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What is POIS / Re: Is POIS a version of CFS?
« Last post by Muon on January 10, 2021, 01:16:51 PM »

Alpha-1 Adrenergic receptor (a1AR) autoantibody at #1. What about POISers? And what about autoantibodies against opioid receptors?
So I ordered Serine. The one that tops the list in human semen. If you look at the benefits of Serine it makes sense that being low on it would cause many of POIS symptoms.

Have you noticed any improvement with this specifically?

(In general, I think supplementing ammino acids is good.. and eating egg/protein)
General POIS Discussions / Re: Replacing amino acids found in semen
« Last post by berlin1984 on January 10, 2021, 11:52:41 AM »
Hormonal Causes and Treatments / Re: Testosterone
« Last post by demografx on January 09, 2021, 09:20:04 PM »
CP2, I googled it and saw this:

“Does Extra Strength Tylenol help you sleep?”

TYLENOL® PM Extra Strength Liquid is a pain reliever and sleep aid that helps you fall asleep fast for a better night's sleep. Provides 1,000 mg of acetaminophen & 50 mg of diphenhydramine HCI.

I noticed there’s diphenhydramine  in this product, which is the main ingredient in  Benadryl. I don’t take the PM product, so I am only getting the acetaminophen, which I assume has some sleep-aid benefit. For me. Again, it works that way for me, but others might not have the same result as mine.
Hormonal Causes and Treatments / Re: Testosterone
« Last post by demografx on January 09, 2021, 09:12:06 PM »
No idea, CP2. But I think if there’s no pain to be treated, Tylenol then works that way. At least it does for me.
Hormonal Causes and Treatments / Re: Testosterone
« Last post by certainlypois2 on January 09, 2021, 08:14:28 PM »

Today is POIS Day Zero (POIS onset), and I didn’t take my usual dose of Benadryl to knock myself out to avoid experiencing early POIS symptoms. I simply
took 8mg TRT (high experimental dose testosterone patches) to counter early-POIS testosterone drop.

Instead of Benadryl I took 1,000mg of:

So far, so good! :)

This is NOT my endorsement or recommendation for anyone else with POIS to try! A good POIS treatment is between you and a trusted doctor. My preferred treatment can be unacceptably risky for many POISers.
Extra daytime SLEEP is still a great aid in POIS-healing for me. And Extra Strength Tylenol helped to facilitate that today. Better than Benadryl: Tylenol didn’t make me groggy!

what is the sleeping aid in tylenol
POIS Research / Re: Muon's Case
« Last post by Muon on January 09, 2021, 11:51:16 AM »
The Pyridostigmine isn't doing anything, it's like eating placebo. Here is what I took so far from top to bottom:

2 days: 1x30mg (10 mg tablets)
10 days: 2x30mg
2 days: 2x60mg
10 days: 3x60mg (60mg tablets)
Hormonal Causes and Treatments / Re: Mast Cell Activation Syndrome
« Last post by Muon on January 09, 2021, 11:16:21 AM »
...Sounds like an 'abnormal' endogenous process due to orgasm that can be triggered by an exogenous substance, in this case semen...

...From second paper:
"Human seminal plasma contains very high concentrations of prostaglandins when compared to other bodily secretions. It is now apparent that PGE2, 19-hydroxyprostaglandin E1 and 19-hydroxyprostaglandin E2 are the three major prostaglandins in human seminal plasma, each being present in millimolar concentrations..."
I think it's the prostaglandins in the semen that cause this. Or it could be caused by the polyamines (spermine, spermidine).

Expression of Antizyme Inhibitor 2 in Mast Cells and Role of Polyamines as Selective Regulators of Serotonin Secretion

"The exact molecular mechanisms by which polyamines selectively regulate the secretion of serotonin from activated MCs remain to be elucidated. However, there are a couple of potential mechanisms that could be hypothesized. Polyamines regulate the gating of various ion channels including calcium channels, enhancing Ca2+ influx in various types of cells [33]–[37]."

Need to take a look at references 33-37 later. It seems polyamines interact with calcium channels. Someone on this forum swallowed his semen and couldn't swallow food properly afterwards (some kind of stasis). Goldstein mentioned that there could be a potential problem with Ca2+ channels in male ejaculation disorders regarding CFS like symptoms.

There also is a site for polyamines present on NMDA receptors.

ROS measurements are overlooked in health care:
Role of Reactive Oxygen Species in Mast Cell Degranulation
General Alternative Causes and Treatments of POIS / Re: Got Cured
« Last post by lw on January 09, 2021, 11:02:27 AM »
Yes sir,
I was tired and in strong pain for 5 days streak. I spoke differently and I couldn't feel things. Life was just a dream, bad, grey dream and I know how you feel.

I'm strongly sure it's anxiety + bad bacterias that stored trauma in the gut.
You need to clean from bacteria and treat your mental health.

For me, before I started healing my gut different things worked:
Fenugreek as it increases testosterone and lowers cortisol.
Poetry and spirituality because it helps with stress.
Anti-Histamines because most of medicaments have additional pain-easer that relieves the pain.

I don't think there are that many kinds of POIS as I have seen in many threads. Most of them are stress+ anxiety + bad bacteria.
I did experience neck pain after orgasm and I think it's related to vagus nerve. That nerve was mostly excited because of bacterial imbalance.

I took many kinds of antibiotics, rifaximin didn't work for me. I think the best one was amoxicillin.
But it must be decided by doctor.

Don't stress, and check in with gastroenterologist .
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