Author Topic: Gather and Post Here Your Medical Tests Results - Discussion Thread  (Read 116432 times)

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #440 on: October 08, 2019, 11:39:39 AM »
Hopeoneday wbc count test results.

Eosinophil gran : 0.1       ref( 0-7)
Neutrophils gran : 43,0L   ref (44-72)
Basophils  gran: 0.5         ref(0-1) 
lymphocytes        52         ref(20-40)

I did found my WBC count test results done 12 years before, they are complitly the same.

Did they look at what type of lymphocyte was elevated HOD?

https://poiscenter.com/forums/index.php?topic=2684.msg31172#msg31172

''(++)presence of cryoglobulins.''

Patients with cryoglobulemia are sensitive to temperature changes and can show blood flow problems due to changes in viscosity.
POIS patients with temperature sensitivity and blood flow problems could check this one out. I had times where it felt like blood flow encountered more resistance than usual. But this could be NO or autonomic related as well. Other molecules might influence viscosity. Viscosity affects sheer stress I believe, sheer stress signals to release NO. If you have NOS issues the endothelium might not respond properly to sheer stress.

The reduced skin blood flow might cause a pale complexion, which is seen in POIS patients.

BLOOD HYPERVISCOSITY IN CRYOGLOBULINEMIA: TEMPERATURE SENSITIVITY AND CORRELATION WITH REDUCED SKIN BLOOD FLOW
« Last Edit: October 08, 2019, 11:52:00 AM by Muon »

demografx

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #441 on: October 08, 2019, 06:03:50 PM »

POST COITAL ALLERGY - A CASE REPORT OF POST ORGASMIC ILLNESS SYNDROME


Thanks, Muon. Passed along to our POIS researchers.

Also invited the author to the forum.
« Last Edit: October 09, 2019, 12:31:00 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #442 on: October 08, 2019, 06:14:56 PM »
Intralymphatic Immunotherapy With Autologous Semen in a Korean Man With Post-Orgasmic Illness Syndrome

''The IgE immunoblotting of autologous seminal fluid incubated with serum from the patient and 1 healthy control showed IgE binding bands at 14, 16, 34, and 55 kD (eFigure 3). The IgE binding band at 55 kD was particularly prominent before ILIT, but it was fainter when seminal fluid was incubated with serum obtained from the patient 8 months after ILIT.''

IgG4 BINDING FACTOR IN HUMAN SEMINAL PLASMA IDENTIFIED AS HEAVY CHAIN OF IMMUNOGLOBULIN

''We have demonstrated that human seminal plasma contains a 16-kD protein that interacts with human IgGl and mouse IgM [4, 7, 81]. In this paper data are presented showing that human seminal plasma contains another factor with an estimated M, of 50 kD that interacts specifically with human IgG4.''

Here are some seminal plasma proteins that bind with immunoglobulins. These two papers have found proteins of similar mass. They could be useful when examining binding bands.

My brother got elevated IgE and I got elevated IgG4. Perhaps these two are acting against specific proteins in seminal fluid. Could be protein masses 55kD (IgE) and 50KD(IgG4). There is a guy here on poiscenter with elevated IgG1 (16kD?).
« Last Edit: October 08, 2019, 06:23:57 PM by Muon »

Hopeoneday

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #443 on: October 09, 2019, 03:25:54 PM »


Did they look at what type of lymphocyte was elevated HOD?

https://poiscenter.com/forums/index.php?topic=2684.msg31172#msg31172

''(++)presence of cryoglobulins.''

Patients with cryoglobulemia are sensitive to temperature changes and can show blood flow problems due to changes in viscosity.
POIS patients with temperature sensitivity and blood flow problems could check this one out.

The reduced skin blood flow might cause a pale complexion, which is seen in POIS patients.

BLOOD HYPERVISCOSITY IN CRYOGLOBULINEMIA: TEMPERATURE SENSITIVITY AND CORRELATION WITH REDUCED SKIN BLOOD FLOW
Intresting Muon, they didnt look what type of laymphocaytes are elevated.

I tought , if there is cryoglobulemins in my bload,
it is not from cancer angle,
because i would be two meter "under" till now.
Temperature intolerance in my
case( i am "dead in hot weather").
This will be intresting to test
for poisers.



« Last Edit: October 09, 2019, 03:30:15 PM by Hopeoneday »
Dr-pois.


Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #445 on: October 16, 2019, 09:04:43 AM »


Did they look at what type of lymphocyte was elevated HOD?

https://poiscenter.com/forums/index.php?topic=2684.msg31172#msg31172

''(++)presence of cryoglobulins.''

Patients with cryoglobulemia are sensitive to temperature changes and can show blood flow problems due to changes in viscosity.
POIS patients with temperature sensitivity and blood flow problems could check this one out.

The reduced skin blood flow might cause a pale complexion, which is seen in POIS patients.

BLOOD HYPERVISCOSITY IN CRYOGLOBULINEMIA: TEMPERATURE SENSITIVITY AND CORRELATION WITH REDUCED SKIN BLOOD FLOW
Intresting Muon, they didnt look what type of laymphocaytes are elevated.

I tought , if there is cryoglobulemins in my bload,
it is not from cancer angle,
because i would be two meter "under" till now.
Temperature intolerance in my
case( i am "dead in hot weather").
This will be intresting to test
for poisers.

''Mixed cryoglobulinemia (MC) is a systemic vasculitis of small to medium-sized vessels due to the vascular deposition of circulating immune-complexes (CIC) and complement. A leukocytoclastic vasculitis is the histologic hallmark of cutaneous manifestations of the disease, while a clonal B lymphocyte expansion in blood, bone marrow, liver, and spleen represents the underlying pathologic alteration responsible for the production of cryo-CIC and non-cryo CIC with rheumatoid factor activity.''
https://journals.lww.com/co-rheumatology/Abstract/2000/01000/Relation_between_infection_and_autoimmunity_in.9.aspx

B lymphocyte level could be elevated. Btw most of the cryoglobulemia cases are not related to cancer but to infection.
« Last Edit: October 16, 2019, 09:07:57 AM by Muon »

nanna1

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #446 on: October 16, 2019, 10:10:41 PM »
Like IDO, arginase-1 is also a major immune suppressor. While IDO depletes tryptophan, arginase depletes arginine and causes a reduction in NK cell activity.

Arginase-1 inhibitor options for testing purposes:
Viagra (sildenafil), 50mg, 90minutes prior to orgasm
Cialis (tadalafil), 20mg, 2.5 hrs prior to orgasm
caffeine, 150mg, 90minutes prior to orgasm
citrulline malate, 7g, 90minutes prior to orgasm

Ideally orgasm should happen at the time of peak concentration of the drug in the body. The below graphs justify the wait times (prior to orgasm) for each drug.

Figure 5: Mean Sildenafil (Viagra) Plasma Concentrations in Healthy Male Volunteers, from: https://www.pfizermedicalinformation.com/en-us/viagra/clinical-pharmacology


Tadalafil (Cialis) pharmacokinetics from: https://www.dovepress.com/comparison-of-tadalafil-pharmacokinetics-after-administration-of-a-new-peer-reviewed-fulltext-article-DDDT


Caffeine pharmacokinetics from: https://www.researchgate.net/figure/Time-caffeine-concentration-profiles-for-five-conditions_fig1_301562749

All of these drugs have been independently shown to increase Natural Killer cells, increase NK cell activity and prevent immune deficiency of effector lymphocytes. Caffeine and citrulline malate are over-the-counter (OTC), can be taken together and are generally safer than the PDE5 inhibitors (Viagra and Cialis). None of the other arginase inhibitors listed above can be taken together because of drug interaction. Before testing arginase inhibitors check with your doctor to make sure you are healthy enough and there are no drug interactions with medications you are currently taking.

Other ways to increase NK cell activity:
Active hexose correlated compounds (AHCC)
liposomal vitamin C (ascorbate, ascorbic acid, and ascorbyl palmitate).



Vitamin C partitioning in the immune system. Lymphocytes and platelets require the highest vitamin C levels to function properly.
 
« Last Edit: November 25, 2019, 10:06:38 AM by nanna1 »
POIS clusters: 1,3,4,5,7
POIS criteria: 1,2,3,4,5
2 stacks that give me complete relief of POIS symptoms are listed here: POIS cure: theory & supplement stack
Find medical test: https://www.findlabtest.com/

demografx

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #447 on: October 17, 2019, 12:07:44 PM »
Amazingly cool graphics!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #448 on: October 19, 2019, 08:23:36 AM »


TSLP(R) inhibitors/antagonists could block a POIS inflammation cascade upstream if this mechanism plays a role in POIS. Problem is that these are very expensive. One example is Telepezumab

Nas

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #449 on: October 19, 2019, 08:42:56 AM »
I highly doubt it will help my POIS but in your case maybe try it. You may never know until you try.

