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General POIS Discussions / Re: Interesting observation - weed speeds up relief, weak reaction to MDMA
« Last post by freuemich on April 23, 2025, 07:32:55 PM »I'm much less sensitive to magic mushrooms than the average person.
POISCENTER
Welcome to POISCenter, the largest information and support forum for Post Orgasmic Illness Syndrome (POIS)
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ABOUT THE POIS STUDY:
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ABOUT THE POIS STUDY:
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Recent Posts
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POIS Research / Re: Google POIS Alerts
« Last post by demografx on April 23, 2025, 11:48:13 AM »Google: POIS Alert
About forum member Animus’ surgical treatment for his POIS.
Correspondence
Published: 22 April 2025
A radical approach to treating post-orgasmic illness syndrome: a correspondence
https://www.nature.com/articles/s41443-025-01071-0
Nature.com is considered a highly prestigious platform for scientific publications
About forum member Animus’ surgical treatment for his POIS.
Correspondence
Published: 22 April 2025
A radical approach to treating post-orgasmic illness syndrome: a correspondence
https://www.nature.com/articles/s41443-025-01071-0
Nature.com is considered a highly prestigious platform for scientific publications
3
Lifestyle Diary and POIS Summaries / Re: Warrior's Health Journal & POIS Protocol
« Last post by Aladin on April 23, 2025, 11:04:31 AM »Another member just launched this:
https://poiscenter.com/forums/index.php?topic=4699.0;topicseen
https://poiscenter.com/forums/index.php?topic=4699.0;topicseen
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POIS Research / Re: Open Microbiome Initiative: ?ollect POIS gut data and look for common patterns
« Last post by Aladin on April 23, 2025, 11:01:57 AM »Great initiative !
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General POIS Discussions / Re: drop24's complete remission of POIS for 1 year+
« Last post by Quantum on April 23, 2025, 07:18:31 AM »I read that Milnacipran worked well for you. You said it was 8/10.Hi freuemich,
How many times did you try Milnacipran with good results and why did you change from Milnacipran to TRT + Escitalopram?
In my POIS Types Chart, those who are reported to have success with milnacipran ( the refererence members) are Hurray and Jan. Personally, I never took milnacipran.
My chart data is collected from testimony and post from members. My own method to control my POIS symtpoms is found at #6 in the chart ( pre-pack with IDO/TDO/NMDAr blockers+ anti-oxidants).
Sorry, Quantum. I was reffering to drop247
https://poiscenter.com/forums/index.php?topic=3312.msg36346;topicseen#msg36346
Ok, no problem, I supposed it was possibly the case. However, Drop247 did not make any update on milnacipran, and never ended being a "reference member" for it, so I supposed that it may had lost effectiveness, or that side effects showed up. It would be interesting to read his answer to your question.
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POIS Research / Open Microbiome Initiative: сollect POIS gut data and look for common patterns
« Last post by Grisha on April 23, 2025, 06:52:13 AM »Hey everyone,
I?ve been living with POIS for a while, and like many here, I?ve gone deep into theory-hopping, forum diving, and trial-and-error protocols.
I?m a scientist by education and a data analyst by profession.
Recently, I started to suspect that POIS in my case is strongly tied to gastrointestinal imbalance ? particularly gut microbiota composition.
I?ve read the Dysbiosis/SIBO/SIFO references in the POIS hypothesis lists, and I believe it?s time we try to collect actual data to see if something unites us ? or at least a subset of us ? on the microbiome level.
🔍 Here?s what I propose:
Let?s start a crowdsourced microbiome comparison project:
If you?ve done a gut microbiome test (like from Genova, Viome, Atlas Biomed, Genotek, BiomeFx, etc.)
And you?re willing to share anonymized results ? great.
No need to post your name. Just the results (PDF/CSV/screenshot) and some basic metadata, like:
Age / gender
POIS duration
Key symptoms
When test was done
Once I get enough data (even 10?20 samples), I?ll compare it to open-access healthy microbiome databases like HMP, American Gut, GMrepo, etc.
🎯 Goal:
See if there are common microbiome traits in POIS sufferers (e.g., lack of butyrate-producing bacteria, SIBO patterns, high enterobacteria, low diversity, etc.)
Try to define POIS-associated microbial fingerprints that could be tested and tracked
Possibly this info can help someone to find better treatment through targeted pre/pro/postbiotics or even antibiotics or whatever helps.
✅ What I?ll do with the data:
Aggregate and anonymize it
Analyze bacterial abundances and compare across POIS users and healthy controls
Publish results here for open discussion
If there?s interest ? maybe even write a summary report we can share more widely
If you want to share, comment below or DM me. I?ll create a Google Form soon to help structure submissions.
If this sounds interesting to you ? or if you have ideas on how to improve it ? I?d love your input.
Let?s stop guessing in the dark. If the gut plays a role in POIS, the data will show it.
