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11
Poll Center / Re: Neutrophils
« Last post by Hopeoneday on December 02, 2024, 05:50:41 PM »

…I am waiting for magic pill :o


Send me one!!

"I inveted one here" :
https://poiscenter.com/forums/index.php?topic=4581.0
I thougt to send one to you for Christmas.
But, I find it a little exspensive, so it is freee for you but not  ;)
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Hormonal Causes and Treatments / Re: Mast Cell Activation Syndrome
« Last post by Hopeoneday on December 02, 2024, 05:36:28 PM »
Hi Sartre02, actualy i think complitly dioposite, you
misunderstend something.

Actualy I discovered xolair as potentilal treatment for pois
5-6 years ago. Later it was suscessifully tested on few poisers,
one under medical supervision, se here a MIRACLE:
https://poiscenter.com/forums/index.php?topic=4581.0
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Hormonal Causes and Treatments / Re: Mast Cell Activation Syndrome
« Last post by sartre02 on December 02, 2024, 01:21:46 PM »
@hopeoneday : claiming no chance for xolair to treat a non -autoimmune condition is out of line , what if they discover it has a multiple mechanisms of action? like NAC that turned out not only beneficial for cough but liver and MANY MORE... never say never
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Lifestyle Diary and POIS Summaries / Re: Warrior's Journal (My POIS Protocol)
« Last post by demografx on December 02, 2024, 11:03:09 AM »

Zinc…improves mood a lot…


Interesting, Warrior.
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Do cases like this imply that it is time for the "O" requirement for POIS to be readdressed?!


It’s still “early” enough in POIS research that we can think flexibly!
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Thanks.

A 2020 animal study says :

- Thiamine has a critical role in spermatogenesis
- The group taking anti-thiamine drug (metronidazole) shows an important drop  of free testosterone, sperm concentration and moderate drop of LH/FSH.
- Anti-oxydant grapefruit might influences some datas.

The study didnt't prove thiamine deficiency explain the drops but it  maybe attributable to thiamine deficiency and oxidative stress.
.

So I think it's not stupid for poisers to try to boost our B1 level and increase anti-oxydant with food.


Thanks, b_jim!
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You might be interested in what r/7e7en87 (https://www.reddit.com/r/POIS/comments/1guili4/comment/lyxhrh4/?context=3) has been sharing at the POIS subreddit. I see overlap with his and your contributions - you might have a similar POIS cluster like I do. His contributions have been huge for my own POIS. He recommends ALA, taurine, TTFD along with magnesium taurate, creatine, methyl donors, cordyceps (high quality brand like Oriveda), D3 and some others. He's constantly updating his stack. I have found him very useful.

That's an interesting sub reddit, especially when he writes that his POIS is alleviated by multiple O's.

He gets POIS after one O.
His POIS is alleviated by multiple O's.
His POIS is worse after one O when preceded by a period of abstaining.

experience 3: "If I ejaculate a few more times in succession, my POIS symptoms become less intense, and the burning sensation decreases as well."
Isn't this the opposite of most people's POIS?
I thought most people get worse POIS symptoms the more times that they have O's?.
Do cases like this imply that it is time for the "O" requirement for POIS to be readdressed?!

He theorises about a chronic fungal infection. I suppose that is possible but imo, everything he describes could just as easily be autoimmune or allergy related or 100 other things.
ex/ another speculative theory (autoimmune?): Could it be the mere presence of sperm at a certain point in their life cycle in a particular area of the body (epidymis, vas deferens, urethra etc) that is triggering this person's POIS rather than an O? etc.
18
Thanks.

A 2020 animal study says :

- Thiamine has a critical role in spermatogenesis
- The group taking anti-thiamine drug (metronidazole) shows an important drop  of free testosterone, sperm concentration and moderate drop of LH/FSH.
- Anti-oxydant grapefruit might influences some datas.

The study didnt't prove thiamine deficiency explain the drops but it  maybe attributable to thiamine deficiency and oxidative stress.
.

So I think it's not stupid for poisers to try to boost our B1 level and increase anti-oxydant with food.
19
1995 animal study showed that taurine helps with normal level restauration of a form of thiamine (phosphate esters ) after its depletion by drug.

I think the combination of taurine + (benfo)thiamine will be my strategy  for 2025.

This combination sounds to be a good idea! Coincidentally a treatment scheme for diabetic neuropathy may actually work in the treatment of POIS as well. Besides benfotiamine some of the following could be also utilized. As an available PKC inhibitor lycopene could be used.
I have just begun on a higher dose (100-150 mg) of benfotiamine, but I can certainly see some benefit. Niacin, lycopene, R-ALA and aspirin are also quite useful. ALCAR was less so and unfortunately for some reason I still have trouble with taurine, but this may be specific to my case.

With reference to oxidative stress and the related pathways, the following new drugs are under study such as taurine, acetyl-L-carnitine, alpha lipoic acid, protein kinase C inhibitor (ruboxistaurin), aldose reductase inhibitors (fidarestat, epalrestat, ranirestat), advanced glycation end product inhibitors (benfotiamine, aspirin, aminoguanidine), the hexosamine pathway inhibitor (benfotiamine), inhibitor of poly ADP-ribose polymerase (nicotinamide), and angiotensin-converting enzyme inhibitor (trandolapril).
https://onlinelibrary.wiley.com/doi/full/10.1155/2013/168039

You might be interested in what r/7e7en87 (https://www.reddit.com/r/POIS/comments/1guili4/comment/lyxhrh4/?context=3) has been sharing at the POIS subreddit. I see overlap with his and your contributions - you might have a similar POIS cluster like I do. His contributions have been huge for my own POIS. He recommends ALA, taurine, TTFD along with magnesium taurate, creatine, methyl donors, cordyceps (high quality brand like Oriveda), D3 and some others. He's constantly updating his stack. I have found him very useful.
20
1995 animal study showed that taurine helps with normal level restauration of a form of thiamine (phosphate esters ) after its depletion by drug.

I think the combination of taurine + (benfo)thiamine will be my strategy  for 2025.


My TTFD has a small amount of magnesium taurinate in it which the brand have done deliberately. I keep hearing about combining it with magnesium and taurine. Must be something to it for sure.
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