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #450 on: October 19, 2019, 08:46:39 AM »
I highly doubt it will help my POIS but in your case maybe try it. You may never know until you try.
I'm not Bill Gates. Check the prices.

Nas

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #451 on: October 19, 2019, 09:58:21 AM »
Ah and I thought you were Bill Gate's Dutch cousin.
My bad :D

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #452 on: October 20, 2019, 08:52:23 AM »
Ah and I thought you were Bill Gate's Dutch cousin.
My bad :D
I wish that was the case. I would have spent tons of money on POIS projects. This mechanism might play a role in the case of aswinpras06. He got Eosinophilia, neutrophilia and enlarged lymph nodes. I bet his IL-5 and IL-8 levels are high, besides elevation of unique mediators from eosinophils. A virus could also make use of allergic inflammatory pathways.

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #453 on: October 21, 2019, 09:11:01 AM »
Antiviral activity of Lactoferrin:

https://link.springer.com/chapter/10.1007/978-1-4757-9068-9_23
https://www.sciencedirect.com/science/article/pii/S1341321X14002864
https://link.springer.com/article/10.1007/s004300050049

https://en.wikipedia.org/wiki/Lactoferrin

The body is able to prevent intestinal infection by raising lactoferrin via innate immunity. What if there is a latent viral infection in the HT-29 cell lining and altering mucosal immunity throughout the entire body including the urogenital system? I once had an iron deficiency as a kid. What if the body raised lactoferrin against intestinal pathogen intrusion/attachment which did bind to iron lowering my iron levels? POIS might lower parameters which are beneficial against pathogens. Pathogens on their turn might activate allergic inflammatory pathways as discussed a few posts back.

I also wonder if the vagus nerve is able to modulate tight junctions.

b_jim

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #454 on: October 21, 2019, 09:23:49 AM »
Lactoferrin is an ingredient of semene.
Taurine = Anti-Pois
Suffering from lyme disease

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #455 on: October 21, 2019, 11:19:41 AM »
VandeMolen's brothers got CD. He got POIS. All three may have dysfunctional Tregs in common.

Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease

''In conclusion, we have shown that in vivo depletion of Tregs by anti-CD25 Ab treatment increases the severity of intestinal inflammation in SAMP mice. Furthermore, using three adoptive transfer experiments, we have shown that Tregs in SAMP mice, including CD25−Foxp3+ cells, are dysfunctional. This study suggests that dysfunctional Tregs may play an important role in SAMP CD-like ileitis. In light of these findings, augmenting the number and/or function of Tregs in vivo may provide an effective new treatment modality for patients with autoinflammatory diseases, such as CD.''

b_jim

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #456 on: October 23, 2019, 04:00:47 AM »
"
Temperature intolerance in my
case( i am "dead in hot weather").
"

I clearly have  intolerence to hot temperature.
If I enter in a warm room it may cause me anxiety panic

« Last Edit: October 23, 2019, 04:06:13 AM by b_jim »
Taurine = Anti-Pois
Suffering from lyme disease

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #457 on: October 23, 2019, 04:54:57 PM »
The Doctor of aswinpras06 made some remarks about - Likely infective etiology-.

Mitochondrial DNA can be released from mast cells which is seen by the body as a pathogen thus building up an innate immune response. Take a look at the next video fragment explaining this concept in detail: https://youtu.be/9QbZp3WcC1Q?t=2156

This could explain POIS induced fever in some individuals. These individuals coudl be tested for mitochondrial DNA and antibodies against mitochondrial DNA.
« Last Edit: October 27, 2019, 11:12:00 AM by Muon »

Muon

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aswinpras06

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #459 on: October 28, 2019, 03:35:15 AM »
https://poiscenter.com/forums/index.php?topic=2684.msg31355#msg31355

My Vit B12 level is elevated as well.

Hi Muon

Elevated B12 is not normal and requires immediate medical attention as per my pulmonologist.  He has recommended to meet an allergist/immunologist as soon as possible to find out the cause.  I am planning to to consult one within next 2 weeks.  you also consult an doctor immediately to find out the underlying cause, because sometimes it may be a  serious problem in the liver or kidney.