The understanding of visceral pain pathways is important in recognizing the serotonin relation and influence of it in pain modulation in IBS. Pain regulation pathways in visceral pain include vagal and spinal afferents that project into the CNS, both facilitating and/or inhibiting the sensory transmission to the spinal cord. Specifically, in visceral pain, there is an antinociceptive action of estrogen on the serotoninergic system due to afferent-driven vagal inhibition of the pain. On the other hand, the pro-nociceptive action occurs because of the enhancement of serotonin secretion in the intestinal mucosal mast cells (IMMCs); cells in which estrogen receptors have been found and that have been associated with its degranulation, increasing the visceral motor response and spinal or supraspinal processing of visceral nociception, mainly in IBS. Furthermore, as described previously, the interference of serotonin in pain modulation depends on the receptors, route of administration, type of pain, and influence of other substances on the release of this neurotransmitter.https://scholar.google.com/scholar?hl=hu&as_sdt=0%2C5&q=An+Association+of+Serotonin+with+Pain+Disorders+and+Its+Modulation+by+Estrogens&btnG=
https://youtu.be/rW2K_WPUQTA?t=1262https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465360/table/jpm-11-00860-t003/?report=objectonlyDiagnosis Atopic DiseasesBloodIgE, IgG1, IgG4Immune IgE (RAST for alpha-gal, casein, gluten, dust mites, fungi, grass, pollen)Anti-IgE receptor antibody (basophil activation)CCL2, CXCL8 (IL-8)Chromogranin AEosinophilic cationic protein (ECP)Food Intolerance Panel (IgG4)HeparinIL-4, IL-6, IL-31, IL-33PGD2TryptaseUrine 24 hours (must be kept and sent cold)Methylhistamine or MIAPGD223BPG=2,3-Dinor-11beta-PGF2alphaSo what will the result show if you run down this panel on a group of POIS patients?
https://www.reddit.com/r/POIS/comments/xckj3r/random_pois_triggered/"Has anyone else had pois symptoms randomly triggered? I haven't ejaculated in months and I haven't had a wet dream in over 2 weeks but I'm feeling a bit how I feel when I'm having pois symptoms can anyone explain!?""I ate some home made Chinese food and it used Worcester sauce I believe that's what messed me up"