a little bit of running or a few push-ups, I get headaches, fever and loss of appetite. My question is, to those of you who have exercise intolerance due to POIS, have any of you recovered from it? I'm completely heartbroken and feel like my life has been torn to pieces. I love sports with all my soul and now my greatest source of happiness in life has been ripped away from me. I need to know there's some hope, I don't know what to do. I'm immensely sad and lost.

Please, help me! :(
« Last Edit: November 28, 2020, 07:47:00 AM by IronFeather »
25-year-old Spanish woman with POIS symptoms for the last 12 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

Muon

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Re: Exercise intolerance - please help
« Reply #1 on: November 28, 2020, 08:04:42 AM »
You are probably not allergic but I bet the same cell is involved. Here are some ideas:

POIS paper treatment summary

Exercise-induced POIS

Online consultation with specialist (is specialized in the type of problems you are describing, still 2 slots free)

POIS doctors list

Mallory:

"I exercise frequently but get a similar headache only when I go running for some reason.. minus the flu symptoms though."

lovelife28:

"I also get the same kind of headaches after a high paced workout."

Effects of endurance exercise on serum concentration of calcitonin gene-related peptide (CGRP): a potential link between exercise intensity and headache

https://poiscenter.com/forums/index.php?topic=2885.msg37012#msg37012

I love sports as well and was pretty good at it, developed exercise intolerance and never recovered.
« Last Edit: November 28, 2020, 08:07:13 AM by Muon »

IronFeather

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Re: Exercise intolerance - please help
« Reply #2 on: November 28, 2020, 11:04:45 AM »
Thank you for all the info, Muon, you're everywhere! Before I posted this I knew I would get a reply from you. It's disheartening to see that you know so much about this syndrome and that you're still suffering it - will we ever be free from this? Will we ever find a cure? I'm so desperate... I don't want to lose my best years being sick from this.

I don't understand this whole exercise intolerance thing at all. Just a few months ago I was going to martial arts classes and doing calisthenics workouts at home, working out like crazy almost every day. And now this? It's as if toxins affected the body in some way, because bleach is a toxic substance after all, right? All this time that I've been sick I've had a weird "electric" feeling where the vagus nerve is supposed to be, right below the sternum. And this horrible sensation of asphyxiation that doesn't seem to be related to the oxygen levels in the blood... could the vagus nerve be malfunctioning? That's what I've been thinking lately, it seems to be incapable of keeping the heart rate down, and to control the levels of inflammation like it's supposed to.

Another weird thing is - I've had, and still have, a weird symptom that consists in shaking or trembling as a result of any physical effort. It feels as if my nerves were malfunctioning and unable to transmit signals like they should...

Has this possibility been explored before? I should check all the threads here and see what I've missed the last few months...
25-year-old Spanish woman with POIS symptoms for the last 12 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

Muon

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Re: Exercise intolerance - please help
« Reply #3 on: November 28, 2020, 03:04:25 PM »
I think that in your case the vagus nerve and/or mast cells are involved. Got the same thing going on with heart rate by the way.

Another weird thing is - I've had, and still have, a weird symptom that consists in shaking or trembling as a result of any physical effort. It feels as if my nerves were malfunctioning and unable to transmit signals like they should....

I know what you are talking about because I got this as well. It's like muscle tension cannot adjust properly, it's some sort of locked and can't recover from exercise either. Trembling doesn't happen with any effort, only if I cross a certain threshold, but that is easily done. Neuromuscular transmission? Calcium signaling? Decreased blood flow/supply? Anyway there seems to be some overlap between us. 

No the possibility hasn't been explored as far as I know, at least in literature.

What is your respiratory rate? https://poiscenter.com/forums/index.php?topic=3591.0
And have you measured your heart rate between lying down flat and standing? Is there a difference?

Spamming this fragment here, comment about exercise:
https://youtu.be/rIUccEITT6E?t=1355
« Last Edit: November 28, 2020, 03:33:11 PM by Muon »

Journey

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Re: Exercise intolerance - please help
« Reply #4 on: November 29, 2020, 06:59:42 AM »
I think that in your case the vagus nerve and/or mast cells are involved. Got the same thing going on with heart rate by the way.

