Recent Posts

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91
Auto-Immune Causes and Treatments / Re: Prednisone / Steroids
« Last post by BuckarooBanzai88 on April 12, 2025, 12:27:35 PM »
Just curious, what are your symptoms? Mine are very much like migraine so I take things that help with migraine and it helps, but you may fall into a different cluster.
92
POIS Research / Re: 2025 POIS SCIENTIFIC RESEARCH STUDY
« Last post by demografx on April 10, 2025, 07:52:48 AM »

Any news here?
The last post seems to be 17/3, which is today, but nothing seemingly new?


Hi Aladin,

The UCLA lab should be shortly ready to start recruiting/running healthy control participants - they are just waiting on a new temperature gauge [received!] - -  and the computer they are shipping from UNL’s lab to UCLA, to arrive on site there. The UCLA lab will be getting it shortly.
[received!]


These delays have been getting UNL to be able to use the POIS funds to place orders with the new vendor and to send them to a new address at UCLA. These are frustrating bureaucracies, but they exist to make sure your money is spent only as allowed.

UCLA unexpectedly asked UNL to pay the travel to POIS participants using their cash cards, which was not what UNL had approved. UNL needs to approve this and they need to request the cards. However, they can start the study without this, as they already have approval for all the control participants as it is (they are not paid travel).
93
POIS Research / Re: Great News - POIS Lab is Almost Ready for the Study !
« Last post by demografx on April 10, 2025, 07:52:15 AM »

Anyone knows about the progress of this study?

The lastest news we had is that the pilot study (testing all the settings and procedures with a few non-POISers test subjects) is about to begin in the coming weeks.  Just some supplies are missing, and some last minutes details with computers, sensors, equipments and else.   Stay tuned !


Thanks, Quantum!
94
What is POIS / Re: Is POIS a version of CFS?
« Last post by Quantum on April 09, 2025, 12:24:59 PM »
Hi Mr.Raba and others,
For those who have both CFS and POIS, see this very recent article on a method that is efficient for some CFS patients:
https://www.medscape.com/viewarticle/treating-fibromyalgia-repetitive-transcranial-magnetic-2025a10008e6?ecd=wnl_tp10_daily_250408_MSCPEDIT_etid7347602&uac=166466AT&impID=7347602

Would it be useful for POIS sufferers ?  I don't know. Maybe one day a research team will try it.   
95
Thank you so much for sharing. I wonder why ginseng helps so much, and if it will cure your pois.
How are you feeling now? Any updates?
96
Lifestyle Diary and POIS Summaries / Re: Warrior's Health Journal & POIS Protocol
« Last post by Warrior on April 08, 2025, 07:14:23 AM »
Since going keto and returning to AB, I have unlocked a new level of metabolic flexibility.

This has resulted in some significant changes in how my body works. I am able to get energy now from both fat and carbohydrates, whereas before, my body was stuck in a permanent state of carbohydrate burning for energy. This made sticking to animal-based really difficult. If I tried eating a fatty steak w/ fruit for example, I would get a severe headache, lethargy, etc.

I can now eat fat and fruit (carbs) together and my body is able to digest both relatively well, regardless of quantities. For example, I can eat a large fatty steak for lunch, and get immediate energy afterwards. Then 20 minutes later eat a big fruit bowel w/ orange juice and have no problems w/ energy or motabolism.

Some odd changes I have noticed since unlocking metabolic flexibility:

- I am able to tolerate methylfolate completely fine now. This was previously not possible.
- I no longer tolerate supplemental D3 (no idea why) - causes absolute havoc on my mind/dopamine. This may or may not be related to high dosages I've done in the past. Regardless, I opt for natural direct sunlight
- I respond well to salt for fixing most electrolyte issues - this was previously not the case, and never felt satisfactory to the 'keto flu' symptoms i used to experience. No matter how much sodium, potassium, or magnesium I took, I still had headaches, etc
- I am able to go longer periods of time without eating carbs. Previously this was not possible, I would feel physically sick and get severe headaches. However the trade off is that I do notice my mood tanks, which previously did not occur (probably because the physical symptoms acted as a feedback loop to encourage me to eat before mood tanking).
- No longer “need” red meat or eggs. I don’t notice much difference before or after eating them, aside for their macronutrient content and long term micronutrients. Whereas before, I would notice not feeling as good if I went days without eating red meat or eggs.

This makes eating strict animal-based much much easier, given I am able to derive energy from both fat and fruit carbs accordingly. I no longer need to take minimum 4 bananas daily when on strict AB. I can just eat fatty meat and fruit intuitively, deriving energy from both. My body is able to seemlessly flick between carb and fat burning as needed.

I still sense my body is able to deepen the metabolic flexibility. It's probably at around 85% efficiency for fat burning.
97
Hormonal Causes and Treatments / Re: Mast Cell Activation Syndrome
« Last post by Muon on April 04, 2025, 08:12:24 AM »
Topical Lidocaine
https://www.reddit.com/r/POIS/comments/1jqagge/lidocaine_use_for_pois_symptom_relief/
”…overuse can even cause death”, per above reddit poster - Demo

Effect of lidocaine on histamine release and Ca2+ mobilization from mast cells and basophils
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-6576.1996.tb05577.x

Quote
Our results indicate that lidocaine directly inhibits histamine release from both rodent mast cells and human basophils
no great evidence that mast cells do or do not play a role in POIS - - demografx



***Forum Administrator (demografx) note:***


AI Overview

Lidocaine, while a useful local anesthetic, poses several hazards, including potential for allergic reactions, cardiovascular complications like arrhythmias and hypotension, and central nervous system effects like seizures and coma, especially with overdose or misuse.
98
Though difficult to respond to very long stayed post, I believe that your problem is quite similar with me mainly in related to POIS and hyperthyroidism problem however your hypothesis of brain damage require a scientific proof. My hyperthyroidism is the outcome of autoimmune response. I didn't have any accident or trauma before but I primely developed POIS and hypothyroidism followed. I believe that  either mast cell activation by O or any other triggering factors could be the culprit. How is your condition now? how did you manage it?
99
POIS Research / Re: Great News - POIS Lab is Almost Ready for the Study !
« Last post by Quantum on April 02, 2025, 11:52:32 AM »
Anyone knows about the progress of this study?
The lastest news we had is that the pilot study (testing all the settings and procedures with a few non-POISers test subjects) is about to begin in the coming weeks.  Just some supplies are missing, and some last minutes details with computers, sensors, equipments and else.   Stay tuned !
100
What is POIS / Re: Is POIS a version of CFS?
« Last post by Pointpleasant88 on April 02, 2025, 11:09:48 AM »
When is the study finished did I hear correctly she said recruiting at the end of the year ?
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