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11

Poll Center / Re: Neutrophils

« Last post by Hopeoneday on November 28, 2024, 06:06:50 PM »

On medical test results topic:
I found 13 from 14 hawe neutropenia or low end neutrophils count.
Found 9 others who reported low white blood cells.

From thouse 9 who reported low white blood cells,
i can bet 99% of them are low neutrophil count, neutropenia.

Exemple, result 3,6 from range 3,5-7 is considered in range,
normall, but actualy it is not normall to hawe lower end neutrophils
count.
This neutrophils count data talk something to us, it is repeating in
poisers.

12

POIS Research / Re: Gather and Post Here Your Medical Tests Results

« Last post by Hopeoneday on November 28, 2024, 05:25:46 PM »

Another poiser with neutropenia, lower end neutrophils count.

- Year of Birth: 2002
- Gender/Age: Male / 22 years
- Test Date: 2024-07-09

## CRP Test (Quantitative) - SERUM
- Result: < 1.0 mg/l
- Reference Range: 0 - 5 mg/l
- Status: Normal

## Total IgE - SERUM
- Result: 62 IU/ml
- Reference Range: Up to 100 IU/ml
- Status: Normal

## RF Test (Quantitative) - SERUM
- Result: < 20.0 IU/ml
- Reference Range: Up to 30 IU/ml
- Status: Normal

## Complete Blood Count (CBC) with Reticulocytes and Manual Differential - VENOUS BLOOD (EDTA)

### Red Blood Cell Parameters
- Erythrocytes: 4.73 million/?l (Reference: 4.5 - 5.
- Hemoglobin: 14.2 g/dl (Reference: 13.5 - 17)
- Hematocrit: 41.8% (Reference: 40 - 53)
- MCV: 88.4 fl (Reference: 82 - 100)
- MCH: 30.0 pg (Reference: 27 - 31)
- MCHC: 34.0 g/dl (Reference: 31 - 36)
- RDW-CV: 12.8% (Reference: 11.5 - 14)
- RDW-SD: 41.4 fl (Reference: 37 - 50)

### White Blood Cell Parameters
- Leukocytes: 5.10 thousand/?l (Reference: 4.5 - 10.5)
- Neutrophils: 54.5% / 2.78 thousand/?l (Reference: 50-70% / 2.7-6.5)
- Eosinophils: 4.3% / 0.22 thousand/?l (Reference: 1-5% / 0.1-0.5)
- Basophils: 0.4% / 0.02 thousand/?l (Reference: 0-1% / 0-0.1)
- Lymphocytes: 32.2% / 1.64 thousand/?l (Reference: 25-45% / 1.5-3.7)
- Monocytes: 8.4% / 0.43 thousand/?l (Reference: 1-12% / 0.2-0.9)
- Immature Granulocytes: 0.2% / 0.01 thousand/?l (Reference: 0-2.5% / 0-0.03)

### Platelet Parameters
- Platelets: 304 thousand/?l (Reference: 150 - 400)
- PCT: 0.33% (Reference: 0.2 - 0.5)
- MPV: 10.9 fl (Reference: 8 - 12)
- PDW: 13.8% (Reference: 8 - 18)
- P-LCR: 32.8% (Reference: 13 - 43)

### Reticulocytes
- Reticulocytes #: 0.0582 10^6/?l (Reference: 0.02 - 0.1)
- Reticulocytes %: 1.23% (Reference: 0.5 - 2)
- IRF%: 7.3% (Reference: 2 - 17)
- RET-He: 32.8 pg (Reference: 28 - 35)

## Full Liver Panel - SERUM

### Autoantibody Tests
- ANA (IIF): NEGATIVE
  - No antinuclear and anticytoplasmic antibodies detected at 1:100 dilution
- Anti-Smooth Muscle Antibodies (ASMA): NEGATIVE
- Anti-Mitochondrial Antibodies (AMA): NEGATIVE
- Anti-Liver Kidney Microsomal Antibodies (anti-LKM): NEGATIVE
  - No AMA, ASMA, anti-LKM antibodies detected in IgG class at 1:100 dilution