Another weird thing is - I've had, and still have, a weird symptom that consists in shaking or trembling as a result of any physical effort. It feels as if my nerves were malfunctioning and unable to transmit signals like they should....

I know what you are talking about because I got this as well. It's like muscle tension cannot adjust properly, it's some sort of locked and can't recover from exercise either. Trembling doesn't happen with any effort, only if I cross a certain threshold, but that is easily done. Neuromuscular transmission? Calcium signaling? Decreased blood flow/supply? Anyway there seems to be some overlap between us. 

No the possibility hasn't been explored as far as I know, at least in literature.

What is your respiratory rate? https://poiscenter.com/forums/index.php?topic=3591.0
And have you measured your heart rate between lying down flat and standing? Is there a difference?

Spamming this fragment here, comment about exercise:
https://youtu.be/rIUccEITT6E?t=1355
Same for example doing planks or pushups or bench pressing the body feels tense and sometimes is shaky it feels as some muscles are sort of locked up during POIS and during exercise they don't adapt depending on the demand as well e.g. when they need to be looser they stay tight or when they need to tighten they are looser so even if I have energy to exercise more I just start feeling odd musculary I notice doing pushups I always get this funny feeling around abs/back/pelvic area someplace around perinum the muscles automatically contract and it gives a funny feeling around that area like the same type of uncomfortableness when you are being tingled by someone not painful but just so weird that it's hard to continue exercising even if you have the strength because it only continues tingling more and when planking competing with others I'd always shake while everyone else could stay in that position without getting that muscle shake and in general I have found it harder to increase strength than others it's as if some weight based exercises have some threshold after which my body doesn't adapt.

mike_sweden

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Re: Exercise intolerance - please help
« Reply #5 on: November 29, 2020, 08:22:11 AM »
I used to be a top athlete in Sweden in my teens and had an absolutely amazing physical strength when i was 7-15 yo

this was torn to pieces by POIS and no i have not recovered, hard exercise is completely out of the question since at least 15 years back

i today make sure to have a job where i don't sit at a desk all day long, i have a job where i walk a lot.

this is a good remedy and in await of a complete cure the best thing to do

stop doing what makes you sick and be prepared to have to switch job and lifestyle completely

understand that you are now different from other people and you have different needs

don't expect people to understand this, most people are ignorant

Journey

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Re: Exercise intolerance - please help
« Reply #6 on: November 29, 2020, 09:54:48 AM »
I used to be a top athlete in Sweden in my teens and had an absolutely amazing physical strength when i was 7-15 yo

this was torn to pieces by POIS and no i have not recovered, hard exercise is completely out of the question since at least 15 years back

i today make sure to have a job where i don't sit at a desk all day long, i have a job where i walk a lot.

this is a good remedy and in await of a complete cure the best thing to do

stop doing what makes you sick and be prepared to have to switch job and lifestyle completely

understand that you are now different from other people and you have different needs

don't expect people to understand this, most people are ignorant
I wonder what causes this great decrease in ability of exercise performance?

IronFeather

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Re: Exercise intolerance - please help
« Reply #7 on: November 29, 2020, 12:29:54 PM »
Muon, it's amazing how much our symptoms overlap! I'd never had any problems with heart rate or exercise before, and I'd never had this shaking before either, even when reaching muscle failure from too many repetitions of an exercise, so when it appeared I thought I was going crazy and that it couldn't possibly be related to POIS. It seems it was all precipitated by using bleach at home - maybe toxins damaging the vagus nerve? Oh, and my respiratory rate right now is 10/min, no idea how much it was before everything went haywire these months. And I've noticed my heart rate jumps up when I stand (from a horizontal position) and goes down when I lay down, but then stabilizes again (this didn't happen before either).

Mike, that's terrible that you had to stop exercising after being in such top condition... I'm afraid that it's going to happen to me, too. I haven't been able to exercise at all since March and I've lost all of my progress and strength. I suppose I must forget about it and just live with this new limitation, but it's hard when it was such a source of happiness and self-esteem for me. It seems that nobody has recovered from exercise intolerance, so... Does walking help you tolerate other types of exercise better? Or do you mean it's the only type of exercise you can do now?

