Testosterone

[Nas]

It seems testosterone stimulates Gaba transmission :
https://www.ncbi.nlm.nih.gov/pubmed/14769394

Intersecting simple theory: There is an excessive release of GABA after ejaculation causing shutdown of many neurotransmitters rather than simple relaxation.

[Muon]

Apparently testosterone exerts an inhibitory effect on mast cells, thus TRT could act as a mast cell stabilizer. See table 1 in 'The neuroendocrinology of mast cells'

[demografx]

Interesting.

[Muon]

Didn't we have a few poisers who were using Progesterone with succes? Take a look at the table again, it's capable of exerting an inhibitory effect on mast cells as well.

[demografx]

Quantum (and others who wish to reply), I’ve been thinking of stopping TRT for a while, because it increases libido (as Quantum pointed out to me privately). And I think we all know what happens with POIS frequency when libido increases

My past primary care physician (I have a brand new one now) said “there is no withdrawal from TRT”.

I’ve been on TRT-for-POIS for 10 years now and I’m curious whether my body, brain, mind and emotions have ‘normalized’ to the point where no-TRT will not necessarily plunge me into the same horror as 10 years ago.

Quantum, do you see a downside? (If the horrors come back, I assume that I could simply get back on TRT).

Thank you!

Hi Demo,

It would worth a try, in my opinion.  Like I have said to you in private, TRT increases libido for sure, and this is no good for when we have POIS.

However, I do not agree with your MD that there is no withdrawal ( but, as you know, the opinions expressed here are not intended to replace medical advice and you will have to discuss it with a health professional).  You have been taking TRT for 10 years, so you own, endogenous production of testosterone is shut down for years.  If you stop at once, it will not revive instantly, and we need at least some testosterone in our body.  A progressive tapering of the dose is much more preferable, and you should discuss this with your specialist or primary care physician.

See https://www.nexelmedical.com/testosterone-therapy/can-you-stop-testosterone-replacement-therapy/ , it is a medical clinic suggesting progressive tapering to avoid emotional and physical sympoms.

The withdrawal for TRT is not as important as what someone may get from drigs acting on the central nervous system, like antidepressant, but they are to be considered as a possibility ( you will for sure read some horror stories on the net, but that's not the norm....).

Note that if someone stops could turkey, the possible emotional and physical symptoms can take some time to appear, when all T will have been eliminated from the body  ( there is a delay).   

A very slow tapering on several weeks or a few months would greatly help to manage any "surprise".

Quantum, I’ve reduced my TRT to one patch (2mg Androderm) per night. I feel better now! (Libido is more under control). Thanks!

[Vandemolen]

Something weird happened. In my latest test my testosterone was 29! In the last 10 years it was always around 10. But I took those previous tests in the afternoon. The latest test I did was at noon. I know there is a difference between a test in the morning and the afternoon. But so big?

I did a new blood test. My testosterone was 15. 50% less than the last time. But within the normal range of my hospital: 10-30. I will go next month to my urologist to talk about the result.

My urologist said that my testosterone is ok. He said that sometimes it can be lower because of a flu or another disease. He does jot know if POIS brings testosterone down, but it could. About a few months I will check my testosterone again to see if it is still ok. Otherwise I will go back to the urologist.

[certainlypois2]

Something weird happened. In my latest test my testosterone was 29! In the last 10 years it was always around 10. But I took those previous tests in the afternoon. The latest test I did was at noon. I know there is a difference between a test in the morning and the afternoon. But so big?

I did a new blood test. My testosterone was 15. 50% less than the last time. But within the normal range of my hospital: 10-30. I will go next month to my urologist to talk about the result.

My urologist said that my testosterone is ok. He said that sometimes it can be lower because of a flu or another disease. He does jot know if POIS brings testosterone down, but it could. About a few months I will check my testosterone again to see if it is still ok. Otherwise I will go back to the urologist.

how much red meat do you consume.  It makes a big difference.

[demografx]

All 3 urologists I consulted were absolutely clueless about POIS.

[Vandemolen]

Something weird happened. In my latest test my testosterone was 29! In the last 10 years it was always around 10. But I took those previous tests in the afternoon. The latest test I did was at noon. I know there is a difference between a test in the morning and the afternoon. But so big?

I did a new blood test. My testosterone was 15. 50% less than the last time. But within the normal range of my hospital: 10-30. I will go next month to my urologist to talk about the result.

My urologist said that my testosterone is ok. He said that sometimes it can be lower because of a flu or another disease. He does jot know if POIS brings testosterone down, but it could. About a few months I will check my testosterone again to see if it is still ok. Otherwise I will go back to the urologist.

how much red meat do you consume.  It makes a big difference.

Not a lot. I eat it maybe once a week.

[Vandemolen]

All 3 urologists I consulted were absolutely clueless about POIS.

I went to this urologist because of the POiS like symptoms out of POiS. Because my testosterone is low for a few years. And because he was the doctor who sended me to prof. Waldinger 9 years ago. He knew him because of the seminars he visited.

[demografx]

Vandemolen, I hope you will be happy working with him.

[Nas]

Demo so TRT does not stop POIS even if you take a patch right before sex?

[demografx]

It doesn’t work like that. It’s a *longterm* buildup of TRT in the system that works. Protocol is 365 days/year.

[Nas]

It doesn’t work like that. It’s a *longterm* buildup of TRT in the system that works. Protocol is 365 days/year.

But you still suffer from POIS after orgasm? Or does it go away in time?

[demografx]

Demo so TRT does not stop POIS...

I never said it stopped POIS.

[demografx]

Day Zero. No POIS today!

I must be dreaming

Nas, if you’re referring to this, I spoke too soon. It simply turned out to be a lighter episode.

[Nas]

So TRT does not stop POIS but it quickens the time to heal correct?

[demografx]

• Yes, it cuts my recovery time in half

• symptoms are far less devastating

• works best on physical symptoms, cognitive not as much

[demografx]

Pre-TRT, my worst physical symptom was extreme exhaustion.

[Muon]

Have you checked your vitamin D level Demo?