Thanks for reading 🙏
Grisha
I?ve been living with POIS for a while, and like many here, I?ve gone deep into theory-hopping, forum diving, and trial-and-error protocols.
I?m a scientist by education and a data analyst by profession.
Recently, I started to suspect that POIS in my case is strongly tied to gastrointestinal imbalance ? particularly gut microbiota composition.
I?ve read the Dysbiosis/SIBO/SIFO references in the POIS hypothesis lists, and I believe it?s time we try to collect actual data to see if something unites us ? or at least a subset of us ? on the microbiome level.
🔍 Here?s what I propose:
Let?s start a crowdsourced microbiome comparison project:
If you?ve done a gut microbiome test (like from Genova, Viome, Atlas Biomed, Genotek, BiomeFx, etc.)
And you?re willing to share anonymized results ? great.
No need to post your name. Just the results (PDF/CSV/screenshot) and some basic metadata, like:
Age / gender
POIS duration
Key symptoms
When test was done
Once I get enough data (even 10?20 samples), I?ll compare it to open-access healthy microbiome databases like HMP, American Gut, GMrepo, etc.
🎯 Goal:
See if there are common microbiome traits in POIS sufferers (e.g., lack of butyrate-producing bacteria, SIBO patterns, high enterobacteria, low diversity, etc.)
Try to define POIS-associated microbial fingerprints that could be tested and tracked
Possibly this info can help someone to find better treatment through targeted pre/pro/postbiotics or even antibiotics or whatever helps.
✅ What I?ll do with the data:
Aggregate and anonymize it
Analyze bacterial abundances and compare across POIS users and healthy controls
Publish results here for open discussion
If there?s interest ? maybe even write a summary report we can share more widely
If you want to share, comment below or DM me. I?ll create a Google Form soon to help structure submissions.
If this sounds interesting to you ? or if you have ideas on how to improve it ? I?d love your input.
Let?s stop guessing in the dark. If the gut plays a role in POIS, the data will show it.
Thanks for reading 🙏
Grisha
7
Lifestyle Diary and POIS Summaries / Re: Warrior's Health Journal & POIS Protocol
« Last post by Warrior on April 23, 2025, 04:20:40 AM »It would be interesting to have a representative sample of POIS'ers to take the OAT-test and to see wether we all have candida-traces...
It would absolutely make sense that if there's a yeast infection in the prostate....
I actually had 2 specialists before doing the OAT suspect Candida, and one of them mentioned the possibility of a Candida/fungal overgrowth in the prostate. I also sense that POIS is more than just a Candida/fungal overgrowth in the GI. I have a sense it's deeper in the body. Prostate would make sense.
One of them was a Dr specialising in low carb, and he actually put me on oregano oil, burberin etc but I didn't follow through as I didn't completely trust his direction.
Would be very interesting for everyone with POIS to do an OAT test during peak POIS symptoms.
As I've mentioned in previous posts, I hit many of the hallmark symptoms/characteristics for Candida/fungal overgrowth. Long history of fungal issues. So it's all adding up really. I actually briefly remember that before I got POIS, I cleared a 10 year fungal toe nail with Terbinafine. I wonder if it 'cleared' the fungal in the toe, but pushed the fungal deeper into other parts of my body causing POIS.
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General POIS Discussions / Re: drop24's complete remission of POIS for 1 year+
« Last post by freuemich on April 22, 2025, 07:18:23 PM »I read that Milnacipran worked well for you. You said it was 8/10.Hi freuemich,
How many times did you try Milnacipran with good results and why did you change from Milnacipran to TRT + Escitalopram?
In my POIS Types Chart, those who are reported to have success with milnacipran ( the refererence members) are Hurray and Jan. Personally, I never took milnacipran.
My chart data is collected from testimony and post from members. My own method to control my POIS symtpoms is found at #6 in the chart ( pre-pack with IDO/TDO/NMDAr blockers+ anti-oxidants).
Sorry, Quantum. I was reffering to drop247
https://poiscenter.com/forums/index.php?topic=3312.msg36346;topicseen#msg36346
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General POIS Discussions / Re: drop24's complete remission of POIS for 1 year+
« Last post by Quantum on April 22, 2025, 05:34:18 PM »I read that Milnacipran worked well for you. You said it was 8/10.Hi freuemich,
How many times did you try Milnacipran with good results and why did you change from Milnacipran to TRT + Escitalopram?
In my POIS Types Chart, those who are reported to have success with milnacipran ( the refererence members) are Hurray and Jan. Personally, I never took milnacipran.
My chart data is collected from testimony and post from members. My own method to control my POIS symtpoms is found at #6 in the chart ( pre-pack with IDO/TDO/NMDAr blockers+ anti-oxidants).
10
POIS Research / Re: A New Survey
« Last post by Aladin on April 22, 2025, 02:24:39 PM »Any news / results from your research?