Journey, I TOTALLY know what you're talking about with that weird tingly feeling! I get it in the middle of the abdomen, just below the sternum. Especially when I do push-ups and that zone tenses up, I feel like I'm damaging something, and that's why I think the vagus nerve is malfunctioning of damaged because of toxins or whatever. And I had the same problem with the difficulty to adapt to more intense exercise, even when I could practice any sports: I progressed from zero to 15 push-ups in three weeks, but then I spent four months trying to improve that number, and could only reach 20 (and barely). Maybe this has something to do with inflammation? If the vagus nerve or some meurotransmitters involved with ir aren't working properly, there could be chronic inflammation going on, that would interfere with the body's cycle of muscle repair and strengthening. Just an idea.
25-year-old Spanish woman with POIS symptoms for the last 12 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

mike_sweden

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Re: Exercise intolerance - please help
« Reply #8 on: November 29, 2020, 05:24:02 PM »
i am saying that you should do as much low intense training as possible

Muon

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Re: Exercise intolerance - please help
« Reply #9 on: November 30, 2020, 02:09:35 PM »
Now when I exercise, even if it's something as innocent as a little bit of running or a few push-ups, I get headaches, fever and loss of appetite.

I remember an exercise session where I pushed my body over a certain threshold triggering fever.

It sounds like the bleach shifted a system into a new equillibrium state, now you are stuck. Bleach-->mast cells-->Vagal tone modulation? I have read about passive tobacco smokers developing endothelial dysfunction but these people do not get fever symptoms. Or the bleach has reprogrammed mast cells and now you are stuck with a new phenotype.

Anyway you should do a heart rate variability test to investigate vagal tone IMHO. The vagus nerve might induce fever by release of pyrogens. It also stimulates release of hormones related to the digestive tract regulating appetite like Leptin, Ghrelin and more.

From what I know headache can be induced by (aside from vasomotor function):
CGRP
Histamine
TNF-alpha
Serotonin

Edit: You might be exercising with a disrupted BBB or endothelial lining opened up by the bleach. In that case things to test:

1) VEGF
2) S100B

In that order

I've written something about it in these threads:
https://poiscenter.com/forums/index.php?topic=2373.msg36204#msg36204
https://poiscenter.com/forums/index.php?topic=2755.msg36205#msg36205
« Last Edit: November 30, 2020, 02:58:48 PM by Muon »

mike_sweden

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Re: Exercise intolerance - please help
« Reply #10 on: December 01, 2020, 03:55:06 AM »
this bleach intolerance got me thinking

toilet paper is very high on bleach, this could be something to investigate

it should very much cause problems in penis, vagina or anus

IronFeather

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Re: Exercise intolerance - please help
« Reply #11 on: December 02, 2020, 08:42:21 AM »

It sounds like the bleach shifted a system into a new equillibrium state, now you are stuck. Bleach-->mast cells-->Vagal tone modulation? I have read about passive tobacco smokers developing endothelial dysfunction but these people do not get fever symptoms. Or the bleach has reprogrammed mast cells and now you are stuck with a new phenotype.

Anyway you should do a heart rate variability test to investigate vagal tone IMHO. The vagus nerve might induce fever by release of pyrogens. It also stimulates release of hormones related to the digestive tract regulating appetite like Leptin, Ghrelin and more.

Absolutely, that's what it feels like, as if something had "broken" or shifted out of its equilibrium state and now I was stuck. The funny thing is, before the bleach, exercise used to be the only thing that was able to stop a POIS attack in me, or at least reduce it by 80-90%, and it did so very effectively (and I used to feel great after a training session, zero headaches, zero symptoms caused by exercise).

Thanks for all the suggestions, those are great ideas, I'll mention this to my doctor to see if she can prescribe me some test where these parameters could be measured. It can be done in a blood test, right? And if the BBB is disrupted somehow, wouldn't it be risky to the brain to exercise in this state?

It's interesting that you mention these hormones that regulate appetite, because when I'm not having POIS symptoms, I'm hungry all the time and eat enormous amounts of food without gaining a single gram of weight. It seems I'm always either in the "food? Yuck, no thanks" state or in the "eat everything in sight and more" state. Something must be out of control, and I suspect you're right and it's probably the vagus nerve.

