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91

General Alternative Causes and Treatments of POIS / Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs

« Last post by kosmo35 on August 05, 2024, 03:21:52 AM »

I've heard that choline supplements (cdp choline, alpha gpc, etc.) although they can be very beneficial at first, tend to have a depressive effect over time. Unlike these, eggs don't seem to have any side effects at the same amount of choline they contain. We can speculate on this. Perhaps the choline bound to the fats in egg yolk makes it more absorbable. I've read that cdp choline has a half-life of 3 days, which causes it to accumulate rapidly in the system, leading to symptoms of overmethylation. I thought that perhaps to get an effect similar to that of eggs, you need to take a third of the equivalent choline, or take it once every three days.
As for omega-3, in the past I've benefited from eating salmon and taking supplements, but personally it hasn't had the same effect as eggs.

92

Lifestyle Diary and POIS Summaries / Re: Warrior's Journal (My POIS Management Protocol & Immune Strategies for Cure)

« Last post by Warrior on August 04, 2024, 06:34:41 PM »

Officially retiring my B complex (Nature's Own Ultra B 150 Forte). I think it no longer serves me and is unecessary. It still helps me in certain ways, but unfortunately makes me socially apathetic, which I confused for while as POIS symptoms.

Methylation nutrients are still very powerful for POIS. From here on, I will continue to supplement the most important onces (when needed) which have seemingly worked very well for me. I usually only take methyl nutrients 1-2x per week these days:

--B12 (methylcobalamin), Folate (folic acid), & B6
--Choline (by eating eggs)
--SAMe

I now need to confirm at some point that none of these actually cause me the side-effects I was experiencing when taking the B complex. This is why it's just so important to take breaks with supplements lol.

Also it's worth mentioning, whenever I stop taking methyl donors for a while, my tinnitus gets much much more worst. The only fix I have found to my tinnitus is methyl donors (B complex, SAMe etc)

93

General Alternative Causes and Treatments of POIS / Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs

« Last post by Warrior on August 04, 2024, 06:09:20 PM »

That's very encouraging kosmo35. I've not got going with benfotiamine (or TTFD) yet but I'm following this thread and I wish you the best with this treatment you are using.

I've read others say similar things about eggs on this forum so that's interesting too. I've always eaten plenty of eggs and definitely not planning to stop. Can we be sure it's choline and not the omega 3 that's important?

I'm not convinced it's 100% of the choline in eggs that are responbile for making us feel so good. I've tried many different types of choline supplementation and none of them come close to how eggs make me feel. They're truly nature's multivitamin with the amount of micronutrients packed into them. Strangely, phosphatidylcholine (the type of choline in eggs but also in liposomal vitamin C) makes me feel eerie when I take it through liposomal vitamin C, but not when I eat eggs. Eggs are a POIS superfood!

94

General Alternative Causes and Treatments of POIS / Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs

« Last post by Sisyphus on August 04, 2024, 02:43:43 PM »

That's very encouraging kosmo35. I've not got going with benfotiamine (or TTFD) yet but I'm following this thread and I wish you the best with this treatment you are using.

I've read others say similar things about eggs on this forum so that's interesting too. I've always eaten plenty of eggs and definitely not planning to stop. Can we be sure it's choline and not the omega 3 that's important?

95

General Alternative Causes and Treatments of POIS / Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs

« Last post by kosmo35 on August 04, 2024, 11:25:16 AM »

To answer Andre's questions, I am a man and I am 24 years old.
I take half a teaspoon of potassium bicarbonate which would be 2500 mg more or less. Using the molecular weight you can calculate the potassium portion, i.e. approximately 974 mg. The calculations come back with the data you reported, in fact the ratio between potassium and potassium bicarbonate is always 0.39.

96

General Alternative Causes and Treatments of POIS / Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs

« Last post by kosmo35 on August 04, 2024, 11:12:04 AM »

Hi everyone, sorry for the absence.
Things are going very well, even better since I switched from benfotiamine to TTFD. I take 2 capsules (100 mg) of the ecological formula's brand. It seems much more effective for cognitive symptoms.
I also discovered something interesting. For the last few months I have routinely eaten 2 eggs a day because it was part of those things that relieved my POIS symptoms in the past. A few weeks ago I stopped taking them because I thought it was no longer necessary. I've felt a lot of POIS symptoms return after orgasm, lack of libido and brain fog.
I started eating eggs again for 5 days and the engine surprisingly started running as before.
I then came across a video by Elliot Overton entitled "I fix my gut! Here's how" in which he explains that he solved his chronic disorders mainly through stimulation of the vagus nerve through TTFD, CDP choline and vitamin b5.
I'm starting to suspect that choline, a precursor of acetylcholine, has a lot to do with my ailments and that the success I've experienced is due to the synergistic action of egg choline and TTFD.

97

Hormonal Causes and Treatments / Re: Mast Cell Activation Syndrome

« Last post by Muon on August 04, 2024, 10:35:23 AM »

Researchers have discovered a hidden talent of mast cells: they can capture and use another type of immune cell called neutrophils. This surprising discovery sheds new light on how our immune system works, particularly during allergic reactions.
https://x.com/vipintukur/status/1819592020547326450

Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay

98

POIS Research / Re: POIS NORD RESEARCH STUDY

« Last post by Egyptian ahmad on August 04, 2024, 09:57:26 AM »

Update?
Also can i contact the doctors in the study? I am a doctor myself maybe i can provide insight.

99

POIS Research / Re: Muon's Case

« Last post by Warrior on August 02, 2024, 06:41:58 PM »

Hi Muon,

Have you tried high dose D3, like getting serum to at least 70ng/mL? And have you tried direct glutathione supplementation or NAC?

100

POIS Research / Re: Muon's Case

« Last post by Muon on August 02, 2024, 04:53:23 AM »

My grandma had positive effects from Enterosalicyl (also improved on birth control pills and on an unknown injected oral substance, probably endocrine related)
My mother gets benefit from ibuprofen
Aspirin helps my POIS.

It seems that the COX/AA pathway is involved.

The above females improved during pregnancy which indicate that hormonal changes affect this inflammatory pathway.