Can you help me understand if Quercetin raises or lowers vitamin b6 and b12 ? and how much ?
I seem to remember a website where it was said they were lowered but I can't find it anymore.
I have found here
https://www.liebertpub.com/doi/full/10.1089/act.2018.29197.mho
that it inhibits CYP3A4, don't know if it matters
To my knowledge, there is no interaction between vitamin b6 and b12, and quercetin.
CYP3A4 is not an issue with B vitamins, but there will be an interaction with the drugs eliminated by this liver enzyme. However, quercetin is only a weak inhibitor fo CYP3A4 ( see https://en.wikipedia.org/wiki/CYP3A4#Ligands for details)
Thank you. I asked because last year I developed a neuropathy (electric zap in 1 foot and a feeling of light internal trembling all over the body) after consuming an excessive amount of vitamin B6.
I was extremely worried when those symptoms started. I consumed 50mg a day which seemed very safe according to the US FDA daily upper limit of 100 mg, but later I found out that in Europe the upper limit is only 25mg and in UK even lower at just 10mg, so there seem to be major concerns about this Vitamin B6 which incredibly the US FDA doesn't know/understand.
Luckily my neuropathy resolved after some months but I have been in contact with people with B6 toxicity who had it for years and can't get out, like a neurological permanent damage.

So I'd like to try quercetin for my POIS but after reading it might create tingling/neuropathy I am a bit worried. I have also found out quercetin significantly inhibits iron absorption, which by itself can create anemia and neuropathy, yes I guess this can be fixed by iron supplements but overall I am bit worried.