My method for prevention and control of my POIS symptoms - 80% to 100% effective

[Quantum]

Nice link https://bebrainfit.com/serotonin-supplements

Yes, and interesting to note that most of these are helpful for POIS at least for some members.  5-HTP, B6, vit D, SAMe, etc.... are often noted as beneficial for members, in their control method.

My preferred sources of tryptophan are pumpkin seeds and turkey breast  ( without nitrate and preservatives, of course   )   

[Michael218]

It's funny Quantum, my worst symptom prior to any prepack was anxiety, brain fog, concentration... I had never really experienced mood issues. Or at least I was.never conscious of them because other symptoms were so intense. But now, with about 80% relief, the only symptoms left are mood issues. I really notice it. Anxiety is gone. But I can become really moody. Thankfully mindfulness enables one to self-enquire and monitor their own state of consciousness, so it can be contained generally on the outside, but internally, there really is a battle of moods bouncing around.... I wonder if you have identified a specific supplement that addresses that one symptom yet?

As you know mainly take B's. I also take Quercetin and Curcumin straight after to get the best of both  worlds as I have no idea which vitamins do what.

I just purchased some SAMe (Nannas sourced NOW brand contains a little folate, b6 and b12 in it which is frustrating as I wanted to take it daily but dont want to become immune to protection from the B's), 5htp and Benfiotiamine in an effort to give Nanna's a try. Also been taking about 5-10 grams of fish oil the past 6 weeks or so.

Anyway won't blabber on... who knows what works... a lot could be to do with diet, so what works for one could simply work because it addresss that person's deficiency in smth...

[Quantum]

Hi Michael,

I am happy to hear that you still have a high level of symptoms relief.  At 80%, you surely have made a leap in your quality of life.

I would say that all of my pre-pack in general is good for stabilizing my mood ( through IDO, TDO inhibition, NMDAr block, and so on).   In my case, omega-3 have a marked beneficial effect on my mood.  Flaxseed as well.  Of course, regular meditation ( 5 to 10 mins daily are enough) is important for my emotional stability.

When I have some leftover POIS symptoms, fenugreek seems to be helping in making my mood a little bit more "mellow", more relational.  this may be linked to its oxytocin-like effect.  I do tolerate it well, it doesn't cause me body odor or other side effects.

Happy Holidays to everyone!

[Michael218]

Great, thanks Quant. Always helpful. Cheers.

[positive_guy]

This was a private conversation, which i have the permission to post.

I was reading, that grapefruit has a negative impact on medicine. Does grapefruit impact or lower the effect of any of the supplements found in those stacks from this forum?

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Quantum wrote:

Hi positive_guy,


The interactions caused by grapefruit go the other way, that is, they raise the concentration of the drug they interact with, by blocking their elimination. What we can have as a harmful effect is the toxic side effects we would have from a higher than usual dose of the herb or drug that grapefruit interact with. The classic example is with the antihypertensive drugs of the calcium channel blockers family ( nifedipine, felodipine, ...) - when taken with grapefruit, their concentration gets higher than usual with the same dose, and the patient will experience hypotension, a bit like if he had taken a double dose of his pills.   

There is no significant interactions reported to date with herbs or vitamins, and grapefruit.  The only I would be cautious with is St-John-Wort, but I have not found any confirmation of this, and this herb is not very used by the forum members ( SJ Wort has a high potential for many interactions with herbs and drugs).

For more informaiton on grapefruit and drug interactions, see https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions .

My own, personal pre-pack has no interactions with grapefruit, and nanna's stack neither. 

This is another advantage of using moderate to low doses of many components rather than high dosage of a few components - you are less exposed to this kind of interaction because you have a better security margin for unusual variations in the bioavailability of your usual dosage.

Have a great, POIS-free day!
Quantum

[positive_guy]

@Quantum

Since your PIOS Stack contains stimulants like caffein and i think also 5-htp supposedly keeps you also awake, do you only take it during the day? How do you deal with this if you want to take it at night?

Don't know its effect on my sleep yet, because i usually combine it with a niacin supplement which also contains caffein, and a couple of times i couldn't sleep. The times when i also took diphenhydramine i could sleep. But i'd like to avoid taking chemical stuff, and i'm not sure diphenhydramine solved my POIS. Also i seem to suffer from bad memory, which supposeldy can also be a side effect of diphenhydramine, but apparently is also in the list of POIS symptoms.

