Histamines for POIS? (Thread about Antihistamines too)

[FloppyBanana]

FYI - Progesterone, testosterone and vitamin D are steroids.
FB

[sameer7777]

Vitamin d steroid

[vamerty]

Vitamin d steroid

I thought the same mate

[berlin1984]

"men with high histamine levels may suffer from premature ejaculations"? Or is it just one of those coincidences?

Or the other way round: One strategy for avoiding hornyness (to delay it to evening for activity with wife or even to delay it to weekend) one think that works for me is Cetirizine (brand name Zyrtec in US).
Side effect: Issues with erection...
Anti-Histamine => Problem getting an erection.

(In general for me, If i don't have an orgasm every x days, I suddenly get very foggy und unfocused. No way for me to work like that. So I have to have an orgasm. But as mentioned above, it's sometimes inconvenient so better to delay it. Sex causes me less problems than masturbation. And masturbation during day and sex in evening would cause a lot of problems. So then comes the cetirizine)

Note: Other bad side effects might be fertility / sperm issues:
https://www.google.com/search?q=antihistamines+fertility&oq=antihistamines+fertility

[Unvers]

Antihistamines sometimes I happened to try them in POIS because taken for allergic rhinitis and it seems to me to improve the symptoms a little, drugs that increase histamine such as modafinil that I would like to try to combat daytime fatigue but I'm afraid they can worsen both POIS and allergy.

Proven antihistamines: cetirizine and mirtazapine, the latter is also an antidepressant and could help if you have cognitive POIS that leads to depression but beware that from a crazy daytime sleepiness and increases appetite, it made me gain a lot of kilos.

My POIS is only cognitive.

[VSmasher]

Can Histamines help POIS? I dont know.

Heres some Histamine information
Histamine is a hormone/chemical transmitter and important protein that is involved in local immune responses, regulates stomach acid production and acts as a mediator in allergic reactions. This is the bad part we most often read about.

Histamine has many good functions too.
* It plays an important role as it is released as a neurotransmitter, necessary for our brain cells to "communicate" properly. Neurotransmitters are chemicals that are used to relay, amplify and modulate electrical signals between a neuron and other cell.

* Histamine is necessary to modulate sleep.
* During an orgasm, histamine is released, and has been connected to the sex flush among women. However, men with high histamine levels may suffer from premature ejaculations.
* Classified schizophrenia patients often have low blood levels of histamine. This can be a side effect of their antipsychotic medication. When this seemed to be the case, as histamine levels were increased, their health improved.

What causes allergies?
Allergies are caused by an immune response to a normally harmless substance, i.e. pollen or dust. When these come into contact with specific antigens in our blood (part of the white blood cells, so-called mast cells) this triggers a response and histamine is released.

The release of histamine causes several allergic symptoms, for it contributes to an inflammatory response and causes constrictions of smooth muscle.
* The allergic reaction causes blood fluids to enter the area, causing swelling. (Vasoactive).
* The constrictions of the smooth muscle are seen during an asthma attack. The muscles surrounding the airway constrict, causing shortness of breath.

An allergic reaction is a response that should not be happening because the substance that triggers is should not be dangerous to us. Sometimes we have the "luxury" to allow our immune system to run its course, but then we have to sniffle our way through the pollen seasons.
Sometimes a harmless looking allergic reaction may develop into a potentially life threatening situation. Take for example, a bee sting.
Anti-histamines are widely available nowadays, and help the body to overcome its immunological "mistakes".

Histamine and amines (histamine-like substances) can be found in foods, but also develop after cooking and storage. This happens especially with fermented foods, but sometimes during normal cooking procedures.
Amines are formed from specific amino acids that are present (to a certain agree) in all foods.

The most common food amines are:
* Histamine
* Phenylethylamine
* Serotin
* Tyramine
* Dopamine

Allergic reactions to these amines can be:
* Vaso-active affects the width of blood vessels
* Vaso-dilating widens the blood vessels
* Vaso-constricting narrows the blood vessels

Even foods that don't contain histamine can trigger an allergic reactions, but often additives are the culprits.
Food products that are known to cause allergies are:
Raw egg white, shellfish, strawberries, citrus fruit and pineapple, chocolate, tomatoes, alcohol, fish and pork.

People usually react pretty soon, during or after the meal, and untreated, the reaction may last 24-48 hours.
When people react e.g. because of tyramine causes, the symptoms are different.