13

General POIS Discussions / Re: Free Flow Discussion about POIS

« Last post by demografx on November 28, 2024, 11:40:59 AM »

My most recent POIS attack was yesterday morning, so I decided (with the aid of OTC meds, such as Tylenol) to sleep or fully rest/eyes closed/in bed, till now, nearly 24 hours later. I feel much better, so I asked PerplexityAI:

My Question:”Can sleeping almost 24 hours hasten treatment for some flulike disorders?”

PerplexityAI Answer:”Sleeping for extended periods, such as nearly 24 hours, can aid recovery from flulike illnesses by boosting the immune system. Sleep promotes the production of cytokines, proteins that help fight infections, and supports energy redirection to immune processes. However, while sleep is beneficial, there is no specific evidence suggesting that sleeping almost 24 hours hastens treatment for flulike disorders beyond normal recovery processes. If symptoms persist despite adequate rest, it is advisable to consult a healthcare professional.”

https://www.perplexity.ai/search/can-sleeping-almost-24-hours-h-tPaDgn0YTC2cpqJAyj2ylw

14

What is POIS / Re: An idea for pois awarnes

« Last post by Robson on November 27, 2024, 07:12:49 PM »

I've been thinking a lot about this syndrome lately. I think that in order to find a cure, we're going to have to confess and ask God and the world for help, or we'll never find a cure.

15

Lifestyle Diary and POIS Summaries / Re: Warrior's Journal (My POIS Protocol)

« Last post by Warrior on November 27, 2024, 06:55:14 PM »

Zinc (LifeExtension's OptiZinc) improves mood a lot. Copper and managnese supplementation do not deliver same benefit (at least in my immediate observations of beginning to take them), even though copper is also low in bloods and manganese consumption is low on AB. Classic nutrient been in my protocol for a while, but I dont take it daily to not cause imbalances. I would have also thought all the red meat I eat would give me enough zinc, but clearly not - which probably more likely suggests POIS inflammation depletes zinc faster than normal.

Copper and zinc are both low in bloods so I began taking it. Wonder if POIS depletes zinc faster than normal. Zinc & mag have also anecdotally improved POIS in the past. Will take zinc daily for a while to build up lvls, as well as copper 2mg to inc both minerals and keep ratio in check. Zinc and copper ratio appears to be important for POIS and immune health in general.

Latest mineral test results:

 Copper 13 umol/L (11-22)
 Zinc 13.9 umol/L (10.0-18.0)
 Selenium 1.65 umol/L (0.80-1.90)

Comprehensive nutritional testing is KING. Chris Masterjohn has an extensive pdf on this. If you have the money, I'd get comprehensive nutritional testing done ASAP. Nutrients play such a huge role when it comes to improving POIS symptoms & overall health/wellbeing. Can see status of many major immune nutrients & replenish before they get too low causing further symptoms i.e., glutathione, D3, minerals zinc, copper, selenium, nutrients vitamin A, E, etc. Co-factor minerals, nutrients, amino acids i.e., taurine, cysteine, rate-limiting nutrients etc.

The problem is money.

16

General Alternative Causes and Treatments of POIS / Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs

« Last post by Warrior on November 27, 2024, 08:09:09 AM »

Good luck with TTFD Warrior. That would be great if it works for you.
It will be interesting to hear how you get along with TTFD compared with the thiamine supplements you have taken previously. I wonder if you will get the so called paradoxical reaction (I didn't experience this).