[Quantum]

Hi PG,

There is no caffeine in my pre-pack, because the green tea extract I use is caffeine-free ( Jamieson brand).  But you are right, some of the elements in my pre-pack give energy a boost, but it is much needed for me when in POIS. 

I never had problem sleeping using my pre-pack, even if taken late in the evening, or in the middle of the night.   I have to say however that I rarely, if never, have problems to sleep.   

Not everyone react the same to 5-HTP, some people take it before sleep as a sleep aid, so you have to see for yourself what is your own reaction to it.

My pre-pack is adjusted to my condition, so I do not feel boosted when taking it.  I will only feel more energized than usual if I take my pre-pack, and some sort of emergency happens so that I have to go and will not have release.  It happened once, and with that much products taken with no POIS, I felt a little like on overdrive.   Well, it showed me that POIS really takes a toll on my energy level, and my pre-pack compensate for it.

I do not drink coffee or use caffeine, I am very intolerant to it, it makes me anxious and shaky.

[romies]

Since your PIOS Stack contains stimulants like caffein and i think also 5-htp supposedly keeps you also awake, do you only take it during the day? How do you deal with this if you want to take it at night?

5-HTP can be both energizing or calming, depending on whether you are serotonin deficient.

Personally anecdote with a single dose 100mg 12 hr extended-release 5htp from Natrol.

When I am in a POIS state, 5-HTP gives me a small boost of energy, typically for 8-12 hrs.
When I am not in a POIS state, 5-HTP makes me sleepy, usually lasting for 24 hrs.

You can experiment it yourself, as long as your are *not* using any SSRI or MAOI.

[Quantum]

Curcumin/turmeric has been a part of my pre-pack right from the start ( I use curcumin with black pepper, so the absorption of the active ingredient is much better)

I also add some curcumin and black pepper to my daily breakfast ( actually, I add them into my cereals, along with blueberries, raspberries, and pumpkin seeds). 

Last week, on vacations, I didn't had any curcumin for a week.   I do not know if it is because of the very high humidity in Mexico, or because of the lack of curcumin, but by the end of the week, I had some minor joint pain, in particular in the index of my right hand ( maybe because of my badminton playing style - I often feel some stiffness the morning after playing, but no pain). I never had pain in that joint before.  After 2 days back here, the pain was entirely gone.   Usually, cold weather is not good for joints pain, so I wonder if it is the curcumin, a good, natural, anti-inflammatory, that has made the difference.

Anyway, peppered curcumin sure helps me with POIS, and is a very valuable part of my pre-pack, having several positive properties ( (IDO inhibitor , anti-inflammatory, antioxidant, mast cells stabilizer, anxiolytic ).  It works good for me, so it must help or compensate for one or more of my metabolic flaws.

 

[Quantum]

Update:   more than 3 years, my pre-pack method is still efficient for me.  I have not developed a tolerance to my pre-pack, it is still working for me.   However, I limit my releases to about 3 a month, spaced at least by one week  ( being over 50, this is not a problem for me ).   My method would not work well with too frequent releases.

[fsol]

Update from me as well: This pre-pack is also still effective for me. I use double dosage as I'm quite tall and relatively heavy. Combined with abstinence and working out, this is so far the best relief method I have tried to far and continues to be it. Thank you Quantum!

[Quantum]

Update from me as well: This pre-pack is also still effective for me. I use double dosage as I'm quite tall and relatively heavy. Combined with abstinence and working out, this is so far the best relief method I have tried to far and continues to be it. Thank you Quantum!

Thanks for your feedback, fsol !,  I am glad that you still have relief with this pre-pack method

[an-y-more]

Can you please elaborate about rosemary acid/essential/water you use? I found only cosmetic rosemary in my country which is not supposed to be taken perorally ( also rosemary acid can cause problems with stomach which is essential since I have gastritis).
Do you just use a drip of steam distillation obtained cosmetic rosemary to water and drink? Has it caused some problems with stomach for you and did you have any problems with mucosa?
Sorry if it's been elaborated already but I quite don't get it and want to be sure to keep my mucosa safe before trying it, thank you!