Alcohol consumption can provide histamine, trigger its release, and prevent a histamine breakdown.
Histamine and alcohol share the alcohol dehydrogenase enzyme during the metabolism stage.
We've seen the important part histamine plays in the functioning of our body - we can't live without it.
But the moment an allergic reaction sets in, it seems to create havoc.
We do well to pay attention, and ask the advice of a specialist if we become allergic, either to food, dust or "unknown" things.

Every new allergic reaction may be stronger than the previous one, and potentially more dangerous.

Don't think it "will pass" or go away by itself. It won't.
If you are allergic, you'll need that anti-histamine "backup" at home, in order to stop the "attack" in its tracks. Don't self-medicate. Ask your doctor's advice. He may want to do some specific tests, in order to prescribe specific medication.
Knowing what to do when you experience an allergic reaction, treat it accordingly (with the right medication) will save you a (frightening) trip to the first aid department.

What are your thoughts/experiences?

Do have science that shows  "men with high histamine levels may suffer from premature ejaculations"? Or is this just a theory?

[Journey]

"men with high histamine levels may suffer from premature ejaculations"? Or is it just one of those coincidences?

Or the other way round: One strategy for avoiding hornyness (to delay it to evening for activity with wife or even to delay it to weekend) one think that works for me is Cetirizine (brand name Zyrtec in US).
Side effect: Issues with erection...
Anti-Histamine => Problem getting an erection.

(In general for me, If i don't have an orgasm every x days, I suddenly get very foggy und unfocused. No way for me to work like that. So I have to have an orgasm. But as mentioned above, it's sometimes inconvenient so better to delay it. Sex causes me less problems than masturbation. And masturbation during day and sex in evening would cause a lot of problems. So then comes the cetirizine)

Note: Other bad side effects might be fertility / sperm issues:
https://www.google.com/search?q=antihistamines+fertility&oq=antihistamines+fertility

I just took 10mg Zyrtec and 500mg Aspirin, maybe slightly unclogs my breathing and lungs and slightly boosts digestion but hard to tell, I may need to wait more hours to see if that has got any sort of effect on POIS

[ozmoses]

I'd highly encourage everyone here to look into the acetylcholinesterase (AChE) deficiency component of POIS as orgasm can create a sort of cholinergic crises for some/many of us. This is why some antihistamines (that are anticholinergic- like first generations (benadryl/chlorpheniramine, etc) are helpful.   Cholinesterase testing is cheap and can be ordered through sites like ultalabtests.com  A deficiency in AChE can result in excessive sweating, excessive urination, fatigue, irritability, soft bowel movements, etc.  We have to be careful with foods/proteins that are high in choline as low AChE means acetylcholine isn't broken down at normal levels.   

In my case, POIS became much worse after H Pylori, streptococcus/enterococcus levels became very high in my gut- found out the GI Map stool testing. I encourage everyone to do this.  Could be a game changer for some... has been for me.  Learning more about AChE has been huge too.  Nootropics like Piracetam, Centrophenoxine and Alpha Lipoic acid help lower or utilize acetylcholine and lower it's burden.   Hot showers/baths/sweating is important for detox. 

[Hopeoneday]

Hi ozmozes.
It is posible for some poisers.
On the odher side, there are poisers types who are been helped by taking
mytelase.. look for Quantum pois type charts..

ALA is capable to move toxins from brain...

[mike_sweden]

i recently moved to new apartment and most of my clogged nose issues has disappeared

most likely dust and mold caused it

[Aladin]

This might be why some of us find relief with antihistamines.

https://www.technologynetworks.com/drug-discovery/videos/antihistamines-for-everything-355944?utm_content=187901568&utm_medium=social&utm_source=facebook&hss_channel=fbp-167184886633926&fbclid=IwAR3xl7N__UySm_vGI0HjVzmmd_kfehZlLSdyj7LSs2JZM3B-jPVgrBXeoIA

[demografx]

Interesting, Aladin. I should probably repeat my cautionary warning: overuse of antihistamines recently landed me in the ER/hospital. I’ve now stopped Benadryl & Afrin, and cautiously use Tylenol.

[Aladin]

Hi demografx, can you tell me more about that? Did you take too high a dosis? Or been using a normal dose for too long?

