THATS WHAT IM TALKING ABOUT DAVEMAN! Yeah man we slap down our theories and filter em down, man you never know then what a doctor can do with that information. One person might mention one chemical or thing to look at that wasnt thought of and BAMN holy crap they end up discovering something new. I'm really excited you guys pulled this off before I croaked lol.
One thing I've been paying attention to... since I use Lyrica sometimes after an unfortunate NE.... noting myself which drugs seems to "block" or counter certain symptoms of POIS. To a researcher, this can help them determine what receptors or chemicals in the brain are being affected by POIS. For instance (and I know this if for later mostly just throwin it out now since im exciteD) Lyrica --> " Pregabalin decreases the release of neurotransmitters including glutamate, norepinephrine, substance P and calcitonin gene-related peptide". So you know, considering how effective it is at countering the cognitive dysfunction of POIS, one of these 4 main effects might be a consideration.
And Im convinced 100% theres a link somehwere to Alzheimers. I have a capacity, when im deep in thought, to have a train of thought of something, develop it in my head, and then bamn I lose concentration and the whole thought train vanishes, and Im completely unable to recall. From glutamate wiki "Excitotoxicity due to excessive glutamate release and impaired uptake occurs as part of the ischemic cascade and is associated with stroke,[4] autism, some forms of intellectual disability, and diseases like amyotrophic lateral sclerosis, lathyrism, and
Alzheimer's disease."
Oh okay, so excessive glutamate can cause memory dysfunction, and levels of it spike after orgasm. Maybe we have to much already? And the O increases it to a level that causes dysfunction. So that might explain why Lyrica which drops those levels, counteracts the cognitive dysfunction so well.
And would explain why Niacin works as well since Niacin is a cofactor in the conversion of glutamate back into glutamine. Thus lower your glutamate levels. Diagram here:
http://themedicalbiochemistrypage.org/images/glutamate-glutamine-cycle.pngWHOA sorry didnt mean to start spouting theories right now, but I JUST came up with this one out of the blue as Im sitting here researching. You guys probably have already looked at all this on another thread lol. Regardless it just prompted me to buy 60 tabs of N-Acetyl-Cysteine 1000mg which supposedly lowers glutamate, and has been looked at for reducing milder versions of some POIS-like symptoms.
BUT THATS HOW US POISERS ROLL! You be in some thread, and you go off researching and just gotta write it down immediately just to get it out there.
itll be a wondrous experience to volunteer just for the oppurtunity to meet other real life POISers.
The hour is late. Thanks for your patience in reading my post lol.
