All explained mepedia:
https://me-pedia.org/wiki/Myalgic_encephalomyelitis
Interesting there seems to be alot of data showing that ME/CFS/POIS could have actual physical reasons for them how do you think what is the very root cause that started the rest of the dysfunction cascade in those disorders?
My personl opinion is toxin-hiden infection-imune(MCAS)-mitohondria...
See here
https://me-pedia.org/wiki/Metabolic_features_of_chronic_fatigue_syndromeSo, you can see from here how mitohondria affect inate imune system.
Second, many people do not understand that the first response our body mounts against a viral, bacterial, or any kind of infection is metabolic. Yes, our chemistry is our first line of defense. Our chemistry reflects our instantaneous state of health. Innate immunity is coordinated by mitochondria and is an essential first step in developing adaptive immunity to any infectious agent. Without innate immunity there can be no antibodies and no NK cell activation, no mast cell activation, and no T cell mediated immunity.
And you can se here and i bolive this to that ours bodies "shot down"
to protect him self, mitochondra(when sense danger).
Naviaux believes the mitochondria are able to sense every kind of danger – from pathogens to pH changes to toxic elements from pesticides, heavy metals, etc. to inflammation. They sense trouble in the form of an infection when they detect a drop in voltage caused by the diversion of electrons (NADH / NADPH) to make viral components or respond to a broad variety of toxins.