From what I've read about people taking thiamine supplements (in various forms) to combat other illnesses ex/ CFS etc, anecdotal reports claim that approx. 2 out of 3 people have typically reported benefits from the extra thiamine, especially with fatigue. That's a decent outcome but only anecdotal, there seems to be almost no medical research.
I believe high dosage thiamine was first experimented with in this way in Parkinson's Disease patients by Constantini about 20 years ago, reporting good results (mainly with fatigue), which then led to others trying it for other illnesses in more recent years. However, so far, it's not led to any significant research.
As for POIS, with so few of us reporting results on this thread so far, I think it's unclear how much thiamine supplements help with POIS.

Thiamine has definitely improved my mood since restarting it, but I haven’t really taken super large megadoses. Only 100-200mg per day, mostly 100mg though. Not sure if I will try mega dosing beyond that, but so far it is with certainty 100% helping my mood be better in general. Didn’t 100% fix my strange reaction to electrolytes (yet), but I’m also taking zinc, copper, and manganese atm which they also all appear to be helping as well on that end. Zinc most notably improves mood/dopamine. But too early to say anything on that front.

I don’t think I’ve noticed anything anecdotally different from taking regular thiamine to TTFD. I’m pretty sure just taking my regular old 150 B Forte with thiamine nitrate 150mg achieved similar therapeutic benefits but I don’t know for sure. I had to stop taking it as it was giving me side effects and my B12, folate, and B6 were all high. Today I just took a smaller B complex by the same brand who makes the 150 Forte and I think it complimented the thiamine well.

17

General Alternative Causes and Treatments of POIS / Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs

« Last post by Sisyphus on November 27, 2024, 05:49:05 AM »

Good luck with TTFD Warrior. That would be great if it works for you.
It will be interesting to hear how you get along with TTFD compared with the thiamine supplements you have taken previously. I wonder if you will get the so called paradoxical reaction (I didn't experience this).

From what I've read about people taking thiamine supplements (in various forms) to combat other illnesses ex/ CFS etc, anecdotal reports claim that approx. 2 out of 3 people have typically reported benefits from the extra thiamine, especially with fatigue. That's a decent outcome but only anecdotal, there seems to be almost no medical research.
I believe high dosage thiamine was first experimented with in this way in Parkinson's Disease patients by Constantini about 20 years ago, reporting good results (mainly with fatigue), which then led to others trying it for other illnesses in more recent years. However, so far, it's not led to any significant research.
As for POIS, with so few of us reporting results on this thread so far, I think it's unclear how much thiamine supplements help with POIS.

18

Lifestyle Diary and POIS Summaries / Re: Reality

« Last post by Meshal on November 27, 2024, 04:54:05 AM »

I came to the same realization two years ago. I was quite sad at first, but then kept reminding myself that we are humans, we adapt with whatever card we're dealt with. And POIS is the card we're dealt with in life.
I started to think of it as an extra limb of my body, something I'll live with and take to my grave. Thus I adjusted my entire outlook of life accordingly. Kept my expectations in check, abandoned any grand ambitions and dreams I would've accomplished had I been cured. And focused just on how to lead a balanced life to get the most joy out of it.

Abandoning is a harsh word, but I seen many people like Quantum in this forum who despite the worst that come out of pois, you can come out of it just fine. You'll just have to live with whatever treatments work for you. Some took 5 years, others took 10 or 20 or even 30. These guys fill me with inspiration that at the end of this road, a balanced life is waiting for me. Yeah it is not perfect, but it's the card we're dealt with.

Only after reaching the balanced life goal I might think of chasing any grand ambitions or dreams left, where POIS wouldn't affect me emotionally that much.

Thanks to this mindset, I can now focus more on treatments accurately instead of the cure.

In the past I would abandon the experiments quickly even if the treatment works partially, because I was so obsessed in the idea of CURE that I would dismiss anything else. But now that I put the idea of a 'CURE' is out of the picture, I can focus, analyze, and execute experiments more thoughtfully and come out with actual results. My mindset right now is more of a "If I mix treatment A that worked and treatment B then C, it might lead me to a balanced life where I choose the RIGHT time for me to suffer the symptoms, and recover from them as fast as possible", instead of the mindset of "if this treatment doesn't cure me, I willl abandon all hope."

