Women with Post Orgasmic Illness Syndrome

[Iwillbeatthis]

Ironfeather could prevent her symptoms from getting worse by exercise. It is known that BDNF increases during exercise. Does she have low (serum) BDNF just like my brother?

Agmatine sulfate increases BDNF and eNOS, I ordered some and it came today so I will test it out

[Muon]

Antihistamines, Serotonin supplements (which ones?) and NSAIDs did not work for her. However TRT works. She felt awful on progesterone.

https://forums.phoenixrising.me/threads/dr-jay-goldsteins-rapid-remission-me-cfs-treatments.34516/page-6#post-582561

Ketamine antagonism? I wonder whether viagra will work for her symptoms (brain feels deprived of oxygen, collapsing blood vessels?).

Agmatine sulfate increases BDNF and eNOS, I ordered some and it came today so I will test it out

https://en.wikipedia.org/wiki/Agmatine#Mechanisms_of_action

[demografx]

Muon, I love your technical graphics!

[Muon]

Dopa responsive headache: Restless head syndrome or a cephalic variant of restless legs syndrome?

Headache and restless legs syndrome responded to levodopa. Does TRT therapy helps Heather because it affects dopamine somehow (or MCs)? Low T is a risk factor for endothelial dysfunction. Endothelium might not respond properly to orgasm. Low Dopamine levels? Or slow conversion to norepi? Or norepi repsonse is exaggerated?

[Muon]

That is interesting. When I was a child I was prescribed 20 days of penicillin injection, is it considered over-prescription?

What was the reason for the prescription?

[Muon]

Timestamp 16:19 POIS discussion: https://youtu.be/rFiehQLjPpk?t=979

Timestamp 43:32 potential POIS extension study in women?: https://youtu.be/rFiehQLjPpk?t=2612

[Muon]

I also have thalassemia minor.

"Due to its immunomodulatory,[17] iron chelating and antioxidant properties, this herb has the potential to be used in beta-thalassemia patients who receive regular blood transfusions and suffer from iron overload" https://en.wikipedia.org/wiki/Silibinin

https://en.wikipedia.org/wiki/Thalassemia#Beta-thalassemia

"Infection: People with thalassemia have an increased risk of infection."

Males are more susceptible to infection compared to women...except when there is an underlying condition.

[Iwillbeatthis]

I remeber as a teeneger wehen i cleaned moldy in room with bleach ,
that did give me lungs colapsing reaction, cant tolerate it for one second.

My mother is obsessed with cleaning, and for years I did have to convincing her to
 that she "poisoning me, us" in house with all those chemicals.
Now she use more natural cleaners and less chemicals.

I had a bit of black mold on the edges of my bedroom windows between the glass and window frames, I've been meaning to clean it for ages but you need to kill mold with white vinegar, hydrogen peroxide. If you use bleach it doesn't kill the roots of the mold and actually releases dangerous mold spores into the air. I still have a bigger mold problem in my ensuite bathroom but I have stopped using that bathroom for months now because of it until its sorted.

Let's see if it has any effect on how I feel when I wake up in the mornings. Every morning I have to clear my throat of phlegm and sometimes it has blood in it, can also have brain fog and more rarely allergies.

If it doesn't then it must be to do with what I'm eating for dinner.

When I saw the functional medicine practitioner at the start of last year he thought I had mold toxicity based on my symptoms. He put me on a protocol for mold toxicity with binders like bentonite, charcoal and liposomal glutathione for detox. It was definitely needed for a month to start functioning properly again ,I felt ill and had brain fog all the time before but this protocol had no effect on my POIS or reactions to showers. Bentonite was probably the best thing from it which I still use from time to time, it can bind to yeast, heavy metals, mold in the gut. My stools improved a lot.

[Muon]

I'm in the middle of exams again and things are stressful. I don't even understand my own symptoms anymore. I used to take vitamins B and never had any problem with them, and now, after the bleach exposure, I can't tolerate them, they give me POIS symptoms - plus a killer headache and insomnia. And it seems that my main symptom, fever, is gone, I never get it anymore, not even after an orgasm.

Recognition and Management of Medication Excipient Reactivity in Patients With Mast Cell Activation Syndrome
"After starting college, he reported increasing headaches and insomnia, and he wanted to resume nortriptyline, which he took in the past with improvement in these symptoms"

It's probably the stress that makes you susceptible to new potential triggers. What I observed over the years for my own case, is that, stress is relatively strong at lowering the threshold for reactivity to other triggers and amplifies ongoing reactions.