[Quantum]

Can you please elaborate about rosemary acid/essential/water you use? I found only cosmetic rosemary in my country which is not supposed to be taken perorally ( also rosemary acid can cause problems with stomach which is essential since I have gastritis).
Do you just use a drip of steam distillation obtained cosmetic rosemary to water and drink? Has it caused some problems with stomach for you and did you have any problems with mucosa?
Sorry if it's been elaborated already but I quite don't get it and want to be sure to keep my mucosa safe before trying it, thank you!

Hi an-y-more,

The exact rosemary oil I use is one from an aromatherapy line, not a cosmetic line.  It is this one :  https://www.avogel.ca/en/essential-oils/rosemary.php ( from A.Vogel).   It is a high quality oil.  But note that the company does not mention that it can be taken orally like I do.  I could also use grounded organic rosemary, that can be found at a health store, in the spice and herbs section, and find what quantity is needed to get a good effect, but I prefer the essential oil, which is more concentrated.  I am very careful using it, so I never had any problem with it.

The bottles from Vogel have a dropper under the cap, so by handling the bottle carefully, I can add only one to two drops in a glass of water.  I then mix carefully before drinking, because if you do not mix it well, the oil drops will naturally float on the surface, and will stay concentrated, and may be irritating if taken up like that, but not when the oil is well mixed in the glass of water.   

I could also choose to mix it in a large spoon of olive oil, but I prefer mixing it in water.

[demografx]

Hi an-y-more, welcome to the forum!

[drop247]

Do you have problems sleeping after taking this? I took Curcumin and Quercetin before an O once at night and couldn't get to sleep until 4 am. Not even 5htp helped.

[Quantum]

Do you have problems sleeping after taking this? I took Curcumin and Quercetin before an O once at night and couldn't get to sleep until 4 am. Not even 5htp helped.

Hi Drop, sorry for the late reply, I didn't see your question before today.

No, for me it does not prevent sleep, maybe because I am so tired after O.   Once, I took my pre-pack 40 minutes before a supposed relation with my spouse, and an emergency occurred and I had to leave the house in order to help someone.... I felt a tremendous amount of energy, having taken all those supplements, but no release after.   It showed me how much of a toll ejaculation has on me.

You may experiment for yourself and see which supplement prevents you from sleeping, so then you can customize your pre-pack according to your personal needs.

[Quantum]

You can read in this thread an interesting discussion about how Romies uses his pre-pack:    https://poiscenter.com/forums/index.php?topic=3164.msg32273#msg32273

( this message and those following this one in that thread)

[Quantum]

Like I have explained at the beginning of the thread, I have low blood pressure when in POIS.   One of the main ingredient in my pre-pack to help raise it back to normal is green tea.
Green tea is helping me raise my blood pressure (BP) for 4 to 6 hours, but now that I take it with the other supplement in my pre-pack, I only have to take it once, as included in my pre-pack, 30 mins to 1 hour before ejaculation. 

At first, when I first discovered that POIS was giving me hypotension, and that green tea was helping to raise my blood pressure back to normal, I was drinking commercial iced tea.  But for years now, I use Green Tea extract capsules, because I have now a very healthy diet, which also helps with POIS, so I do not drink sugary drinks anymore. The green tea capsules I take are very effective and high quality, with standardized EGCG and standardized polyphenols, which are the antioxidants in it  ( I use the Jamieson ones - I have no commercial link with them - the one I use are these:  https://www.amazon.ca/Jamieson-Green-Tea-Phytosome-Complex/dp/B001Q8BBFS )  .

So, green tea, one of my first anti-POIS supplement, is still part of my pre-pack today

[Quantum]

Just a reminder of how I have developped my custom pre-pack:
- Started with the supplements I kenw were helping me with POIS even if not enough ( magnesium adn green tea were my firts allies against POIS) - Then I read and searched a lot on the forum to better understand POIS and see what would help me.- I added only one supplement at a time, and test it for some weeks, to see if better results. If better relief than the previous pack alone, I kept it.- keeping all those added to date, I tried many others but only one new supplement at a time, at least 2 times ( unless it was clearly worsening my POIS).- after 6 months, I had pretty much the same composition that I still use today, 5 years later.
You can see all the ingredients and why I added them, in the initial post of this thread, at https://poiscenter.com/forums/index.php?topic=2090.msg16604#msg16604