[demografx]

This might be why some of us find relief with antihistamines.

https://www.technologynetworks.com/drug-discovery/videos/antihistamines-for-everything-355944?utm_content=187901568&utm_medium=social&utm_source=facebook&hss_channel=fbp-167184886633926&fbclid=IwAR3xl7N__UySm_vGI0HjVzmmd_kfehZlLSdyj7LSs2JZM3B-jPVgrBXeoIA

Interesting, Aladin. I should probably repeat my cautionary warning: overuse of antihistamines recently landed me in the ER/hospital. I’ve now stopped Benadryl & Afrin, and cautiously use Tylenol.

Hi demografx, can you tell me more about that? Did you take too high a dosis? Or been using a normal dose for too long?

Aladin, it was mostly due to a 10-day-overuse of Benadryl, Afrin, & Tylenol. But also after many years of on & off relatively high dosages
~Demo~

[from my post at Testosterone thread:
https://poiscenter.com/forums/index.php?topic=17.720]

I’m writing this from the hospital. Admitted to ER last night for “observation for ‘dizziness’ “, hope to be released soon…

Discharged yesterday.

I’m almost embarrassed to be writing this, but what landed me in the hospital ER (emergency room)?

High doses of Benadryl, Tylenol, & Afrin caused severe dizziness & loss-of-balance reaction. I almost fell 3-4 times prior to calling my primary care physician.

But I owe it to the forum to get over my personal embarrassment in order to issue a WARNING to
everyone who has been following my protocol at this Testosterone topic/thread!

At least 15 hospital-and-personal doctors and nurses and medical technicians were involved in my case. They all said the same thing: if you Google and/or follow the drug manufacturers’ recommendations for Benadryl, Tylenol, and Afrin, THE STATED MAXIMUM DOSAGES ARE WAY TOO HIGH - - AND DANGEROUS - - FOR MANY PEOPLE!

This will not necessarily be true for everyone, but it certainly seems true for my age group (I’m age 75), according to many, many similar reports (complaints!) that the hospital doctors have seen from “ENT” physicians. Ear, Nose, Throat.

Another complicating factor in my case: history of cardiac artery disease, with 5-way bypass open heart surgery about 10 years ago.

So, everyone please be very careful if you are interested in following my POIS protocol. I also stopped temporarily my TRT increase regimen, even though it’s been approved by my new endocrinologist…because I experienced severe itching. Tonight I’m back to my lower dose of 6mg Androderm patch nightly.

I have decided to quit Benadryl & Afrin (Afrin is not for my POIS protocol) permanently! Not one medical practitioner had anything good to say about them. I also pointed out to the hospital medicos (and to this forum in previous posts) that Harvard Medical School studied Benadryl and found a link to dementia.

Stay safe, everyone!

Harvard Study: Benadryl & dementia
https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667

[berlin1984]

happy2 cyrtec + benadryl thread: https://poiscenter.com/forums/index.php?topic=2549.0

[Oid]

I've been taking cetirizine(zyrtec) for a month.
My symptoms are mostly cognitive, and i can definitely tell that they are reduced.
Some depression remains but it's much better than nothing.

[demografx]

I've been taking cetirizine(zyrtec) for a month…

Thanks, Oid!

Your sober endorsement of Zyrtec is helping me to move closer to try switching from
“nasty [for me] Benadryl” to Zyrtec.

A Benadryl warning from Harvard:
https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667

[ozmoses]

Hi ozmozes.
It is posible for some poisers.
On the odher side, there are poisers types who are been helped by taking
mytelase.. look for Quantum pois type charts..

ALA is capable to move toxins from brain...

Mytelase would be more in line with taking a AChE inhibitor.  Interesting.  In that case, I'll bet that the 1st generation H1 antihistamines probably wouldn't work well for them.  For me, I definitely need anticholinergics...    ALA does mop up acetylcholine from my understanding... piracetam and glycine too. 

[berlin1984]

Cross linking:

Post orgasmic illness syndrome successfully managed with antihistamine: A case report

"In our patient, the treatment that proved most efficacious was daily fexofenadine, leading to a 90% symptom improvement. Interestingly, when our patient took diphenhydramine, he did not achieve much symptomatic improvement despite similar mechanisms of action."

[Vandemolen]

My POIS-doctor gave me montelukast. I have to take it 5 hours before sexual activity. Important is that you also take ibuprofen with the ibuprofen. The doctor said that at least 5 of his POIS-patients experience a big relief from it. Only montelukast does not work.