I try to do exercises on a regular basis, but I always struggle to keep it going due to the pain and other symptoms. Work itself makes me rather exhausted usually, so much so that I tend to delay and skip on basic household chores. By the time I get home I just want to sit down for an hour or two even if work wasn’t so bad. However simply walking around causes some muscle fatigue. The other more important deterrent from exercise is when I develop DOMS which lasts for days and feels like a mini POIS episode. However not only exercise, but muscle damage itself can also lead to POIS. Just a few months ago we had a job where four of us had to move a heavy object of about 200 kg up a floor. This only took about one minute, however two days later my arms were really sore and at the same time POIS symptoms were increased as well, also indicated by very bloodshot eyes.
Nevertheless DOMS in my case feels like the crash or malaise (PEM) that ME/CFS people often talk about. I can still move around at least, however I feel really ill. I develop DOMS most often by doing exercises at home even if it was only for half an hour. It happens less likely during work even though we often carry moderate weights and this goes on for hours. I guess the exertion is spread more evenly in this case. Even so my symptoms progressively deteriorate during work and I often get moderately unwell by the time I go home (usually 4-6 hours). If it was a longer day (8-10 hours) then the pain and fatigue would be clearly worse. Of course the intensity of the work also counts. Just as clear is the fact that the burning intensity of the urine is in linear correlation with the muscle pain. After an average day it would burn moderately, however after a longer day and a stronger fatigue it would also burn quite severely. Interestingly after sitting for a few hours the muscle pain would get better and the burning intensity of the urine would also reduce at the same time. Nevertheless both would remain bothersome even when I was at rest for a longer time.
What this all implies is that there is clearly a bidirectional flux of LPOs between the muscles and the urine. This means that during POIS the prostate and the urinary tract are saturated by LPOs that spread towards the muscles and other body parts like the brain, which is a reverse flow if we consider excretion. However during high DOMS and low POIS the LPOs spread toward the urinary and intestinal tract as an outlet by excretion. Even so in case of POIS/CFS the saturation is at a moderate level even in a nominal state and any increase would cause saturation again leading to more apparent symptom levels whole body wide.
Surprisingly ME/CFS people have severe muscle pain without any particular complaint of a burning urine. This can only mean that in their case the LPOs originate from their muscles, which are also mostly trapped there, where they cause strong local symptoms. At the same time though they have less systemic symptoms. Indeed they have brain fog and a lower level of flu like symptoms, but the LPOs may not propagate so freely through their bodies as in case of POIS. Those who are bed-ridden probably have a very high level of oxidative stress in their muscles. Unfortunately for them the rate of radical production exceeds their ability to remove them locally. The case of CP/CPPS is less clear as they also have similar urinary tract and prostatic problems as in POIS and yet they have no such reported systemic issues as in our case or at least not to such a degree. This must either mean that the level of inflammation is stronger in case of POIS or that it permeates the body much more readily by passing through the bloodstream. Another distinction could be that POIS is characterized by massive spikes of deterioration and at least a degree of amelioration usually around 7 day. While the other diseases may be somewhat more steady, though they are also deteriorated by stressors like physical activity, dietary elements and so on. Given that the focal point of the inflammation is the genitourinary system in both prostatitis and POIS the elimination by externalization is also easier than in case of ME/CFS.
While these diseases may appear very different they actually have much in common. For this reason general treatment strategies should be also similar and mostly aim to reduce ROS in all three diseases.
While lactic acid is not directly involved in DOMS, it may be possible that some of its metabolites actually are. The conversion of aldehydes involves numerous esters and in case of an LPO excess it is likely that lactate esters are also formed in great quantity adding to the toxic burden of the body.
(DOMS) is muscle pain that begins after you've worked out. It normally starts a day or two after a workout. Pain felt during or immediately after a workout is a different kind of muscle soreness. It’s called acute muscle soreness. It was once thought that a buildup of exercise-induced lactic acid was to blame for DOMS, but this common misconception has been debunked.
Acute muscle soreness is due to lactic acid buildup. DOMS, on the other hand, is not related to lactic acid buildup; it’s due to microscopic tears and muscle damage.https://www.healthline.com/health/doms