A genetic vagus nerve malfunction, perhaps...?

Mike, I had no idea that toilet paper contained bleach! Hmm, that's interesting. I suspect we have a dysfunctional vagus nerve for some reason, that reacts very strongly to chemicals.
25-year-old Spanish woman with POIS symptoms for the last 12 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

Journey

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Re: Exercise intolerance - please help
« Reply #12 on: December 02, 2020, 02:34:59 PM »

It sounds like the bleach shifted a system into a new equillibrium state, now you are stuck. Bleach-->mast cells-->Vagal tone modulation? I have read about passive tobacco smokers developing endothelial dysfunction but these people do not get fever symptoms. Or the bleach has reprogrammed mast cells and now you are stuck with a new phenotype.

Anyway you should do a heart rate variability test to investigate vagal tone IMHO. The vagus nerve might induce fever by release of pyrogens. It also stimulates release of hormones related to the digestive tract regulating appetite like Leptin, Ghrelin and more.

Absolutely, that's what it feels like, as if something had "broken" or shifted out of its equilibrium state and now I was stuck. The funny thing is, before the bleach, exercise used to be the only thing that was able to stop a POIS attack in me, or at least reduce it by 80-90%, and it did so very effectively (and I used to feel great after a training session, zero headaches, zero symptoms caused by exercise).

Thanks for all the suggestions, those are great ideas, I'll mention this to my doctor to see if she can prescribe me some test where these parameters could be measured. It can be done in a blood test, right? And if the BBB is disrupted somehow, wouldn't it be risky to the brain to exercise in this state?

It's interesting that you mention these hormones that regulate appetite, because when I'm not having POIS symptoms, I'm hungry all the time and eat enormous amounts of food without gaining a single gram of weight. It seems I'm always either in the "food? Yuck, no thanks" state or in the "eat everything in sight and more" state. Something must be out of control, and I suspect you're right and it's probably the vagus nerve.

A genetic vagus nerve malfunction, perhaps...?

Mike, I had no idea that toilet paper contained bleach! Hmm, that's interesting. I suspect we have a dysfunctional vagus nerve for some reason, that reacts very strongly to chemicals.
Usually Histamine surpresses hunger and Leptin too and increases happen with reduced Histamine and increased Ghrelin.

Muon

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Re: Exercise intolerance - please help
« Reply #13 on: December 03, 2020, 02:41:20 PM »
It's interesting that you mention these hormones that regulate appetite, because when I'm not having POIS symptoms, I'm hungry all the time and eat enormous amounts of food without gaining a single gram of weight. It seems I'm always either in the "food? Yuck, no thanks" state or in the "eat everything in sight and more" state. Something must be out of control, and I suspect you're right and it's probably the vagus nerve.

You also had low vitamin D which may indicate changes in microbiome. Videos about that here:
https://poiscenter.com/forums/index.php?topic=257.msg37837#msg37837

I'm wondering whether something binds to your iron during POIS and decouples out of POIS (regarding your iron being low during POIS).

Fragment about vitamin D, brainstem and acetylcholine: https://youtu.be/74F22bjBmqE?t=472
« Last Edit: December 03, 2020, 03:08:21 PM by Muon »

Muon

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Re: Exercise intolerance - please help
« Reply #14 on: December 10, 2020, 05:33:30 PM »
I'm really glad you brought this topic up Quantum, because it's made me read up on mast cells and exercise, and I think that the fact that neuropeptides released along with adrenaline (along with many other neurotransmitters) can activate mast cells is significant.

Adrenaline doesn't activate the mast cell but inhibits via beta 2 adrenergic receptor activation. It can be tested by using Pseudoephedrine: https://en.wikipedia.org/wiki/Pseudoephedrine#Mechanism_of_action

In addition to that, perhaps exercise could do something to the vagal tone (someone should look it up). Doesn't heat induce acetylcholine release? Exercise could do something similar. Anyway I get the impression that the cardiovascular system doesn't respond properly to exercise.