Perhaps fever went away after the exposure to bleach? Did something happen to the methylation cycle regarding reactions to B vitamins?

[Muon]

Wow, I didn't know they had excluded women... sounds totally stupid to me too. But then, it's not too surprising, since POIS is still presented as a male-only syndrome in some scientific papers. I wonder why the enormous difference in the amount of male patients and female patients... do women speak about it less?

In my opinion, it's because POIS is (basically) CFS in women. Not my own conclusion, but I found it on the internet and think it's very intriguing..

Mono--->CFS--->CFS went away---> stuck with POIS.
Age 25: Mono
Age 25-27: CFS
Age 27-29 and beyond: POIS but no CFS
https://www.thenakedscientists.com/forum/index.php?topic=14697.msg344849#msg344849

Something happened between the disappearance of CFS and onset of POIS. Some modulation.
Infection of vagus nerve? Could the latter modulated the microbial composition of the GI tract leading to an altered immune response upon orgasm?

[Iwillbeatthis]

2) No, I was very young when I first masturbated, less than 3 years old. I used to do it very often as a kid, probably daily, unless I was sick. I used to be sick pretty often too, which I later found out was caused by a food intolerance (a very bad one, almost an allergy) to soy.

Wow this is crazy I didn't know kids that young ever did that.

[Muon]

Wow this is crazy I didn't know kids that young ever did that.

Probably a typo. I guess it's 13.

[Iwillbeatthis]

Probably a typo. I guess it's 13.

I thought the same at first but she did say "really young" and as a kid, Iron feather can you clear this up lol.

[Muon]

Female premature orgasm: Does this exist?

[Muon]

Dawndollygolden
https://www.reddit.com/r/POIS/comments/ln4lai/female_pois_symptoms/

Female POIS Symptoms

I know that women are few and far between on this sub, but as a woman I would like to bring light to some of the symptoms I face with POIS. I have debilitating POIS. One orgasm can trigger up to a month of symptoms that mimic bipolar disorder and premenstrual dysphoric disorder. Abstaining from orgasming is the only cure I've found so far. While practicing abstinence all of these symptoms disappear. But here are the symptoms I find most noticeable.

MENTAL

General brain fog
Decreased ability to stay focused (ADD like symptoms)
Becoming significantly more disorganized

EMOTIONAL

Anxiety
Manic Depression - rapid swings between high risk behaviors (drinking, unprotected sex, drugs) and paralyzing sadness
Irritability
Urges to have angry outbursts
Apathy towards romantic partner
Decreased patience with my child
Suicidal thoughts (usually occurs after multiple orgasms in succession)
Increase of nightmares
Crying- so much nonsensical crying

PHYSICAL

Extreme fatigue
Insomnia
Allergy symptoms
Watery eyes
Sneezing fits
Itchy skin
Runny nose
Increased appetite
Bloating
Back pain
Vaginal odor
Increased vaginal discharge
Acne break outs
Worse menstrual cramps
Increased menstrual bleeding
Weight gain
Increase of yeast infections and bacterial vaginitis
Increase of UTIs
Constipation
Trouble regulating body temperature (especially feet)
Severely decreased libido
Vaginismus symptoms

So far for treatment I have tried Vitamin D, Vitamin C, Caffeine, antihistamines, Kratom. None of these have helped me.

glintglib:
"I have some questions for you.... Did you have POIS from the first time you started having sex or further along in time? If it is the latter can you tie it in to any substance, drug or other event going on in your life at the time? Have you had your hormone levels tested the day after an O? Hmmm you have increased appetite and weight gain. I have the opposite problem. Yes women are few and far between which has always intrigued me, what is different about those that do. If it is say a gut microbiome issue then women should be just as common as men with POIS."

dawndollygolden:
"I can't pinpoint a start date, but I've experienced bipolar symptoms and chronic fatigue ever since I was in high school. I have masterbated since I was 13 (and during my teen years definitely experienced porn addiction- which is my theory on what may have created a hormonal imbalance). I did not actually have sex with a partner until 23, and that sex rarely gets me to an O. After abstaining from masterbating I began to realize I felt like an entirely different person. That made me really begin questioning the source of my chronic fatigue.

I have had blood work done and hormonal levels checked- all were normal. I have not had them checked immediately after an O. I can say that my emotional symptoms were non-existent during my pregnancy, although the physical and mental stayed."