From what I'm reading, it seems that VDR taq AA is quite common. Genetic Genie says that it's often either VDR taq or VDR bsm which is homozygous : "
VDR Tak and VDR Bsm are usually inverse from eachother. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR Bsm. However, this is not always the case."
See also :
https://selfdecode.com/snp/rs731236/#, they say A is the most common allele and rather a good thing.
Fortuitously, I just saw something which may interest Muon :
"These leprosy data suggest that one of the genetic factors influencing this Th1-Th2 shift in humans may be VDR genotype, with tt homozygotes tending to produce a TH1-type immune response and TT homozygotes producing a Th2-type response. https://sci-hub.do/10.1086/314536However I can't understand the papers which use TT/tt in place of AA/GG for VDR taq (most of the papers), so I don't know which is which.
As for my results, I'm more interested by the COMT mutations. What I'm reading on rs4680 AA is spot on and relates to dopamine / norepinephrine levels, vulnerability to dependence, etc.
Nanna1 said VDR taq mutation could also impact COMT,
when discussing about endorphins.
It's a pity my 23andme data isn't complete on methylation, it looks like I have many mutations.
Also, about SOD2 A16V mutation :
https://selfdecode.com/snp/rs4880/#