Edit:
Ok here it is, I thought I had read it somewhere, page 499:
https://poiscenter.com/forums/index.php?topic=3140.msg32139#msg32139

"For example, during exercise there is a progressive decrease in PNS tone and a parallel increase in SNS tone. There are unique situations in which the autonomic response is characterized by either dual activation or dual inhibition. For example, in human adults, sexual arousal is characterized by a dual excitation."

The body might already be in a SNS dominant state, exercise could be seperating them even further apart. Perhaps a chronic dominant SNS state could increase adrenergic receptor density in general making you more sensitive to incremental increase in SNS tone.

Edit again:
PE may support the above statement:
"The present study found the balance between the sympathetic and the parasympathetic system was changed in favor of the sympathetic action in patients with lifelong PE. This imbalance might trigger lifelong PE."

"A converse viewpoint is that overactivation of a1-adrenoreceptors via the SNS might lead to PE"

Autonomic Nervous System Dysfunction in Lifelong Premature Ejaculation: Analysis of Heart Rate Variability

Quote from: Muon
In addition to that Pyrrhus. We see POIS patients with exercised induced POIS or exercise intolerance.
"For example, during exercise there is a progressive decrease in PNS tone and a parallel increase in SNS tone. There are unique situations in which the autonomic response is characterized by either dual activation or dual inhibition. For example, in human adults, sexual arousal is characterized by a dual excitation."
Vagal tone: A physiologic marker of stress vulnerability

I have seen some members here on the Phoenix Rising forum having succes with Pyridostigmine for PEM, if you combine it with the above story it makes sense:
List of ME/CFS Recovery and Improvement Stories
Ref
« Last Edit: December 10, 2020, 05:39:18 PM by Muon »

Investigator

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Re: Exercise intolerance - please help
« Reply #15 on: December 11, 2020, 07:09:29 AM »
If I do moderate exercise (such as a long walk), this is good for me. However, a more intense cardio workout can in itself cause POIS. What about muscle training?

I wanted to train for strength and exercise with dumbbells at home. I started super basic (due to lack of shape) and kept it basic for a while. It was going well, until one day I felt encouraged that I got stronger and decided to push myself to more reps than usual. That was yesterday. You can guess: strong POIS symptoms today. Brain fog, dizziness, fatigue. I really associate it with the increased workout load and not with the last ejaculation (the last one was 5 days ago, I had mild POIS the day after and then recovered, so right now I don't consider myself under the influence of that ejaculation from 5 days ago. POIS today is surely due to the dumbbells exercises from yesterday). 

Possible hypothesis, suggested by an andrologist I've spoken with some time ago: maybe a drop in free testosterone. This would unite the two types of cases of POIS: ejaculation or more serious exercise. I will check my free testosterone next time I wake up in serious POIS. 

By the way, my POIS follows a definite day-cycle pattern. I WAKE UP with it. Always, the onset of symptoms takes place when I wake up, after a long sleep. It never starts randomly during the day. Then by the evening, symptoms are better. I am back thinking of something hormonal, since hormones follow daily cycles. Maybe free testosterone (or something else) goes low, and then with activity during the day, it accumulates again?

When my POIS started, I was in amazing shape, too. I would often swim 4km a day. Now I cannot imagine anything like that.

Muon

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Quantum

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Re: Exercise intolerance - please help
« Reply #17 on: December 11, 2020, 11:09:26 AM »
Hi Iron Feather,
Sorry for joining the conversation late, I have been quite busy because of the pandemic ( I work in the health care system).

I brought the subject of exercise induced POIS-like symptoms on the forum about 4 years ago ( here at https://poiscenter.com/forums/index.php?topic=2373.msg19865#msg19865 - I saw Muon have quoted posts in this thread, earlier).  In my case, symptoms from exercise are less severe than those from POIS, but nevertheless, they can be a hindrance for normal activity and work, especially the day after.   I used to take both a pre-pack and a post-pack, when doing sport.  With time, I saw that limiting the time I exercise is very important, and keeping the intensity at moderate.  For example, the more often I get out of breath during sport, the more I will have symptoms the next day.   My sports are badminton and tennis, and I always play double ( simple is too demanding for me), and I play in very casual league, I cannot play with athletic and competitive persons.  Also, the more I sweat during sport, the more I am subject to have severe symptoms afterward.