19

General Alternative Causes and Treatments of POIS / Re: Thiamine Megadoses (Vitamin B1) and Thiamine Analogs

« Last post by Warrior on November 26, 2024, 05:57:35 PM »

I used to take a 150 B Forte Complex almost daily, sometimes twice daily (https://www.chemistwarehouse.com.au/buy/124176/nature-s-own-ultra-b-150-forte-60-tablets). This contains 150mg of thiamine nitrate per pill. This supplement was so transformative for my POIS, I took it for years. I could never find another B complex that made me feel so damn good. I could never really figure out what within it was so responsible for the medicinal benefits.

I always put it's medicinal effects down to replenishing methyl donors, but now I'm not convinced thats the whole picture.

I had to stop the B complex recently because it began giving me side-effects. Just making me more apathetic/anhedonic than usual. I took this as too many methyl donors and probably running out of certain nutrients that are methyl buffers. I also got lots of bloodwork done recently, and it all showed adequate B6, high B12 and folate. So I knew my methyl donors were adequately replenished. I eat and eggs and meat very frequently as well. So I stopped taking it and felt fine for a while, until recently began noticing my mood has been really off. Taking electrolytes seemed to exascterbate the problem as well, as I had just recently switched to keto which has been a gamechanger for my libido and energy. Every time I took potassium and magnesium, my mood would become more apathetic and less motivated.

I've always seemed to have electrolyte issues even on AB, and now that I was reacting to electrolytes after 4-5 weeks of no issues, I decided to research and came across thiamine as an important nutrient for regulating electrolytes.

3 days ago I finally decided to take TTFD 100mg and am already experiencing a significant improvement in mood and energy. I don't know for sure, but I'm more bullish than ever that thiamine is really important for our condition. Not to mention all the interesting thiamine megadosing info for complex chronic diseases i.e., POTS, long-covid, etc.

I seem to also be tolerating my electrolytes better as well, but this whole thing will probably be a work in progress for a while too. In hindsight though, I think I was actually megadosing B1 (150-300mg per day) through my B complex unknowingly. That was probably providing a lot of medicinal benefit that I over attributed to methyl donors.

Basic plan at this point is to take a moderately dosed B complex vitamin maybe 1-3x per week, but thiamine daily for a while. Eventually maybe switch thiamine to every 2nd day or so. Will come to understand it all better with time.

20

General POIS Discussions / Re: Covid 19 Long Haulers

« Last post by Progecitor on November 26, 2024, 03:27:35 PM »

Earlier this year (February) I had a covid infection once again. It wasn’t anything bad, as it felt like a regular illness. I had a sore throat for about a week, but it wasn’t strong. Around the third week I had the usual covid eye, which means that one of the eyes was very bloodshot for almost a week and it was not resolving even when taking supplements that usually help at least a little and temporarily. Around this time I also lost the sense of smell as I breathed into a coffee bag and couldn’t feel anything at all, which is also indicative of covid.
Around two months ago (October) I caught covid once again. This time the sore throat was even less of a problem, however my voice was very thin for about a week. Some of my relatives and acquaintances also had very thin voices for days. The enlarged lymph nodes on my neck got even bigger in the beginning. The infection lasted for almost a month and my colleagues also complained about their condition to be not resolving. They also complained about joint pain and at least one colleague about the loss of smell. Around the third week I got the covid eye again. The left eye was really bloodshot even though the right eye was fairly alright. Depression also felt worse in conjunction. Even though I had been taking a lot of supplements that were usually useful for bloodshot eyes, only a marginal improvement was seen. Once again this lasted for almost a week, when the usual supplements became noticeably more effective and the recovery was rather rapid afterwards.
While I catch the covid infection rather frequently, I could not note any permanent deterioration at least apart from the first infection.