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If I could tell you in one sentence I would have done so, but you have to see the whole process to understand how it all comes together. I am not exactly sure how much hypoxia is involved, but ROS is a certain culprit and there is clearly a glycolytic shift in our metabolism partly due to mitochondrial dysfunction. Mitochondrial dysfunction itself may come about due to a variety of reasons (e.g. sepsis, senescence, autoimmunity, etc). If we consider the treatments that we, ME/CFS and long covid patients have used with some degree of success, then it is easy to see that HIF-1a regulation is majorly involved in disease control. It is especially interesting to see that post-exertional malaise (PEM) in long covid patients last for about a week, similarly to a POIS episode, when there is a back shift towards oxidative phosphorylation. However the tricarboxylic acid (TCA) cycle remains impaired with somewhat elevated glycolytic metabolites even at baseline. This is quite relevant from my point of view as I have POIS/CFS and this exactly could explain the difference between my acute (dominated by POIS) and chronic phases (dominated by CFS).
The condition involves problems with how the body produces energy, often due to issues with the mitochondria. Some treatments for ME/CFS and long COVID focus on a protein called HIF-1a, which seems important for managing symptoms. The way energy shifts in the body during these conditions may explain the similarities between long COVID and POIS.
As I stated yesterday:
technical jargon can alienate readers
Alright! I won’t post about scientific matters in the future! It took away much of my time and I have more important things to do anyway. Hopefully our researchers are going to fully figure out POIS soon!
I can appreciat the effort you put into your posts, but this is a sulky attitude. In my everyday technical writing I also tend to overcomplicate things and go down endless rabbit holes of derivations. But most often brevity trumps endless elaborations, if you want to get a point across in scientific matters. As suggested earlier, in the future, you could restrict your posts to the key messages and put your intermediate reasonings into a text file attachment. This allows forum members to follow your arguments in-depth, if they wish.
As I stated yesterday:
technical jargon can alienate readers
Alright! I won’t post about scientific matters in the future! It took away much of my time and I have more important things to do anyway. Hopefully our researchers are going to fully figure out POIS soon!
As I stated yesterday:
technical jargon can alienate readers
Amazing. I'm still a little worried about AI but for us it's a fantastic tool. Have fun typing your name and you will see that he knows you better than you know yourself!I did what you suggested. Amazing, b_jim!
Latest post from Progec is ok, it is connected to a mater and wery
well summarized.
Enyone who want to understand what he is wroted, can easly learn
on google, yust can ask what it is.
• PINK1
• HIF-1alpha factors
• ME/CFS
• mitophagy
• mitochondria
• glycolytic metabolism
• hypoxia
• oxidative stress
• PEM induction