Histamines for POIS? (Thread about Antihistamines too)

[Bulbo]

Hello everyone. I tried antihistamine (desloratidine 5mg) and the muscle weakness and brain fog were gone.I was almost normal except for feeling sleepy. I was able to remember things but I felt very sleepy (which is a side effect of anti histamines).

How long has desloratadine been working to improve your pois symptoms?

Desloratidine 5mg helped me for about 6 hours

[Vincent M]

Thanks. Be sure to let us know if it continues to help you in the following weeks.

[b_jim]

I will make an IgE test (and probably testosterone).
Should I have an ejaculation the day after (12 hours before) ?
Which iGE should be tested, total or specific ?

[FornicationDENIED]

I will make an IgE test (and probably testosterone).
Should I have an ejaculation the day after (12 hours before) ?
Which iGE should be tested, total or specific ?

If POIS is allergic, IgE will be present after ejaculation only, so you must ejaculate and take the test as soon as possible after O.I would suggest to ejaculate sooner than 12 hours before test because by that time the IgE already activated mast cells and the reaction already occured.

[b_jim]

Thanks for answer. Not easy to do then i will probably test hormones only. And I will try claritine.

edit : i have the claritine now. I will test it the next days. I have bloodtest for hormones, white cells, some vita and minerals. I think I will ejaculate 12-16 hours before bloodtest. Results soon.

[Chris]

So i want to try antihistamine for first time.Is claritin(loratadine) ok ? Should i follow any particular method ? Any tips ?

[Chris]

I didnt get any answer in my previous post on this topic but anyways.

I tried claritin(loratadine) yesterday and i didnt have any result.Obviously antihistamines doesnt work for me nor niacin.

So i have to look for other meds.Just hoping to be more lucky next time.

[b_jim]

I think we should focus on testosterone not only its normal blood level but its synthesis and cofactors.

[Stef]

Yike, once again I tried the diphenhydramine and it seemed to work great! I was so happy until late the next day (tonight) when the effects wore off and now I have symptoms again full force!

Next try: abstaining for months!! PS: I say this now, but a weekish later I'll be thinking "it's not gonna be this bad. I'm gonna go for it". Around in a circle it seems sometimes...

Prancer -- have you considered taking the diphenhydramine
for a few days in a row?  It might help you get through the worst of it.

Stef

[Prancer]

Yike, once again I tried the diphenhydramine and it seemed to work great! I was so happy until late the next day (tonight) when the effects wore off and now I have symptoms again full force!

Next try: abstaining for months!! PS: I say this now, but a weekish later I'll be thinking "it's not gonna be this bad. I'm gonna go for it". Around in a circle it seems sometimes...

Prancer -- have you considered taking the diphenhydramine
for a few days in a row?  It might help you get through the worst of it.

Stef

Hey Stef! Yes, I take it just about every night to help me fall asleep. To reduce my pois symptoms, I took it before orgasm, but it also definitely helps to take it while in pois. It seems to calm my overactive mind down, which is a big problem for me during a bad pois day because the constant thinking REALLY messes up my cognition. I take it only at night because I become drowsy.

Prancer

[underwater]

Area for further inquiry:

"Seminal Plasma Protein Hypersensitivity" has been widely discussed with respect to disturbing female responses to male semen (it is as rare as pois). I see this as an interesting area to study, as it may offer some clues.   Those afflicted women respond/react
to the direct introduction of the "male proteins" by a variety of debilitating symptoms. These have been alleviated by anti-histamines.

[Disaster]

I am very allergic to my own semen. If  i don't wipe it well or catch in a tissue then I can end up sneezing a lot and it weakens my spine where i can throw out my back. I have a similar issue to sweating. But no antihistamine helps at all i tried a bunch of. H1 and H2s. There is something called Mast cell activation disease MCaD and basically it means the mast cell which release histamines is malfunctioning and creates weird allergies.


Has anyone tried singulair, Ketotifen or Xolair?

[ozmoses]

Anyone have labs done to show their histamine levels?  I'd be curious to know what others have seen.

I actually had histamine labs done and just got the results.  71 ng/ml  Apparently the lab reference range is 12-127 but the Walsh/Pfeiffer Fuctional Range is 40-70. 

Not exactly sure what to make of this, but I'm starting a mild anti-histamine regimen.

[POISrival]

I have been taking a Syrup made from Chlorpheniramine maleate(AntiHistaminic)+Dexamethasone(Glucocoriticoid Steriod usually prescribed for adrenal fatigue) even when I don't orgasm. I feel quite different. I'm getting more flashes of full functionality.

[fidalgo]

I have been taking a Syrup made from Chlorpheniramine maleate(AntiHistaminic)+Dexamethasone(Glucocoriticoid Steriod usually prescribed for adrenal fatigue) even when I don't orgasm. I feel quite different. I'm getting more flashes of full functionality.

Intersting...

What dose are you taking?
Dou you improve a lot??
I?m thinking in experiment that...
What the brand name of your Syrup?

[POISrival]

Hello Fidalgo!

Each 5ml of the syrup contains 2mg chlorpheniramine maleate and 0.5 mg dexamethasone. Usually 10-15ml before orgasm is enough and the same dose next day in the morning. if you have POIS permanent downsides like I do, it might be helpful to take it on No-orgasm days. please, consult a doctor first tho and read about the side effects and contraindications to avoid any risks.
It helps me with OCD, makes orgasms more enjoyable, suppresses my stress and lessens my dissociation problems. it works as if it eliminates the side effects and gives my a brain a chance to recover.
The brand name is Apidone. It's a locally produced over-the-counter drug in Egypt.

[POISrival]

Just wanted to update I still get excellent results with the syrup.

[stevenoc]

I have been trying to get apidone syrup as id love to try it. Only found it on a few websites and keep getting problems. I think ill buy the ingredients separately but that's quite expensive.

[stevenoc]

Managed to get some dexamethasone 0.5mg tablets. I started taking at a low dose and didnt notice any difference. Then I got bad POIS and took 3 tablets. And I have to say so far it has worked great at only 1.5mg. I don't feel tired. I don't have an achy head. I don't feel depressed and so on....I feel totally normal. I took the tablets yesterday morning and haven't felt the need to take any today. Only side affect is that it took me a while to get to sleep last night. Its still early on and will update in a couple of weeks to test it in the long term.

[sameer7777]

but that steroids you are taking please be careful ............!!