Like IDO, arginase-1 is also a major immune suppressor. While IDO depletes tryptophan, arginase depletes arginine and causes a reduction in NK cell activity.
Arginase-1 inhibitor options for testing purposes:Viagra (sildenafil), 50mg, 90minutes prior to orgasm
Cialis (tadalafil), 20mg, 2.5 hrs prior to orgasm
caffeine, 150mg, 90minutes prior to orgasm
citrulline malate, 7g, 90minutes prior to orgasm
Ideally orgasm should happen at the time of peak concentration of the drug in the body. The below graphs justify the wait times (prior to orgasm) for each drug.
Figure 5: Mean Sildenafil (Viagra) Plasma Concentrations in Healthy Male Volunteers, from:
https://www.pfizermedicalinformation.com/en-us/viagra/clinical-pharmacology
Tadalafil (Cialis) pharmacokinetics from:
https://www.dovepress.com/comparison-of-tadalafil-pharmacokinetics-after-administration-of-a-new-peer-reviewed-fulltext-article-DDDT
Caffeine pharmacokinetics from:
https://www.researchgate.net/figure/Time-caffeine-concentration-profiles-for-five-conditions_fig1_301562749All of these drugs have been independently shown to increase Natural Killer cells, increase NK cell activity and prevent immune deficiency of effector lymphocytes. Caffeine and citrulline malate are over-the-counter (OTC), can be taken together and are generally safer than the PDE5 inhibitors (Viagra and Cialis). None of the other arginase inhibitors listed above can be taken together because of drug interaction. Before testing arginase inhibitors check with your doctor to make sure you are healthy enough and there are no drug interactions with medications you are currently taking.
Other ways to increase NK cell activity:Active hexose correlated compounds (AHCC)
liposomal vitamin C (ascorbate, ascorbic acid, and ascorbyl palmitate).
Vitamin C partitioning in the immune system. Lymphocytes and platelets require the highest vitamin C levels to function properly.
