https://me-pedia.org/wiki/Myalgic_encephalomyelitis#Other_diagnostic_criteriaThe following are some syndromes and diseases that have been associated with or misdiagnosed as ME:
fibromyalgia[87]
chronic Lyme disease[88][89]
idiopathic intracranial hypertension[86]
postural orthostatic tachychardia syndrome[90][91]
irritable bowel syndrome[87]
thyroid disease[92]
Ehlers-Danlos syndrome[92]
Sjögren's syndrome[92]
multiple chemical sensitivity[87]
Clinical findings
Alem Matthees is an Australian ME patient that filed an FOI request for data from the PACE trial. At a great cost to his health, Alem appealed the denial of the data and won. This data proved the results published in The Lancet were untrue. Alem's health suffered significantly in part from the efforts required for the FOI request and tribunal
Although there is no definitive biomarker, several signs and findings have been frequently observed in clinical settings:
Clinical findings fit in POIS
High antibody titers to specific infections (including EBV,[33]HHV-6,[34][35]and Coxsackie B[36][37] among others)
hormone imbalance[38]
immunological abnormalities[39][40][41]
low natural killer cell function[42]
low red blood cell magnesium[43]
postural orthostatic tachychardia (POTS)[44][45]
physical and mental exertion, sensory input cause relapse (PEM)[46][47]
Signs and symptoms fit in POIS and MCAS
Myalgic encephalomyelitis is a neurological disease that affects multiple bodily systems, causing a widespread combination of symptoms.[28] Symptoms can range from mild to very severe and can include:
ataxia (coordination difficulties)
cognitive dysfunction
fatigability
gastrointestinal symptoms
headache
low-grade fever, temperature instability
muscle weakness and fatiguability
myalgia (muscle pain)
neck and back or spinal cord stiffness
neuralgia (nerve pain)
othostatic intolerance
post-exertional malaise
sensitivity to heat or cold
sensitivity to light, sound and/or touch
sleep dysfunction[28]