From these observations, I have learned to:
  • never exercise for more than 90 minutes, and 1 hour is the best
  • never do sports more than 2 times a week, with at least 1 day off between, and of course, 1 day off after ejaculation ( considering I have taken my pre-pack, of course, because than 2 to 3 days off would be needed)
  • A lot of electrolytes intake before, during and after sport.  I take slightly salted water during sport ( 2 ml of salt in 600ml of water, approx.), I take 400ml of organic coconut water just after playing ( a great source of potassium and magnesium - it is like a natural "gatorade", but without the coloring and artificial flavors...), I eat a banana just after, too, for the potassium, and on top of that, I take 8 to 16 mEq of potassium in supplement form.
  • the morning after, if I feel I have no energy and have to go to work or else, I take a complex-B with vitamin C, and some other supplements that gives me energy, like astaxanthin or green tea extract or else.
These help in lowering the potential fatigue and low blood pressure and sluggishness, the next day. 

You say that you feel nervousness/trembling after exercise.  In my case, it is less intense, but just after sport, I do not feel the fatigue yet - it is like I am on a "sympathetic system high", from the adrenaline/noradrenaline production form sport.  It takes a few hours for this effect to reside, and then, the fatigue and low blood pressure sink in, and the parasympathetic/vagus system seems to take the upper hand.

Whatever really happens, it feels like there is an over-reaction followed by another over-reaction in the opposite direction.

Maybe it is a deficiency in COMT, the enzyme responsible for eliminating the noradrenaline/adrenaline surplus after intense exercise ?   hard to say.  One thing is sure, I cannot do as much sports as I would like, and my recovery time is much longer than it should normally be.

Another of my hypothesis comes from the fact that my recovery is longer if I have been out of breath more often during exercise.  It lead me to study the Cori Cycle.  In summary, when we need more oxygen in less time, our body goes anaerobic.  This saves time, but produces lactic acid, and this transfer part of the metabolic burden to the liver  ( https://web.archive.org/web/20080423042037/http://www.elmhurst.edu/~chm/vchembook/615coricycle.html ) I have a very slow, sluggish, liver.  So, I suppose that after sport, the additionnal detox my liver has to take on is responsible, at least in part, for my fatigue and symptoms.  Anyway, taking great care of my liver helped me both for exercise and for POIS.  You can see more details in this specific "liver detox" thread, at  https://poiscenter.com/forums/index.php?topic=2431.msg20521#msg20521 .


About you reaction to chlorine, I do not think it could be an allergy, it could be something like a high sensitivity to chlorine, and what you get could be a kind of chlorine poisoning.  You could try using another disinfectant for a week or two, and see if things improve.   Chlorine is highly toxic for humans.  For surfaces, you could use isopropyl alcohol, and there are a lot of other chlorine-free disinfectants available too on the market.   Also, be sure not to use chlorine in your laundry. And, even if you did not go in a chlorinated swimming pool, you could see if some of the suggestions in the following article could be safe and useful for you:  https://thedetoxspecialist.com/blog/detox-your-body-from-chlorine-after-swim/ .

Until you find something that really helps you improve your exercise tolerance, I guess you will not have the choice to know and respect your new limits. 
Take care of yourself, as much as possible !
« Last Edit: December 11, 2020, 11:16:46 AM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Muon

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Re: Exercise intolerance - please help
« Reply #18 on: December 11, 2020, 06:11:47 PM »
And, even if you did not go in a chlorinated swimming pool...

My uncle could not enter chlorinated swimming pools as a kid. He developed a rash all over his body.
« Last Edit: December 11, 2020, 06:14:03 PM by Muon »

Muon

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Re: Exercise intolerance - please help
« Reply #19 on: December 24, 2020, 01:41:08 PM »
Fibromyalgia syndrome: a pain modulation disorder related to altered limbic function?

"A 30 mg nimodipine capsule usually works in about 45 min, often producing relaxation, increased energy, a decrease in tender point sensitivity, improved exercise tolerance and enhanced mental clarity."