Author Topic: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs  (Read 57 times)

berlin1984

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Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« on: June 09, 2021, 02:58:47 PM »
About 2 to 3 years ago I remember people discussing on a forum how high-dose thiamine helped their POIS symptoms. So I tried thiamine then Benfotiamine. When I first started Benfotiamine, I believed that it produced a noticeable improvement in POIS symptoms. It was not an instant prepack improvement. It took a few days of constant supplementation.

 I lost my bottle of B1 a few months ago, but I noticed that I still don't have and POIS symptoms on my diet-stack. I broke my diet and my stack for blood test and supplement test several times. And when I resumed my diet-stack without B1 I still get full relief.

By coincidence when researching the ingredients of another supplement, I digged deeper into the Thiamine/Tiamine/Vitamin B1 rabbit hole and discovered megadosing (e.g. taking several hundrer mg of B1)

Could High-Dose Thiamine (B-1) Help with ME/CFS, Fibromyalgia, and the Neurological Complications of Ehlers-Danlos Syndrome?
https://www.healthrising.org/blog/2021/04/15/thiamine-b-1-chronic-fatigue-syndrome-fibromyalgia/

Mega-Dose Thiamine: Beyond Addressing “Deficiency”
https://www.eonutrition.co.uk/post/mega-dose-thiamine-beyond-addressing-deficiency

https://www.hormonesmatter.com/thiamine-fibromyalgia-cfs-me-chronic-lyme-sibo/

Megadosing is not about eliminating a deficiency, (which apparantely a lot of people have). It's about saturating the body with B1 to kick-start certain body functions (enzymes) into working even though they were not..(I'm not sure I understand it yet)

Regarding other forms mentioned on the forum like benfotiamine or Sulbutiamine: As I understand they have different bioavailability and also ability to cross blood brain barrier, so dosing there is different.

As another cofactor, Magnesium is needed.

Maybe someone tried this..
Please don't just randomly take a lot of pills, inform yourself first about the topic.

Rollo

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #1 on: June 09, 2021, 05:52:40 PM »
Very interesting!

I have had succes with high dose Taurine (4,5-9g) and Magnesium seems to amplify the effect aswell.
If i read correctly both Taurine and Thiamine are important for the production of PON1 and therefore play a role in reducing low-density lipoproteins and therefore reducing oxidative stress...

https://pubmed.ncbi.nlm.nih.gov/17645625/
https://www.researchgate.net/publication/339625084_Effects_of_thiamine_treatment_on_oxidative_stress_in_experimental_diabetes

demografx

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #2 on: June 09, 2021, 06:02:52 PM »

Please don't just randomly take a lot of pills, inform yourself first about the topic.


Hi Berlin,

Many thanks for a much-needed reminder for many of us!!
« Last Edit: June 09, 2021, 08:36:31 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Hopeoneday

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Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs
« Reply #3 on: June 10, 2021, 04:24:10 PM »
I did try this in past, about 2-3 times, but never with sucsese...
I did try this treatmant for my pois induced Parcinson like symptomes..
All 3 times i tryed to incriese dosing by 100mg then 200 then 400Mg..
as soon as i start incriesing dose more then 500mg, i started to hawe worsen
my symptomes, the i stopped.
Dr-pois.