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POIS Research / Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Last post by Muon on January 14, 2021, 07:31:17 PM »
You can just give a hyperlink to the post itself for reference, no need to double post screenshots. Perhaps other members can chime in how to set it up and give suggestions.
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Yes, it's not that easy given the format of the results (screenshots). I guess that the only solution is to have first a kind of table synthesizing the anomalies and their frequency, then the screenshots of the results, person by person, which will take some space.

Edit @Muon : ok, I'll do that.
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POIS Research / Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Last post by Muon on January 14, 2021, 07:17:02 PM »
I wouldn't bother trying to find an explanation and go in-depth....at least for now. Priority is to collect, filter and summarize data in a separate thread about genetic results. People can draw conclusions from that. I would first think about how you would set up such thread regarding format if I were you. Btw I have no knowledge about genetics, I'm a complete n00b regarding that subject. It's all hocus pocus to me. You guys probably know more about it than I do.

Edit: I see plenty of papers mentioning links between Th1 and VDR. I will look at it later. There is actually a theory out there that says you should avoid vit D to fix autoimmune disease and that the body downregulates vitamin D to restore Th1 response. I posted about that somewhere can't recall the name. It's probably in the vit D thread.
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Poll Center / Re: Time of day and POIS
« Last post by an-y-more on January 14, 2021, 06:58:27 PM »
I'm not sure about better but I do enjoy nightitme more for some reason. And my daytime regime in these years was always slipping to night much easier than other way around.
 During a summer I used to stay up at night and sleep during a day usually and it was pretty common that in the morning (vaguely around 7 o clock) I would start to feel shaky like I had tremor or some tension problems. This wasn't fatigue or anything like that. Seems about a time melatonin drops at your graph..
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From what I'm reading, it seems that VDR taq AA is quite common. Genetic Genie says that it's often either VDR taq or VDR bsm which is homozygous : "VDR Tak and VDR Bsm are usually inverse from eachother. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR Bsm. However, this is not always the case."
See also : https://selfdecode.com/snp/rs731236/#, they say A is the most common allele and rather a good thing.

Fortuitously, I just saw something which may interest Muon : "These leprosy data suggest that one of the genetic factors influencing this Th1-Th2 shift in humans may be VDR genotype, with tt homozygotes tending to produce a TH1-type immune response and TT homozygotes producing a Th2-type response. https://sci-hub.do/10.1086/314536
However I can't understand the papers which use TT/tt in place of AA/GG for VDR taq (most of the papers), so I don't know which is which.

As for my results, I'm more interested by the COMT mutations. What I'm reading on rs4680 AA is spot on and relates to dopamine / norepinephrine levels, vulnerability to dependence, etc.
Nanna1 said VDR taq mutation could also impact COMT, when discussing about endorphins.

It's a pity my 23andme data isn't complete on methylation, it looks like I have many mutations.


Also, about SOD2 A16V mutation : https://selfdecode.com/snp/rs4880/#
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What is POIS / Re: Is POIS a version of CFS?
« Last post by Muon on January 14, 2021, 05:29:02 PM »
For the latest posts on the Phoenix Rising forum: New Posts
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Your SOD2 is homozygous like mine is, your VDR Taq is homozygous - the same as me and everyone else in this forum who have posted results

Not here sorry, it's green. (the SOD2)
https://poiscenter.com/forums/index.php?topic=2684.msg37429#msg37429
That might not matter for general or just chance nuances.

VDR taq I have indeed.

Yes I know, I said only me and Prospero had red SOD2 and then the rest of us all had VDR taq red, maybe it wasn't clear.
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POIS Research / Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Last post by Muon on January 14, 2021, 04:46:58 PM »
Yes, I'll try to do this - but not today. Yet, all this is very incomplete and I guess that we (on the forum) can't really interpret all this data.

Ok, prospero offered to make such thread. Just take your time. You can add stuff bit by bit slowly. Make sure to reserve some extra comments in case of expansion (there is a limit on the amount of characters per post).
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Your SOD2 is homozygous like mine is, your VDR Taq is homozygous - the same as me and everyone else in this forum who have posted results

Not here sorry, it's green. (the SOD2)
https://poiscenter.com/forums/index.php?topic=2684.msg37429#msg37429
That might not matter for general or just chance nuances.

VDR taq I have indeed.
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POIS Research / Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Last post by Muon on January 14, 2021, 02:51:16 PM »
Some people posted their genetic profile for methylation and detox according to 23andme and Genetic Genie. Here is mine.

Your SOD2 is homozygous like mine is, your VDR Taq is homozygous - the same as me and everyone else in this forum who have posted results

+1. Someone should create a new thread and filter out the genetic results. Compile them please. Who is willing to make such thread?
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